1

2018 EAU Muscle-invasive and Metastatic Bladder Cancer Guidelines

Search Strategies

Database: Embase <1974 to 2017 June 1>, OVID Medline Epub Ahead of

Print, In-Process & Other Non-Indexed Citations, Ovid MEDLINE(R) Daily

and Ovid MEDLINE(R) 1946 to Present, EBM Reviews - Cochrane Central

Register of Controlled Trials <April 2017>, EBM Reviews - Cochrane

Database of Systematic Reviews <2005 to May 24, 2017>

Search Strategy:

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1 exp bladder tumor/ or exp Urinary Bladder Neoplasms/ (124426)

2 exp transitional cell carcinoma/ or exp Carcinoma, Transitional

Cell/ (39920)

3 (bladder adj3 (cancer* or carcin* or malig* or tumor* or tumour*

or neoplas*)).tw,kw. (109694)

4 (transitional cell adj3 (cancer* or carcin* or malig* or tumor*

or tumour* or neoplas*)).tw,kw. (23481)

5 ((urothelial or urothelium) adj3 (cancer* or carcin* or malig* or

tumor* or tumour* or neoplas*)).tw,kw. (28163)

6 (upper urinary adj3 (cancer* or carcin* or malig* or tumor* or

tumour* or neoplas*)).tw,kw. (3595)

7 or/1-6 (167575)

8 limit 7 to yr="2015 -Current" (22689)

9 limit 8 to english language [Limit not valid in CDSR; records

were retained] (21853)

10 ((exp animals/ or exp animal/ or exp nonhuman/ or exp animal

experiment/ or animal model/ or animal tissue/ or non human/) not

(humans/ or human/)) or ((rats or mice or mouse or cats or dogs or

animal* or cell lines) not (human* or men or women)).ti. (11025686)

11 ((child/ or Pediatrics/ or Adolescent/ or Infant/ or

adolescence/ or newborn/) not (adult/ or aged/)) or ((baby or babies or

child or children or pediatric* or paediatric* or peadiatric* or

infant* or infancy or neonat* or newborn* or new born* or kid or kids

or adolescen* or preschool or pre-school or toddler*) not (aged or

adult* or elder* or senior or men or women)).ti. (4317025)

12 conference abstract.pt. or Congresses as Topic/ (2673433)

13 case report/ or case reports/ or (case report not (literature

review or systematic review)).ti. (4142121)

14 note/ or editorial/ or letter/ or Comment/ or news/ (3888419)

15 10 or 11 or 12 or 13 or 14 (23655201)

16 9 not 15 (14406)

17 (Systematic review or meta-analysis).tw,pt. (386714)

18 Meta analysis/ (208620)

19 (Medline or Embase or Cochrane).tw. (272580)

20 random:.mp. or randomized controlled trial.pt. (3238827)

21 clinical trial:.mp. or controlled clinical trial.pt. (2716382)

22 double-blind:.mp. or placebo:.tw. or blind:.tw. (1185977)

23 (prospective* or retrospective*).tw. (2839655)

24 exp cohort analysis/ or exp Cohort Studies/ (2117797)

25 exp case control study/ or exp Case-Control Studies/ (1019319)

26 (cohort* adj3 (study or studies or analy*)).tw. (435984)

27 (case* adj2 control*).tw. (294210)

28 exp cross-sectional study/ or exp Cross-Sectional Studies/ or

cross sectional.tw. (740368)

29 (followed or follow up).tw. or exp follow up/ or exp Follow-Up

Studies/ (4473613)

30 exp longitudinal study/ or exp Longitudinal Studies/ (330938)

2

31 comparative study/ or controlled study/ or major clinical study/

(9448861)

32 longitudinal.tw. (447589)

33 ((evaluat* or multicenter) adj3 (studies or study)).tw.

