10099910**

121.157P17 99.3.19 2.0 3.=+99.3**21.39671.3

*1*292749.8764.1-14.3-1.9%93767.5855.1-87.6-11.4%94779910.3-131.3-16.9%95793.5887.6-94.1-11.9%96833883-50-6.097846901-55-6.598878.9946.7-67.8-7.7

994-6**

96-100*

960.2870%0.510%0.500%1.297%2.497%3.79%970.2710%0.500%0.640%1.411%1.917%3.33%980.2530%0.657%1.627%2.537%0.704%3.25%990.3490%0.603%0.078%1.030%0.431%1.46%1000.3360%0.886%-0.767%0.455%

161**

161**

--*

--979897981 52.25102.1497.74104.86104.362-6.54100.33110.17100.33110.173-24.12100.00102.14100.00102.144- -8.87100.57105.38100.57105.385 -8.23105.39104.47105.39104.47100-0.767%1.212%

()100-0.767WPI-

**

*1.989801~98129701~97122. *

**

20061001002007102.12 102.12 2008102.14 104.86 200996.97 104.36

10.6%55.8%4.2%29.4%

*

(%)0.013 ()0.017 0.009 0.017 0.008 0.012 0.077 0.015 0.010 0.028 ()0.242 ()0.025 ()0.025 ()0.022

**98(1323)11*

909590952.47,57048,14643,57140,22070.3%V 2,9391,8492,5591,817V ()4,7825,5713,7612,313V 1,1292,4251,0642,298V 1,8032,1341,7062,091V 2,3901,1252,2341,097 181252179239 4414544145(0.11%) 810502762499

***

--*

--979897981 52.25102.1497.74104.86104.362-6.54100.33110.17100.33110.173-24.12100.00102.14100.00102.144- -8.87100.57105.38100.57105.385 -8.23105.39104.47105.39104.47100-0.767%1.212%

()1000.886***

161**

1.2.()*12**

950.43960.510970.5000.07980.6570.147990.6030.1031000.8860.2290.549

1996-20061996**

1996200620060-44 870 1,125 1.29 813 0.93 45-54 563 1,154 2.05 932 1.65 55-64 783 1,017 1.30 1,010 1.29 65-74 784 1,214 1.55 893 1.14 75-84 252 629 2.50 440 1.75 84 18 60 3.33 40 2.22 3,270 5,199 1.59 4,128 1.26

(

94-9843.2125.2

9912(-1.5%-2.8%)4-5%100*

**95111598916

104082392-934

--*

--161*

--94-9947.65*

--5(94-98)43.2125.2*

(-)B C-B%-%()A% C%92103.4 0.200 0.7993125.0 20.9%21.6 0.360 -0.0794143.6 14.8%18.6 5.80.763%(12.8)0.410 -4.5395165.5 15.3%22.0 16.762.175%(5.2)0.430 -6.9496167.2 1.0%1.6 13.011.629%11.4 0.510 -0.2897181.0 8.3%13.8 5.5350.675%(8.3)0.500 -0.1698194.9 7.7%13.9 3.5160.400%(10.4)0.657 0.10 99Q146.4 3.4380.389%0.603 -0.11(25.2)

