ROYAL CONTINENTAL HOTEL

Via partenope 38/44

5TH INTERNATIONAL CONFERENCE ON THORACIC ONCOLOGY

NAPLES, June 23rd - 25th 2016

programmE

Dear Collegue,

It’s my great pleasure to invite you to partecipate

at the 5th International Conference on Thoracic

Oncology (CIOT) that, in its biennal recurrence,

will take place in Naples from June 23rd to June

25th 2016 and that I have the privilege to chair.

Setted immediately after ASCO, the Conference

will give an update on the data coming from

clinical research in Thoracic Oncology, directly

from the voice of its more representative Authors

in an appointment that by alternation with the

World Congress on Lung Cancer of IASLC, we

would like more to be lasting inside of the

international congressional track.

About the 70% of Faculty is composed of foreign

speakers, international KOLs deeply involved in

the field of lung cancer treatment and research.

Foreign delegations are expected and welcome.

The official language of the Conference will be

English.

The city of Naples and the Conference location,

just on the waterfront and Castel dell’Ovo, will be

the appropriate frame for this exciting event.

I’m trusting that you should appreciate the effort

of the organizing secretariat to realize this scientific

meeting, doing credit to us with your attendance

in Naples.

Arrivederci

The President of 5th CIOTCesare Gridelli

WELCOME FROM THE PRESIDENT

Fortunato CiardielloFilippo de MarinisCesare Gridelli

Cesare Gridelli

SCIENTIFIC & ORGANIZING COMMITTEE

PRESIDENT OF THE CONFERENCE

PARKING FACILITIESThe indoor car parking, located aside the Hotel, will beat disposal of all the delegates at their charge;

SECRETARIAT AND REGISTRATION DESKSThe pre-registration and on site registration desks willbe at the disposal of participants as follow:

Thursday, June 23 - 12.00/20.00 hrsFriday, June 24 - 08.00/19.00 hrs

Saturday, June 25 - 08.00/14.00 hrs

At the secretariat desk will be available the followingservices:• On site registration (cash, cheques)• Pre-registrations A - L• Pre-registrations M - Z• Faculty registration • CME credits desk

CLOAKROOMIt will be at disposal of all the guests free of charge.Delegates are kindly requested not to leave theirpersonal belongings after the closing time.

BARLocated in the Conference area it will be at thedisposal of the participants at their charge.

INSURANCEConference organizers cannot accept liability forpersonal injuries or for loss of or damage to propertybelonging to congress participants, either during or asa result of the Conference.

CLIMATEJune weather in Naples is generally sunny and warm.The temperature often rises during the day at anaverage of 25°. Light summer clothing is mostsuitable. Rain is also possible; light raincoat andsomething warm for the evening are advisable

CURRENCYThe official currency in Italy is the Euro (€).

TIPPINGService is usually included in the bill in bars andrestaurants but tips are welcome.

BANKBanks are open from Monday to Friday from 08.30 to13.30 hrs and from 15.00 to 16.00 hrs. Banks areclosed on Saturday and Sunday. Many banks haveautomatic currency exchange machines that also takecredit cards.Most hotels, restaurants and shops accept foreigncurrency and major credit cards.

ELECTRICITYVoltage is 220V AC, 50Hz. Plugs have two or threeround pins. Foreign voltage could require and adapter.

CONFERENCE VENUE

Royal Continental Hotel Via Partenope 38/44, Napoli

Tel. (+39) 081 245 2068

The Royal Continental is located on the Napleswaterfront and offers an ideal location with superbviewers of the gulf and Posillipo hillside. It is about 500metres from the famous shopping area and from themain cultural area of the city.The meeting takes place in the Auditorium located atthe ground floor of the Royal Continental Hotel

HOTEL ACCOMMODATIONOrganizing secretariat SOS Scientific OrganizingService S.r.l. (rossella.spinetti@alice.it), will be at yourdisposal for any information on hotel reservations.

GENERAL INFORMATION PRACTICAL INFORMATION

All fees are requested in Euros.It’s possible to register individually by visiting AIOTwebsite www.oncologiatoracica.it in the propersection following the instructions.

