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R E S E A R C H Open Access
The relationship between hip abductor musclestrength and iliotibial band tightness inindividuals with low back painAmir M Arab1*, Mohammad R Nourbakhsh2
Abstract
Background: Shortening of the iliotibial band (ITB) has been considered to be associated with low back pain (LBP).
It is theorized that ITB tightness in individuals with LBP is a compensatory mechanism following hip abductor
muscle weakness. However, no study has clinically examined this theory. The purpose of this study was toinvestigate the muscle imbalance of hip abductor muscle weakness and ITB tightness in subjects with LBP.
Methods: A total of 300 subjects with and without LBP between the ages of 20 and 60 participated in this cross-
sectional study. Subjects were categorized in three groups: LBP with ITB tightness (n = 100), LBP without ITB
tightness (n = 100) and no LBP (n = 100). Hip abductor muscle strength was measured in all subjects.
Results: Analysis of Covariance (ANCOVA) with the body mass index (BMI) as the covariate revealed significant
difference in hip abductor strength between three groups (P < 0.001). Post hoc analysis showed no significant
difference in hip abductor muscle strength between the LBP subjects with and without ITB tightness (P = 0.59).
However, subjects with no LBP had significantly stronger hip abductor muscle strength compared to subjects with
LBP with ITB tightness (P < 0.001) and those with LBP without ITB tightness (P < 0.001).
Conclusion: The relationship between ITB tightness and hip abductor weakness in patients with LBP is not
supported as assumed in theory. More clinical studies are needed to assess the theory of muscle imbalance of hip
abductor weakness and ITB tightness in LBP.
BackgroundShortening of the iliotibial band (ITB) has been consid-
ered to be associated with low back pain (LBP) [1-4].
Stretching of the ITB is frequently recommended in
LBP treatment programs [1,3,5]. However, the exact
cause of ITB shortness in persons with LBP has not yet
been determined. Anatomically, the ITB is a continua-
tion of the tendinous portion of the tensor fascia lata
(TFL) muscle with some contributions from the gluteal
muscles. TFL/ITB is a synergist of gluteus medius mus-
cle in hip abduction [6]. Hip abductor muscles play a
significant role in control of rotational alignment of the
limb and maintaining pelvic lateral stability in single leg
stance [1,6,7]. Gottschalk et al [8] believe that the pri-
mary function of hip abductors is to stabilize the
femoral head in the acetabulum during different parts of
the gait cycle. The anterior and middle parts of the glu-
teus medius have a more vertical pull and help initiate
abduction, which is then completed by the TFL/ITB. It
is critical that these muscles fire properly through the
support phase of the gait cycle, as they eccentrically
lengthen while helping to stabilize the pelvis and control
femoral adduction in the transverse plane [8].
It is theorized that weakness of hip abductor may
cause a compensatory dynamic valgus knee alignment
resulting in increased stress on the ITB and conse-
quently ITB shortness [7,9].
Jull and Janda have hypothesized a common muscle
imbalance pattern of weakness in gluteus medius and tight-
ness of ITB in chronic musculoskeletal pain syndromes in
the lumbar-pelvic-hip area such as chronic LBP [10-12].
Investigators categorized muscles, based on their primary
functions, as “phasic” or “postural”, and indicated that in
response to dysfunction or overuse, the phasic muscles
* Correspondence: [email protected] of Physical Therapy, University of Social Welfare and
Rehabilitation Sciences, Evin, Tehran, Iran
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tend to be inhibited or weakened; while the postural mus-
cles tend to develop higher tone and ultimately shorten
[10-15]. In this classification, the gluteus medius; primary
muscle for hip abduction, is categorized as phasic and TFL/
ITB; the synergist muscle, is categorized as postural muscle.
It is assumed that when primary muscle responsible
for a specific joint movement is weakened, the synergis-
tic muscle is substituted and become overactive to be
the primary muscle responsible for that movement
[10,15,16]. Based on these assumptions, it is speculated
that ITB shortness in patients with LBP is a compensa-
tory mechanism following hip abductor weakness.
