2019 Neuroscience Symposium

Brain Oscillations in Parkinson’s Disease

UTSA Neurosciences Institute

Sponsored by The UTSA Neurosciences Institute

(in order of appearance)

Robert Turner PhDU of Pittsburgh

Jerrold Vitek MD PhDU of Minnesota

Charles Wilson PhDUT San Antonio

Mark Bevan PhDNorthwestern

Jerrold L. Vitek MD PhDMcKnight Professor & Chair

University of Minnesota

Oscillatory activity in the basal ganglia: Is it enough to explain Parkinson’s disease?

Robert S. Turner PhDProfessor of Neurobiology

University of Pittsburgh

Oscillations & deep brain stimulation

Judith R. Walters PhDSenior Investigator

NINDS

Exploring the significance of exaggerated oscillatory local field potential activity in the Parkinsonian rat

Marc Bevan PhDProfessor in Physiology Northwestern University

Maladaptive plasticity of the subthalamic nucleus in mouse models of Parkinson’s disease

Charles J. Wilson PhDEwing Halsell Chair

University of Texas San Antonio

How do oscillations engage brain networks? Entrainment & synchrony in the basal ganglia

September 12, 2019 | 9a-5pBSE 2.102 | UTSA Main CampusFree & open to the public

The motor symptoms of Parkinson's disease result from abnormal pa7erns of ac9vity in survivingnondopaminergicneuronsofthethebasalgangliafollowinglossofdopaminergiccellsinthesubstan9anigra.Themostprominentcomponentofabnormalac9vityis anexaggeratedoscilla9oninthebetafrequencyrange(10-30Hz)infieldpoten9alsandneuronalfiringpa7ernsinhumanswiththediseaseandinanimalmodelsofparkinsonism.

Followingan introduc9on toParkinson’sdisease,deepbrain s9mula9onandpathologicoscilla9onsbyDr.Jerrold Vitek, our panel will present a series of lectures that address 1) the causal role for exaggeratedoscilla9ons inParkinson's disease; 2) experimentalstudiesof theorigin of normal andmaladap9vebasalgangliaoscilla9ons;and3)exis9ngandpoten9altreatmentsaimedatdisrup9ngoscillatoryac9vityassociatedwiththediseasesymptoms.

Judith Walters PhDNINDS