470 PATENT ABSTRACTS

4873313 4874609

S P E C I F I C H Y B R I D O M A C E L L T R E A T M E N T O F H U M A N V I R A L L I N E A N D M O N O C O L O N A L I N F E C T I O N S

A N T I B O D I E S P R O D U C E D F R O M S U C H S P E C I F I C H Y B R I D O M ~ Janet L Rideout, David Barry, Sandra N Lehr- C E L L L I N E A N D M E T H O D O F man, Clair Martha St, Phillip A Furman as- U S I N G S U C H M O N O C L O N A L signed to Burroughs Wellcome Co

A N T I B O D I E S T O D E T E C T C A R C I N O E M B R Y O N I C Treatment of AIDS or humans carrying or in-

A N T I G E N S fected with the AIDS virus or having antibodies to the AIDS virus is disclosed using the com- pound Y-azido- 3'-deoxythymidine or a

Frances Crawford, John Shively, Charles Todd, pharmaceutically acceptable basic salt thereof. Y H Jo Yang assigned to Beckman Research In- Also disclosed is the use of the 5'-mono-, di- and stitute of City of Hope triphosphate of 3'-azido-3'-deoxythymidine or a

pharmaceutically acceptable basic salt thereof A specific hybridoma cell line produces mono- for the same purpose. clonal antibodies which are effective in detecting carcinoembryonic antigens (CEA). The specific hydribome line and monoclonal antibodes are 4874693 designated as T84.66-A3.I-Hll. The mono- clonal antibodies are preferably applied to tis- M E T H O D F O R A S S E S S I N G sues and fluids to detect the degree of binding of P L A C E N T A L D Y S F U N C T I O N such monoclonal antibodies to such carcinoem- bryonic antigens. Mark Bogart

A method is presented for detecting placental dysfunction that is diagnostic of aneuploid chromsomal abnormalities. It is particularly use-

4873348 ful for diagnosing pregnancies at risk for fetal aneuploid chromosome abnormalities, and con-

O X Y P R I C I N , A N E W A N T I B I O T I C sists of quantitating the hormone human chroionic gonadotropin (HCG) alone or in com- bination with the free alpha subunit of HCG

Imre Szilagyi, Gyul Dekany, Judi Frank, Gabor (alpha-HCG). In a preferred embodiment of the Horvath, Gabor Kulcsar, Budapest, Hungary invention, bodily fluids from women between 18 assigned to Chinoin Gyogyszer es Vegyeszeti and 25 weeks of gestation are assayed using an Termekek, Gyara R T immunoassay. Levels of 2.5 or more multiples of

the median value for normal pregnancies Oxypricin, an antibiotic of the Formula (II) See (MOM) for HCG and/or alpha-HCG are indica- Patent for Chemical Structure II having anti- tive of fetal chromosome abnormalities. This test biotic activity is disclosed, will detect approximately 70% of fetuses with

chromosome aneuploidy.

4874703 4874601

E X P R E S S I O N V E C T O R S F O R U S E R A D I O L A B E L L I N G K I T I N E. C O L I

Richard J Flanagan, Hudson, Canada assigned S Richard Jaskunas assigned to Eli Lilly and to Merck & Co Inc Company

A kit for the direct and rapid preparation of The present invention provides a transcriptional radiolabelled compounds is disclosed corn- and translational activating sequence derived prising a Resin-S-Hg-R component where R is from the lambda pL transcriptional activating an organic group together with MZ* where M is sequence and the E. coli lpp translational ac- an alkali metal and Z* is a radiol~alogen isotope, tivating sequence. The activating sequence has