WHAT IS COVERED BY THE FEE?The registration fee includes an unlimited access to allscientific sessions, a full set of congress material andlunch on Friday June 24.

ADMISSIONName badges will be used as passes. All participantsand official guests are kindly requested to wear theirname badge during the Meeting activities and socialevents. The badge will allow the entrance to thescientific sessions and lunch.

.

REGISTRATION FEES

ATTRACTIONS

NAPLES

Spaccanapoli

Palazzo Reale& Museo di Capodimonte

Piazza del Plebiscito

Napoli Sotterranea

Quartiere Spagnolo

Rione Sanità

S. Chiara

Maschio Angioino

Cristo velato

KEY ATTRACTIONS

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6

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9

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SCIENTIFIC INFORMATION

MAIN SCIENTIFIC PROGRAMME OUTLINEThe scientific programme covers three days (ThursdayJune 23, Friday June 24 and Saturday June 25, 2016)and consists of State-of-the-Art Lectures, MainLectures, Debates and Face to Face sessions.

The “Debates” sessions will be about controversialtopics in thoracic oncology; the “Face to Face”sessions instead will go on vexed questions and theywill deal with two speakers and to add requests fromsome “shooters” put in charge in order to stimulatethe audience for a lively discussion.

WEBSITEVirtual Meeting of the Conference will be availableafter the end of the Meeting on AIOT official websitewww.oncologiatoracica.it.

ITALIAN MINISTRY OF HEALTH - CME CREDITS The accreditation has been asked for entirely meeting.To obtain Italian credits the delegates must attend inthe 100% percentage of the time sessions. Anelectronic device will be arrange.

At the moment of registration each participant will receivethe evaluation forms and learning questionnaire of thescientific sessions. These forms and questionnairemust be filled in and return to the “CME credits” desk. Electronic tags will be used to record the CME credits.

The electronic readers will be placed just outside the“Auditorium”. It will be sufficient to pass through theelectronic device to have the credits recorded.

To obtain credits, Italian participants must be:

• record both the entrance and the exit of eachMeeting day

• return the electronic tag to the Organizing Secretariatat the end of the Conference

• return the evaluation forms and questionnaire dulyfilled into the “CME credits” desk. The anagraphicaldata must compulsorily be indicated since requiredby the Italian Ministry of Health

Please note that should you loose or fail the tag,you will be charged € 10,00 by the OrganizingSecretariat.

FACULTYGuidelines for Speakers and Chairs

For Chairs:• Locate your session Room in due time

• Be in the Room assigned for presentation at least 10minutes before the beginning of the session

• Respect the timing allowed to the session and eachpresentation

• All presentations, discussions and questions are inEnglish

For Speakers:• Follow the instructions indicated at the paragraph“Audiovisual Instructions”

• Locate your session Room in due time

• Be in the Room assigned for presentation at least 10minutes before the beginning of the session to meetthe Chairs

• Respect the timing allowed for your presentation

• All presentations, discussions and questions are inEnglish

AUDIOVISUAL INSTRUCTIONSA multimedial projection centre will be at the disposalof the Speakers at the ground floor of the RoyalContinental Hotel aside the Auditorium.

ONLY PC DATA PROJECTION WILL BE AVAILABLE AT THE CONFERENCE

The “Auditorium” will be provided with the laptop.Use of one’s laptop is not allowed.

Should Speakers have their personal laptop, a CDRom or a USB key, they are kindly requested to go tothe multimedial projection centre to have theirpresentation copied. The presentation will be thenforwarded through a LAN network from multimedialprojection centre directly to the computer in thepresentation room.

We recommend to contact the multimedial projectioncentre the day before your presentation. At any rate,presentation material must be available:

• 45 minutes before for Power Point presentation onCD Rom or USB key

• 1 hour before for presentation on PersonalComputer

CERTIFICATE OF ATTENDANCEAttendance certificates will be issued on request to allregularly registered participants at the SecretariatDesk at the end of the meeting.

