ii New Patents 4880805 4880835 USE OF ALKYLENEDIAMINE DERIVATIVES FOR THE TREATMENT OF BLOOD FLOW DISTURBANCES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM Erwin Bohm, Jens-Peter Holck, Wolfgang Kampe, Herbert Leinert, Bernd Muller- Beckmann, Klaus Strein, Ladenburg, Federal Republic Of Germany assigned to Boehringer Mannheim GmbH The present invention is concerned with the use of compounds of the general formula: See Patent for Chemical Structure (I) wherein A is an optionally substituted phenyl or heteroaromatic radical, R6 and R7 are hydrogen or lower alkyl, X is an alkylene chain containing up to 6 carbon atoms, Y is a valency bond or a )C double bondO group and B is an optionally substituted phenyl or heteroaromatic radical, as well as of their pharmacologically acceptable salts for the treatment of blood flow disturbances. The present invention also provides pharmaceutical compositions which contain these compounds. 4880833 SYNERGISTIC PHARMACEUTICAL COMPOSITIONS, THEIR PRODUCTION AND USE Jozsef Knoll, Walter Birkmayer, Katalin Kalloy, Jen Marton, Zoltan Ecsery, Budapest, Hungary assigned to Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara RT The invention relates to a synergistic pharmaceutical composition, which comprises as an active ingredient a combination of 1-phenylalanine and (-)-deprenyl ((-)-N-(1 phenylisopropyl) N- methyl N-propinylamine hydrochloride) and optionally carbidopa (3-(3, 4-dihydroxyphenyl) 2-hydrazino 2-methyl-propionic acid mono- hydrate) or benzerazide (N-(DL-seryl)-N'-( 2,3,4-trihydroxybenzyl) hydrazine) in associa- tion with conventional inert, non-toxic solid or liquid pharamaceutical carriers. The invention further relates to the preparation of these compositions and to the use thereof for the treatment of depressive symptoms. ORAL LIQUID PHARMACEUTICAL COMPOSITIONS OF SULINDAC Moo K Park assigned to Formulations Develop- ment Labs Inc Pharmaceutically elegant oral liquid compositions of sulindac are prepared using calcium sulindac in a vehicle comprising a glycol, a polyol, optional ethanol and pharmaceutical ad- ditives. 4882149 PHARMACEUTICAL DEPOT PREPARATION Myron Spector assigned to Ed Geistlich Sohne A G fur Chemische Industrie Pharmaceutical depot preparation for implanta- tion into base tissue comprising natural bone mineral from which the naturally associated fat and bone-proteins have been removed whereby said bone is sterile and non-allergenic, said bone mineral having absorbed thereon and/or adsor- bed therein one or more physiologically active substances. The physiologically active substance is advantageously an antibiotic or taurolidine or tauraltam or a protein or polypeptide assisting bone regeneration. 4882315 AMINOGLYCOSIDE STEROIDS, A PROCESS FOR THEIR PREPARATION, THEIR USE AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM Laura Chiodini, Mauro Gobbini, Sergio Man- tegani, Daniel Ruggieri, Aldemio Temperilli, Gabriella Traquandi, Patrizia Ferrari, Busto Arsizio, Italy assigned to Farmitalia Carlo Erba SpA See Patent for Chemical Structure I Compounds I (either R1--OH, C1-C4 alkoxy and R2=H, C1-C4 alkyl, or Rl+R2ffia chemical bond; R3=an aminodeoxy or aminodideoxy or aminotrideoxy sugar residue of the D and L series, the glycosidic linkage being alpha or beta)

4880805 Use of alkylenediamine derivatives for the treatment of blood flow disturbances and pharmaceutical compositiosn containing them

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Page 1: 4880805 Use of alkylenediamine derivatives for the treatment of blood flow disturbances and pharmaceutical compositiosn containing them

ii New Patents

4880805 4880835

USE OF ALKYLENEDIAMINE DERIVATIVES FOR THE

TREATMENT OF BLOOD FLOW DISTURBANCES AND PHARMACEUTICAL

COMPOSITIONS CONTAINING THEM

Erwin Bohm, Jens-Peter Holck, Wolfgang Kampe, Herbert Leinert, Bernd Muller- Beckmann, Klaus Strein, Ladenburg, Federal Republic Of Germany assigned to Boehringer Mannheim GmbH

The present invention is concerned with the use of compounds of the general formula: See Patent for Chemical Structure (I) wherein A is an optionally substituted phenyl or heteroaromatic radical, R6 and R7 are hydrogen or lower alkyl, X is an alkylene chain containing up to 6 carbon atoms, Y is a valency bond or a )C double bondO group and B is an optionally substituted phenyl or heteroaromatic radical, as well as of their pharmacologically acceptable salts for the treatment of blood flow disturbances. The present invention also provides pharmaceutical compositions which contain these compounds.

4880833

SYNERGISTIC PHARMACEUTICAL

COMPOSITIONS, THEIR PRODUCTION AND USE

Jozsef Knoll, Walter Birkmayer, Katalin Kalloy, Jen Marton, Zoltan Ecsery, Budapest, Hungary assigned to Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara RT

The invention relates to a synergistic pharmaceutical composition, which comprises as an active ingredient a combination of 1-phenylalanine and (-)-deprenyl ((-)-N-(1 phenylisopropyl) N- methyl N-propinylamine hydrochloride) and optionally carbidopa (3-(3, 4-dihydroxyphenyl) 2-hydrazino 2-methyl-propionic acid mono- hydrate) or benzerazide (N-(DL-seryl)-N'-( 2,3,4-trihydroxybenzyl) hydrazine) in associa- tion with conventional inert, non-toxic solid or liquid pharamaceutical carriers. The invention further relates to the preparation of these compositions and to the use thereof for the treatment of depressive symptoms.

ORAL LIQUID PHARMACEUTICAL

COMPOSITIONS OF SULINDAC

Moo K Park assigned to Formulations Develop- ment Labs Inc

Pharmaceutically elegant oral liquid compositions of sulindac are prepared using calcium sulindac in a vehicle comprising a glycol, a polyol, optional ethanol and pharmaceutical ad- ditives.

4882149

PHARMACEUTICAL DEPOT PREPARATION

Myron Spector assigned to Ed Geistlich Sohne A G fur Chemische Industrie

Pharmaceutical depot preparation for implanta- tion into base tissue comprising natural bone mineral from which the naturally associated fat and bone-proteins have been removed whereby said bone is sterile and non-allergenic, said bone mineral having absorbed thereon and/or adsor- bed therein one or more physiologically active substances. The physiologically active substance is advantageously an antibiotic or taurolidine or tauraltam or a protein or polypeptide assisting bone regeneration.

4882315

AMINOGLYCOSIDE STEROIDS, A PROCESS FOR THEIR

PREPARATION, THEIR USE AND PHARMACEUTICAL

COMPOSITIONS CONTAINING THEM

Laura Chiodini, Mauro Gobbini, Sergio Man- tegani, Daniel Ruggieri, Aldemio Temperilli, Gabriella Traquandi, Patrizia Ferrari, Busto Arsizio, Italy assigned to Farmitalia Carlo Erba SpA

See Patent for Chemical Structure I Compounds I (either R1--OH, C1-C4 alkoxy and R 2 = H , C1-C4 alkyl, or R l+R2f f i a chemical bond; R3=an aminodeoxy or aminodideoxy or aminotrideoxy sugar residue of the D and L series, the glycosidic linkage being alpha or beta)