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SPONTANEOUS PRETERM BIRTH

Intra-amnioticinfection

Multiplefactors

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MMP families

Interstitialcollagenases (MMP-1

and MMP-8)

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MMP-1 and MMP-8

degrade fibrillar collagen types I and III

spontaneous preterm birth ?

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determine whether matrix

metalloproteinase-8, which isproduced by neutrophils, is a useful

marker for the detection of intra-amniotic infection

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Study designcase-control study using enzyme-linked immunosorbent assays to

detect matrix metalloproteinase-8

PlaceUniversity of Pennsylvania, theUniversityof Florida, and Yale University

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Thirty women had culture-provenintra-amniotic infection (cases)

21 of whom had intact membranes

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Table I. Demographic characteristics

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ROC for optimalthreshold

MMP-8 in 27 of 30 women with intra-

amniotic infection

MMP-8 in 10 of 47 control specimens (P