8. EU projects - Reaching-Out – Ebola Crisis Demonstration

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Date:Classification: Reference:

This document is produced under the EC contract 700151. It is the property of the Reaching Out consortium and shall not be distributed or reproduced without the formal approval of the Reaching Out Steering Committee

“RESTRICTED” - Restricted circulation to a limited number of consortium members (including the

Commission Services) – EU Project1

Date:Classification:Reference:

1“CONFIDENTIAL” only for members of the consortium (including the Commission Services) – EU Project

DEMONSTRATION OF EU EFFECTIVE LARGE SCALE THREAT AND CRISIS MANAGEMENT OUTSIDE THE EU (REACHING-OUT)

EBOLA CRISIS DEMONSTRATION, DECEMBER 10-13, 2018, CONAKRY (GUINEA)

Olga VYBORNOVA, Jean-Luc GALACTMA-UCL

A European Commission H2020 ProgrammeThis document is produced by the REACHING OUT consortium and the research leading to these results has received funding

from the European Community’s H2020 Framework programme (H2020-DRS-2015) under grant agreement no 700151

BrusselsPANDEM Final Conference

March 15, 2017

Scenario with complex intricated deadly diseases

in Conakry, Guinea

Need for quick differential diagnosis

Ebola Hemorraghic Fever (outbreak)

Lassa HF (Guinea endemic disease)

Yellow Fever (imported cases)

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Rationale for the scenario: 1st deployment& diagnostic support to Africa (DRC)

- Strengthening local Dx capabilities

(infectious diseases) in South Kivu

province (Bukavu DR Congo) since 2012.

- NGS assessment of local pathogens:

V.cholerae; ESBL-producing Enterobacteria

Bukavu

- Kananga, West Kasai, Democratic

Republic of Congo, April 2009 – Military

(BE MoD)

- First laboratory deployment to assess

Kasaï endemic monkeypox

Kananga

Food Defence demonstration and BE-LFL,

FP7-EDEN, Bologna, Italy, 2016

Joint “Clueless Snowman” exercise, Munich,

BE-LFL / Institute of Microbiology, Bundeswehr,

2016

N’Zerekore Ebola Treatment unit, Guinea:

BE-LFL deployment, 2014-2015

LFL: Light Fieldable Laboratory B-LiFE

B-LIFE Deployment during Ebola outbreak in Guineaand beyond (demo, joint exercise)

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MISSION

ACTIVATION

ACCOMMODATION,

MEDEVAC

SECURITY IN REMOTE

LOCATION

NEED 2

TRANSPORT AND

LOGISTICS

NEED 3

ONSITE SECURITY AND

BIOSAFETY

NEED 5

POCT / RDT

NEED 6

INACTIVATION AND

DECONTAMINATION

NEED 7

SITUATIONAL

AWARENESS AND

FAST DATA

TRANSMISSION

NEED 9

SAMPLES TRACK AND

TRACE, UNIFICATION

OF DATA FORMATS,

LIMS

NEED 4

DIAGNOSTIC

CAPABILITIES

NEED 8

DECISION SUPPORT

NEED 10

INTEGRATION OF

SOCIAL ISSUES

NEED 11

RELIABLE

COMMUNICATION

NEED 1

TRAINING

NEED 12

INTEROPERABILITY

AND SCALABILITY





TOOLS CORRESPONDING TO THE NEEDS

• Around 60 tools currently available from partners (6 Universities, 3 Industrial partners, 3 SMEs, 1 RTO, 1 EU institution, 3 End users)

• Selection for the field demo will be made at and after the table top exercise in March 2018

• Tools integration in the Reaching Out Collaborative Portal and interfaces based on standard plugs

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REACHING OUT COLLABORATIVE PORTAL

Collaborative multi-level information sharing

and processing

Training

Transportation and logistics

On-site security and biosafety

Diagnostic capabilities, POCT/RDT

Inactivation and decontamination

Situation awareness

Decision support

LIMS, data management

Anthropological and social

Communication

PORTAL Interoperability and scalability





DEMONSTRATION OBJECTIVES

Develop and implement «Ebola outbreak in Africa» scenario

Assess the Reaching Out Collaborative Portal

Integrate new tools into user SOPsto establish a consistent toolbox

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DEMO SCENARIO PREPARATION: MISSION CYCLE

-

TRAINING - PROCEDURE & METHODS

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TRANSPORT AND LOGISTIC SUPPORTBRUSSELS AIRLINES / AIRFRANCE / MILITARY ?

TRACKING AND TRACING SAMPLESFROM COLLECTION TO SAMPLE PROCESSING

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RAPID DIAGNOSTIC TESTS IN NEGATIVEPRESSURE GLOVE BOX

HANDWRITTEN RESULTS, NO DATA FORMATTING, NO SHARED DATABASE

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FAST, RELIABLE DATA TRANSMISSION AND SITUATIONAL AWARENESS

B-LiFE

/ ESA

BC-Probe: non-contact LIDAR sensor

Handheld device: - Efficient decontamination ?

- Residual hazard ?

Site restoration and repatriation

Efficient and safe assessment

of Bio-contamination and decontamination: new tool !

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February, 2016

Decision support in a fieldable laboratory management during

an epidemic outbreak of disease

Olga Vybornova and Jean-Luc Gala

December 2016

LIMS: SOP, Guidelines, Procedures, Methods, ….

ACCURATE AND SAFE IDENTIFICATION TESTS REQUIRE«OPTIMIZED PLANNING AND MANAGEMENT»

AND LABORATORY INFORMATION AND MANAGEMENT SYSTEM

(LIMS)





EVALUATION OF EBOLA CRISIS DEMO

New RO-tools and interface with Collaborative PORTAL:Comparison of crisis management BEFORE & AFTER

Measurable criteria and KPI:� Time for information in the field to reach the right

interlocutor� Usability of the results

- Content correctly formatted: readable, understandable, exploitable?

- Are results addressed to the right interlocutor? - Timely received? Comprehensive or correctly focused?- Are the results usable to make correct decisions by crisis

managers and other stakeholders?

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Date:Classification:Reference:

19“CONFIDENTIAL” only for members of the consortium (including the Commission Services) – EU Project

demonstRation of EU effective lArge sCale tHreat and crIsis maNaGement OUTside the EU — Reaching Out (700151)

This document and the information contained are REACHING OUT

Contractors’ property and shall not be copied or disclosed to any third

party without REACHING OUT Contractors’ prior written authorization.

Project co-funded by the European Commission within theH2020 Framework Programme (2014-2020)

This document is produced under the EC contract 700151. It is the property of the REACHING OUT consortium and shall not be distributed or reproduced without the formal approval of the REACHING OUT Steering Committee

Documents

8. EU projects - Reaching-Out – Ebola Crisis Demonstration