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$424 Thursday, November 10, 2005 Poster Abstracts
expression was higher in the chronic ischemic lesions than in the acute lesions. Contusion: Under chronic ischenfic condition, brains may respond for neuroprotection by increasing the expression of C×43 and UCPs.
1270 Transient lsehemie Attack in Chinese
Ng, PW ~, Sha, KY ~. 1United Christian Hospital, Hong Kong SAR
Background: Transient ischemic attack (TIA) is a syadrome character- ized by sudden onset of focal neurological deficit due to a vascular lesion wlffch resolves within 24 hours. Patients suffered from TIA have a high risk of subsequent vascular events. However there is limited data in Chinese patients. Method: Tiffs is a retrospective review of all Chinese patients admitted to United Christian hospital (serving a population of 600,000) with a diagnosis of TIA in 2003 -2004. The presentation, cerebrovascular risk factors, investigation results, treatment and subsequent events were noted. Result: In 2003-200:1, 212 Chinese patients were discharged with a diagnosis of TIA. There were 115 male and 97 female. Their age ranged from 32-96 years. The commonest symptom on presentation was motor weakness (62%) followed by speech problem (19%). All except 1 patients had CT scan of the brain done. 50% of CT brain results were normal, 21% showed non specific ischemic changes whereas 20% showed infarcts in the corresponding territory. Most common risk factors were hypertension (70%), hyperlipidaemia (148%) and diabetes mellitus (28%). Carotid doppler was carried out in 69 patients with only 6 showing sigtffficant stenosis. Anti-platelet or atttithrombotic was given to 204 patients with aspirin in 89%. Vascular events occurred in 44 patients (20.7%) during a follow up of 4 to 28 months and 55% of these took place within 90 days. Conclusion: In view of the high risk of vascular outcomes, aggressive management was warranted in Clffnese patients presented as TIA.
1271 Chronic Chlamydia pneumoniae infection and stroke in Cameroon: a case-control study
Njamnshi, A t'z, Njanmshi, C 4, Ngu Blackett, K 3'2, Mbuagbaw, j3,2, Gupta, S 5. 2Central Hospital Yaounde-Neurology Service, Cameroon; :Department of lnternal Medicine and Specialties, Faculty of Medicine and Biomedical Sciences, University Of Yaounde I, Cameroon; 3University Hospital Cotter, Yaounde, Cameroon; 4Cardiac Clinic, Department of Medicine, Department of Medicine, University of Cape Townm South Africa; SDepartment of Cardiology, Whipps Cross University Hospital, London, United Kingdom
Objective: To detemrine the relationslffp between chronic Chlamydia pneumoniae infection and stroke in Cameroon. Methods: Sixty-four consecutive patients, aged 26 to 80 years, presenting with stroke at two University Teaching Hospitals in Yaound6 Cameroon, were enrolled into tiffs study between March 2000 and December 2001. Patients were matched for age, sex and hypertension with 64 controls. We measured IgG (1/64) and IgA (1/16) titres against Chlamydia pneumoniae in both patients and controls using micro-immunofluorescence assay. Results: There was no significant difference between the patients and controls with respect to current smoking status (p -- 0.48), alcohol intake (p - 0.41), body mass index (p -- 0.41), waist-to-lffp ratio (p - 0.17), waist circumference (i3 - 0.06), and diabetes (13 -- 0.71). IgG antibodies were detected in 41 (164.1%) patients and 35 (54.7%) controls (odds ratio [OR] 1.51, 95% confidence intervals [CI] 0.8 to 3.1, p - 0.25). IgA antibodies were detected in 51 (79.7%) patients and 27 (42.2"/0) controls (OR 5.0, 95% CI 2.3 to 10.8, p < 0.0001). In the subgroup of confirmed ischaenffc stroke, the association with IgA antibodies became even stronger (OR 22.6, 95"/0 CI 5.0 to 102.5,
p < 0.000001), but there was no association with IgG antibodies (OR 1.:1, 95% CI 0.6 to 3.3, p - 0.43). Contusions: The current study confirms the strong statistical associa- tion between chronic Chlamydia pneumorfiae infection and stroke, for the first time in a resident indigenous central African population. These findings may have important policy implications in sub-Saharan Africa.
1272 Stroke in Sickle-cell patients in Yaounde
A.K. Njamnslfi 1, E. N. Mbong 1, P. Ongolo-Zogo 1, V. Djientcheu 1, L. Dongmo 1, D. Mbanya ~, W. Munak 1Neurology Service, Central Hospital Yaounde; Faculty of Medicine & Biomedical Sciences, University of Yaounde, Cameroon
Background/Purpose: Sickle-cell disease has been reported as the first cause of stroke in clffldren in Yaounde (Cameroon) but the prevalence of stroke in tiffs population has never been studied. We therefore carried out a cross-sectional study to determine the prevalence and some characteristics of stroke in sickle-cell disease children in Yaounde. Patients/Methods: Homozygous SS sickle cell patients attending two sickle-cell clinics over a three-month period were subjected to a questionnaire and physical examination including a complete neuro- logical examination to look for features of past or present stroke. Stroke was confirmed where possible with a brain CT scan. Results: 120 homozygous sickle-cell patients (mean age 13.49 ± 8.79 years) were included in the study. Eight cases of stroke (mean age 16.6 d_ 11.2 years) were identified, giving a stoke prevalence of 6.67%. Ischaenffc stroke was thrice as common as hemorrhagic stroke and the former more frequent in subjects less than 20 years (5.21% as against 0.00 %); the latter in patients older than 20 (8.33% as against 4.17%). The missed stroke diagnosis rate was 25.00%. None of the risk factors examined showed a significant association with stroke. Contusions: Stroke is a serious, unrecogtffzed complication of sickle- cell disease in Yaounde. There is an urgent need to implement stroke morbidity reduction measures in Cameroonian sickle cell patients and to perform larger studies to examine risk factors, within the context of a comprehensive sickle-cell disease control programme.
1273 Good corrdations between Serum Adiponeetin Levels and other Hematological markers of Cardiovascular Disease's risks in patients with past history of Stroke
Nomura, E ~, Naka, H a, Takahashi, T ~, Kohriyama, T ~ , Matsumoto, M ~. 1Department of Clinical Neuroscience and Therapeutics, Hiroshima University, Graduate School of Biomedical Sciences, Hiroshima, Japan; 2Department of Neurology, Suiseikai Kujikawa Hospital, Hiroshima, Japan
Purpose: Adiponectin, a newly found adipose tissue-specific collagen- like protein, has been noted as an important antiatherogenic protein, and its serum levels have been reported to be lower in patients with atherogenic diseases, such as diabetes or dyslipidemia. Our purpose of tiffs study was to explore the correlations between adiponectin and other hematological markers of cardiovascular disease's risks in patients with a past history of stroke. Subjects and Methods: One hundred and three patients (mean age 69.0 years, 53.4 % male) with a past history of stroke (179 ischemic and 24 hemorrhagic) were enrolled. We determined the levels of insulin, HbAlc, total cholesterol (TC), high density lipoprotein cholesterol (HDL), triglycerides (TG), apolipoprotein A1 (apo-Al), apolipopro- rein B (apo-B), adiponectin, high sensitive CRP (Its CRP), and plasminogen activator inhibitor type l (PAI-1). Correlations between them were calculated with Spearman rank correlation coeffident. Results: Adiponectin levels showed sigtffficant inverse correlations with insulin (p - 0.0002), H b A l c (p - 0.0266), TG (p - 0.0036), apo-B (p -- 0.0009), hsCRP (p _ 0.0024), and PAL1 (p _ 0.0157) levels,