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A Biomimetic Electrostatic Imaging System Proposed for Real-time In-vivo Surgical Guidance of Tumor Resection
Jonathan Friedman, PhD, Peyman Golshani, MD/PhD, Mani Srivastava, PhD
Networked and Embedded Systems Laboratory / Golshani Laboratory for Neuroscience --- University of California, Los Angeles.
Contact Information
Jonathan Friedman, PhD – [email protected] Golshani, MD/PhD – [email protected] Srivastava, PhD – [email protected]
Networked and Embedded Systems Laboratory (NESL)http://nesl.ee.ucla.edu
Golshani Laboratory for Neurosciencehttp://golshanilab.neurology.ucla.edu/
Golshani LabDepartment of NeurologyDavid Geffen School of Medicine, UCLA
Mark M. Souweidane, MDNewYork-Presbyterian Hospital/Weill Cornell Medical Center
Future Work: Reduce Size and Scale of Electrodes
Results: World’s First Biomimetic Electrostatic Imager
The Problem: “Inoperable” Brain Tumors
Proposed Approach: Biomimetic Electrostatic Imaging
Generating the Background Field (in the Ocean)
Modeling the Disturbance Field
Background FieldBackground Field Conductive Object (Induced Dipole) In Field
Conductive Object (Induced Dipole) In Field
Disturbance Field Caused by Object
Disturbance Field Caused by Object
Disturbance as Observed by Different Electrode Pairs
Disturbance as Observed by Different Electrode Pairs
11 22
33
“Electric” Fish Detect Changes to a Self-
Generated Electric Field
“Electric” Fish Detect Changes to a Self-
Generated Electric Field
Calibration and Compensation
ExpectedExpected
ObservedObserved
CalibrationCalibration
CompensationCompensation
Induced Dipoles Rotate in the FieldInduced Dipoles
Rotate in the Field
Model is Fit to Tank Measurements
Model is Fit to Tank Measurements
Custom Gantry & Cantilever
Custom Gantry & Cantilever
“Large” Scale Target Tank Trials
Metal Pipe (Target)
Metal Pipe (Target)
Gantry Moves Target
Gantry Moves Target
Imager’s ElectrodesImager’s Electrodes
Each Card Supports 17 Electrodes
Each Card Supports 17 Electrodes
68 Total Electrodes68 Total
Electrodes
Multiple BEI Units Can Connect to the Same Host
Multiple BEI Units Can Connect to the Same Host
Inexpensive Disposable Flex-PCB Electrodes
Inexpensive Disposable Flex-PCB Electrodes
High Density AlphaSTAR Coated Electrodes
High Density AlphaSTAR Coated Electrodes
Preparing for Real-time Imaging in Awake Behaving
Animal Models
Preparing for Real-time Imaging in Awake Behaving
Animal Models
2-Photon uScope Provides Reference2-Photon uScope
Provides Reference
Craniotomy for Electrode AccessCraniotomy for
Electrode Access
Rig Images Courtesy Jiyoung Park
World’s First 16 Electrode BEI Images
Pipe Target Nearing Edge of Electrode Array – Accuracy Degrades
Pipe Target Nearing Edge of Electrode Array – Accuracy Degrades
Actual Location of Pipe Target
(Yellow Circle)
Actual Location of Pipe Target
(Yellow Circle)
Cross Section View of Tank at Depth
Cross Section View of Tank at Depth
Pipe Target Beyond Sensor Array – Accuracy Degrades Substantially
Pipe Target Beyond Sensor Array – Accuracy Degrades Substantially
White Pixels Show Areas of Increased Conductivity
White Pixels Show Areas of Increased Conductivity
Real-time Functional Imaging of Cardiac Conduction
ABSTRACT: Electric Field Disturbance Imaging
Conductivity of Tumor Tissue is 10x Lower than
Normal Brain Tissue
Conductivity of Tumor Tissue is 10x Lower than
Normal Brain Tissue
The Brain!The Brain!
State of the Art Neuroprobes Destroy
Tissue and Cannot Image
State of the Art Neuroprobes Destroy
Tissue and Cannot Image
Goal: Provide Simultaneous Real-Time Functional and Anatomical Imaging of Brain Tissue Using Quasi-Static Electric Fields
CurrentCurrent ProposedProposed
Determine Spatial Conductivity of Tissue from Disturbance to
Self-Generated Electric Field (like
MRI)
Determine Spatial Conductivity of Tissue from Disturbance to
Self-Generated Electric Field (like
MRI)
Surface Probe (non-destructive)Surface Probe
(non-destructive)
Tumor Clearly Visible on MRI, BUT…
Tumor Clearly Visible on MRI, BUT…
…MRI Structure and RF Transducers Preclude Real-time Use in OR
…MRI Structure and RF Transducers Preclude Real-time Use in ORStereotactic Camera Systems Register
the Patient to the MRI – ineffective once the tissue resection begins
Stereotactic Camera Systems Register the Patient to the MRI – ineffective once
the tissue resection begins
Better Boundary Guidance Would Yield Better Outcomes & Enable Resections Currently Considered
Too High Risk
Better Boundary Guidance Would Yield Better Outcomes & Enable Resections Currently Considered
Too High Risk
The Same Approach Could Be Used to Visualize the Conductive (Purkinje)
Fibers -- Reducing 8 Hour Guess-and-Check Catheterization Lab Procedures
to Less Than One Hour While Guaranteeing Efficacy of Treatment
The Same Approach Could Be Used to Visualize the Conductive (Purkinje)
Fibers -- Reducing 8 Hour Guess-and-Check Catheterization Lab Procedures
to Less Than One Hour While Guaranteeing Efficacy of Treatment
Fluroscope Imagery is Non-Functional and Cannot Visualize the Relevant Anatomy
Fluroscope Imagery is Non-Functional and Cannot Visualize the Relevant Anatomy
Fluroscope Uses Ionizing Radiation – Proposed Approach is Intrinsically
Safe
Fluroscope Uses Ionizing Radiation – Proposed Approach is Intrinsically
Safe
o>10,000 Sample PointsoOver 6 Hours of MeasurementoHighest Resolution Study Published
o>10,000 Sample PointsoOver 6 Hours of MeasurementoHighest Resolution Study Published
