1987-1995 a UNIDO special project 1995-today An independent international organization

1987-19951987-1995a UNIDO a UNIDO special special projectproject

1995-today1995-todayAn independent An independent international international organizationorganization

The ICGEB mandateThe ICGEB mandate

To provide a Centre of excellence for research and training in genetic

engineering and biotechnology addressed to developing countries and economies in transition

55 FULL MEMBER STATES

71 SIGNATORY COUNTRIES

The ICGEB structureThe ICGEB structureICGEB is one Centre, made of two

Components and a network of Affiliated Centres

Trieste Component(Italy)

New Delhi Component(India)

ICGEB

Trieste

to Venice to Pula

(Croatia)

toAustria

Piran (Slo)

In-house research projects Long-term post-doctoral fellowships Short-term fellowships Ph.D. Program Organization of meetings, courses and

workshops Collaborative Research Funding Program Collaboration with industrial sector Scientific services to Member Countries

INSTRUMENTS OF ACTION

INSTRUMENTS OF ACTION

Workshops and Courses

Member CountryResearch Laboratories

Member CountryResearch Laboratories

ICGEB Basic and Applied ResearchInstitutional and Scientific

Services

TechnologyTransfer

Research Grants

Pre- and Post-Doc Fellowships

Trained Scientists

ICGEB: activity 1988-ICGEB: activity 1988-20052005Publications in peer-reviewed international journals

1383

Long-term fellowships

504 awarded880 man/year

Short-term training 5480 persons trained

Research grants262 awardedFor a total of USD 12,343,780

Patents 34 filed

Technology Transfer Agreements

72 signed

2006 BUDGETTOTAL = 15,569,000 €

42%

24%

34%TRIESTE COMPONENT

NEW DELHICOMPONENT

CENTRE + DG LAB

2006 BUDGETTOTAL = 15,569,000 €

41%

9%2%

17%

12%

3%

12%

2%

2% SCIENTIFIC &TECHNICAL STAFF

ADMINISTRATIVESTAFF

TRAVEL

EXTRA-MURAL

CONSUMABLES +LIBRARY

EQUIPMENT

PREMISES

SUNDRIES

RESERVE

ICGEB: Instruments of ICGEB: Instruments of actionaction In-house research projects Long-term post-doctoral fellowships Short-term fellowships Ph.D. Program Organization of meetings, courses and

workshops Collaborative Research Granting Program Collaboration with industrial sector Scientific services to member Countries

Human Health (Basic and applied research in infectious diseases

and the genetic component of tumors and

cardiovascular pathologies)

Crop improvement (Biotic and abiotic stress, plant transformation, insect

resistance, biopesticides)

Biosafety risk assessment

Technology development and transfer

Cooperation with other UN bodies

RESEARCH AND DEVELOPMENT FOCUS

ICGEB Trieste Research ProgramICGEB Trieste Research Program

Molecular Medicine (gene therapy of cardiovascular disorders, HIV infection)

Molecular Pathology (genetic disorders, regulation of mRNA processing)

Molecular Immunology (genetics of antibodies, molecular biology of rotavirus)

Virology (papillomavirus and cell cycle regulation)

Bioinformatics and protein structure Microbiology Proteomics Biotechnology

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Delhi ComponentResearch & Development Focus

• Human Health (Basic and applied research in

infectious diseases & structural biology)

• Agriculture ( Biotic and abiotic stress, plant

transformation , insect resistance, biopestcides etc)

• Technology development and transfer

Vaccine Related Research

• Malaria vaccine research

• Hepatitis B & E

• Dengue viral infection (vaccines and diagnostics)

• Tuberculosis ( basic immunology & vaccine

research )