To our knowledge, no study has clinically examined
the theory of muscle imbalance of hip abductor weak-
ness and ITB tightness in patients with LBP.
However, some studies have examined the relationship
between hip abductor strength and ITB syndrome in run-
ners. With the use of different designs and testing proce-dures, controversial results have been reported in the
studies. Fredericson et al [17] examined hip abductor
strength in distance runners with ITB syndrome and a
control group of healthy distance runners and found that
distance runners with ITB disorder have weaker hip
abduction strength compared with healthy subjects. Mac-
Mahon and colleagues [18] in a study of 50 runners in
which they prospectively evaluated peak hip adduction
moments at the beginning of the training programs,
found that 7 of the runners subsequently developed ITB
disorders and all of whom had significant increased peak
hip adduction moments (representative of the decreased
ability of the hip abductors to eccentrically control
adduction) when compared with non-injured runners.
Thus, strengthening of the hip abductors has been
recommended for symptom improvement in subjects
with ITB dysfunction [17]. In contrast, Grau et al [19]
compared the hip abductor strength in 10 healthy run-
ners and 10 runners with ITB syndrome and concluded
that weakness of hip abductors does not seem to play a
role in the etiology of ITB syndrome in runners.
Some reports have also demonstrated an association
between LBP and hip abductor muscle weakness [20-22].
Considering the literature, it seems that the relation-
ship between hip abductor muscle weakness and ITBtightness in patients with chronic LBP warrants further
research. The purpose of this study was to evaluate the
muscle imbalance of hip abductor weakness and ITB
tightness in LBP by investigating the relationship
between tightness of ITB and hip abductor muscle
strength in subjects with LBP.
Methods
Subjects
A total of 300 subjects with and without LBP between
the ages of 20 and 60 participated in this prospective
cross sectional study. Individuals with LBP were selected
among the patients in the orthopedic and physical ther-
apy departments. At first 100 subjects with LBP who
were diagnosed with ITB tightness were selected. Then,
100 subjects with LBP without ITB tightness and 100
subjects with no LBP, matched in age and gender to
those with ITB tightness, were selected from the same
clinical settings as control groups. All the subjects
signed an informed consent form approved by the
human subjects committee at the University of Social
Welfare and Rehabilitation Sciences before participating
in the study.
Selection Criteria
Subjects with LBP were included if they had a history of
LBP for more than six weeks prior to the study or had
at least three episodes of intermittent low back pain,
each one lasting more than one week, during the year
prior to the time of the study. Subjects without LBPwere included if they had no spinal column pain and
had no radicular pain in their lower extremities during
one year period before the study. Subjects were excluded
if they had history of spinal surgery, spinal or pelvic
fracture, hospitalization for trauma of motor vehicle
accident, fractures of the lower extremity, hip/knee dys-
functions such as knee valgus/varus, pregnancy, any sys-
temic disease such as arthritis, tuberculosis, liver and/or
kidney failure. Subjects with leg length discrepancies,
because of its potential effect on ITB length [23] were
also excluded. The leg length was measured from the
anterior superior iliac spine to the distal medial malleo-
lus with a measuring tape and subjects with leg length
difference greater than 10 mm were excluded [20,23].
Procedure for diagnosing ITB tightness
The Ober test, a common and widely accepted test for
measuring the length of the ITB, was used to assess the
ITB tightness [9,17,23-25]. This test was performed in
the side lying position. Subject’s lower leg was flexed at
the hip and knee joints. The examiner, standing behind
the subject, with one hand, stabilized the pelvis and pas-
sively abducted and extended the upper leg with the
knee flexed with the other hand. Maintaining extension
and neutral position of the hip, the examiner allowed
the testing leg to drop toward the table. If subject ’s legremained abducted, the subject was considered as hav-
ing ITB tightness. Based on test results, subjects with
LBP were categorized as with or without ITB tightness.
