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APPLICATION FORM

YSP-Travel Fellowships for 13th FAOBMB Congress, Bangkok,23'29 Novembet'2012.

Name of Applicant: Dr. Atlu Shadat Mohammod Noman

position: Associate Professor & Research X'ellow (Bangladesh Council for Scientific

& Industrial Research)

Address of Applicant: (Normally this will be your institutional or office address)

Principal InvestigatorLaboratory of Eukaryotic Gene Expression & Function

&, Associate ProfessorDepartment of Biochemistry & Molecular BiologyUniversity of ChittagongChittagong-4331BangladeshMobile: +88-0172-7 7 7 37 67

Land Phone: +88-03 l-2606068Fax: +88-031-726310

Email address: asmnomancubd@gmail.som

Membership of FAOBMB Constituent Society: (lndicate the Constituent Society of

FAOBMB in your country/region of residence which you are a membet'). Please see Societies

profile under i'About FAOBMB: Constituent Member" on the webpage at:

http://faobmb.net

Bangladesh Society for Biochemistry & Molecular Biology

Date of Birth: December 15,1978

Applicants must be no more than 35 years of age at the closing date for application:

(31 July, 2012).

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Proof of Age: (Certification by the Head of your Institution or Department is required)

I certify on the basis of official documentation which I have seen (e.g. passport, birthcertificate or driver's licence) that the date of birth of the applicant Dr. Abu ShadatMohammod Noman is ...15/.. .12...[978....., &S shown above.

(DD/MonthNear)

Signed:

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Position:

ChairmanDepartment of Biochemistry & Molecular BiologyUniversity of ChittagongChittagong-4331Bangladesh

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Curriculum VitaeProvide a brief CV showing education and research training, including any prizes orawards: (no more than one page)

NAME

Abu Shadat Mohammod Noman, Ph. D.

ERA COMMONS USER NAME

Noman

POSITION TITLE

Associate ProfessorUniversity of Chittagong, Bangladesh&, Research Fellow, BCSIR, Bangladesh

EDUCATIONiTRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.)

INSTITUTION AND LOCATIONUTURTT/Trainino YEAR(s) FIELD OF STUDY

University of Rajshahi, Bangladesh B.Sc. 1 999 BiochemistryUniversity of Rajshahi, Bangladesh Master 2000 Biochemistry and

Molecular Biology

Aichi Medical University, JapanPhD 2010 lnnate lmmunity

and CancerUniversity of Massachusetts Medical School, MA(ln collaboration with Hollings Cancer Center)

Postdoc 2011 lnnate lmmunityand Cancer

Bangladesh Council for Scientific & lndustrialResearch

ResearchFellow

2012 lnnate lmmunityand Cancer

A. Research Traininq

1999- 2000 Master Level Research with Dr. Rezaul Karim in Rajshahi University2000- 2002 Post Master Level Research with Dr. Rezaul Karim in Rajshahi

University2002-2004 Higher Research on Protein Engineering in Chemico Laboratories,

Bangladesh2004-2006 Higher Research on arsenic toxicity in Chittagong University,

Bangladesh2007- Higher Research on arsenic toxicity with Dr. Yoshiyuki Kawamoto,

Chubu University, Japan2007- 2010 Graduate Research with Professor Dr. Takashi Yokochi, Department

of Microbiology and lmmunology, Aichi Medical University, Japan2010- 2011 Postdoctoral research with Michael Brodsky at University of

Massachusetts Medical School and, in collaboration with Dr. Zihai atHollings Cancer Canter.

2012-Continue Research Fellow of Bangladesh Councilfor Scientific and lndustrialResearch.

B. Academic Awards:

1 999- 20002007-20102009-20102009- 20102010-20112012

Bangladesh Council of Scientific and lndustrial Research ScholarAikikai Foundation Scholarship, JapanHonors Scholarship by Japan Student Services Organization

Japan Medical Association Memorial ScholarshipNational lnstitute of Health Fund, USABest Poster Award in Bangladesh Society for Biochemistry & MolecularBiology

2012-Continue Fellow Bangladesh Council for Scientific and lndustrial Research

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List of Publications in International Journals*

Selected peer-reviewed publications (from a total of 27).

