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A Novel Dermoscopic Probe for Determining Elasticity Measurements of the Skin. Group 7: Erica Bozeman Markesha Cook Stephanie Cruz January 24, 2007. Design Objective. - PowerPoint PPT Presentation
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A Novel Dermoscopic Probe for Determining Elasticity
Measurements of the Skin
Group 7:Erica BozemanMarkesha CookStephanie Cruz
January 24, 2007
Design Objective "Structural alterations within cancerous skin-lesions
cause unexpected patterns of anatomical deformation in response to mechanical forces."
Dr. Michael Miga
Hypothesis:If structural alterations in skin cancer lesions differs from that of normal skin when a mechanical force is applied, then a systematic method of measuring the force response of a skin lesion can be compared to that of normal skin to determine the presence of skin cancer.
Conduct phantom experiments Design skin-friendly stretching apparatus Develop systematic method of testing skin forces
Skin Cancer Types of skin cancer
Basal Cell carcinoma Squamous cell carcinoma Melanoma
Facts and Statistics Over 1 million new cases of
skin cancer diagnosed in US (2006)
1 American dies of melanoma every 67 minutes
Treating melanoma costs about $740 million each year
World Health Organization 60,000 deaths worldwide/yr 48,000 melanoma; 12,000
other
http://images.main.uab.edu/healthsys/ep_0137.jpg
http://www.aad.org/aad/Newsroom/2005+Skin+Cancer+Fact+Sheet.htm
Current Methods of Detection Clinical eye
Accuracy varies with experience Biopsy
Dermoscopy 10X magnification, liquid
polarizing lens Only ~75-80% accurate
Serial photography Software expensive (~30,000) Slow Specialty clinics
In vivo confocal microscopy Experimental
http://www.jfponline.com/images/5206/5206JFP_AppliedEvidence-fig4.jpg
Dermatologist Recommendations
Dr. Darrel Ellis Faster More accurate Less expensive
Ideal device Small enough to carry in pocket and use with one hand
Our Proposed Device
Safe Easy Non-invasive Quick Effective Cost-efficient
Force Sensor
Initial Design:
Sony XCD-X710CR camera
Mild Skinadhesive
Potential Design
SKIN25.4
mm
Sony XCD-X710CR camera
Mild Skinadhesive
Force Sensor
130 mm
FOV: 32mm
Design Specifications:Ultra-Low Profile Load Cell - S215 Strain Gauge Technology
Mechanical motion electronic signal
Measures up to 8 N (2 lb-force)
Dimensions: 27.94 x 5.99 mm (1.1
x .236 in) Rigidly mounted on
platform beam Cost:$155
Using the PDE Toolbox:
Assessing the Expected Outputs of
our Device
Step 1:
Step 2:
Melanoma
Е ≈ 52 kPa
ν ≈ 0.485
Normal Skin
Е ≈ 10 kPa
ν ≈ 0.485
Colormap of Stress in the X-direction
σx= Force/ Area
σx ≈ 18 kPa
Area=0.01m x .02m
Force ≈ 3.6 N
Now Let’s Compare the Geometric Shapes:
Rectangular CrescentCube
Budget
Force Sensor $155.00
Probe Materials $50
3M Micropore Surgical tape $10.00
Important Design Dates
End of January Finalize Device Design
Mid February Independent Testing Completed
End of February Device Built
Mid March Comparative analysis using Dr. Miga’s model
April Finalize results; prepare for design presentation
References www.skincancer.org http://www.eurekalert.org/pub_releases/2006-10/osoa-ltt
101606.php http://www.smdsensors.com/detail_pgs/s100.htm http://www.omega.com/literature/transactions/volume3/s
train.html M. I. Miga, M. P. Rothney, J. J. Ou, "Modality independent
elastography (MIE): Potential applications in dermoscopy", Medical Physics, vol. 32, no. 5, pp. 1308-1320, 2005.
Tsap, Leonid V. et al. Efficient Nonlinear Finite Element Modeling of Nonrigid Objects via Optimization of Mesh Models. Computer Vision and Image Understanding. Vol 69, No. 3 March 1998 pp. 330-350.
Wan Abas, W.A.B and J.C. Barbenal. Uniaxial Tension Test of Human Skin In Vivo. J. Biomed. Engng. Vol 4 January 1982 pp.65-71.
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