HAN BioCentre Centre of Expertise in Biotechnology & Analysis

Christien Lokman

28 May 2015

WHY?

For well educated students

For teachers who know the ‘state of

the art’

For companies, to support in research

and innovation

Industry and

universities

Research HAN

BioCentre

Education: Bachelor, Master, Courses

BIODISCOVERY

DISCOVERY

Development of smart screeningssystems

antimicrobial/antifungal

– Medical

– Agro & Food

– other

C. elegans screeningssystem

– Medical (obesity)

– Safety/Toxicity

Oil from yeast

In cooperation with Wageningen UR

Companies: Nuplex, van Wijhe, Latexfalt,

Holland Colors, Parenco, Dyadic, MicCell, MVO

ANALYSIS

Biological screening systems Analytical chemistry Bio-informatics Molecular biology

PCR/qPCR

SDS-PAGE

LC-MS

HPLC

FPLC

GC

Fluorescence microscopy

Amphotericin

0

20000

40000

60000

80000

100000

120000

0:0

0

0:3

7

1:1

5

1:5

3

2:3

0

3:0

8

3:4

6

4:2

3

5:0

1

5:3

9

6:1

7

6:5

4

7:3

2

8:1

0

8:4

7

9:2

5

10:0

3

10:4

0

11:1

8

11:5

6

12:3

3

13:1

1

13:4

9

14:2

6

15:0

4

15:4

2

time (h)

Lu

min

escen

s

water

NaPb

DMSO 1:100

Amph 20 µM

Amph 10 µM

Amph 5 µM

Amph 2,5 µM

Amph 1 µM

Amph 0,5 µM

Amph 0,1 µM

PRODUCTION

Fermentation & downstream processing • From 1 to 20 L (E. coli, lactic acid bacteria, Bacillus,

Helicobacter, filamentous fungi, basidiomycetes,

yeast)

• Downstream processing

– IEX

– GPC

– Microfiltration

– Ultrafiltration

• Strain selection

• Genetic modification of m.o.

APPLICATION

In collaboration with companies and universities

Food/Feed

Agro

Health

Sustainable energy

• AM-Pharma

• Aquamar

• Argos Oil

• Avatar Biotechnologies (USA)

• Avebe

• Basidiofactory

• Benilabs

• B.O.B.

• Cellution Biotech

• C4C

• Christian Hansen (DK)

• CSK Food Enrichment

• CU+TOP

• Cyto-Barr

• DMV International

• DSM

• Dyadic Nederland

• European Veterinary Laboratory

• Falco Diagnostics

• Filtex

• Innovative SeedTechnology

• TNO Quality of Life

• Koppert

• LabTie

• Meddens Diagnostics

• MicCell

• Micreos

• Nsure

• Nuplex

• NVWA

• NYtor

• Parenco

• Productschap Tuinbouw

• ProteoNic

• Quaker

• Rainbow Sustainable solutions

• RIVM

• Shell

• Uniqema/Croda

• Unilever

• Van Wijhe

• Vitaleech Bioscience

• Vivalt screening

• Xenikos

Consortia

Centre of Biobased Economy

Green Health

IJ5-lab

others

What do we offer?

- Contract research

- Cooperative research • Basidiofactory

• Vivalt screening

- Lab facilities • Basidiofactory

• Vivalt screening

- Workshops

APPLICATION DISCOVERY ANALYSIS PRODUCTION

What do companies bring?

- Knowledge/new developments

- Guest lectures

- Facility sharing

- Internships

APPLICATION DISCOVERY ANALYSIS PRODUCTION

www.hanbiocentre.nl

28th of January 2016

Conference HAN BioCentre 10 years