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NEW TEST SERIES-IIIDuration: 2.00 hours Max Marks:100

1. This question paper contains 40 objective type questions. Q. 1 to 40 carry 2 marks each.

2. Q. 41 to 50 are common data based or linked question.

3. In case of wrong answer 0.5 marks will be deducted.

4. Using HP pencil, darken the appropriate double under each digit of your registration numberand the letters corresponding to your paper code.

5. Calculator is allowed in the examination hall.

6. Charts, graph sheets or tables are NOT allowed in the examination hall

7. Rough work can be done on the question paper itself. Additionally blank pages are given atthe end of the question paper for work.

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CENTRE - LIC BUILDING, 3rd FLOOR, CIVIL LINES, SAGAR (M.P.)

Mob.: 9753030576, 9907039445, 9981779766, 9893319142

PY TEST SERIES-III

1. Identify the drug which is not used in the treatment of malaria caused by Plasmodium falciparum(a) Artemisinin (b) Primaquine(c) Quinine (d) Mefloquine

2. Hydrogen deuterium discharge lamp is used in(a) IR spectrophotometer (b) Polarometer(c) UV spectrophotometer (d) GLC

3. Eseramine, 8-norphysostigmine and eseroline are main constituents of(a) Calabar bean (b) Periwinkle(c) Chhotachand (d) Crow-fig

4. Infra-red light can be detected by(a) Photographically (b) Electrically(c) Thermoconductivity (d) Photoelectric cells

5. Alkaloids are not precipitated by(a) Mayers reagent (b) Dragandroff reagent(c) Picric acid (d) Millons reagent

6. Cyclophosphamide an anticancer agent acts as(a) Alkylating agent before metabolism (b) Alkylating agent after metabolism(c) Phosphorylating agent after metabolism (d) DNA intercalating agent

7. The HLB value of antifoaming agent is in the range of(a) 6-9 (b) 1-3(c) 15-18 (d) 8-16

8. The most serious adverse effect of Amphotericin B is(a) Renal damage (b) Fever

(c) Thrombophlebitis (d) Loss of hearing9. Tropane alkaloids are not present in

(a) Datura stramonium (b) Erythroxylum coca(c) Lobelia inflate (d) Duboisia myoporoides

10. A UV visible spectrophotometer does not contain(a) Monochrometer and detector (b) Thermocouple(c) Amplifier and recording device (d) Source of light and filter

11. Select the antimalarial drug act by inhibiting plasmodial dihydrofolate reductase(a) Chloroguanide (b) Chloroquine(c) Primaquine (d) Halofantrine

12. When wavelength of a radiation is 5 , the value of wave number (cm-1) is

(a) 40000 (b) 30000

(c) 20000 (d) 10000

13. Cephalin is converted into emetine by(a) Methylation of phenolic C (8) carboxyl

group(b) Methylation of phenolic C (6) hydroxyl

group(c) Hydration of ethylene C (8) group (d) Oxidation of methyl C (8) group

14. Artemisinin contains the following group in its structure(a) An endoperoxide (b) An exoperoxide(c) An epoxide (d) An acid hydrazide

15. Pellagra occurs due to deficiency of

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(a) Riboflavin (b) Pyridoxine(c) Pantothenic acid (d) Niacin

16. Select the structural analoge/antimetabolite: cytotoxic immunosuppressive drug(a) Vincristine (b) Cyclophosphamide(c) Azathioprine (d) Cyclosporine

17. Energy required for various transition is in the following order

(a) - * > - * > n - * > n - *(b) - * > n - * > n - * > - *

(c) - * > n - * > - * > n - *

(d) n - * > n - * > - * > - *

18. Mechanism of cellular resistance to polyfunctional alkylating drugs is(a) Reduced production of glutathione(b) Decreased DNA repair capability(c) Increased permeability of the drug(d) None of the above

19 The powdered drug gives emerald green color with bromine water and dilute ammonia solutionThis test is used for identification of

(a) Cinchona (b) Cancer tree(c) Deadly night shade leaf (d) Chhotachand

20. UV spectroscopy is suitable for the identification of(a) Fatty acids (b) Compound with isolated double bond(c) Saturated alkanes (d) ,- unsaturated carbonyl compound

21. Which of the following chemotherapy drug is likely to be toxic to gonads(a) Adriamycin (b) Vinblastine(c) Paclitaxel (d) Procarbazine

22. In UV spectroscopy, thechanges in electronic energy is always associated with changes in(a) Rotational energy (b) Vibrational, Rotational and Translational(c) Vibrational and Rotational energy (d) Any of the above

23. The seeds of a plant which is known as clearing nuts contain diaboline. The plant is(a) Strychnos nuxblenda (b) Strychnos wallichiana(c) Strychnos potatorum (d) Strychnos ignatii

