$384 Thursday, November 10, 2005 Poster Abstracts

detrimental effect in intact females (SMD 0.46, CI -0 .02 to 0.81, P < 0.05). Limited data were present for aged animals and the full dose-response relationship was not available in all experimental groups. Conclusion: These data support Estrogen as a candidate treatment for ischemic stroke al though further pre-clinical studies are also warranted.

1112 Obesity as a Stroke risk factor in Chile: a case-control study

Diaz V 1, Pastene j1, Behrens M I 1. 1Departamento de Neurologia y Neurocirugfa Universidad de Chile, Chile

Background: Sixty per cent of the population in Chile is overweight and 23% is obese. The prevalence increases with age and low socio- economic status. Objective: To study if obesity measured by abdominal circumference (AC) and body mass index (BMD is a risk factor for stroke. Methodology: Case control study. Cases: 104 hemorrhagic and ischemic stroke patients over 40 years old diagnosed by CT and MRI. Controls: 104 inpatients without stroke, matched by sex and age. Weight, AC, BMI, hypertension, diabetes, cholesterol levels, tobacco, physical activity alcohol consumption and family history of obesity were measured in cases and controls and compared using t test, logistic regression (LR) and People's Republic of China curves. Results: Mean age was 64.6 y. Mean weight was 73.8 Kg for cases and 72.0 Kg for controls (p -- 0.26). Abdominal drcamference was not a risk factor (OR -- 0.92, 95"/0 CI 0.84 to 1.02). BMI was a risk factor only in men (OR -- 1.46, 95"/0 CI 1.05 to 2.02, p - 0.02). Using LR to estimate the risk of stroke due to obesity measured by abdominal cir- cumference and BMI and adjusted for hypertension, diabetes, blood cholesterol levels, and tobacco selected only family history of stroke as an independent risk factor (OR - 2.37, 95"/0 CI 1.07 5.23, p -- 0.03). People's Republic of China curves for abdominal circumference and BMI showed that these measures did not predict stroke. Conclusions: Abdominal circumference as a measure of obesity was not a risk factor for stroke. BMI was a risk factor only in men.

I l I 3 A 5 years prospective study of inddence, nlorbit[ity and mortality prolile of cerebrovascular stroke in rural Bengal of Eastern India

Bhattaeharya, S 1, Saha, S 2, Basu, A 2, Das, S 2. 2North Bengal Medical College, Bengal, India; ~Bangur Institute Of Neurology, Kolkata, India

Background: Communi ty based longitudinal study on stroke is rare in India. It has predicted that the stroke incidence will be higher in developing countries than developed countries. Objective: A 5 years prospective s tudy was planned to determine the incidence rate, risk factors, morbidity and mortality profile of stroke in rural Bengal of eastern India, since 70% of the Indian populat ion resides in villages. Methodology: In a two stage procedure, 20717 subjects out of 20842 people from a cluster of 12 villages were surveyed by house-to-house method and the screened cases were examined by a team of neurologist including post stroke surveillance for one year. Result: Altogether 128 first ever stroke cases were detected over 5 years showing an average annual incidence rate of 123.57 per 100,000 (age adjusted incidence rate [AAIR]-262/100,000; based on USA popula- tion, 1991). Sex specific A A I R (274/100000) among women is slightly higher than men (253/100000). Age specific stroke incidence rate showed increasing rate from fourth decade up to seventh decade where the rate was mmvimum. First 30 days mortali ty was 18% with men suffering twice more than women. Follow up after one year revealed speech improvement in 47"/0, residual spasticity in 46"/0 and inde- pendency in activities of daily living in 62% cases. Age and sex matched case control study has shovm that hypertension (O.R-2.79),

heart disease (O.R-6.20) and smoking (O.R-3.92) were significant risk factors. Conclusion: Tiffs study had indicated a higher age adjusted rate of stroke in India as compared to that o f developed country and hypertension, heart disease, smoking are important risk factors.

1114 Carotid Atherosderosis in a group of patients with Stroke

Btlownlik NB 1, Hassan Z 2, Rahinan HZ 3, Islam R 3, Haque A ~ , Haque S 1 . 1Dept. of Neurology, Bangladesh Institute of Research and Rehabilitation in Diabetes, Endocrine & Metabolic Disorders (BIRDEM), Dhaka, Bangladesh," 2Research Division, Bangladesh Instiu~te of Research and Rehabilitation in Diabetes, Endocrine & Metabolic Disorders (BIRDEM), Dhalca, Bangladesh; SDeptartrnent of Neurology, Bangabandhu Sheikh Mujib Medical University, Dhaica, Bangladesh

Backgrouud: Flow limiting atherosderotic stenosis involving carotid artery is one of the predisposing factors for stroke. We have studied a group of Diabetic and non Diabetic patients with stroke to see atherosclerotic stenosis o f carotid vessels and to find out the asso- da t ion of risk factors among the groups. Subjects and Methods: Age and sex matched 77 Diabetic and 32 non Diabetic patients were included. Doppler study of neck vessels was done to assess stenosis. Results: Non Diabetic patients with stroke had significantly higher systolic and diastolic BP (mean ± SD, m_m Hg) then Diabetic patients; systolic 150 ± 15 vs. 137 ± 19, p < 0.001; and diastolic 89 ± 9 vs. 81 3_ 7, p < 0.001. Non Diabetic patients have significant low level of HDL (mean 3_ SD, mg/dl) compared to Diabetic patients; 30.0 ± 6 vs. 37.5 ± 11.5, p < 0.001. Significant flow disturbances was observed in Right and Left internal & common carotid (RICA, LICA, RCCA, and LCCA) arteries among the groups. Stenosis in R ICA and LICA in Diabetic and Non Diabetic patients were 39"/0 vs. 25%, p < 0.001 and 40% vs. 25%, p < 0.001 and stenosis in RCCA and L C C A were 50% vs. 30%, p < 0.001 and 50% vs. 35%, p < 0.025 respectively. Conclusion: Result of this study suggests that both the parameters of BP were higher in non diabetic patients with stroke and they also had low H D L but diabetic patients with stroke had significant higher atherosclerotic stenosis in carotid arteries than the n o n diabetic patients with stroke.

1115 Stroke as the Ftrst manifegtation of Systemic Cancer

Blecic, S l, Redondo, p1, Jeangette, S ~, Taccone, F 1. 1Stroke Unit, Department of Neurology, Erasme Hospital, Brussels, Belgium

Objective: To describe a group of patients (pts) in w h o m stroke was the first manifestation of systemic cancer and therefore the stroke mechanisms pathogenesis. Background: Stroke is a frequent complication in patients with occurring in nearly 15% of pts. However pts presented with stroke as first manifestation of cancer have been rarely reported. Design]Methods: 4236 pts with first stroke were admitted to the stroke mfft between January 1991 and October 2003. Mean age was 66.6 7.9 years. A complete stroke work-up was performed in all. In case of death post -mortem examination was performedfor most. Results: After first work-up 3/4236 pts (0.04%) were diagnosed as having stroke and systemic cancer. One had a B-cell lymphoma, the second a lung cancer and the third a colic tumor. In the 3, single M C A infarction was found. Mechanisms were disseminated intravascular coagulation (DIVC) for the first and non bacterial thrombo-embolic endocarditis (NBTE) for the others. 105 pts (2.5%) had vascular event within the first mon th after the index event with average time of 21,8 3.0 days (range ~30) . 18/105 (17.5 "/0) were found to have cancer. In all, ischemic stroke was the initial presentation. Mean age of these pts was 52,1 4.1 years (24 80). They were 13 women. Vascular areas