Measuring hip abductor muscle strength
Hip abductor muscle strength, in this study, was quanti-
tatively measured by a pressure meter similar to the one
described by Helewa et al [26,27]. The reliability and
validity of this procedure has previously been established
[20,26]. The unit used in this study first was calibrated
and had 99% measurement accuracy. To measure mus-
cle strength, subjects assumed the standard positions for
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testing the hip abductor muscle strength [28]. We fol-
lowed the detail instructions by others [ 9,17 ,22] to
selected standard contact points to measure the muscles
strength. The pelvis was fixed and the inflated bag of
the pressure meter was placed between the examiner ’s
hand and the specified contact point for test on the sub-
ject ’s tigh [22]. The pressure meter used in this study
provided measurements in kPa units, which is defined
as force per unit area. To assure reliability of measure-
ments, hip abductor strength assessments were per-
formed by one therapist. We selected standard contact
point, recommended for manual muscle testing, and
used the same size inflated bag for all strength measure-
ments. At the end of the test procedure, the subjects
were asked if pain was a limiting factor to produce
voluntary muscle contraction in assessment of muscle
strength. The subjects who had pain during the testing
procedure which affect strength testing were excluded
from the study. Intra-class correlation analysis revealedICC (3,1) values equal to 0.92 for reliability of hip
abductor muscle strength assessments [20].
Data Analysis
Subjects who with LBP tested positive on the Ober test
were considered as having ITB tightness and those
with negative test were classified as having LBP with-
out ITB tightness. Because the effect of Body Mass
Index (BMI) and body size on muscle function and
strength [29-31], Analysis of Covariance (ANCOVA)
with the BMI as the covariate in the analysis was cal-
culated to compare the hip abductor muscle strength
across the three groups.
ResultsDescriptive data related to subjects for all three groups
is presented in Table 1. There was no statistically signif-
icant difference in subjects’ age, height, weight and BMI
among the three groups. Refer to Table 1 for detailed
data.
Descriptive statistics (Mean, SD) for hip abductor
muscle strength in three groups and the results of
ANCOVA are provided in Table 2.
The findings of ANCOVA with the BMI as covariate
revealed significant difference in hip abductor strength
between three groups (P < 0.001). Post hoc analysis showed
that there was no significant difference in hip abductor
muscle strength between the LBP subjects with and without
ITB tightness (P = 0.59). Subjects with no LBP had signifi-
cantly stronger hip abductor muscle strength compared to
subjects with LBP with ITB tightness (P < 0.001) or those
with LBP without ITB tightness (P < 0.001).
DiscussionThe results of this study, in agreement with others
[20-22], showed that subjects with LBP, in general, pre-
sent with weaker hip abductor muscles compared to
those without LBP. The results of this study showed
that in subjects with LBP, those with ITB tightness had
no significantly weaker hip abductor muscle strength
compared to individuals without ITB tightness (Table 2).
Considering these findings, it seems that hip abductor
muscle weakness is not more pronounced in individuals
with LBP with ITB tightness. These findings are in con-
trast with the notion proposed by others [10,15,16] that
Table 1 Mean Age, Height and Weight of the Subjects in each group.
With No LBP LBP with ITBT LBP with no ITBT P-values
Mean SD Mean SD Mean SD
Age 43.4 4.41 44.23 13.04 42.58 14.1 0.32
Weight (Kg) 70.18 11.45 72.77 11.92 69.10 10.1 0.25Height (m) 1.65 0.09 1.66 0.09 1.66 0.09 0.43
BMI (Kg/m2) 25.68 4.1 26.11 3.34 25.03 3 0.07
LBP = Low Back Pain
ITBT = Iliotibial Band Tightness
Table 2 Hip abductor muscle strength for the three groups and ANCOVA with BMI as the covariate.
Variables With No LBP LBP with ITBT LBP with no ITBT P-valuesANCOVA
Mean SD Mean SD Mean SD
Hip AbductorStrength (Kpa)
33.51 7.29 27.07 8.01 27.87 7.95 0 < 001 *
LBP = Low Back Pain
ITBT = Iliotibial Band Tightness
* Post Hoc Analysis: LBP with ITBT vs. LBP without ITBT: P = 0.59;
No LBP vs. LBP with ITBT: P < 0.001;
No LBP vs. LBP without ITBT: P < 0.001
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ITB tightness could be a compensatory mechanism for
providing pelvic lateral stability in subjects with hip
abductor weakness.
