DECEMBER 31, 2015 ISSUE 2

Letter From the CEO:

The offices of The WBDC are booming with activity. As we wind down 2015 and move into 2016, we are excited to showcase our programming and events. While our programs will be centered around the mind-body connection and holistic lifestyle, education will be a key focus. Education of patients, carriers, physicians, hospitals and clinics is vital in order to attack the inadequate medical care that women with bleeding disorder so often receive. I receive messages every day from women who are struggling either for a proper diagnosis, or they have their diagnosis and their physicians downplay their symptoms and refuse to treat. The WBDC is in the beginning phases of developing partnerships that will raise the level of awareness regarding women with bleeding disorders

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NEW PRODUCTS & CLINICAL TRIALS

BOARD SPOTLIGHT:

Jack Smith

Breaking Barriers

DECEMBER 31, 2015 ISSUE 2

THE BENEFITS OF EATING ANTI-INFLAMMATORY FOODS

We have all heard the phrase “You are what you eat”. Believe it or not, it is actually the truth. Through your diet, you can transform yourself and change the way you live and feel.

In a culture of fast food, instant gratification, and long work days, eating a proper diet seems daunting. To make the problem worse, the foods that are healthy are often more expensive than cheaply made fast food. That trade off has a price though, and one that we have come to accept as ‘normal’.

Inflammation is part of the body’s immune response. This response helps us heal, however, when it gets out of control it damages the body and causes issues like rheumatoid arthritis, among others.

Foods high in sugar and saturated fats, can spur inflammation. They cause overactivity in the immune system which can lead to joint pain and fatigue. As much damage as these foods can do to a body, the right foods can undo damage and inflammation.

What are the right types of foods? Add these foods into your diet regularly to help reduce inflammation and pain: fatty fish (salmon), whole grains, dark leafy greens, nuts, soy (not heavily processed), low fat dairy, colorful vegetables (especially tomatoes), ginger, turmeric, garlic and onions. You should also include plant based fats like olive oil. All fruits have anti-inflammatory properties and berries are considered one of the best for reducing inflammation.

Eating a poor diet affects more than your waist line, it can increase pain throughout the body. When you have an underlying issue, reducing chronic pain is always a struggle and one that a proper diet can help control. With a few minutes each week of planning and preparation, you can set yourself up for success.

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DECEMBER 31, 2015 ISSUE 2

WBDC PROGRAMS ~ Coming to a city near you~

Girls’ Night Out ~ An evening of education, socialization and relaxation. Each GNO events will differ slightly, however, each will include our core values which are centered around educating and empowering women, as well as living a healthy lifestyle.

Knowledge is Power (KIP) Webinars ~ The WBDC hosts monthly webinars featuring expert speakers on a variety of topics, as they relate to women's bleeding disorders. These cover medical, psychosocial, and the challenges of living with a chronic disorder.

WBDC Retreat ~ A women’s only retreat with the perfect combination of education, advocacy and leadership training, support and learning techniques for pain and stress management.

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DECEMBER 31, 2015 ISSUE 2

CSL Behring files for approval of hemophilia therapies in Europe and Japan

Germany-based biotherapeutics firm CSL Behring has submitted its Marketing Authorization Application to the European Medicines Agency for its novel investigational recombinant factor VIII single-chain (rVIII-SingleChain) for the treatment of hemophilia A. In the pivotal clinical trial, rVIII-SingleChain met all primary endpoints.

“Our focused research and development and strong relationship with the bleeding disorders community led us to seek further advancements in the care and treatment of hemophilia,” said Andrew Cuthbertson, chief scientific officer and director of R&D, at Australian parent company CSL Limited (ASX: CSL). “Today, we have the only recombinant single-chain factor VIII product in late-stage development for the management of hemophilia A. We look forward to, upon approval, providing this innovative specialty biotherapy to patients in the EU and European Economic Area,” he added.

