The Drug Enforcement Administrations Special Testing and Research Laboratorygenerated this monograph using structurally confirmed reference material.

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Form Chemical Formula Molecular Weight Melting Point (oC)Base C11H17NO2 195 Not DeterminedHCl C11H17NO2 . HCl 231 151.1

O

NH2

CH3CH3

OCH3

1. GENERAL INFORMATION

IUPAC Name: 1-(3,4-dimethoxyphenyl)propan-2-amine

CAS#: 120-26-3

Synonyms: 3,4-DMA

Source: DEA Reference Material Collection

Appearance: White powder (HCl)

UVmax(nm): Not Determined

2. CHEMICAL AND PHYSICAL DATA

2.1 CHEMICAL DATA

The Drug Enforcement Administrations Special Testing and Research Laboratorygenerated this monograph using structurally confirmed reference material.

Page 2 of 5SWGDRUG.org/monographs.htmLatest Revision: 12/16/2013Chemical Shift (ppm)

0

0.5

1.0

3

Chemical Shift (ppm)8 7 6 5 4 3 2

0

0.5

1.0

1.5

2.0

2.5

3.0

3.5

3216111

solvent impurity

Maleic Acid

HDO

TSP

1H NMR: 3,4-dimethoxyamphetamine HCl Lot # MP150-151 Batch 1; D2O; 400 MHz

Chemical S...

6

Chemical Shift (ppm)

00.10.20.30.4

111

Chemical Shift (ppm)

21

3. QUALITATIVE DATA

3.1 NUCLEAR MAGNETIC RESONANCE

Method NMR D2O

Sample Preparation: Dilute analyte to ~10 mg/mL in D2O containing TSP for 0 ppm reference and maleicacid as quantitative internal standard.

Instrument: 400 MHz NMR spectrometerParameters:

Spectral width: at least containing -3 ppm through 13 ppm Pulse angle: 90o Delay between pulses: 45 seconds

The Drug Enforcement Administrations Special Testing and Research Laboratorygenerated this monograph using structurally confirmed reference material.

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m/z200180160140120100806040

[x 105

]In

tens

ity

1

219

5

180

179

164

152

137

121

107

91776551

44

EI+

EI Mass Spectrum: 3,4-dimethoxyamphetamine HCl Lot # MP150-151 Batch 1

m/z200180160140120100806040

[x 10

3 ]In

tens

ity

195

180

17916

4

152

137

121

107

9177655144

EI+

3.2 Gas Chromatography/Mass Spectrometry

Sample Preparation: Dilute analyte ~1 mg/mL base extracted into chloroform.

Instrument: Agilent gas chromatograph operated in split mode with MS detector

Column: DB-1 MS (or equivalent); 30m x 0.25 mm x 0.25mm

Carrier Gas: Helium at 1 mL/min

Temperatures: Injector: 280oC

MSD transfer line: 280oC MS Source: 230oC MS Quad: 150oC Oven program: 1) 100oC initial temperature for 1.0 min 2) Ramp to 300oC at 12oC/min 3) Hold final temperature for 9.0 minInjection Parameters:

Split Ratio = 20:1, 1mL injectedMS Parameters: Mass scan range: 30-550 amu Threshold: 100 Tune file: stune.u Acquisition mode: scanRetention Time:

8.184 min

The Drug Enforcement Administrations Special Testing and Research Laboratorygenerated this monograph using structurally confirmed reference material.

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3.3 INFRARED SPECTROSCOPY (FTIR)Insrument: FTIR with diamond ATR attachment (3 bounce)Scan Parameters: Number of scans: 32

Number of background scans: 32Resolution: 4 cm-1

Sample gain: 8Aperture: 150

Wavenumber (cm-1)3500 3000 2500 2000 1500

%Tr

ansm

ittan

ce

20

30

40

50

60

70 31632974

2939 29082833

270026052590

25732509

15991508

14661443

14291338

12671232

11531144

11201043

10241011

930850 795 768

739625

563461

440

Wavenumber (cm-1)1700 1600 1500 1400 1300 1200 1100 1000 900 800 700

%Tr

ansm

ittan

ce

20

30

40

50

60

70

1599

150814661452

14431429 1417

138913711363

13381267

12321203

11531144

1120

10431024

1011989

958 930916893

850804

795 768739

625600

563

461440

FTIR ATR (Diamond, 3 Bounce): 3,4-dimethoxyamphetamine HCl Lot # MP150-151 Batch 1

The Drug Enforcement Administrations Special Testing and Research Laboratorygenerated this monograph using structurally confirmed reference material.

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http://en.wikipedia.org/wiki/Dimethoxyamphetamine

4. ADDITIONAL RESOURCES

Wikipedia