FACULTY GUIDELINES

Andrea Ardizzoni (Bologna, I)

Paul Baas (Amsterdam, NL)

Federico Cappuzzo (Livorno, I)

Fortunato Ciardiello (Naples, I)

Lucio Crinò (Perugia, I)

Filippo de Marinis (Milano, I)

Enriqueta Felip (Barcelona, E)

Shirish M. Gadgeel (Detroit, US)

Marina Garassino (Milan, I)

Vanesa Gregorc (Milan, I)

Cesare Gridelli (Avellino, I)

Francesco Grossi (Genova, I)

Fred Hirsch (Denver, US)

Vera Hirsc (Montreal, CDN)

Niki Karachaliou (Barcelona, I)

Mario Mandalà (Bergamo, I)

Alessandro Morabito (Naples, I)

Nicola Normanno (Naples, I)

Antonio Passaro (Milan, I)

Luis Paz Ares (Madrid, E)

Maurice Perol (Lyon, F)

Franco Perrone (Naples, I)

Antonio Rossi (Avellino, I)

Lorenzo Spaggiari (Milan, I)

FACULTY PROGRAMME

June 23rd, 2016 Thursday

WELCOME LECTURE FROM THE PRESIDENT OF ESMONEW DEVELOPMENT INGENETIC ALTERATIONSDETECTION: FROM THETISSUE TO LIQUID BIOPSY

14.30 Introduction: C. Gridelli (Avellino, I)

14.40 Welcome Lecture F. Ciardiello (Naples, I)

FACE TO FACE ITREATMENT OF MALIGNANTMESOTHELIOMA: TRIMODALITYAGGRESSIVE STRATEGY VSCHEMOTHERAPY

Chair: F. de Marinis (Milan, I)

15.10 Pro trimodality strategy L. Spaggiari (Milan, I)

15.30 Pro chemotherapy P. Baas (Amsterdam, NL)

15.50 Discussion

16.00-17.30 EDUCATIONAL SYMPOSIUM NSCLC E NUOVI FARMACI:SIAMO PRONTI ALLA SFIDA? Grazie al contributo non condizionante di

Modera: C. Gridelli (Avellino, I)

Rispondono:

Il paziente wild-typeA. Morabito (Napoli, I)

Il paziente oncogene addictedM. Garassino (Milano, I)

L'immunoterapiaV. Gregorc (Milano, I)

17.30-18.30 EDUCATIONAL SYMPOSIUM ATTUALITÀ E PROSPETTIVENEL TRATTAMENTO DELNSCLC ALK+

Grazie al contributo non condizionante di

Moderano: F. de Marinis (Milano, I)C. Gridelli (Avellino, I)

17.35 Il trattamento del NSCLC Alk+: Crizotinib stato dell’arteF. Grossi (Genova, I)

17.50 NSCLC Alk+: dalle evidenzeall’algoritmo ideale di trattamentoA. Ardizzoni (Bologna, I)

18.05 Personalizzazione del trattamentonel NSCLC Alk+A. Morabito (Napoli, I)

18.15 Panel discussion

June 24th, 2016 Friday

OPENING CEREMONY

09.00 AIOTC. Gridelli (Avellino, I)

09.10 AIOT FELLOWSHIP

LECTURE ITREATMENT OF SCLC ANDNEUROENDROCRINE TUMORS

09.20 Introduction: F. Ciardiello (Naples, I)

09.25 Speaker: P. Baas (Amsterdam, NL)

LECTURE IINOT BIOMARKER DRIVENTREATMENT OF ADVANCEDNSCLC: STANDARD,MAINTENANCE AND NEWCHEMOTHERAPY AGENTS

09.45 Introduction: F. de Marinis (Milan, I)

09.50 Speaker: L. Crinò (Perugia, I)

FACE TO FACE II1-2 VS 3- GENERATIONANTI-EGFR TKI IN FIRST-LINE ADVANCED NSCLC M+

Chair: F. de Marinis (Milan, I)

10.20 Pro 1-2 generationF. Perrone (Naples, I)

10.40 Pro 3-generation L. Paz-Ares (Madrid, E)

11.00 Discussion

SPECIAL SYMPOSIUM ITREATMENT OF NSCLC WITHALK GENETIC ALTERATION:WHO IS THE BETTER?