1. S. Wu, K. Dole, F. Hong, A. S. Noman, J. Issacs, B. Liu andZ. Li. Chaperone

gp96-independent Inhibition of Endotoxin Response by Chaperone-based Peptide

Inhibitors. Journal of Biological Chemistry 287, 19896-19903 (2012) (IF 5.328)

2. A. Haque, A. S. M. Noman, N. Koide, E. Odkhuu, Y. Naiki, S. Hashimoto, T.

Komatsu, T. Yoshida and T. Yokochi. An ADP ribosylation factor-GTPase activating

protein negatively regulates the production of proinflammatory mediators in response

to lipopolysaccharide. Cancer Immunolopy and Immunotherapy 60, 1439-1446 (2Oll)(rF 3.7e)

3. A. Haque, N. Koide, I. I.-E-Khuda, A. S. M. Noman, E,. Odkhuu, B. Badamtseren,

Y. Naiki, T. Komatsu, T. Yoshida and r. Yokochi. Flavopiridol inhibits

lipopolysaccharide-induced TNF-a production through inactivation of nuclear factor-

rcB and mitogen-activated protein kinases in the MyD88-dependent pathway.

Microbiolog,, and Immunolog,,55, 160-l 67 (2011) (lF 1.304)

4. A. S. M. Noman, N. Koide, F. Hassan, II-E-Khuda, J. Dagvadorj, G.Tumurkhuu,

S. Islam, Y. Naiki, T. Komatsu, T. Yoshida and T. Yokochi. Retinoblastoma protein-

interacting zinc finger 1 (RIZI) regulates the proliferation of monocytic leukemia

cells via activation of p53. Caner Investigation 28, 806-812 (2010) (IF 2.390)

5. A. S. M. Noman, N. Koide, II-E-Khuda, J. Dagvadorj, G. Tumurkhuu, Y. Naiki, T.

Komatsu, T. Yoshida and T. Yokochi. Retinoblastoma protein-interacting zinc finger

l, a tumor suppressor, augments lipopolysaccharide-induced proinflammatory

c1'tokine production via enhancing nuclear factor-kappaB activation. Cellular

Immunolog,t 264, 114-1 I 8 (201 0) (lF 2.265)

6. A. S. Noman, N. Koide, II-E-Khuda, J. Dagvadorj, G.Tumurkhuu, Y. Naiki, T.

Komatsu, T. Yoshida and T. Yokochi. Retinoblastoma protein-interacting zinc finger

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1 (RlZl) participates in RANKL-induced osteoclast formation via regulation ofNFATcI expression. Immunology Letters 131,166-169 (2010) (IF 2.526)

7. I. I.-E-Khuda, N. Koide, A. S. Noman, J. Dagvadorj, G. Tumurkhuu, Y. Naiki, T.

Komatsu, T. Yoshida and T. Yokochi. Seladin-1 is a novel lipopolysaccharide (LPS)-

responsive gene and inhibits the tumour necrosis factor-alpha production and

osteoclast formation in response to LPS. Immunology 131,59-66 (2010) (IF 3.39S)

8. J. Dagvadorj, Y. Naiki, G. Tumurkhuu, A. S. Noman, I. t.-E-Khuda, N. Koide, T.

Komatsu, T. Yoshida and T. Yokochi. Tumor necrosis factor (TNF)-o augments

lipopolysaccharide (LPS)-induced SOCS-3 protein expression via preventing the

degradation (p). Immunology 129,97-104 (2010) (IF 3.398)

9. G. Tumurkhuu, N. Koide, J. Dagvadorj, A. S.Noman, l. I.-E-Khuda, Y. Naiki, T.

Komatsu, T. Yoshida and T. Yokochi. Bl cells produce nitric oxide in response to a

series of toll-like receptor ligands. Cellular Immunologt 261, 122-127 (2010) (IF

2.26s)

10. G. Tumurkhuu, N. Koide, T. Hiwasa, M. Ookoshi, J. Dagvadorj, A. S.Noman, I.

I.-E-Khuda, Y. Naiki, T. Komatsu, T. Yoshida and T. Yokochi. ONO 3403, a

synthetic serine protease inhibitor, inhibits lipopolysaccharide-induced tumor necrosis

factor-{alpha} and nitric oxide production and protects mice from lethal endotoxic

shock. Innate Immunity17,97-105 (2011) (IF 4.00)

I l. J. Dagvadod, G. Tumurkhuu, Y. Naiki, A. S. Noman, I. I.-E-Khuda, B. Badamtseren,

T. Komatsu, N. Koide, T. Yoshida and T. Yokochi. Endotoxin-induced lung injury in o-

galactosylceramide-sensitized mice is caused by failure of interleukin-4 production in lung

natural killer T cells. Clinical and Experimental Immunology 162, 169-177 (2010) (lF

3.36)

