Gen. Pharmac. Vol. 15, No. 6, pp . i - x , 1984 Pergamon Press Ltd. Printed in Great Br i ta in

NEW PATENTS

This Section contains abstracts and, where appropriate, illustrations of recently issued United States patents and published patent applications filed from over 30 countries under the Patent Cooperation Treaty. This information was obtained from recent additions to the Pergamon PATSEARCH ® online database in accordance with interest profiles developed by the Editors. Further information about Pergamon PATSEARCH ® can be obtained from Pergamon International Information Corporation, 1340 Old Chain Bridge Road, McLean, Virginia 22101 U.S.A.

Copies of complete patents announced in this Section are available from Pergamon International Information Corporation for $8 per copy. Payment with order is required. Orders outside North America add $2 for air postage. Order by patent number for Pergamon International only.

4426380

BENZOFURAN-2-ONES AND PHARMACEUTICAL

COMPOSITIONS

Paul Wenk, Werner Breitenstein, Marcus Baumann, Allschwil, Switzerland assigned to Ciba-Geigy Corporation

RI

R 2 ~ ~ O O

The invention relates to novel furans, especially benzofuranones of the general formula See Pa- tent for Chemical Structure (I) in which R1 represents hydrogen or an aliphatic radical, R2 represents an amino group di-substituted by a divalent hydrocarbon radical, and the aromatic ring A may be additionally substituted, and their salts and/or isomers, processes for the manufac- ture of compounds of the formula (I) and their salts and isomers, pharmaceutical preparations containing these compounds, and their use as the active ingredients of medicaments as anti- inflammatory agents, analgesics or light- screening agents and/or for the manufacture of pharmaceutical preparations.

4427649

PHARMACEUTICAL COMPOSITIONS

John T Dingle, John L Gordon, Geraint Jones, Clive G Knight, John S Lowe, Whittlesford, United Kingdom assigned to Imperial Chemical Industries Limited; National Research Develop- ment Corporati

Pharmaceutical liposome compositions con- taining an anti-inflammatory steroid derivative bearing a lipophilic substituent, for example cor- tisol 21-hexadecanoate. Method of treatment of inflammation at a site involving an enclosed cavity, for example the treatment of rheumatic disease, comprising injecting a said pharma- ceutical liposome composition into said cavity. Specified new steroid derivatives, for example fluocinolone acetamide 21-hexadecanoate.

4427~2

PYRIDINE ALKYL BENZOIC AND THENOIC ACID COMPOUNDS

AND THEIR PHARMACEUTICAL COMPOSITIONS

Tada Tanouchi, Masanori Kawamura, Masaki Havashi, Takatsuki, Japan assigned to Ono Pharmaceutical Co Ltd; Kissei Pharmaceutical Co Ltd

R6 R6 4 3 2

6 6

R 5

5 ~ A _ E _ R 1 6 k . ~ ~2

N

The pyridine derivatives of the general formula: See Patent for Chemical Structure I (wherein A represents an alkylene group containing from 1 to 5 carbon atoms unsubstituted or substituted by a hydroxy group, B represents a single bond,