Some investigators have also hypothesized a common
muscle imbalance pattern of weakness in hip abductor
and tightness of ITB in chronic LBP [10-15] . I t is
assumed that when the primary muscle responsible for
hip abduction; gluteus medius, is weakened, the syner-
gistic muscle; TFL, is substituted and become overactive
to be the primary muscle [10,15,16]. Thus, in theory, it
is thought that hip abductor weakness, shown in sub-
jects with LBP, is accompanied with ITB tig htness in
these subjects. Based on these assumptions, if the pro-
posed theory was true, one would expect a significant
difference in the hip abductor strength between subjects
with LBP with ITB tightness and those without ITB
tightness. In this study, however, no significant differ-
ence was found in hip abductor strength between LBPsubjects with and without ITB tightness (Table 2). Based
on these findings, it seems that ITB tightness might not
probably occurred following hip abductor weakness in
subjects with LBP as it has been assumed in theory.
The hip abductors help to control rotational align-
ment of limb and maintain pelvic stability in single leg
stance [1,6,7]. It is theorized that weakness of hip
abductor muscle may cause a compensatory dynamic
valgus knee alignment resulting in increased stress on
the ITB. Eggen et al [32] found that knee valgus move-
ment increased after the hip abductors insufficiency.
The fact that no significant difference in hip abductor
muscle strength was found in subjects with LBP with
ITB tightness compared to those without ITB tightness
may be due to this that subjects with obvious knee val-
gus were excluded from this study. Furthermore,
although the gluteus medius and ITB are both hip
abductors, the gluteus medius is an external rotator of
the hip whereas TFL/ITB is an internal rotator of hip.
Thus, the function of hip abductor muscle could not be
completely substituted by ITB. Similar findings have
been reported elsewhere in other musculoskeletal disor-
ders. Sims et al [33] found a significant difference in
gluteus medius activation and no significant difference
in TFL in s ub jects w ith clinical unilateral hiposteoarthiritis compared to a control group. Grau et al
[19] in a study of 10 healthy runners and 10 runners
with ITB syndrome concluded that hip abductors weak-
ness does not seem to play a role in the etiology of ITB
syndrome in runners. It seems that function of muscles
and joints in the lower extremity are highly interrelated
and weakness or tightness of the muscles might be
affected by several factors such as knee, ankle, foot and
other disorders [34]. Although no significant difference
was found in hip abductor strength between LBP groups
with and without ITB tightness, this may be due to the
fact that subjects, in this study, were not totally con-
trolled for disorders in other joints in lower extremity.
Another issue should be considered is “pain interfer-
ence” and intensity level of pain. Some investigators sta-
ted that muscle dysfunction in LBP patients might be
related to pain, called “pain interference” [35]. They pro-
posed that general ability of voluntary contraction in all
muscles might be reduced in patients with LBP because
of the pain sensation. Our findings could be criticized
because low-level pain might produce the changes the
researchers were testing for, whereas those with high
pain intensity may have the changes. In this study, the
subjects were asked if pain was a limiting factor to pro-
duce voluntary muscle contraction in assessment of
muscle strength. The subjects who had pain during the
testing procedure were excluded from the analysis.
However, one of the limitations of this study was thisissue that intensity level of pain was not rated. We
wanted to have a more heterogeneous population of
patients with chronic LBP with different level of pain.
Another area of concern in our study is that the exami-
ner performing muscle strength test was aware of health
status of the participants and ITB tightness. However, the
examiner tried to have no bias on strength test results.
Cross-sectional studies, including this one, cannot deter-
mine the pathophysiology of such association. The rela-
tionship between ITB tightness and hip abductor
weakness could still be investigated in a longitudinal study.