12. N. Koide, Y. Naiki, A. Morikawa, G. Tumurkhuu, J. Dagvadorj, A.S. Noman, I.

I.-E-Khuda, T. Komatsu, T. Yoshida and T. Yokochi. Nystatin-induced nitric oxide

production in mouse macrophage-like cell line RAW264.7. Microbiolog,t and

Immunologt 53,295-300 (2009) (lF 1.304)

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13. G. Tumurkhuu, N. Koide, J. Dagvadorj, A. s. M. Noman, I.I.-E-Khuda, y. Naiki,T. Komatsu, T. Yoshida, M. oda, M. Nagahama, J. Sakurai and T. yokochi. The

inhibition of lipopolysaccharide-induced tumor necrosis factor-alpha and nitric oxide

production by Clostridium perfringens alpha-toxin and its relation to alpha-toxin-

induced intracellular ceramide generation. International Journal of Medical

Microbiolog,,299, 554-562 (2009) (lF 4.173)

14. J. Dagvadorj, Y. Naiki, G. Tumurkhuu, A. S. Noman, I. I.-E-Khuda, N. Koide, T.

Komatsu, T. Yoshida and T. Yokochi. Interleukin (IL)-10 attenuates

lipopolysaccharide-induced lL-6 production via inhibition of I{kappa}B-{zeta}

activity by Bcl-3. Innate Immunity 15,217-224 (2009) (IF 4.00)

15. A. S. Noman, N. Koide, I. I.-E-Khuda, J. Dagvadorj, G. Tumurkhuu, y. Naiki, T.

Komatsu, T. Yoshida and T. Yokochi. Thalidomide inhibits lipopolysaccharide-

induced tumor necrosis factor-o production via down-regulation of MyD8B

expression. Innate Immunity 15, 33-41 (2009) (IF 4.00)

16. A. S. Noman, N. Koide, F. Hassan, I. I.-E-Khuda, J. Dagvadorj, G. Tumurkhuu,

S. lslam, Y. Naiki, T. Komatsu, T. Yoshida and T. Yokochi. Thalidomide inhibits

lipopolysaccharide (LPS)-induced nitric oxide production and prevents LPS-mediated

lethality in mice. FEMS Immunolog,, and Medical Microbiology 56,204-211 (2009)

(tF 2.441)

17. I. I.-E-Khuda, N. Koide, A. S. Noman, J. Dagvadorj, G. Tumurkhuu, y. Naiki, T.

Komatsu, T. Yoshida and T. Yokochi. Astrocyte elevated gene-1 (AEG-1) is induced

by lipopolysaccharide as toll-like receptor 4 (TLR4) ligand and augments TLR4

signalling. Imntunology 128,700-706 (2009) (lF 3.321)

18. I. I.-E-Khuda, N. Koide, F. Hassan, A. S. Noman, J. Dagvadorj, G. Tumurkhuu,

Y. Naiki, T. Komatsu, T. Yoshida and r. Yokochi T. Novelmechanism of Ul8666A-

induced tumor necrosis factor (TNF)- o production in RAW 264.7 macrophage cells.

Clinical and Experimental Immunologgt l55,552-558 (2009) (IF 3.36)

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19. A. S. Noman, N. Koide, II-E-Khuda, J. Dagvadorj, G. Tumurkhuu, Y. Naiki, T.

Komatsu, T. Yoshida and T. Yokochi. Thalidomide inhibits epidermal growth factor

(EGF)-induced cell growth in mouse and human monocl,tic leukemia cells via Ras

inactivation. Biochemical and Biophysical Research Commnnications 374,683-687

(2008) (rF 2.s23)

20. M. Kato, Y, Goto, N. Ohgami, Y. Kawamoto, K. Hossain and A. S. M. Noman.

Prevention against environmental factor-induced diseases. Annual report of Research

Institute of Lfe and Health Sciences 4,29-32 (2008)

21. A. S. M. Noman, M. A. Hoque, M. M. Haque, F. Pervin and M. R. Karim.

Nutritional and anti-nutritional components in Pachyrhizus erosus L. tuber. Food

Chemistry 102,1112-lll8 (2007) (fF 4.268)

22. A. S. M. Noman, M. R. Karim, M. A. Hoque and P. K. Sen. Purification and

some properties of amylase from post harvest yam bean (Pachyrhizus erosus L.)

tuber. Food Chemistry 99, 444-449 (2006) (IF 4.268)

23. A. S. M. Noman, M. S. Islam, N. A. Siddique and K. Hossain. High Frequency

Induction of Multiple Shoots from Nodal Explants of Vitex negundo using Silver

Nitrate. International Journal of Agriculture & Biology 10, 633-637 (2008)

