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NEW TEST SERIES - IIDuration: 2.00 hours Max Marks:

100

1. This question paper contains 50 objective type questions. Q. 1 to 40 carry 2 marks each.

2. Q. 41and 50 are common data based question, each carry two marks.

3. In case of wrong answer 0.5 marks will be deducted.

4. Using HP pencil, darken the appropriate double under each digit of your registration

number and the letters corresponding to your paper code.

5. Calculator is allowed in the examination hall.

6. charts, graph sheets or tables are NOT allowed in the examination hall

7. Rough work can be done on the question paper itself. Additionally blank pages are givenat the end of the question paper for work.

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NEW TEST SERIES-II

1. Which of the following statement is correct about -interferons

(a) It produced by T lymphocyte and natural

killer cell

(b) It induced by mitogens or lecithins

(c) It encoded on chromosomes 12 (d) All a

2. Which antiviral drug is generally used for CMV(a) Ganciclovir and foscarnet a (b) Idoxurudine and foscarnet

(c) Idoxurudine and methisazone (d) Idoxurudine and ribavarin3. In which capsule filling equipment the powder must be free flowing

(a) Zanasi (b) Macofar

(c) MG-2 (d) Parke davis a4. the capacity of capsule size 1 is

(a) 0.68 ml (b) 250 gm(c) 0.37 ml (d) 320 gm a

5. In the higher energy state of a molecule, if the spins of the electron are paired then it is called as

(a) Excited triplet state (b) Excited singlet state a(c) Excited doublet state (d) Excited grounded state

6. Cidofovir is antiviral drug which is(a) Guanine nucleoside analogue (b) Pyrimidine analogue

(c) Acyclonucleotide analogue a (d) Purine analogue

7. Erweka KEA equipment is used for the purpose of(a) High speed capsule weighing (b) Dedusting and polishing a

(c) Cleaning and polishing (d) Filled capsule sorting machine8. Pan polishing of capsule is done in

(a) Driacoater tablet coating pan (b) Glatt coater tablet coating pan(c) Accela cota tablet coating pan (d) None a

9. The drug which is used in urinary tract infection in patients with renal impairment is

(a) Methanamine mendelate (b) Nalidixic acid

(c) Nitrofurantoin (d) Norfloxacin a10. Sealing temperature of the gelatin film in usually in the range of

(a) 30-32 oC (b) 32-35 oC(c) 35-37 oC (d) 37-40 oC a

11. The purpose of vitamin A palmitate encapsulation is

(a) Taste masking (b) Sustained release(c) Reduce gastric irritation (d) Stabilization to oxidation a

12. Which of the coating material of microencapsulation is water soluble resin(a) Ethyl cellulose (b) Polyamide

(c) Cellulose acetate thalate (d) Gelatin a

13. Which of the microencapsulation process is not used when the core material is liquid(a) Multiorifice centrifugal (b) Air suspension a

(c) Spray drying and congealing (d) Coaservation phase separation14. Which drug is used in the treatment of filariasis

(a) Albendazole (b) DEC a

(c) Thibendazole (d) Nicolosamide15. The energy required for various transition in UV- Visible spectroscopy obeys the following order

(a) * > n * > *> n * a (b) * > *> n * > n *

(c) * > n * > n *> * (d) * > n *> n * > *

16. The absorption maximum for methyl chloride is . than methyl iodide

(a) Less a (b) More(c) Equal (d) None

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17. A antihelmintic drug which inhibit specific fumerate reductase enzyme and also arrest nematode

cell division in metaphase. The drug is

(a) Ecgonine + methyl alcohol + cinnamic acid(b) Ecgonine + methyl alcohol + benzoic acid a

(c) Ecgonine + methyl alcohol + truxillic acid(d) Ecgonine + methyl alcohol + citric acid

18. Which of the following statement is correct about IR spectroscopy

(a) Inter molecular hydrogen bonds are sharp and well defined(b) Intramolecular hydrogen bonds give rise to broad bands

(c) Inter molecular hydrogen bonds are concentration dependent(d) All a

19 Lower the base adsorption of solid and higher the density of the mixture then the capsule will be

(a) Smaller a (b) Larger

(c) Intermediate (d) Not predicted20. Which of the capsule is considered to be dry

(a) Capsule with 20-30% RH at 25 to 30 oC (b) Capsule with 20-30% RH at 21 to 24 oC

a(c) Capsule with 10-20% RH at 25 to 30 oC (d) Capsule with 10-20% RH at 21 to 24 oC

21. A antihelmintic drug which inhibit specific fumerate reductase enzyme and also arrest nematodecell division in metaphase. The drug is

a) Albendazole (b) DEC

(c) Piperazine (d) Thibendazole a22. Which alkaloidal drug are used for only extraintestinal amoebiasis