ConclusionIn conclusion, the results of this study, in contrast with
presented theory, revealed no significant difference in hip
abductor strength between subjects with LBP with and
without ITB tightness. However, our data indicated that
both LBP subjects with ITB tightness and those without
ITB tightness have significantly lower hip abductor muscle
strength compared with subjects without LBP. It seems
that in clinical evidence, ITB tightness might not be due
to a compensatory mechanism following hip abductor
weakness in subjects with LBP. More clinical studies are
needed to assess the stated hypothesis regarding the the-
ory of muscle imbalance between hip abductor muscleweakness and ITB tightness in patients with LBP.
Clinical implications
The results of this study could be beneficial to clinicians
when prescribing therapeutic exercises for patients with
ITB tightness, particularly those with LBP.
Consent/ethicsThis research was reviewed and was approved by the
Human Subject Committee at University of Social Wel-
fare and Rehabilitation Sciences.
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Abbreviations
ITB: Iliotibial Band; LBP: Low Back Pain; TFL: Tensor Fascia Lata
Author details1Department of Physical Therapy, University of Social Welfare and
Rehabilitation Sciences, Evin, Tehran, Iran. 2Department of Physical Therapy,
North Georgia College and State University, Dahlonega, GA, USA.
Authors’ contributions
Both authors have made substantial contributions to conception and design,
acquisition of data, analysis and interpretation of data and have been
involved in preparing the manuscript. Both authors read and approved the
final manuscript.
Competing interests
The authors declare that they have no competing interests.
Received: 29 June 2009Accepted: 13 January 2010 Published: 13 January 2010
References
1. Lee D: The Pelvic Girdle. An approach to examination and treatment of
the lumbo-pelvic-hip region. New York: Churchill Livingston, 2 1999, 153-
169.
2 . Ober FR: The role of the iliotibial band and fascia lata as a factor in the
causation of low-back disabilities and sciatica. J Bone Joint Surg 1936,
18:105-110.3. Chaitow L: Maintaining body balance, flexibility and stability. A practical
guide to the prevention and treatment of musculoskeletal pain and
dysfunction. New York: Churchill Livingstone 2004, 95.4. Vasilyeva LF, Lewit K: Diagnosis of muscular dysfunction by inspection.
Rehabilitation of the Spine Baltimore: Williams &WilkinsLiebenson C 1996,
113-142.
5. Kasunich NJ: Changes in low back pain in a long distance runner after
stretching the iliotibial band. Journal of Chiropractic Medicine 2003, 2:37-40.
6. Neumann DA: Kinesiology of the musculoskeletal system: Foundations
for physical rehabilitation. St. Louis: Mosby 2002.
7. Fulkerson JP: Disorders of the patellofemoral joint. Baltimore, MD: Williams
& Wilkins, 3 1997.
8. Gottschalk F, Kourosh S, Leveau B: The functional anatomy of tensorfasciae latae and gluteus medius and minimus. J Anat 1989, 166:179-189.
9. Piva SR, Goodnite EA, Childs JD: Strength around the hip and flexibility of
soft tissues in individuals with and without patellofemoral painsyndrome. J Orthop Sports Phys Ther 2005, 35:793-801.
10. Jull G, Janda V: Muscle and motor control in low back pain: Assessment
and management. Physical Therapy for the low back. Clinics in Physical
Therapy New York: Churchill LivingstonTwomey LT, Taylor JR 1987, 253-278.
11. Janda V: Muscle and back pain - Assessment and treatment of impaired
movement patterns and motor recruitment. Associated course to the 5th
international symposium of the Physical Medicine Research Foundation,
Oxford, England 1992.
12. Janda V: Muscle strength in relation to muscle length, pain and muscle
imbalance. Muscle strength. International Perspectives in Physical Therapy (8)
Churchill Livingston, EdinburghHarms-Ringdahl K 1993.
13. Norris C: The Muscle debate. Journal of Bodywork and Movement Therapies
2000, 4:232-235.
14. Chaitow L, Delany JW: Clinical application of neuromuscular techniques.Churchill Livingstone, China 2002, 22-26.
15. Sahrmann SA: Diagnosis and treatment of movement impairment
syndromes. St. Louis: Mosby, Inc. 2002.