The MAA is based on the AFFINITY clinical development program, which includes a Phase I/III open-label, multicenter trial examining safety and efficacy. The pharmacokinetics of rVIII-SingleChain compared with recombinant human antihemophilic factor VIII (octocog alfa) was also studied.

Seeks approval of hemophilia B agent rIX-FP in Japan

CSL Behring has also submitted its New Drug Application to Japan’s Pharmaceuticals and Medical Devices Agency (PMDA) for its investigational fusion protein linking recombinant coagulation factor IX with recombinant albumin (rIX-FP).

rIX-FP is a long-acting recombinant albumin fusion protein for people with hemophilia B, a congenital bleeding disorder characterized by deficient or defective factor IX. Based on the 2011 National Survey of Coagulation Disorder, hemophilia B occurs in around one to two of every 100,000 male births in Japan.

The US Food and Drug Administration, the EMA and Swissmedic are currently reviewing CSL Behring’s license applications for rIX-FP. ~ www.thepharmaletter.com

CSL Behring, Regulatory filings, rVII-SingleChain, Hemophilia A and B, rIX-FP, Europe, Japan, CSL Limited

Board Spotlight: Jack Smith

Jack Smith has 32+years of corporate Marketing, Advertising and Promotion. He was the Founder and Chief Executive Officer of Jackson Marketing Company, a Michigan Avenue, Chicago marketing and advertising agency specializing in brand name advertising and promotions, to create increases in sales through unique incentive programs. Jackson Marketing Company’s commercial clients included Black & Decker, Zenith, WGN, Success Magazine, Combined Insurance, Beacham Cosmetics, Prudential, Westin, Marriott and Fingerhut.

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DECEMBER 31, 2015 ISSUE 2

Jackson Marketing Company also assisted as consultants in promotions and advertising with notable sports related companies including the Chicago Cubs, Chicago White Sox, Chicago Bears, Forsythe Racing and ESPN. 

From 1975 to 1977 Jack Smith was responsible for pre-opening group sales and corporate sponsorships for the grand opening of Marriott's Great America now known as Six Flags.

In 2000, Jack created Bizware and RapidOffice.com, where he helped develop sales channels for the online services that automate selling cycles, maximize clients' consumer facing business communications, consistently present client's value proposition, and automatically initiate follow-up strategies. Bizware developed and deployed a direct-sales training program that reached over 5,000 sales associates in North America and Asia.

Since 2004, Jack has written numerous business plans and helped fund a variety of projects totaling $55MM in private equity. In 2010, Pelican Capital Advisors was created in response to the US market meltdown, Jack began developing a structured finance model utilizing life settlements to assist a dozen small to medium size businesses obtain nearly $1,000,000,000 of capital they needed to grow and expand. With the change in the Feds direction Spectre Industries has identified and targeted crypto-currency and the Gold industry for growth and expansion.

Jack has been diligent in learning the needs of women with bleeding disorders and the history of our community. He has become a highly respected member of our board in a short time. Thank you Jack for your support and dedication!

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DECEMBER 31, 2015 ISSUE 2

Upcoming Events:

January 8, 2016 January 20, 2016 March 2016

Austin, TX Jackson Hole, WY North CA

Girls’ Night Out Hemophilia for Clinicians Girls’ Night Out

BOARD & STAFF

Tammy Davenport, CEO/President pro tem

Samantha Costa, CFO

Randy DeSantis, Vice President

Ashley Gregory, Secretary

Darlene Shelton, Treasurer

Donald J. Smith, Board Member

Kendall Dean, RN , Board Member ~ Please visit our website for detailed bios on each member of our board and staff, as well as our Ambassador network and Medical Advisory Council.

You can opt-in to be on our mailing list on our website, www.womenbleed.org. For sponsorship and advertising information, contact Samantha Costa, CFO at samantha@womenbleed.org. For programming information, contact tammy@womenbleed.org.

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