PATENT ABSTRACTS

properties. The stabilized growth factors can be implanted into a patient, thereby providing a means for producing an in vivo controlled release of a growth factor to the patient.

5100774

M E T H O D S F O R D E T E C T I N G G R O W T H F A C T O R R E C E P T O R

E X P R E S S I O N

Ewa Rakowicz-Szulczynska assigned to The Wistar Institute of Anatomy & Biology

Methods are provided for the detection of the synthesis of growth factor receptors or cell sur- face antigens by tumor cells, and for the isolation thereof.

499

5100921

A N G U C Y C L I N O N E S F R O M S T R E P T O M Y C E T E S , A P R O C E S S

F O R T H E P R E P A R A T I O N T H E R E O F , A N D T H E U S E

T H E R E O F

Susanne Grabley, Joachim Wink, Carlo Giani, Gerhard Seibert, Wolfgang Raether, Susanne Dobreff, Axel Zeeck, Kfederal Republic Of Ger- mana assigned to Hoechst Aktiengesellschaft

New angucyclinones with a therapeutic action can be prepared with the aid of a strain of the genus Streptomyces.

5100785

P O L Y C Y C L I C E T H E R A N T I B I O T I C

Walter P Cullen, Hiroshi Maeda, John C Rud- dock, Junsuke Tone assigned to Pfizer Inc

A new acidic polycyclic ether antibiotic UK- 58,852 has the formula: See Patent for Chemical Structure See Patent for Tabular Presentation wherein R and R 1 are both hydrogen, and can be prepared by the submerged aerobic propagation in aqueous nutrient media of Actinomadura sp. ATCC 39697. The antibiotic and its cationic salts are active against a variety of micro- organisms and are effective in controlling coc- cidiosis, enteritis, swine dysentery and theileriosis as well as being effective in promo- tion of growth and/or improving efficiency of feed utilization in swine and ruminants. Two minor components, wherein R is H and R1 is CH3 and wherein R and RI are both CH3, have also been isolated from the fermentation.

5101016

F A C T O R V I I I C O A G U L A N T P O L Y P E P T I D E S A N D

M O N O C L O N A L A N T I B O D I E S T O T H E M

Theodore Zimmerman, Carol A Fulcher as- signed to Scripps Clinic and Research Founda- tion

Polypeptides have been discovered which ex- hibit high specific VIII:C coagulant activity. Monoclonal antibodies to the polypeptides are also disclosed.

5101017

A N T I B O D I E S F O R P R O V I D I N G P R O T E C T I O N A G A I N S T P. V I V A X

M A L A R I A I N F E C T I O N

5100806

M E T H O D F O R D E T E C T I N G E D W A R D S S Y N D R O M E

James N Macri

A method for determining if a pregnant woman is at significant risk of carrying a fetus with Ed- wards syndrome comprising measuring the pre- gnant woman's maternal blood levels of the free beta subunit of human chorionic gonadotropin.

Pablo Rubinstein, Margaret Nichols assigned to New York Blood Center Inc

A monoclonal antibody which identifies the human blood group Duffy (ab) is provided, Such monoclonal antibody blocks the penetration of P. vivax malaria parasite into human red blood cells by virtue of effective blocking of the target molecule of the P, vivax malaria parasite. Such monoclonal antibody has a combining site having the same stereochemistry as the ligand site on P. vivax, and elicits anti-idiotypic anti- bodies that react with the parasite.