PATENT ABSTRACTS 443

4814323 4814435

PROCESS FOR THE TREATMENT AND THE PREVENTION OF AIDS

AND OTHER DISORDERS INDUCED BY THE LAV/HTLV III

VIRUS

.I M Andrieu, P Even, Alain Venet, 75007 Paris, France

The invention relates to a process for the treat- ment and the prevention of the acquired immunodeficiency syndrome (AIDS) and AIDS related complex (ARC) induced by the LAV/HTLV III virus in a patient infected with said virus, comprising administering to said pat- ient an effective amount of a compound selected from cyclosporins.

4814433

METHOD FOR OBTAINING A PAPAIN-FREE ANTIBODY

FRAGMENT PREPARATION

Robert Fredrickson assigned to Miles Inc

A method for obtaining a papain-free F(ab’)Z antibody fragment preparation derived from papain digested whole IgG antibody employing an antibody to papain for binding to and removing papain-associated digestion products from the preparation. The method is particularly useful for digesting whole IgG antibodies which are otherwise sensitive to pepsin digestion to provide F(ab’)Z antibody fragments from which Fab’ antibody fragments can be obtained having available free sulfhydryl groups in the hinge re- gion.

METHOD OF PRODUCING A FACTOR VIII (AHF) CONTAINING

FRACTION

Otto Schwarz, Yendra Linnau, Vienna, Austria assigned to Immuno Aktiengesellschaft fur chemisch-medizinisch Produkte

There is disclosed a method of producing a Fac- tor VIII (AHF) containing fraction having a specific activity of at least 2.5 units of Factor VIII/mg protein as well as a portion of immuno- globulin G (IgG) of 10 mg/lOOO units of Factor VIII at the most. Its risk of transmission of viral or bacterial infections is to be avoided or largely reduced. The method consists in that undesired proteins are at first precipitated from a Factor VIII (AHF) containing plasma fraction in the presence of SPS. The purified Factor VIII con- taining solution is treated with suitable salts or salt mixtures in order to obtain a Factor VIII containing precipitate. This precipitate is dis- solved, lyophilized and finally heat-treated.

4816249

MONOCLONAL ANTI-IDIOTYPE ANTIBODIES

Ronald Levy, Jeanette Dilley, David Maloney, Richard A Miller assigned to The Board of Trustees of the Leland Stanford Junior Univer- sity

Monoclonal anti-idiotype antibodies against cell surface Ig of human B-cell tumors, labeled conjugates of such antibodies, immuno- therapeutic compositions containing such anti- bodies, and a process for making such antibodies. The nodular lymphoma of a patient treated with a monoclonal anti-idiotype anti- body against the cell surface IgM of the patient’s tumor went into complete remission.

4814434 4816250

INDUCER OF T-SUPPRESSOR CELLS PREPARING VACCINE AGAINST

HERPES SIMPLEX VIRUS Marcia F Goldfarb assigned to Ventres Laboratories Inc

A biologically active composition extracted from thymus tissue, capable of inducing imma- ture bone marrow cells to differentiate into com- petent suppressor T-cells.

Gordon R B Skinner, Alexander Buchan, Solihull, United Kingdom assigned to Univer- sity of Birmingham

A vaccine against a DNA virus, for exmaple, Herpes simplex virus. is prepared by incubating