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Revising Kidney Paired Donation Pilot Program Priority
PointsKidney Transplantation Committee
Fall 2015
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What problem will the proposal solve?
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What problem will the proposal solve?
How does the proposal address the problem statement?
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Supporting Evidence
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Increased the # of matching opportunities for 99% and 100% CPRA candidates
Prioritizing by pair characteristics increased the # of matching opportunities for hard to match pairs Blood type O candidates Candidate’s whose paired donor is non-O
Supporting Evidence – Overall Trends
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Members participating in KPDPP will need to communicate the changes as a part of informed consent, particularly about the remedy for a failed exchange
Proposal does not require additional data collection
No changes to current routine site surveys
Anticipated Board Date: December 2015
Implementation Date: Pending programming
How will members implement this proposal?
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Increase the number of transplants Increase # of matches found Incentivize transplant hospitals to participate Use data to improve chance of timely offers to candidates most likely to
accept
Improve equity in access to transplants Addresses increased difficulty in matching certain blood types and CPRA
levels Improves access for candidates in failed exchanges
How does this proposal support the OPTN Strategic Plan?
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Dr. Mark Aeder Committee Chair [email protected]
Regional representative name (RA will complete) Region X Representative email address
Melinda Woodbury Committee Liaison [email protected]
Questions?
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Extras
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If the: Then the match will receive:
Candidate is a 0-ABDR mismatch with the potential donor
200 points
Candidate has a CPRA greater than or equal to 80%
125 points
Candidate is a prior living organ donor 150 points
Candidate was less than 18 years old at the time the candidate was registered in the OPTN KPD program
100 points
Candidate and potential donor are registered for the OPTN KPD program in the same region
25 points
Candidate and potential donor are registered for the OPTN KPD program in the same DSA
25 points
Transplant hospital that registered both the candidate and potential donor in the OPTN KPD program is the same
25 points
Potential donor has at least one of the other antibody specificities reported for the candidate
- 5 points
Current KPD Priority Points
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***All OPTN matches receive 100 base points
If the: Then the match will receive:
Candidate is registered for the OPTN KPD program .07 points for each day according to Policy 13.7.F: OPTN KPD Waiting Time Reinstatement
Candidate is a 0-ABDR mismatch with the potential donor 10 points
Transplant hospital that registered both the candidate and potential donor in the OPTN KPD program is the same
75 points
Candidate and potential donor had a previous crossmatch that was one of the following:•Negative•Positive and acceptable with desensitization•Positive and acceptable without desensitization
75 points
Candidate was less than 18 years old at the time the candidate was registered in the OPTN KPD program
100 points
Candidate is a prior living organ donor 150 pointsCandidate ABO is:O
100 points
B 50 pointsA 25 pointsAB 0 pointsPaired donor ABO is:O
0 points
B 100 points
A 250 pointsAB 500 points
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Revised Priority Points
All OPTN matches will continue to
receive 100 base points
If the: Then the match will receive:Candidate CPRA is:0-19
0 points
20-29 5 points30-39 10 points40-49 15 points50-59 20 points60-69 25 points70-74 50 points75-79 75 points80-84 125 points85-89 200 points90-94 300 points95 500 points96 700 points97 900 points98 1250 points99 1500 points100 2000 pointsCandidate is an orphan candidate 1,000,000 points
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Revised Priority Points
All OPTN matches will continue to
receive 100 base points
Supporting Evidence
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CPRA ScalesCPRA Current
PolicyProposed
CPRA Sliding Scale
0-19 0 020-29 0 530-39 0 1040-49 0 1550-59 0 2060-69 0 2570-74 0 5075-79 0 7580-84 125 12585-89 125 20090-94 125 300
95 125 50096 125 70097 125 90098 125 125099 125 1500
100 125 2000
Supporting Evidence
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*Sum of all candidates across all 136 match runs. Some candidates appeared in multiple match runs.
Impact of CPRA Sliding Scale On Matches# Matches Found
CPRA # Candidates* % of Candidates Current Policy CPRA Sliding Scale
0% 7,714 23.9 229 211
1-49% 2,767 8.6 178 175
50-79% 1,851 5.7 174 182
80-89% 1,467 4.5 117 98
90-94% 1,684 5.2 43 42
95-97% 2,068 6.4 39 39
98% 1,336 4.1 23 23
99% 3,507 10.8 31 39
100% 9,941 30.7 22 35
All 32,335 100.0 856 844
Impact of CPRA Sliding Scale on Very Highly SensitizedMatch Rates
(# matches / # candidates)CPRA #
Candidates*% of
CandidatesCurrent Policy CPRA Sliding Scale
0% 7,714 23.9 3.0% 2.7%1-49% 2,767 8.6 6.4% 6.3%
50-79% 1,851 5.7 9.4% 9.8%80-89% 1,467 4.5 8.0% 6.7%90-94% 1,684 5.2 2.6% 2.5%95-97% 2,068 6.4 1.9% 1.9%
98% 1,336 4.1 1.7% 1.7%99% 3,507 10.8 0.9% 1.1%
100% 9,941 30.7 0.2% 0.4%All 32,335 100.0 2.6% 2.6%
Supporting Evidence
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*Sum of all candidates across all 136 match runs. Some candidates appeared in multiple match runs.