Chair: C. Gridelli (Avellino, I)

11.30 CrizotinibF. Hirsch (Denver, US)

11.50 CeritinibE. Felip (Barcelona, E)

12.10 AlectinibS.M. Gadgeel (Detroit, US)

12.30 Discussion

SPECIAL SYMPOSIUM IIIMMUNOTHERAPY OF NSCLC: REALITY AND HOPES

Chair: S.M. Gadgeel (Detroit, US)

14.00 NivolumabV. Hirsh (Montreal, CDN)

14.20 AtezolizumabL. Paz-Ares (Madrid, E)

14.40 PembrolizumabC. Gridelli (Avellino, I)

15.00 DurvalumabM. Garassino (Milan, I)

15.20 AvelumabE. Felip (Barcelona, E)

15.40 Discussion

16.15-17.15 SPECIAL SESSIONPORTA A PORTA:INFORMAZIONE EAPPROFONDIMENTOSULL'IMMUNOTERAPIA.ESPERIENZE A CONFRONTO

Grazie al contributo non condizionante di

Presenta: F. de Marinis (Milano, I)

Intervengono:

M. Mandalà (Bergamo, I)L. Crinò (Perugia, I)

17.15-18.15 EDUCATIONAL SYMPOSIUM MEDICINA PERSONALIZZATA NEI PAZIENTI EGFR M+:CONTINUUM OF CARE CONQUALITÀ DI VITA

Grazie al contributo non condizionante di

Modera: C. Gridelli (Avellino, I)

17.15 L’equilibrio tra efficacia etollerabilità in I linea M. Garassino (Milano, I)

17.30 L’importanza di rivalutare ilpaziente a progressione di malattia:l’analisi mutazionale N. Normanno (Napoli, I)

17.45 Le nuove prospettive in II linea F. de Marinis (Milano, I)

18.00 Discussione

18.15-18.45 EDUCATIONAL LECTURENEW TREATMENT OPTIONIN A-SQUAMOUS NSCLC

Grazie al contributo non condizionante di

Presenta: C. Gridelli (Avellino, I)

June 25th, 2016 Saturday

SPECIAL SYMPOSIUM IIIRESISTANCE TO EGFR TKI’s

Chair: F. Ciardiello (Naples, I)

09.00 Mechanisms of resistanceN. Normanno (Naples, I)

09.20 OsimertinibF. de Marinis (Milan, I)

09.40 Rociletinib and othersS.M. Gadgeel (Detroit, US)

10.00 Discussion

FACE TO FACE IIINEW ANTIANGIOGENETIC AS SECOND-LINE TREATMENT OF NSCLC EGFR WT: NINDETANIB VS RAMUCIRUMAB

Chair: A. Ardizzoni (Bologna, I)

10.20 Pro nindetanib V. Gregorc (Milan, I)

10.40 Pro ramucirumabM. Perol (Lyon, F)

11.00 Discussion

SPECIAL SYMPOSIUM IVNEW TARGETS

Chair: M. Perol (Lyon, F)

11.20 c-MET F. Cappuzzo (Livorno, I)

11.40 K-RAS L. Crinò (Perugia, I)

12.00 RETA. Passaro (Milan, I)

12.20 B-RAFN. Karachaliou (Barcelona, I)

12.40 ROS-1 A. Rossi (Avellino, I)

13.00 Discussion

LEVEL SPONSOR

OTHER SPONSOR

BRONZE SPONSOR

PLATINUM SPONSOR

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GOLD SPONSOR

SCIENTIFIC SECRETARIATAIOT - Associazione Italiana di Oncologia Toracica

Via Salaria, 237 - 00199 RomaTel. +(39) 333 65 93 541 - Fax (+39) 06 85 40 679

oncologiatoracica@yahoo.it - www.oncologiatoracica.it

ORGANIZING SECRETARIAT bySOS S.r.l.

Via Salaria, 237 - 00199 Roma Tel. (+39) 333 65 93 541 - Fax (+39) 06 85 40 679

www.scientificorganizingservice.com - rossella.spinetti@alice.it

THIS PROGRAMME AND REGISTRATION FORM ARE AVAILABLE ON AIOT WEBSITE

www.oncologiatoracica.it

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