(1073363)

34 ((population or hospital) adj based).tw. (291410)

35 (groups or trial* or controlled or compar*).tw. (14678769)

36 or/17-35 (24486470)

37 16 and 36 (10977)

38 limit 37 to ed=20160401-20170602 use ppez [Limit not valid in

Embase,CCTR,CDSR; records were retained] (1689)

39 limit 37 to dd=20160401-20170602 use oemezd [Limit not valid in

Ovid MEDLINE(R),Ovid MEDLINE(R) Daily Update,Ovid MEDLINE(R) In-

Process,Ovid MEDLINE(R) Publisher,CCTR,CDSR; records were retained]

(2631)

40 2017*.dc. or 2017*.ep. (1326771)

41 40 and 37 (2034)

42 limit 37 to yr="2016 -Current" use cctr (300)

43 limit 37 to yr="2016 -Current" use coch (16)

44 38 or 39 or 41 or 42 or 43 (5267)

45 gall bladder.ti,ab. (13314)

46 44 not 45 (5203)

47 remove duplicates from 46 (4057)

48 (T2* or T3* or T4* or N1 or N2 or N3 or M1 or cT2* or cT3* or

cT4* or "cT1-4N0-3" or "cT1-4 N0-3").tw,kw. (692991)

49 ((high or higher) adj grad*).tw,kw. (136248)

50 exp advanced cancer/ (65864)

51 exp metastasis/ or exp Neoplasm Metastasis/ (695234)

52 exp tumor invasion/ (30320)

53 (metastatic or metastasis or metastases).tw,kw. (981160)

54 ((advanced or inoperable or unopera* or unresectable or

nonresect* or non resect*) adj5 (cancer* or carcin* or malig* or tumor*

or tumour* or neoplas*)).tw,kw. (308826)

55 ((muscle adj5 (invasive or invasion)) not "non invasive").tw,kw.

(14919)

56 ((invasive not "non-invasive") adj5 (cancer* or carcin* or

malig* or tumor* or tumour* or neoplas*)).tw,kw. (144416)

57 or/48-56 (2247032)

58 47 and 57 (2148)

SEARCH 2

1 exp bladder tumor/ or exp Urinary Bladder Neoplasms/ 124405

2 exp transitional cell carcinoma/ or exp Carcinoma, Transitional Cell/ 39914

3

(bladder adj3 (cancer* or carcin* or malig* or tumor* or tumour* or

neoplas*)).tw,kw. 109670

4

(transitional cell adj3 (cancer* or carcin* or malig* or tumor* or tumour* or

neoplas*)).tw,kw. 23479

5

((urothelial or urothelium) adj3 (cancer* or carcin* or malig* or tumor* or

tumour* or neoplas*)).tw,kw. 28154

6

(upper urinary adj3 (cancer* or carcin* or malig* or tumor* or tumour* or

neoplas*)).tw,kw. 3592

7 or/1-6 167537

8 limit 7 to yr="2015 -Current" 22656

3

9 limit 8 to english language [Limit not valid in CDSR; records were retained] 21821

10

((exp animals/ or exp animal/ or exp nonhuman/ or exp animal experiment/

or animal model/ or animal tissue/ or non human/) not (humans/ or human/))

or ((rats or mice or mouse or cats or dogs or animal* or cell lines) not

(human* or men or women)).ti. 11023437

11

((child/ or Pediatrics/ or Adolescent/ or Infant/ or adolescence/ or newborn/)

not (adult/ or aged/)) or ((baby or babies or child or children or pediatric* or

paediatric* or peadiatric* or infant* or infancy or neonat* or newborn* or

new born* or kid or kids or adolescen* or preschool or pre-school or toddler*)

