iv New Patents

A compound of the general formula I; See Pa- tent for Chemical Structure (I) in which R is hydrogen or a halogen or an alkyl, alkyloxy, alkylthio, trifluoromethyl, amino, alkylamino, dialkylamino, hydroxy, cyano, carboxy, alkylsulphinyl, alkylsulphonyl, sulphamido, alkylsulphamido, dialkylsulphamido, car- bamoyl, alkylcarbamoyl, dialkylcarbamoyl, phenylcarbamoyl, diphenylcarbamoyl, pyridyl- carbamoyl, dipyridylcarbamoyl, benzyl, alkyl- carbonyl, benzoyl, alkyloxycarbonyl, phenoxycarbonyl, alkylcarbonyloxy, ben- zoyloxy, alkylcarbonylamino, benzamido, phenyl, phenoxy or phenylthio group, X is oxy- gen or sulphur or an imino, alkylimino, phenylimino, benzylimino, sulphinyl, sulphonyl, carbonyl, carbonylmethylene, methylenecar- bonyl, carbonylvinylene or vinylenecarbonyl group, or X represents a valency bond or a straight-chain alkylene group containing 1 to 4 carbon atoms and Ar is a phenyl, naphthyl, pyridyl, quinolinyl, isoquinolinyl, thienyl, ben- zothienyl, thieno(3,2-b)thien-2-yl or thieno(2,3- b)thien-2-yl group, it being possible for the group Ar to be unsubstituted or substituted with one or more halogen or alkyl, alkyloxy, alkyl- thio, trifluoromethyl, amino, alkylamino, dia- lkylamino, hydroxy, cyano, carboxy, alkylsulphinyl, alkylsulphonyl, sulphamido, alkylsulphamido, dialkylsulphamido, car- bamoyl, alkylcarbamoyl, dialkylcarbamoyl, phenylcarbamoyl, diphenylcarbamoyl, pyridyl- carbamoyl, dipyridylcarbamoyl, benzyl, alkyl- carbonyl, benzoyl, alkyloxycarbonyl, phenoxycarbonyl, alkylcarbonyloxy, ben- zoyloxy, alkylcarbonylamino or benzamido group; each alkyl moiety containing 1 to 4 straight- or branched-chain carbon atoms; the compound being in separate enantiomeric form or mixtures thereof or a pharmaceutically ac- ceptable salt thereof is useful in the treatment of all the pathological conditions in which PAF- acether may be directly or indirectly implicated.

4788179

A method of treating patients suffering from amyotrophic lateral sclerosis (ALS) by ad- ministering dipeptide derivatives of the formula See Patent for Chemical Structure wherein RI is hydrogen, a lower alkyl group, cyclohexyl or benzyl; Z is one of the groups See Patent for Chemical Structure wherein if Z is a group (a), R2 and R3 together represent an additional bond between the carbon atoms bearing R2 and R3, or ifZ is a group (b), R2 is hydrogen; R4 and R5 are hydrogen or lower alkyl, or R5 may also be phenyl; and R6 is hydrogen or methyl; hydrates or pharmaceutically acceptable acid additions salts thereof. Pharmaceutical com- positions containing effective ALS symptom counteracting amounts of such dipeptide derivatives may be administered by infusion, in- jection, orally, rectally or percutaneously.

4788180

P H A R M A C E U T I C A L C O M P O S I T I O N S

Maurice Bloch, London, N3 1ES, United King- dom

A pharmaceutical composition comprises magnesium oxide, hydroxide or a non-toxic salt of magnesium in a slow-release carrier; this material may be combined with or co-prescribed with a diuretic or cardiac glycoside or adrenergic receptor blocking agent or a calcium antagonist for the treatment of hypertension or angina pec- toris.

4788187

B E N Z O C Y C L O B U T E N E A M I N O A L K Y L E N E E T H E R S A N D

THIOETHERS, P H A R M A C E U T I C A L

COMPOSITION A N D U S E

METHOD OF TREATING AMYOTROPHIC LATERAL

SCLEROSIS WITH DIPEPTIDE DERIVATIVES AND PHARMACEUTICAL

COMPOSITIONS FOR USE THEREIN

Leopold Flohe, Hans Barth, Roetgen, Federal Republic Of Germany assigned to Gruenenthal GmbH

Donald E Kuhla, Henry F Campbell, William L Studt assigned to Rorer Pharmaceutical Cor- poration

A class of benzocyclobutene aminoalkylene ether and thioether compounds exhibiting pharmacological activity, including anti- secretory and anti-ulcerogenic activity, pharma- ceutical compositions comprising these compounds, and methods for the treatment of gastrointestinal hyperacidity and ulcerogenic disorders in mammals using said compositions.