• Technology development and transfer

Eichwald, C., Jacob, G., Muszynski, B., Allende, J.E., Burrone, O.R. 2004. Uncoupling substrate and activation functions of rotavirus NSP5: phosphorylation of Ser67 by CK1 is essential for hyper-phosphorylation. Proc. Natl. Acad. Sci. USA 101, 16304–16309 Rudresh, S.R., Ramagopal, U.A., Inai, Y., Goel, S., Sahal, D., Chauhan, V.S. 2004. De novo design and characterization of a helical hairpin Eicosapeptide: Emergence of an anion receptor in the linker region. Structure 12, 389–396 Mayor, A., Bir, N., Sawhney, R., Singh, S., Pattnaik, P., Singh, S.K., Sharma, A., Chitnis, C.E. 2005. Receptor-binding domains lie in central regions of Duffy-binding-like domains involved in red cell invasion and cytoadherence by malaria parasites. Blood 105, 2557-2563 Pagani, F., Raponi, M., Baralle, F.E. 2005. Synonymous mutations in CFTR exon 12 affect splicing and are not neutral in evolution. Proc. Natl. Acad. Sci. USA 102(18), 6368-6372 Petlickovski, A., Laurenti, L., Li, X., Marietti, S., Chiusolo, P., Sica, S., Leone, G., Efremov, D.G. 2005. Sustained signaling through the B-cell receptor induces Mcl-1 and promotes survival of chronic lymphocytic leukemia B-cells. Blood 105, 4820-4827 Sanan-Mishra, N., Pham, X.H., Sopory, S.K., Tuteja, N. 2005. Pea DNA helicase 45 overexpression in tobacco confers high salinity tolerance without affecting yield. Proc. Natl. Acad. Sci. USA. 102(2), 509-514 Singh, D.K., Kumar, D., Siddiqui, Z., Basu, S.K., Kumar, V., Rao, K.V.S. 2005. The strength of receptor signaling is centrally controlled through a cooperative loop between Ca2+ and an oxidant signal. Cell 121, 281-293 Todorovic, V., Giadrossi, S., Pelizon, C., Mendoza-Maldonado, R., Masai, H., and Giacca, M. 2005. Human origins of DNA replication selected from a library of nascent DNA. Mol. Cell 19, 567-575



COLLABORATIVE RESEARCH PROGRAMME(1999-2005)

0 20 40 60 80 100

1999

2000

2002

2003

2004

2005

RATE (%)

AWARDS

APPLIED


TOTAL FUNDED

0

200.000

400.000

600.000

800.000

1.000.000

1.200.000

1999 2000 2002 2003 2004 2005


AVERAGE GRANT

0

10.000

20.000

30.000

40.000

50.000

60.000

1999 2000 2002 2003 2004 2005

Q u ic k T im e ™ a n d aT IF F (L Z W ) d e c o m p re s s o r

a re n e e d e d to s e e th is p ic tu re . I C G E BI N T E R N A T I O N A L C E N T R E F O R G E N E T I C E N G I N E E R I N G A N D B I O T E C H N O L O G Y

Q u ic k T im e ™ a n d aT IF F (L Z W ) d e c o m p re s s o r

a re n e e d e d to s e e th is p ic tu re .

I C G E B - T W A SJ o i n t P l a n t B i o t e c h n o l o g y P r o g r a m m e

E x p r e s s i o n o f I n t e r e s t o n R e s e a r c h G r a n t A p p l i c a t i o n s

G e n e r a l i n f o r m a t i o n a n d a p p l i c a t i o n p r o c e d u r e s

T h e I C G E B - T W A S P r o g r a m m e s u p p o r t s n o v e l , i n n o v a t i v e b a s i c r e s e a r c h f o c u s e d o n p l a n t b i o t e c h n o l o g y a n d ,i n p a r t i c u l a r , o n r e s i s t a n c e t o a b i o t i c s t r e s s . O n e o f i t s m a i n o b j e c t i v e s i s t o s t r e n g t h e n / b u i l d c a p a c i t y i np l a n t b i o t e c h n o l o g y i n c o u n t r i e s w h e r e t h i s t y p e o f a c t i v i t y i s p o o r l y r e p r e s e n t e d .

T h e P r o g r a m m e w i l l b e i m p l e m e n t e d i n t h r e e i n d i v i d u a l a n d c o n s e c u t i v e p h a s e s :

P h a s e 1R e s e a r c h e r s i n t e r e s t e d t o a p p l y f o r a f u t u r e I C G E B - T W A S r e s e a r c h g r a n t a r e i n v i t e d t o s u b m i t a L e t t e r o fI n t e n t ( L I ) . E a c h P r i n c i p a l I n v e s t i g a t o r w i l l b e a b l e t o s u b m i t o n l y o n e L I i n t h i s r e v i e w r o u n d .

A p p l i c a t i o n s s h o u l d n o r m a l l y c o n s i s t o f a n i n t e r n a t i o n a l c o l l a b o r a t i o n b e t w e e n 2 t o 4 i n v e s t i g a t i n g t e a m s ( c o -a p p l i c a n t / s ) f r o m d i ff e r e n t c o u n t r i e s . I n a d d i t i o n , a t l e a s t o n e a p p l i c a n t ( P I o r c o - a p p l i c a n t ) s h o u l d b e f r o ma n I C G E B M e m b e r S t a t e ( l i s t a t t a c h e d a s A n n e x 1 ) a n d a n o t h e r a p p l i c a n t ( P I o r c o - a p p l i c a n t ) s h o u l d b e f r o ma a c o u n t r y l i s t e d a m o n g t h o s e i d e n t i fi e d a s s c i e n t i fi c a l l y l a g g i n g b y T W A S ( l i s t a t t a c h e d a s A n n e x 2 ) .