16. Comerford MJ, Mottram SL: Movement and stability dysfunction-
contemporary developments. Man Ther 2001, 6:15-20.
17. Fredericson M, Cookingham CL, Chaudhari AM, Dowdell BC, Oestreicher N,
Sahrmann SA: Hip abductor weakness in distance runners with iliotibial
band syndrome. Clin J Sport Med 2000, 10:169-175.
18. MacMahon JM, Chaudhari AM, Andriacchi TP: Biomechanical injury
predictors for marathon runners: striding towards iliotibial band
syndrome injury prevention. Conference of the International Society of
Biomechanics in Sports, Hong Kong 2000.
19. Grau S, Krauss I, Maiwald C, Best R, Horstmann T: Hip abductor weakness
is not the Cause for iliotibial band syndrome. Int J Sports Med 2008,
29:579-583.
20. Nourbakhsh MR, Arab AM: Relationship between mechanical factors andincidence of low back pain. J Orthop Sports Phys Ther 2002, 32:447-60.
21. Nadler SF, Malanga GA, DePrince M, Stitik TP, Feinberg JH: The relationship
between lower extremity injury, low back pain and hip muscle strengthin male and female collegiate athletes. Clin J Sport Med 2000, 10:89-97.
22. Nadler SF, Malanga GA, Feinberg JH, Prybicien M, Stitik TP, DePrince M:
Relationship between hip muscle imbalance and occurrence of low back
pain in collegiate athletes. a prospective study. Am J Phys Med Rehabil
2001, 80:572-577.
23. Fredericson M, Weir A: Practical management of iliotibial band friction
syndrome in runners. Clin J Sport Med 2006, 16:261-268.
24. Magee DJ: Orthopedic physical assessment. Philadelphia: W. B. Saunders, 3
1997, 482.
25. Gose JC, Sweizer P: Iliotibial band tightness. Orthop Sports Phys Ther 1993,
10:399-407.
26. Helewa A, Goldsmith CH, Smythe HA: The modified sphygmomanometer.
An instrument to measure muscle strength: A validation study. J Chronic
Disord 1981, 34:553-561.27. Helewa A, Goldsmith C, Smythe H: Patient, observer and instrument
variation in the measurement of strength of shoulder abductor muscles
in patients with rheumatoid arthritis using a modifiedsphygmomanometer. J Rheumatol 1986, 13:1044-1049.
28. Kendall FP, McCreary EK, Provance PG: Muscle testing and function.
Lippincott Williams & Wilkins, Philadelphia, 4 1993.
29. Jaric S: Muscle strength testing: use of normalisation for body size. Sports
Med 2002, 32:615-631.
30. Aasa U, Jaric S, B BM, Johansson H: Muscle strength assessment from
functional performance tests: role of body size. J Strength Cond Res 2003,
17:664-670.
31. Markovic C, Jaric S: Movement performance and body size: the
relationship for different groups of tests. Eur J Appl Physiol 2004, 92:139-149.
32. Eggen J, Carcia C, Gansneder B: Hip abductor fatigue affects knee motion
during the landing phase of a drop jump. J Athl Train 2003, 38(suppl):S-
22.33. Sims KJ, Richardson CA, Brauer SG: Investigation of hip abductor
activation in subjects with clinical unilateral hip osteoarthritis. AnnRheum Dis 2002, 61:687-692.
34. Fergusen LW: Knee pain: Addressing the interrelationships between
muscle and joint dysfunction in the hip and pelvis and the lower
extremity. Journal of Bodywork and Movement Therapies 2006, 10:287-296.
35. Moseley GL, Hodges PW: Are the changes in postural control associated
with low back pain caused by pain interference?. Clin J Pain 2005,
21:323-329.
doi:10.1186/1746-1340-18-1Cite this article as: Arab and Nourbakhsh: The relationship between hip
abductor muscle strength and iliotibial band tightness in individualswith low back pain. Chiropractic & Osteopathy 2010 18:1.
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