(a) Emetine (b) Chloroquine a(c) Quinine (d) Diloxanide furoate

23. Capsule is not used for KBr, KCl and NH4Cl etc. because

(a) These are extremely soluble (b) They release in stomach

(c) They irritate in stomach (d) All a24. max = 0.87 X 10

20.P.a. In this equation P is transition probability with values from

(a) -1 to +1 (b) 0 to +1 a

(c) +1 to 10 (d) All25. The mechanism of action of emetin is

(a) Arrest intraribosomal translocation of t-RNA- amino acid comples a

(b) DNA helix destabilization and strandbreakage

(c) Inhibit ornithin decarboxylase (d) Inhibit fungal cytochrome P-450

26. R band originate due to(a) * (b) n * a

(c) * (d) n *

27. Thickness of hard gelatin capsule wall depends on(a) Viscosity of gelatin sol (b). Speed of dipping

(c) Time of dipping (d) All a28. Gynocomastia, loss of libido and oligozoospermia is side effect of

(a) Cotrimazole (b) Ketokonazole a(c) Miconazole (d). Fluconazole

29. Which antihelminthesis drug causes flaccid paralysis in worms and used in the treatment of

ascariasis(a) DEC (b) Pyrantel palmatate

(c) Piperazine A (d) Thibendazole30. In UV visible spectroscopy it has been found that increase in the polarity of the solvent genrally

shift n * and n * bands to

(a) Longer wavelength (b) Shorter wavelength a(c) Both (d) Not shift at all

31. Which of the following antifungal is first line drug for dermatophyte infection including

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oncomycosis

(a) Terbinafine a (b) Griseofulvin

(c) Ketokonazole (d) Amphotericin B32. The absorption maximum in the UV spectrum of 2,4 hexadiene is

(a) 217 nm (b) 227 nm a(c) 222 nm (d) 232 nm

33. Hamycin was isolated from

(a) S. nodosus (b) S. pimprina a(c) S. noursis (d) S. fusarum

34. The antiviral drug amantadine act on which phase of virus cycle

(a) Phase 1- attachment and penetration (b) Phase III-synthesis of viral component

(c) Phase IV- assembly of viral protein a (d) Phase V- release of the virus35 Which antiviral drug is not used simultaneously with zidovudine

a) Aspirin (b) Cetrazine

(c) Paracetamol a (d) Streptomycin36. In a linear molecule of carbon dioxide, the number of vibrational degrees of freedom is

(a) 2 (b) 3(b) 4 a (d) 9

37. In IR technique, the solvent may be used are

(a) Chloroform (b) Carbon disulphide(c) Carbo tetra chloride (d) All a

38. Most important dose dependent toxicity of dapsone is(a) Methamoglobinamia (b) Hepatitis

(c) Haemolysis a (d) Dermatisis

39. The absorption maximum for O-H stretching depends upon(a) Concentration (b) Nature of the solvent

(c) Temperature (d) All a

40. The tetracycline with highest antileptotic activity is(a) Minocyclin a (b) Doxycyclin

(c) Oxytetracyclin (d) Demeclocyclin

41. The following figure represent a drug acting on viral M2 proteins(a) Amantadine (b) Rimantadine

(c) Trifluridine (d) Vidarabine

52. The drug acts during -------- stage Tri(a) On early steps in viral replication (b) During the late step of viral assembly

(c) Both (d) None

LINKED QUESTION.

53 the drug that is fungicidal and acts by non competitive inhibitor of squalene epoxidase ,and first

line drug for dermatophyte infectionThe drug is

54(a) Hypotensive (b

)

Antidiabetic

(c) Antineoplastic (d

)

All a

LINKED QUESTIONS55. The virus directed reverse transcriptase enzyme is inhibited by

(a) acylovire (b) Amantadine

(c) Vidarabine (d) Zidovudine a

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56. The above drugs is analogue of

(a) deoxycytidine (b) thymidine. a(c) purine (d) deoxyguanosine

LINKED QUESTION

57. The drug that can be used orally for intestinal amoebiasis intravaginally for trichomonas vaginitis

and topically for dermatophytosis.(a) Ornidazole (b) Quinodoclore a

(c) Hamycine (d) Furazolidone58. The following antiamoebic drug should not be used in children because

(a) Anaemia (b) Risk of causing blindness a

(c) Gastric irritation (d) Reduse g.f.r

LINKED QUESTION59. The following anthemintic has been found to be safe during pregnancy

(a) Pyrantal pamoate (b) Piperazine a

(c) Albendazole (d) Thiabendazole

60. The mode of action of these drug are(a) Alteration of microfiliariasis membrane (b) Blocking glucose uptake a

(c) Block the response of ascariasis muscle toacetyle choline a

(d) Inhibit oxidative phasphorylase

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