24. max of 2,4-hexadiene is(a) 211 nm (b) 227 nm(c) 230 nm (d) 243 nm

25. The stomata present in vinca is(a) Anisocytic type (b) Anomocytic type(c) Paracytic type (d) Diacytic type

26. Most common route for administration of anticancer drug Melphalan (Alkeran)(a) Oral (b) Intravenous

(c) Intramuscular (d) All27. The starting material for the synthesis of thiotepa, an alkylating agent is

(a) Chloropropane and aziridine(b) Trichlorophosphine sulfide and aziridine(c) Trichlorophosphine sulfide and dimethylamine(d) Trichlorophosphine sulfide and ethylene diamine

28. Teclozan, chlorbetamide and chlorphenoxamide, are the luminal amoebicides belongs to thefollowing category(a) Dichloroacetamide (b) Hydroxyquinolines(c) Nitrothiazole salicylamide (d). Benzylamine derivatives

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29. Cisplatin is an anticancer agent. Chemically it is(a) Cis-diamine monochloroplatinum (b) Trans-diamine dichloroplatinum(c) Cis-diamine dichloroplatinum (d) Cis-diamine trichloroplatinum

30. Intensity is expressed in terms of(a) Absorbance (b) Wave number(c) Wavelength (d) Frequency

31. The drug exhibit Nitrosourea with minimal bone marrow suppression and effective in treatingpancreatic, islet cell carcinoma(a) Lomustine (b) Carmustine(c) Streptozocine (d) Procarbazine

32. The number of vibrational degree of freedom of ethane is(a) 12 (b) 20(c) 15 (b) 18

33. Choice of drug in treating autoimmune hemolytic anemia is(a) Cyclosporine (b) Rho(D) immune globulin(c) Cyclophosphamide + factor XIII (d) Prednisone

34. Which of the following factors determine antimalarials agent efficacy

(a) Species (b) Life-cycle stage-dependencies(c) Both (d) None

35 Which of the following agent is used in hypertension(a) Opium (b) Sarpagandha(c) Belladonna (d) Nux vomica

36. Substance that mechanically enhance the hardness of the skin by precipitating proteins withoutpenetrating cells is called(a) Adsorbants (b) Astringents(b) Emollients (d) Demulcents

37. Contraindications to chloroquine therapy include(a) Patients with retinal/visual field

abnormalities

(b) Patients predisposed to porphyria

(c) Both (d) Patients with renal insufficiency38. Rauwolfia contains not less than

(a) 0.02% of alkaloids (b) 0.25 of alkaloids(c) 2.4% of alkaloids (d) o.14% of alkaloids

39. Combination of allopurinol with this anticancer drug can cause an increase in toxicity(a) 6-thioguanine (b) 6-mercaptopurine(c) flurouracil (5-FU) (d) azatadine

40. Alkyl substitution in an alkene cause the following effect(a) Hypochromic shift (b) Bathochromic shift(c) Hypsochtomic shift (d) Hyperchromic shift

Linked question41. Which one of the following drugs is prescribed for the treatment of Philadelphia chromosome

positive patients with Chronic myeloid Leukemia(a) Pentostatin (b) Methotrexate(c) Imatinib (d) L - Asparaginase

42. The pharmacological activity of above drug is mainly due to inhibition of activity of(a) Tyrosine kinase (b) Protein kinase C(c) Ribonucleoside diphosphate reductase (d) Dihydrofolate reductase

Data For 43-44

A compound X with molecular formula C2H4O exhibits a strong absorption band at 1730 cm-1 in

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IR spectrum. On reduction it is converted into Y which shows a strong band at 3640 cm -143. Assign the band in X to

(a) CH3 (b) C = C(c) C = O (d) CH2 C=O

44. The strong band in Y is due to(a) -C-C (b) -C-O-C-

(c) =CH2 (d) -OHData For 45-46

Calculate the max for the following compounds. Base value for benzaldehyde in ethanol is250 nm

45. maxof p-bromobenzaldehyde in nm is

(a) 265 (b) 275(c) 255 (d) 260

46 maxof o-bromobenzaldehyde in nm is

(a) 275 (b) 255(c) 265 (d) 260

Data For 47-48

One of the plant have leaf which is unequal at base with acute apex and glabrous lamina. Themargin of leaf is entire but in some cases sinuated. Corolla is thin, acuminate, triangular tocircular in shape. Flowers are funnel shaped with pedicel which is never erect.

47. The plant is(a) Cinchona (b) Thorn apple(c) Datura Camptotheca

48. The main alkaloid present in above drug is(a) Atropine (b) Hyoscine(c) Hyoscymine (d) Quinine

Linked question

49. The choice of drug against Tape Wprms infection is

(a) Pyrantel (b) Praziquental(c) Mebendazole (d) Ivermectin

50. The mechanism of action of the above drug involve(a) Inhibition of polymerization of protein

-tubulin of the parasite(b) Develop spastic paralysis by activating

nicotinic receptor in the worm(c) Devlop paralysis due to leakage of

intracellular Ca++ in the parasite(d) Develop tonic paralysis by acting

through glutamate gated Cl- channel

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