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Epoetin Alpha1. Epoetin Alpha (EPO; Erythropoietin)

2. Eprex3. ,

Injection solution; Prefilled Syringe 6000, 4000 3000 U/ml; 1ml

4. Erythropoietic drug; Hematopoietic drug;

Antianemics5. - Anemia

, , , Zidovudine,

- Anemia

6. - IV SC 50-100 U/kg 1-3

( hemoglobin 2g/dl ) 25 U/kg 4

- hemoglobin 2

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g/dl 50 U/kg 3

1 1 - 200 U/kg 1-3

- maintainance doseDialysis : 75 U/kg 3

Nondialysis : 75-150 U/kg 3 - hemoglobin 10-12

g/dl - IV infusion

7.

- erythropoietin

(tissue oxygenation)- Erythropoietin endogeneousglycoprotein hormone

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- Eprex purified glycoprotein

biological activity immunological reactivity human erythropoietin

- Eprex (Erythropoiesis)

close precursors ofnature erythrocites late erythroidprogenitor cells

8.

C;

9. - Humanalbumin /

-

10. -

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ischemic vascular disease,

- hemoglobin serumelectrolytes

- hemoglobin

2 g/dl hemoglobin -

- potassium hyperkalemia dialysis prescription

11. - 28.6%- Thrombosis vascular accesssites 13.0%

- Flu-like symptoms,

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7.6 %- , >10%

12.

13.

- 2-8

- Single-use vials; 1ml 2 - Multiple dose vials; 2 ml 1

14.

- IV Half life

4 7-8 - SC Half life 28

15. 1 Prefilled Syringes = 1,921 (

VAT 7%)16.

ED ()

17. 1)

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(National Drug Committee). .. 2547. :

; 2547.2) Lacy CF, Armstrong LL, Gddman MP,Lance LL. Drug information handbook.11th ed. Ohio: Lexi-Comp; 2007-8.

3) MIMs annual Full Prescribing

Information. 14th

Edition (3) 2005.4) http://www.thomsonhc.com5) Eprex

Prefilled Syrings 6000 U/ml - , 2551.

http://www.thomsonhc.com/http://www.thomsonhc.com/