A s w e r e a l i z e t h a t c o n t a c t s w i t h s c i e n t i s t s a n d i n s t i t u t i o n s a m o n g d e v e l o p i n g c o u n t r i e s m a y b e d i ffi c u l t , t of a c i l i t a t e t h e s u b m i s s i o n o f t h e L e t t e r o f I n t e n t , P r i n c i p a l I n v e s t i g a t o r s w i l l b e r e q u e s t e d t o s u b m i t j u s t ab r i e f r e s e a r c h p r o p o s a l i n d i c a t i n g n a m e a n d f u l l a ffi l i a t i o n o f t h e i r p o t e n t i a l c o l l a b o r a t o r s .

L e t t e r s o f I n t e n t w i l l b e r e v i e w e d a n d s e l e c t e d b a s e d o n t h e s c i e n t i fi c e x c e l l e n c e o f t h e r e s e a r c h t e a m , t h ei m p o r t a n c e a n d f e a s i b i l i t y o f t h e r e s e a r c h p r o p o s e d a n d t h e p o t e n t i a l i m p a c t o f t h e r e s e a r c h r e s u l t s o n t h ep a r t i c i p a t i n g c o u n t r i e s .

P h a s e 2I n l i n e w i t h t h e m a i n o b j e c t i v e o f t h e p r o g r a m m e , I C G E B - T W A S w i l l o r g a n i z e a “ C o o r d i n a t i n g W o r k s h o p ”w h i c h w i l l t a k e p l a c e i n t h e c o u r s e o f 2 0 0 6 , i n v i t i n g t h e P I s o f t h o s e L e t t e r s o f I n t e n t t h a t w i l l b e p o s i t i v e l ye v a l u a t e d a n d e x t e n d i n g t h i s i n v i t a t i o n t o o t h e r s c i e n t i s t s w o r k i n g i n t h e c o u n t r i e s i n v o l v e d ( I C G E B a n dT W A S l i s t s ) . T h e a i m o f t h i s m e e t i n g w i l l b e t h a t o f f a c i l i t a t i n g t h e i n c o r p o r a t i o n o f s c i e n t i s t s f r o m l e a s td e v e l o p e d c o u n t r i e s i n t h o s e p r o j e c t s t h a t d o n o t a l r e a d y i n c l u d e t h e m .

P h a s e 3T h e c a l l f o r f u l l y d e v e l o p e d a p p l i c a t i o n s w i l l b e c i r c u l a t e d 4 - 6 w e e k s a f t e r t h e W o r k s h o p .

T h e m a x i m u m d u r a t i o n f o r t h e p r o j e c t i s 3 y e a r s . T h e a n n u a l I C G E B - T W A S g r a n t w i l l n o t e x c e e dE u r o 1 6 , 0 0 0 .

T h e s u b m i s s i o n d e a d l i n e f o r t h e L . I . i s : - - - - - - - - - - .

L e t t e r o f I n t e n t t o b e s u b m i t t e d t o t h e f o l l o w i n g a d d r e s s :I C G E B - O ffi c e o f t h e D i r e c t o r - G e n e r a l , a t t n . M s . N e r i n a B r a n d o l i n , P a d r i c i a n o 9 9 , I - 3 4 0 1 2 T r i e s t e , I t a l y



NUMBER OF TRAINEE/YEAR FUNDED (1989-2004)

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GEOGRAPHICAL DISTRIBUTION OF FELLOWSHIPS FUNDED (1989-2004)

23%

7%

24%

46%LATIN AMERICA

AFRICA

ASIA

EUROPE

2005 FELLOWSHIP PROGRAMME

32 NEW FELLOWSHIPS AWARDED:

• 19 PRE-DOCTORAL

•13 POST-DOCTORAL

CURRENTLY, 75 FELLOWS ON BOARD



ICGEB meetings and coursesparticipants 1988-2004

(Member States/Signatory Countries nationals and ICGEB scientists)

0

100

200

300

400

500

600

700

800

900

1989 1990 1991 1992 1993 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004

EL June 2005

ICGEB meetings and coursesparticipants 1988-2004

(Member States/Signatory Countries nationals and ICGEB scientists)

Europe37%

Africa10%

Latin America31%

Asia22%

EL June 2005

Meeting proposals received(annual calls 1988-2006)

Europe29%Africa

14%

Latin America36%

Asia21%

EL June 2005

Meetings hosted by Affiliated Centresin Member States

1988-2005

Europe12%

Africa12%

Latin America59%

Asia17%

EL June 2005



International Center for Genetic Engineering and Biotechnology Fondazione Cassamarca

ICGEB Biosafety Outstation at Ca’ Tron

Biosafety Unit

What role does ICGEB play in Biosafety

• Dissemination of information Biosafety Bibliographic Database Risk Assessment Searching Mechanism (RASM) GMO RES COM Publications WebPages and Biosafety News