128/253

--98()69912(-1.7%-2.8%)47.65*

--1/3984.9%5.76%(3.247%)50~80%9912(-1.7%-2.8%)4%~5%100*

-- 2/3*

-- 3/3992 *

22,2448.68%8,2347.85%370-0.76%

128.84%14-2.05%1,124-10.00%

62-3.01%239-3.57%3,869-0.57%

4,6693.76%3,284-2.70%703-6.22%

631.13%514.20%741-12.91%

73115.72%480-3.52%657-16.63%

17,9106.57%7,3855.17%412-1.32%

252.36%5122.06%20,702-0.29%

609.89%240.46%408-8.58%

11310.98%13811.20%1,2270.20%

0.5-5.92%6-7.12%10,745-1.27%

11-16.06%336-15.94%29,4830.14%

--3,010-0.37%--

45,8447.42%23,6673.47%516-3.67%

215533668622064766430.02372713155448089315755310590.0563906468

103515301910833523140.04656248312572037912922956660.1364360722

161735940716515998760.02117063938823374205682230.0677509081

121171627412384845720.0220912262837271192979994620.0503030625

134105006813528146420.00877265833076792173234652490.0513067868

1702548931714057260.00675947093298842032873623-0.0034799181

()2006-200954.94

4.94 200.988***

()3-6 3 3 4-6**

()622.1%61.4%

***

4-620

0.648%

582.3**

()***

()(80%)****

97-98 972009.03.21**

98()97()1AMLODIPINE45 44.862ATORVASTATIN (Lipitor)17 16.893VALSARTAN16 16.114FACTOR VIII16 15.185CLOPIDOGREL15 13.366GLIMEPIRIDE14 13.967IMATINIB12 11.338ROSUVASTATIN(Crestor)12 -9PIOGLITAZONE11 10.3110LOSARTAN1110.2711RISPERIDONE-9.72169

***

Chart2

132062182014122358818373421221212384804480638971117207704

451488298016448900824321034925549476404976066101612289029

833429771021069814740358592234623397305743723992368320235

1253660172036583576960481163438345123906708387693278597560

1339748712662377408707815639752176321783892456466745897862173346087863

1406749115287517024446742035759822843256097354102349696761844063868186414

15256827131773555534831042823551663223183889547286358147714038314359737446

15941090013501571985274244311627907343778917029647980669472766204924447706

()

Atorvastatin

Ezetimibe

Fluvastatin

Lovastatin

Pravastatin

Rosuvastatin

Simvastatin

Total

Year

()

()

/20012002200320042005200620072008

Atorvastatin574183419629926362360775450696458249944611630056633403169309087

Ezetimibe....287991250074771111115224226

Fluvastatin6140156715169691607891590590317769905193336612100453422931497

Lovastatin79884441057436317547214262961582781531225042708154420147077858

Pravastatin922277611108468150536511667179313990604141569451384299816430074

Rosuvastatin....1984638178363033167981841947742

Simvastatin1948103921635070249727132916690325642879293993223353929741185940

Total4857424870099523102970445142547720145482081168182018189553802214106422

23

/20012002200320042005200620072008

Atorvastatin13206218245148829883342977112536601721339748712140674911515256827131594109001

Ezetimibe....66237728751702177355553350157198

Fluvastatin141223588164489008210698147365835769408707815444674203483104282527424431

Lovastatin183734212243210349403585922604811634639752176575982284355166322162790734

Pravastatin212123848255494764346233973383451239321783892325609735318388954377891702

Rosuvastatin....45646674410234969728635814964798066

Simvastatin448063897497606610574372399670838769589786217676184406771403831947276620

Total11172077041612289029236832023532785975603346087863386818641443597374464924447706

Statins20012002200320042005200620072008

Simvastatin40.11%30.86%24.25%20.46%17.63%17.48%17.69%19.24%

Ezetimibe....0.02%0.74%4.07%7.11%

Pravastatin18.99%15.85%14.62%11.70%9.62%8.42%7.30%7.67%

Lovastatin16.45%15.08%17.04%18.45%19.12%14.89%8.15%3.31%

Fluvastatin12.64%10.20%8.90%11.16%12.21%11.50%11.08%10.71%

Atorvastatin11.82%28.00%35.19%38.24%40.04%36.37%34.99%32.37%

Rosuvastatin....1.36%10.61%16.71%19.59%

Total100.00%100.00%100.00%100.00%100.00%100.00%100.00%100.00%

0000000

0000000

0000000

0000000

0000000

0000000

0000000

0000000

Simvastatin

Ezetimibe

Pravastatin

Lovastatin

Fluvastatin

Atorvastatin

Rosuvastatin

Year

Drug Expenditure()%

132062182014122358818373421221212384804480638971117207704

451488298016448900824321034925549476404976066101612289029

833429771021069814740358592234623397305743723992368320235

1253660172036583576960481163438345123906708387693278597560

1339748712662377408707815639752176321783892456466745897862173346087863

1406749115287517024446742035759822843256097354102349696761844063868186414

15256827131773555534831042823551663223183889547286358147714038314359737446

15941090013501571985274244311627907343778917029647980669472766204924447706

()

