Abstracts S129

and blood flow coefficient (BF) were calculated from time intensitycurve automatically. The pathological specimen was hematoxylin andeosin stained and tumor differentiation was graded by the Edmondsongrading system. The correlation between tumor perfusion parameterson CEUS and tumor differentiation was analyzed statistically.Results: The perfusion parameters of ISI, DC, AUC and BF in tumorsrelative to liver parenchyma were significantly different among differ-ent differentiation grades of HCC. As the differentiation grade in-creased in HCCs, the value of ISI, AUC and BF increased, while thevalue of DC decreased in time intensity curve (p�0.05).Conclusion: The quantitative analysis with CEUS gives different tu-mor perfusion parameters in different differentiation grades of HCC,which provides a noninvasive imaging method to assess the biologicalbehavior of HCCs.

1114

Contrast Enhanced Ultrasound: An Early Experience withDEFINITY®Chris Edwards, Princess Alexandra Hospital, AustraliaS King, Princess Alexandra Hospital, AustraliaM Benson, Princess Alexandra Hospital, Australia

The approval by the Therapeutic Drugs Administration of the 2ndgeneration micro-bubble contrast agent DEFINITY® has sparked anew wave of interest in the use of contrast agents in ultrasound. In ourdepartment we have a particular interest in the use of contrast ultra-sound for the diagnosis of a range of pathologies of the liver. The PAHospital is well placed to take advantage of this new diagnostic tool asit has Queensland’s largest hepatology department dealing with a widerange of chronic liver diseases including the management of Hepato-cellular Carcinoma. It is also Queensland’s primary site for liver andkidney transplantation performing approximately 120 kidney and 40liver transplants for adult patients each year.This poster presentation outlines an early experience with the use of theagent DEFINITY® and provides a visual pictorial of the enhancementpatterns of a range of focal liver lesions. . A number of simple caseswill be presented to highlight its potential as well as a discussion onfuture directions and research. The illustrated examples will includelesions such as Haemangioma, Focal Nodular Hyperplasia, Hepatocel-lular Carcinoma and Liver Metastases.The aim of this presentation is to highlight some of the unique advan-tages of ultrasound contrast agents compared with other complimentaryimaging modalities.

1115

Utility of Sonazoid-Enhanced Ultrasonography and Real-TimeVirtual Sonography in the Treatment of HepatocellularCarcinomaYuji Eso, Osaka Red Cross Hospital, Gastroenterology andHepatology, JapanAzusa Sakamoto, JapanAtsuyuki Ikeda, JapanHiroki Nishikawa, JapanRyuichi Kita, JapanSumihiro Okabe, Osaka Red Cross Hospital, Gastroenterology andHepatology, JapanTohru Kimura, Osaka Red Cross Hospital, Gastroenterology andHepatology, JapanYukio Osaki, Japan

Objective: Sonazoid-enhanced Ultrasonography(CEUS) has become

the important technique in the treatment support of hepatocellular

carcinoma. We evaluated the utility of Sonazoid-enhanced Ultrasonog-raphy and Real-time Virtual Sonography(RVS) in the treatment ofhepatocellular carcinoma with radiofrequency ablation(RFA) based onour experiences.Methods: Among RFA(233 cases) that we performed by June fromJanuary, 2008, we examined 110 cases that used RVS and/or CEUS atthe same time.Results: Among 110 cases, RVS was used in 25caces, CEUS was usedin 56cases, both of them were used in 29cases. Almost of the reasonswhy we used supporting images for RFA were the identification ofnon-ablated part in the case of the additional treatment or the recon-firmation of the position of the target tumor. Though these cases wereall slightly difficult to ablate and necessary to use supporting images,we were able to obtain enough ablative margins in 64% (70/110cases).Conclusions: As images supporting RFA, Real-time Virtual Sonogra-phy which identifies a tumor based on position information, and Son-azoid-enhanced Ultrasonography which identifies a tumor based onbloodstream information are complementary, and it is thought that bothimages can raise precision of RFA.

1116

Pilot Study of Contrast-Enhanced Transrectal Ultrasound forDifferential Diagnosis of Prostatic Nodules in the Transition andPeripheral ZonesXiang Fei, Department of Ultrasound, Chinese People’s LiberationArmy General Hospital, ChinaJie Tang, Department of Ultrasound, Chinese People’s LiberationArmy General Hospital, ChinaYanmi Li, Department of Ultrasound, Chinese People’s LiberationArmy General Hospital, ChinaLi Xu, Department of Ultrasound, Chinese People’s Liberation ArmyGeneral Hospital, China

Objective: To evaluate the clinical application of contrast-enhancedtransrectal ultrasound (CETRUS) in differential diagnosis of prostaticnodules in the transition and peripheral zones.Methods: This study was approved by the institutional reviewboard; all patients gave their written informed consent. Fifty-ninepatients with 63 nodules in transition and peripheral zones weredivided into BPH(26 patients) and PCa(33 patients) groups accord-ing to pathological finding. The age of BPH and PCa groups were(70�4.93) years, (69.69�12.37) years respectively. Serum PSAlevels of BPH and PCa groups were (12.97�8.22) ng/ml,(97.22�125.24) ng/ml respectively. Serum PSA levels were signif-icant difference (p�0.05) in two groups. All patients underwentCETRUS examination and lesion-targeted TRUS guided biopsysuccessively on the same day. The characteristics of parametricimaging were observed and 10 parameters of AUC, mTT, PI, TTP,IMAX, ResT, RT, WiR, WoR, WiRxWoR were measured withSonoProstate software.Results: There were significant difference in 9 parameters of mTT, PI,TTP, IMAX, ResT, RT, WiR, WoR, WiRxWoR (p�0.05) between the2 groups. There were no correlations in the match of AUC and TTP,mTT and PI, mTT and IMAX, PI and ResT, ResT and WiR(p�0.05),while other matches of 2 parameters demonstrated that positive ornegative correlations were significant difference by bivariate correla-tion(p�0.05). These correlations could be reflected with parametricimaging in both groups.Conclusions: CETRUS can be used as a noninvasive manner to iden-tify nodules in prostate and correlations of parameters can be directly

reflected with parametric imaging.