24. M. R. Islam, S. M. R. Islam, A. S. M. Noman, J. A. Khanam, S. M. M. Ali, S.

Alam and M. W. Lee. (2007) Biological Screening of a Novel Nickel (ll) Tyrosine

Complex. Mycolog,t 35, 25 -29 (IF 2. I 33)

25. M. E. Haque, M. F. Hossen, M. S. Islam, and A. S. M. Noman. Biological

screening of some ferrocene derivative metal complexes. International Journttl of

Agriculture & Biology 8,774- 777 (2006)

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AbstractIndicate below the abstract that is submitted by you for presentation at the ySp and theFAOBMB Congress in Bangkok (include all authors, affiliation(s) and the text of theabstract)

Title: Novel Regulators of rLR4 for Tuning LpS Responses

Abu shudur Mohammod Nomanl*,Takahashi yokochi2, & Zihai Lil

1. Department of Biochemistry & Molecular Biology, University of Chittagong,Chittagong-43 3 1, Bangladesh.

2. Department of Microbiology & Immunology, Aichi MedicaluniversitySchool of Medicine, Nagakute, Aichi 480-1195, Japan.

3. Department of Microbiology & Immunology, Medical university of SouthCarolina, Charleston, SC 29425, USA

*correspondence: asmnomancubd@smail.com, Tel: 88-031-2606001 (Ext. 4334),Cell: 88-0172-7773767.

Abstract

Toll like receptor (TLR.) 4 is essential for sensing gran'l negative bacterial cell wall

component LPS (lipopolysaccharide). Heat shock protein gp96 is important in the

innate function of macrophages. Function of TLR4 is abrogated in gp96 Ko mice.

Hence, we used gp96 null or over expressed RAW264.7 ceil lines to explore novel

LPS responsive genes. We compared the pattern of genes expression between these

two types of cells in presence of LPS. A series of genes, RIZI, AEG1, ASAPi, ancl

SELADIN1 has been found to be down regulated in gp96 null cells whereas over

expressed in RAW254.7 cells" RIZ1 and AEGI regulated TLR4 signalling positively

whereas ASAP1, and SELADIN-1 are negative regulators. LPS induced production ofNO, TNF-alpha, IL-6, and osteoclast formation were regulated by these factors.

Therefore, RIZ1, AEGI, ASAPI, and SELADIN-I are instrumental to tune TLR4

pathway for sensing LFS.

Key words: TLR4, LPS, gp96, RIZI, AEG1, ASAPI, and SELADINl.

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Personal StatementIndicate briefly here your Research Interests and Career Goals, why you are interestedto participate in the YSP Program (including what you will bring to the YSP and whatyou hope to gain from it): (no more than one page)

Research Interest & Career Goals

Last several years we are interested on understanding the molecular mechanism by

which inflammation and cancer are interconnected with each other. To understand the

mechanism we have focused on Toll like receptors (TLRs). TI-Rs are important in the

innate function and cancer. These receptors are essential for sensing micretbial

components and have critical role in onco-inflammation. We have fixed our goals on

answering two questions: First, who are the regulators inside TLR pathways? Second,

how entire TLR pathway is regulated? Now we are interested to understand the role of

TLRs during environmental stress especially on arsenic exposure. Arsenic

contamination causes an environmental tragedy in the some pafts of the world

especially in Bangladesh. Arsenic has been reported to be associated with several

complications including cardiovascular diseases, lung, renal dysfunctions and cancers.

However, still there is no therapeutic strategy against arsenic mediated toxicity.

Earlier, we and others have been observed that a number of toll-like receptors (TLRs),

and several cytokines and their receptors were significantly altered in arsenic-exposed

mice. We, therefore believe that TLRs and its regulator gp96 would be instrumental to

understand the mechanism of arsenic mediated inflammatory responses and cancer.

Now we are aiming to investigate the status of TLR and gp96 in the arsenic exposed

people in Bangladesh. We hope, our effort will be helpful to create a therapeutic

strategy against arsenic mediated onco-inflammation.

In YSP, I will present our previous research findings on novel regulators of TLR4

signalling for sensing LPS and response. In YSP, we will get an open platform to

discuss our findings with the scientists and experts in the conference. Definitely, we

will get effective suggestions from the conference. We believe these suggestions will

tune our work. The out come will be helpful for the better understanding of the

pathogenesis of LPS-related diseases, such as systemic inflammatory response

syndrome and septic shock. Finally, the total out come will help us to design a

therapeutic strategy bgainst LPS-related diseases.

