PATENT ABSTRACTS

5187074

M E T H O D O F H Y D R O X Y L A T I O N W I T H A T C C 55086

Laszlo R Treiber, Russell B Lingham, Byron H Arison, Lawrence F Colwell, Georgette Dezeny, Nancy E Kohl assigned to Merck & Co Inc

A novel dipeptide isostere is the biotransformed product after incubation with a culture o f Strep- tomyces. It inhibits HIV protease, and is useful in the prevention or treatment of infection by HIV and the treatment of AIDS, either as a com- pound, pharmaceutically acceptable salt, pharmaceutical composition ingredient, whether or not as a prodrug or as a combination with other antivirals, anti-infectives, immuno- modulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described.

5187080

D N A E N C O D I N G A N A N T I G E N I C P R O T E I N D E R I V E D F R O M

E I M E R I A T E N E L L A A N D V A C C I N E S F O R P R E V E N T I O N O F

C O C C I D I O S I S C A U S E D B Y E I M E R I A T E N E L L A

209

New glycopeptide antibiotic A83850, com- prising A83850A, and A83850B, is produced by Amycolatopsis albus strain NRRL 18532. A83850A and A83850B can be reduced to give new biologically active derivatives. The A83850 antibiotics have activity against Gram-positive bacteria comparable to that of vancomyein.

5187087

R E C O M I N B A N T H E R P E S V I R U S O F T U R K E Y S A N D L I V E V E C T O R

V A C C I N E S D E R I V E D T H E R E O F

Pulus J A Sondermeijer, Johannes Claessens, Albert P Moekett, Boxmeer, Netherlands as- signed to AKZO N V

The present invention is concerned with a recombinant Herpesvirus of Turkeys (HVT), containing a heterologus gene incorporated into an insertion-region of the genome of HVT. The invention also relates to a vector vaccine com- prising such a recombinant HVT which ex- presses a heterologous antigenic polypeptide and induces an adequate immune response on infec- tion of an appropriate host animal.

William H Andrews, Virginia Brothers, James G Files, Iren Kuhn, Michael T McCaman, Stacey Sias, Leland Paul, Thomas Gore, Karel New- man, John L Tedesco assigned to Solvay & Cie S A

Nucleic acid molecules are provided which encode antigenic proteins capable of inducing in a chicken an immune response conferring pro- tection against Eimeria tenella. Expression vec- tors containing the nucleic acid molecules are also provided. Methods for producing the pro- teins or antigenic polypeptides having amino acid sequences included within these proteins are also provided.

5187082

P R O C E S S F O R P R O D U C I N G A 8 3 8 5 0 A N T I B I O T I C S

Robert L Hamill, Raymond Yao assigned to Eli Lilly and Company

5187151

U S E O F B I N D I N G P R O T E I N W I T H I G F - I A S A N A N A B O L I C G R O W T H

P R O M O T I N G A G E N T

Ross G Clark, Venkat Mukku assigned to Gene- ntech Ine

A method is disclosed for producing an anabolic state in a mammal by co-administration by sub- cutaneous injection of a combination of effective amounts of IGF-I and an IGF binding protein in a defined molar ratio in the absence of growth hormone so as to produce a greater anabolic response in the mammal than that achieved using IGF-I alone in an amount equal to that used for IGF-I in the combination. Preferably, the IGF-I is native-sequence, mature human IGF-I, the binding protein is IGFBP-3, and the mammal is human or a non-human animal of economic importance such as a cow or pig.