CUSTOM STABLE ISOTOPE LABELING SERVICES

STABLE ISOTOPE LABELED COMPOUNDS

NucleoSyn provides custom

Stable Isotope (2H, 15N, 13C) Labeled Compoundsto support projects dedicated to:

Bioanalytics Omics research Molecular imaging Biomarker discovery

LIFE SCIENCE APPLICATIONS

TYPICAL PRODUCT PACKAGING

4Life ScienceC H E M I C A L S

SPECIAL REPORT

Autumn 201701

a Biosolve Group company

Custom Stable Isotope Labeling Services

Stable Isotopes Labeled Compounds

NucleoSyn now provides custom

Stable Isotope (2H, 15N, 13C) Labeled Compoundsto support projects dedicated to:

Bioanalytics Omics research Molecular imaging Biomarker discovery

and a lot more…

Contract Research Organisation specialized in Fine Organic Chemistry

Life Sciences Applications

Typical Product Packaging

4Life ScienceC H E M I C A L SBIOANALYTICS

CUSTOM STABLE ISOTOPE LABELING SERVICES

NUCLEOSYN NOW DELIVERS STABLE ISOTOPES(2H, 13C, 15N) labeled standards / building blocks

STABLE ISOTOPE LABELING OF COMPOUNDS

NucleoSyn provides custom Stable Isotope Labeled (SIL) CompoundsNucleoSyn, leading supplier of innovative DNA & RNA related products and synthetic lipids, launches new product line & services dedicated to support your bioanalytical, Omics and ADME/DMPK projects: Stable Isotope Labeled (SIL) Compounds.

For a variety of applications in Life Sciences

• Experience of labeling a wide range of chemotypes: heterocycle, natural product, amino acid & peptide…

• For stable isotope dilution assays, prefered labeled isotopes : 15N & 13C (Golden Standard) over 2H labeling in order to ensure optimum co-elution with the unlabeled analytes and op-timum isotopic purity

• Incorporation of isotopic labels at specific positions of the compound, including site selective and multiple site selective schemes

• Custom 2H, 15N, 13C, building blocks and reagents synthesis

• Either with 2H, 15N or 13C or a combi-nation of them

Stable Isotope Labeled Compounds (2H, 15N, 13C ) : Few examples

Custom Stable Isotope Labeling Services

• Any size possible from µg to multigram quantities

• In pure form or standardized solution

• In low actinic amber color glassware (light sensitive product)

• Under argon (air sensitive product)

Shipment:

• Shipped cold (e.g. dry ice shipping for temperature sensitive product if necessary)

• Worldwide delivery

Tracers in metabolism and Omic studies using mass spectrometry or NMR spectroscopy

Internal standards in quantitative bioanalysis by LC / MS

Tools to enhance PK of drugs, drug candidates (Deuterium medicinal chemistry)

Tracers for assessing absolute bioavailability of drug candidate

Typical Product Packaging

4 LIFE SCIENCE CHEMICALS

+ and more...

Stable Isotope Labeled Compounds used as:

WWW.GREYHOUNDCHROM.COM

Typical Certificate of Analysis (CoA)for Custom Stable Isotope Labeled Analytical Standard

CoA includes:

Title: CoA, name

Name of reference material in sufficient detail and structure Identification number

(lot, batch)

Physical description, Identification &

Purity assesment

Recommended storage conditions

Isotopic purity / enrichment & Normalized isotopic mass distribution table

Issuance date with approval signatureExpiry / retest date

Purity (chemical purity %w/w)

Intended useAddress of issuing body

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CUSTOM STABLE ISOTOPE LABELING SERVICE

STABLE ISOTOPE LABELED COMPOUNDS

NucleoSyn provides custom

Stable Isotope (2H, 15N, 13C) Labeled Compoundsto support projects dedicated to:

Bioanalytics Omics research Molecular imaging Biomarker discovery

LIFE SCIENCE APPLICATIONS

TYPICAL PRODUCT PACKAGING

4Life ScienceC H E M I C A L S

a Biosolve Group company

WWW.GREYHOUNDCHROM.COM

CUSTOM STABLE ISOTOPE LABELING SERVICE

LIFE SCIENCE APPLICATIONS

STABLE ISOTOPE LABELED COMPOUNDS

TYPICAL PRODUCT PACKAGING