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Attachments:

o Letters of recommendation from two referees.

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Aichi Medical University School of MedicineDepartment of Microbiology and Immunology

Nagakute, Aichi 480-1195, Japan.Tel: +81-561-62-3317

Fax: +81-561-639787E-mail : )zokochi@aichi-med-u.ac jp

January 1,5,2010

lrtter of Recommendation for Mr. Abu Shadat Mohammod Noman

The aim of this letter is to recommend Mr. Abu Shadat Mohammod Noman who has beencompleted a Ph.D. course from my department. He has successfully completed the PhD course as

one of the best students in the third students, which is originally the four years course. As a Ph.D.student, he has shown an outstanding performance in our school. He has achieved A grade in allthe courses and published several excellent scientific paired review papers in renowned PubMedjournals.

He has investigated the mechanism of thalidomide in regulating cell growth and inflammatoryresponses. Later he has elucidated new function and mechanism of tomor suppressorretinoblastoma protein interacting gene finger (RIZ) 1. He successfully find out the interaction ofRIZ1 and another tumor suppressor p53 in regulating inflammatory property and cell cycle arrest.Identification of role of new gene in p53 pathway has potential to understand DNA damageresponses and apoptosis to develop therapeutic strategy against several human complications. Hiscurrent study is very much important in this respect. He knows all the basic biochemical,molecular biological and genetic approaches to study cell cycle check point. He is author andcoauthor of a remarkable original scientific PubMed articles. In my department he was guided tobecome an independent researcher, and now he is capable to run a project independently.

I am sure that his knowledge on regulation and function of signal transduction pathways andexperiences on all the basic biochemical, molecular biological and genetic approaches will soonmake him a young promising researcher.

I strongly believe that his dedication to research, sincerity, dignity, hardworking capability, wellmanner, cooperative approach, and independent judgment skill will assist him to contributescience at a remarked level. I am confident he will provide an admirable service to any where hedeserve to join as an expert of Biology. His expertise knowledge and technological know howwill assist him for setting up specific research area and supervision as well.

I would like to wish Mr. Noman all the very best with his future pursuits and I will gladly furnishany additional information should it be desired.

/---, / /- /.

#,, ,L l- /'Takahashi Yokochi, MD.; PhDProfessor and ChairDepartment of Microbiology & Immunology

Dr. Md. Khaled HossainM.Sc. (Biochemistry), University of Rajshahi, BangladeshPh.D, Nagoya University, Japan

Associate ProfessorDepartment of Biochemistry & Molecular Biology

University of Rajshahi, Rajshahi 6205, Bangladesh

Recommendation Letter for Abu Shadat Mohammod Noman

It is my great pleasure to write a recommendation letter for Mr. Abu Shadat MohammodNoman who has completed his undergradriate and master level education with brilliant academicrecords from the Department of Biochemistry & Molecular Biology, University of Rajshahi,Bangladesh. He is well known to me since 1998 when he got admission in the Department.

As my student, I found him to be very much diligent and devoted to academic works. Iam highly impressed by his performance in carrying his research. Presently he is doing ph.D.

level study in Aichi Medical University School of Medicine, Japan under an optimisticsupervision of Professor Dr. Takashi Yokochi. As a Ph.D. student, he has shown an outstandingperformance and published some scientific papers in reputed journals.

His working habits are impeccable. He is punctual, extremely weil prepared and verywell acquainted with scientific topics. He has a keen interest in the different fields of biologicalsciences that is evident to me by his enthusiasm to read scientific papers of other fields. I did notfind anv major rveak point of Mr. Noman in his research which can be mentioned here.

Sincerely yours,

Phone: +BB0-12I-150041-9lExt. 4109 (Dept.). Fax: +88-0127-150064, E-mail: khossain69@yahoo.com

(Md. Khaled Hossain)

Submission methods: You can apply in either of two ways:

. by sending an email with scanned attachments to the Chair of the FAOBMBFellowship Committee, Prof. Piamsook Pongsawasdi:piamsook.p@chula.as.tb or piamsook.p@gmail

This is the preferred method. If using this method, please assemble the ApplicationForm and the Attachments into a single PDF file.

. by sending a hard copy of the application form and supporting documents to:

Professor Piamsook Pongsawasdi,Department of Biochemistry, Faculty of Science,Chulalongkorn University,Bangkok 10330, Thailand.

Closing Date: Applications must be received by 31 July, 2012 (Bangkok time, GMT + 7Hours). Applicants will be notified by email of the decision of the Committee by no laterthan 1 5 September, 2012.

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