not (aged or adult* or elder* or senior or men or women)).ti. 4316158

12 conference abstract.pt. or Congresses as Topic/ 2672942

13

case report/ or case reports/ or (case report not (literature review or

systematic review)).ti. 4141421

14 note/ or editorial/ or letter/ or Comment/ or news/ 3887516

15 10 or 11 or 12 or 13 or 14 23650377

16 9 not 15 14379

17 (Systematic review or meta-analysis).tw,pt. 386414

18 Meta analysis/ 208500

19 (Medline or Embase or Cochrane).tw. 272420

20 random:.mp. or randomized controlled trial.pt. 3237905

21 clinical trial:.mp. or controlled clinical trial.pt. 2715626

22 double-blind:.mp. or placebo:.tw. or blind:.tw. 1185706

23 (prospective* or retrospective*).tw. 2838253

24 exp cohort analysis/ or exp Cohort Studies/ 2117213

25 exp case control study/ or exp Case-Control Studies/ 1018995

26 (cohort* adj3 (study or studies or analy*)).tw. 435626

27 (case* adj2 control*).tw. 294069

28

exp cross-sectional study/ or exp Cross-Sectional Studies/ or cross

sectional.tw. 739963

29 (followed or follow up).tw. or exp follow up/ or exp Follow-Up Studies/ 4472118

30 exp longitudinal study/ or exp Longitudinal Studies/ 330873

31 comparative study/ or controlled study/ or major clinical study/ 9445760

32 longitudinal.tw. 447381

33 ((evaluat* or multicenter) adj3 (studies or study)).tw. 1072904

34 ((population or hospital) adj based).tw. 291297

35 (groups or trial* or controlled or compar*).tw. 14674072

36 or/17-35 24478967

37 16 and 36 10956

38

limit 37 to ed=20160401-20170530 use ppez [Limit not valid in

Embase,CCTR,CDSR; records were retained] 1687

39

limit 37 to dd=20160401-20170530 use oemezd [Limit not valid in Ovid

MEDLINE(R),Ovid MEDLINE(R) Daily Update,Ovid MEDLINE(R) In-Process,Ovid

MEDLINE(R) Publisher,CCTR,CDSR; records were retained] 2617

40 2017*.dc. or 2017*.ep. 1310493

41 40 and 37 2013

42 limit 37 to yr="2016 -Current" use cctr 300

43 limit 37 to yr="2016 -Current" use coch 16

44 38 or 39 or 41 or 42 or 43 5246

4

45 gall bladder.ti,ab. 13311

46 44 not 45 5182

47 remove duplicates from 46 4040

48

(T2* or T3* or T4* or N1 or N2 or N3 or M1 or cT2* or cT3* or cT4* or "cT1-

4N0-3" or "cT1-4 N0-3").tw,kw. 692734

49 ((high or higher) adj grad*).tw,kw. 136198

50 exp advanced cancer/ 65849

51 exp metastasis/ or exp Neoplasm Metastasis/ 695066

52 exp tumor invasion/ 30289

53 (metastatic or metastasis or metastases).tw,kw. 980787

54

((advanced or inoperable or unopera* or unresectable or nonresect* or non

resect*) adj5 (cancer* or carcin* or malig* or tumor* or tumour* or

neoplas*)).tw,kw. 308750

55 ((muscle adj5 (invasive or invasion)) not "non invasive").tw,kw. 14915

56

((invasive not "non-invasive") adj5 (cancer* or carcin* or malig* or tumor* or

tumour* or neoplas*)).tw,kw. 144368

57 or/48-56 2246260

58 47 and 57 2139

59 exp non muscle invasive bladder cancer/ 2071

60 ((non-muscle or nonmuscle or non muscle or "without") adj3 invasive).tw,kw. 11425

61 exp carcinoma in situ/ 77121

62

((low risk or superficial or early) adj3 (cancer* or carcin* or malig* or tumor*

or tumour* or neoplas*)).tw,kw. 175094

63

(NMIBC or (non adj3 invasive) or carcinoma in situ or CIS or Papilloma or

PUNLMP).ti,ab. 458710

64

((T0 or Ta or T1 or TIS or G1 or G2 or G3 or S0 or S1 or cT1 or N0 or M0) adj3

(cancer* or carcin* or malig* or tumor* or tumour* or neoplas*)).tw,kw. 31091

65

((low grade* or lower grade* or limited or ((stage or grade) adj (0* or 1* or

I*)) or well-differentiated) adj3 (cancer* or carcin* or malig* or tumor* or

tumour* or neoplas*)).tw,kw. 153828

66 or/59-65 834189

67 47 and 66 957

68 58 or 67 2366

69 47 not 68 1674

Search 3

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