PATENT ABSTRACTS 5ol 5104661 REVERSE LOADING OF LIPOSOMES John Lau assigned to Technology Unlimited Inc The first part explains the discovery, and means to employ the discovery that whole, intact vesicles and iiposomes are not the sole means of burden (drug) delivery by targeting molecules. The second part teaches the discovery of reverse loading of vesicles and liposomes to obtain fully functional core volume load of a useful burden without the trauma degradation of the active burden material, and with greatly extended shelf life. 5104787 plant extracts infected with mild isolaates or healthy plant tissue. This immunological probe has been utilized in enzyme-linked immuno- sorbent assays as a rapid technique for iden- tifying citrus infected with severe isolates of CTV. Field tests on recently planted trees in a commercial citrus grove have verified the effec- tiveness of the immunoassay. 5104790 MONOCLONAL ANTIBODIES TO SPECIFIC ANTIGENIC REGIONS OF THE HUMAN IMMUNODEFICIENCY VIRUS AND METHODS FOR USE METHOD FOR APPARATUS FOR A DEFINED SERUMFREE MEDICAL SOLUTION USEFUL FOR CORNEAL PRESERVATION Richard L Lindstrom, Debra Skelnik A defined serumfree medical solution for appli- cations in Ophthalmology, that contains one or more cell nutrient supplements which maintains and enhances the preservation of eye tissues, in- cluding human corneal tissues at low temperatures (2 degrees C. to 15 degrees C.). This solution is composed of a defined aqueous nutrient and electrolyte solution, supplemented with a glycosaminoglycan(s), a deturgescent agent(s), an energy source(s), a buffer system(s), an antioxidant(s), membrane stabilizing compo- nents, antibiotic(s), ATP precursors and nutrient cell supplements. Alan R Flesher, Mary K Shriver assigned to Genetic Systems Corporation Monoclonal antibodies capable of binding antigenic determinants within regions of the core proteins of the Human Immunodeficiency Virus and immortalized celI lines producing those monoclonal antibodies are provided. The monoclonal antibodies find use in a variety of ways, in- cluding HIV antigen detection in biological samples. Using these methods, individuals may be identified who are infected with HIV but~ who have not yet developed anti-HIV antibodies. The methods also find use in monitoring in vitro growth of HIV, and the efficacy of therapeutic a- gents and vaccines. 5104853 5104789 MONOCLONAL ANTIBODIES WHICH DISCRIMINATE BETWEEN STRAINS OF CITRUS TRISTEZA VIRUS Thomas A Permar, Stephen Garnsey assigned to The United States of America as represented by the Secretary of Agriculture Monoclonal cell lines producing antibodies to severe citrus tristeza virus have been developed. The antibodies react with crude plant extracts infected with severe isolates, but not with crude ALVEOLAR SURFACTANT PROTEINS HAVING CYS TO SER MUTATIONS Bradley Benson, Robert T White, James W Schilling, Douglas I Buckley, Robert M Scar- borough assigned to California Biotechnology lnc Various specific human SP-18 and human SP-5 derived peptides have alveolar surfactant protein (ASP) activity. These peptides are prepared using synthetic methods or by recombinant tech- niques. The peptides of the invention include surfactant proteins having serine replacements for the cysteines.

5104787 Method for apparatus for a defined serumfree medical solution useful for corneal preservation

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Page 1: 5104787 Method for apparatus for a defined serumfree medical solution useful for corneal preservation

PATENT ABSTRACTS 5ol

5104661

R E V E R S E L O A D I N G O F L I P O S O M E S

John Lau assigned to Technology Unlimited Inc

The first part explains the discovery, and means to employ the discovery that whole, intact vesicles and iiposomes are not the sole means of burden (drug) delivery by targeting molecules. The second part teaches the discovery of reverse loading of vesicles and liposomes to obtain fully functional core volume load of a useful burden without the trauma degradation of the active burden material, and with greatly extended shelf life.

5104787

plant extracts infected with mild isolaates or healthy plant tissue. This immunological probe has been utilized in enzyme-linked immuno- sorbent assays as a rapid technique for iden- tifying citrus infected with severe isolates of CTV. Field tests on recently planted trees in a commercial citrus grove have verified the effec- tiveness of the immunoassay.

5104790

M O N O C L O N A L A N T I B O D I E S T O S P E C I F I C A N T I G E N I C R E G I O N S

O F T H E H U M A N I M M U N O D E F I C I E N C Y V I R U S

A N D M E T H O D S F O R U S E

METHOD FOR APPARATUS FOR A D E F I N E D S E R U M F R E E

M E D I C A L S O L U T I O N U S E F U L F O R C O R N E A L P R E S E R V A T I O N

Richard L Lindstrom, Debra Skelnik

A defined serumfree medical solution for appli- cations in Ophthalmology, that contains one or more cell nutrient supplements which maintains and enhances the preservation of eye tissues, in- cluding human corneal tissues at low temperatures (2 degrees C. to 15 degrees C.). This solution is composed of a defined aqueous nutrient and electrolyte solution, supplemented with a glycosaminoglycan(s), a deturgescent agent(s), an energy source(s), a buffer system(s), an antioxidant(s), membrane stabilizing compo- nents, antibiotic(s), ATP precursors and nutrient cell supplements.

Alan R Flesher, Mary K Shriver assigned to Genetic Systems Corporation

Monoclonal antibodies capable of binding antigenic determinants within regions of the core proteins of the Human Immunodeficiency Virus and immortalized celI lines producing those monoclonal antibodies are provided. The monoclonal antibodies find use in a variety of ways, in- cluding HIV antigen detection in biological samples. Using these methods, individuals may be identified who are infected with HIV but ~ who have not yet developed anti-HIV antibodies. The methods also find use in monitoring in vitro growth of HIV, and the efficacy of therapeutic a- gents and vaccines.

5104853

5104789

M O N O C L O N A L A N T I B O D I E S W H I C H D I S C R I M I N A T E

B E T W E E N S T R A I N S O F C I T R U S T R I S T E Z A V I R U S

Thomas A Permar, Stephen Garnsey assigned to The United States of America as represented by the Secretary of Agriculture

Monoclonal cell lines producing antibodies to severe citrus tristeza virus have been developed. The antibodies react with crude plant extracts infected with severe isolates, but not with crude

A L V E O L A R S U R F A C T A N T P R O T E I N S H A V I N G C Y S T O S E R

M U T A T I O N S

Bradley Benson, Robert T White, James W Schilling, Douglas I Buckley, Robert M Scar- borough assigned to California Biotechnology lnc

Various specific human SP-18 and human SP-5 derived peptides have alveolar surfactant protein (ASP) activity. These peptides are prepared using synthetic methods or by recombinant tech- niques. The peptides of the invention include surfactant proteins having serine replacements for the cysteines.