()

Atorvastain

Ezetimibe

Fluvastatin

Lovastatin

Pravastatin

Rosuvastatin

Simvastatin

Total

Year

Drug Exp. (millions)

07

07

132062182014122358818373421221212384804480638971117207704

451488298016448900824321034925549476404976066101612289029

833429771021069814740358592234623397305743723992368320235

1253660172036583576960481163438345123906708387693278597560

1339748712662377408707815639752176321783892456466745897862173346087863

1406749115287517024446742035759822843256097354102349696761844063868186414

15256827131773555534831042823551663223183889547286358147714038314359737446

15941090013501571985274244311627907343778917029647980669472766204924447706

()

()

Atorvastatin

Ezetimibe

Fluvastatin

Lovastatin

Pravastatin

Rosuvastatin

Simvastatin

Total

Year

Drug Exp. (millions)

-

()=

()=

NCE)**

-proposedPold*Qold=period2(Pold*Qold2)-period1(Pold*Qold2)*Source: Gerdtham UG. The effect of cahnges in treatment patterns on drug expenditure? Pharmacoeconomics 1998;13(1):127-34.*

takepron18,80%1. Takepron1.516 (5% 20)2,779 2.

**

ABC(B-A)/CTakepron 2,852,757 1,463,401 7,579,870 -18%

(1979)Ikegami N et al. Why Medical Care Costs in Japan Have Increased Despite Declining Prices for Pharmaceuticals. Pharmacoeconomics 1998; 14 Suppl. 1: 97-105.**

(1998-2004)1999-20012002-20041998200420***

(V) (P) (N)1998-2001 17.2~17.310.6~15.5-7.714.9~20.8 5.4~5.53.4~4.9-2.64.7~6.52001-2004 26.4~28.523.0~24.9-11.614.5~18.2 8.1~8.77.1~7.7-4.04.6~5.7

***

(%) D+E-A () (-) ()A (%) () B () C () D=B+C (%) () (E) (%) (%) 92200-6.99%0.7993 230.630.615.27%0.6100.610.075%-0.078 -0.0722.55%--30.07 94 251.721.19.18%1.5701.570.206%-0.701 -4.5322.55%6.79%-20.23 95 240.2-11.5-4.62%3.11803.1180.400%-7.319 -6.9422.55%-28.10%7.30 96 232-8.2-3.38%0.82300.8230.103%-0.252 -0.2822.55%-10.50%8.77 97 235.63.61.55%0.4900.4920.060%-0.189 -0.1622.55%13.42%-3.30 98247.311.75.05%0.27200.2720.032%0.312 0.122.55%2.18%-11.12 99Q158.60.113%6 (93-98) 239.57 3.84%1.15 1.32260.1460%12.46%129392397-99998259945()986

--96-9831.05%*

-- *

93 23,172 15.3%44,518 - 19,174 - 4,451 91,315 - 61 0.075%1.144%0.8348 0.891294 25,139 8.5%46,390 - 12,258 -4,763 7.0% 88,550 - 157.2 0.206%2.223%0.7907 0.863595 23,959 -4.7%44,571 -3.9% 11,500 -6.2%5,261 10.5% 85,291 -3.7%307.6 0.400%3.793%0.8795 0.920796 23,146 -3.4%44,778 0.5% 11,010 -4.3%5,621 6.8% 84,555 -0.9% 81.6 0.103%3.794%0.9366 0.953997 23,506 1.6%45,539 1.7% 11,723 6.5%5,634 0.2% 86,402 2.2% 49.2 0.060%3.328%0.9487 0.964598 24,707 5.1%47,164 3.6% 12,555 7.1%5,812 3.2% 90,238 4.4% 27.2 0.032%3.247%0.9402 0.958819398294-9899393-956.496-981.09%93-983.7496-981.92%95-980.52593-952.496-983.5%93-982.92%