• Capacity building Biosafety annual workshops Biosafety Research at our Outstation in Ca’ Tron Co-operation and training with Member State biosafety authorities in biosafety and risk assessment Construction of the Italian national BCH

• International co-operation Voluntary Code of Conduct (1991) Co-operation with UNIDO, UNESCO, UNEP, FAO, and CBD-Biosafety Clearing-House (BCH) Participation in Inter-Agency Network for Biosafety (IANB)

ICGEB TO ASSIST THE UN SECRETARIAT IN FULFILLING THE MANDATE RECEIVED FROM THE SECURITY COUNCIL TO REINFORCE ETHICAL NORMS AND THE CREATION OF CODES OF CONDUCT FOR SCIENTISTS THROUGH INTERNATIONAL AND NATIONAL SCIENTIFIC SOCIETIES AND INSTITUTIONS THAT TEACH SCIENCES OR ENGINEERING SKILLS RELATED TO WEAPONS TECHNOLOGIES

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RELATIONSHIP WITH OTHER INTERNATIONAL ORGANISATIONS

A/60/184

General Assembly Economic and Social Council

United Nations

Distr.: General 2 August 2005

Original: ENGLISH General Assembly Sixtieth session Item 56(b) of the provisional agenda* Globalization and interdependence: science and technology for development

Implementation of General Assembly resolution 58/200 Science and Technology for Development

Report by the Secretary-General

* A/60/150

Summary

The present report is prepared in response to General Assembly resolution 58/200. It summarizes work carried out by entities in the United Nations system in the area of biotechnology.

A/60/184

General Assembly Economic and Social Council

United Nations

Distr.: General 2 August 2005

Original: ENGLISH

PARAGRAPH 10: AS THE ONLY OPERATING LABORATORY IN THE FIELD OF GENETIC ENGINEERING AND BIOTECHNOLOGY WITHIN THE UNITED NATIONS SYSTEM, AND AS A MAJOR TRAINING AND INFORMATION RESOURCE FOR DEVELOPING COUNTRIES, THE ICGEB UNDERTAKES A SPECTRUM OF ACTIVITIES REFLECTING ALL FIVE PROGRAMME AREAS [OF AGENDA 21]. AS A TECHNICAL ARM, IT IS CLEARLY IN A POSITION TO CLOSELY COLLABORATE WITH OTHER AGENCIES IN FIELDS SUCH AS INNOVATION DEVELOPMENT, BIOSAFETY, TECHNOLOGY TRANSFER, INVESTMENT STRATEGIES AND MANAGEMENT, INCLUDING THE DEVELOPMENT, ACQUISITION AND COMMERCIALIZATION OF BIOTECHNOLOGY PRODUCTS, SERVICES AND INDUSTRIAL PROCESSES, AS WELL AS IN GLOBAL BIO-INFORMATIC NETWORKING.

Other references in paragraphs 6, 12, 21, 30, 50, 51, 52, 53, 54, 79 & 80

http://www.icgeb.orghttp://www.icgeb.org

TERMS OF SERVICE OF THE REMAINING TEN MEMBERS OF THE CSA

NEW DELHI, 16 FEBRUARY 2005

“WE NOTE CONTINUING WORK TO EXPLORE ESTABLISHING AN INTERNATIONAL CENTRE FOR GENETIC ENGINEERING AND BIOTECHNOLOGY CENTRE [COMPONENT] IN AFRICA, TO HELP RESEARCH INTO VACCINES FOR THE DISEASES THAT ARE AFFLICTING THE CONTINENT”.

“WE SUPPORT THE ESTABLISHMENT OF THE THIRD COMPONENT OF THE INTERNATIONAL CENTRE FOR GENETIC ENGINEERING AND BIOTECHNOLOGY IN AFRICA”.

SECOND AFRICAN MINISTERIAL CONFERENCE ON SCIENCE AND TECHNOLOGY(DAKAR, SENEGAL, 26-30 SEPTEMBER 2005)

WHY?

•SET-UP OF A CRITICAL MASS•DEMAND-DRIVEN RESEARCH AND TRAINING PROGRAMMES•PROVIDE ACCESS TO TECHNOLOGIES•DEVELOP ENTREPRENEURSHIP AND INDUSTRY/LABORATORY RELATIONS•ACT AS A CLEARING HOUSE FOR THE REGION•ENSURE ADEQUATE SYNERGIES WITH THE AAB AND THE ICGEB AFFILIATED CENTRES•MULTIPLYING EFFECT WITH TRIESTE AND NEW DELHI.

AND AN ICGEB COMPONENT INLATIN AMERICA?

Documents

1987-1995 a UNIDO special project 1995-today An independent international organization