--9869810993-6.0%9912-8.1%-2.9%99-5.2%1000.5%*

-- 1/5 992(-2.9%)2B12-15%3.82%991.463%0.9 *

--2/5*992+*

1,735-5.39%4325.80%3,5776.70%1,0988.85%6,8413.61%920-3.01%2397.74%1,7617.67%5539.00%3,4724.82%1,218-1.32%2996.93%2,5596.11%7827.91%4,8584.47%928-2.86%2495.30%1,9375.06%5376.64%3,6513.16%1,059-2.06%2446.42%2,0935.50%5754.20%3,9713.24%161-4.10%388.00%2766.68%563.77%5312.97%6,020-3.22%1,5006.40%12,2046.24%3,6017.49%23,3253.82%

-- 3/5 992**

Sheet2

seasontypesum_drugsum_DSVCsum_DIAGsum_cure

2008Q21Fl20814914667861168747102125550040179522347127868673473761539

2008Q22Fl10280972283397778095705970370452846980461356537139023485

2008Q23Fl1335894323380712213322822075899186567372689780660050262038

2008Q24Fl95126322179207881375111228347073981940660012934725354051

2008Q25Fl103113423250188830419511632203775323235063804922428540000

2008Q26Fl148221342151111992469119698932368070923119935342513

65761001507015454700709398581523412690857034120549269222283626

Q2Fl21471843.2%47599122.0%17315595222.6%26567437481078906130438398080422262

Q2Fl10465311.8%22892080.3%8008780162.9%1005569592866300162606534445592712

Q2Fl13779813.2%32968712.0%12511656412.4%2172953376729034191899213147587832

Q2Fl9935434.4%23053653.9%8266659914.9%1317190694211553962571799127113392

Q2Fl10664923.4%23782542.3%9045232292.4%1695674995446329965083696629655465

Q2Fl1491320.6%338252-1.1%1124731450.4%120783472364369921137425916687

67808633.1%153678622.0%56272655442.9%8968915852759754554218110154236288350

Q2Fl238587711.1%544446314.4%195027573112.6%29616268793541083146769228792879674

Q2Fl121018715.6%274713520.0%93019634616.1%1155005073401268872622745054455701

Q2Fl151726110.1%371356712.6%140072530312.0%24107899275787355102390369659955260

Q2Fl10891639.6%258491812.1%91599824310.8%1457730694707530269266407730485795

Q2Fl119326111.9%273888615.2%102571297813.4%1911581236257763473749041334486808

Q2Fl17284715.9%40849020.8%13045096016.0%1268671626175391081699176976788

756859611.6%1763745914.8%635335956112.9%10023600943156116014756147840279240026

*-- 4/5*

-- 5/5H1N1(201026)**

Sheet1

Sheet2

Sheet3

--100*

--1/32-55-305100 *

-- 2/3 94-9897981**

11943713,091,0780.2061571.700.83019.454953812,996,4510.4003084.970.3007.255965116,668 ,8370.103823.880.2917.40397633,657,7590.060491.210.39310.3889858180.0326.4200.325991-6365.70.11399.90.1330.482

1.(1)85-93 (2)94 (3)9596.04.12 (4)96.04.14 (5) 2. -- 3/385-95 **5X30X

8687888990919293949585131274508741,1139839229221,0249981,0258,43886543468901,0531,2111,2381,2131,2021,2481,1921,10210,69387755941,9012,8623,7544,5344,4804,7204,5704,36331,77788422358231,0801,4601,6891,9481,9982,09011,32389361131,0292,0212,7913,5383,6903,73116,91490733482,1563,7855,4285,2235,49322,43391565571,7643,0023,2903,44112,0549250606881,3571,7443,85093822391,3962,4134,04794371879041,09195385105105564731,9334,0636,1218,43112,86316,69421,83423,90126,816123,129

() ----()4.026.8865 100()0.70*

4(9810)(1)86203B76.3(2)22001B13,052(3)97017B1,498(4)T3 (Triidothyronine)27001B3,573

18.20.020%**

TSH(EIA/LIA)09112BTSH (thyroid stimulating hormone) 27004CTSH(EIA/LIA)09112B14.2*

1.

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6 60% 62 30% 26 20% 6611

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**

(

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**

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**

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100***

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**

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THANK YOU FOR YOUR ATTENTION**

**************:,"""",""""****

****