Supporting Evidence
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*Sum of all candidates across all 136 match runs. Some candidates appeared in multiple match runs.
Impact of CPRA Sliding Scale on Age
Match rates(# matches / # candidates)
Candidate Age
# Candidates*
% of Candidates
Current Policy CPRA Sliding Scale
0-17 626 1.9 1.9% 0.8%
18-34 6,362 19.7 2.5% 2.5%
35-49 9,543 29.5 2.3% 2.2%
50-64 12,650 39.1 3.0% 2.9%
65+ 3,154 9.8 2.9% 3.1%
All 32,335 100.0 2.6% 2.6%
Supporting Evidence
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*Sum of all candidates across all 136 match runs. Some candidates appeared in multiple match runs.
Match Rates(# matches / # candidates)
Race/Ethnicity # Candidates*
% of Candidates
Current Policy
CPRA Sliding Scale
White 21,045 65.1 2.5% 2.4%
Black 5,068 15.7 2.8% 2.8%
Hispanic 4,463 13.8 2.0% 2.2%
Asian 1,358 4.2 6.1% 6.2%
Other 399 1.2 1.8% 2.3%
All 32,333 100.0 2.6% 2.6%
Impact of CPRA Sliding Scale on Race/Ethnicity
Supporting Evidence
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If the: ABO is: Then the match will receive:
Candidate O 100 pointsB 50 pointsA 25 pointsAB 0 points
Paired Donor
O 0 pointsB 100 pointsA 250 pointsAB 500 points
Supporting Evidence
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*Sum of all candidates across all 136 match runs. Some candidates appeared in multiple match runs.
Impact of Candidate ABO Points
# Matches Found Match Rates(# matches / #
candidates)
Candidate ABO
# Candidates*
% of Candidates
Current Policy
(0 points)
Candidate ABO Points
(0-100 points)
Current Policy
(0 points)
Candidate ABO Points
(0-100 points)
A 5,965 18.4 266 255 4.5% 4.3% AB 411 1.3 11 10 2.7% 2.4% B 5,148 15.9 237 230 4.6% 4.5% O 20,811 64.4 342 367 1.6% 1.8% All 32,335 100 856 862 2.6% 2.7%
Supporting Evidence
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*Sum of all candidates across all 136 match runs. Some candidates appeared in multiple match runs.
Impact of Candidate ABO Points on Race/Ethnicity
Match Rates(# matches / # candidates)
Race/ Ethnicity
# Candidates* % of Candidates
Current Policy (0 points)
Candidate ABO Points
(0-100)
White 21045 65.1 2.5% 2.5%
Black 5068 15.7 2.8% 2.9%
Hispanic 4463 13.8 2.0% 2.0%
Asian 1358 4.2 6.1% 6.1%
Other 399 1.2 1.8% 1.8%
All 32333 100.0 2.6% 2.7%
Supporting Evidence
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*Sum of all candidates across all 136 match runs. Some candidates appeared in multiple match runs.
Impact of Candidate ABO Points on Age
Match Rates(# matches / # candidates)
Candidate Age
# Candidates*
% of Candidates
Current Policy (0 points)
Candidate ABO Points
(0-100)
0-17 626 1.9 1.9% 1.4%18-34 6,362 19.7 2.5% 2.5%35-49 9,543 29.5 2.3% 2.3%50-64 12,650 39.1 3.0% 3.1%65+ 3,154 9.8 2.9% 2.8%All 32,335 100.0 2.6% 2.7%
Supporting Evidence
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*Sum of all candidates across all 136 match runs. Some candidates appeared in multiple match runs.
Impact of Paired Donor ABO Points # Matches Found Match Rates
(# matches / # candidates)
Paired Donor ABO
# Candidates*
% of Candidates
Current Policy
(0 points)
Paired Donor ABO
(0-500 points)
Current Policy
(0 points)
Paired Donor ABO
(0-500 points)
A 16,607 48.5 273 299 1.64% 1.80% AB 1,454 4.2 5 6 0.34% 0.41% B 5,939 17.4 215 213 3.62% 3.59% O 10,226 29.9 363 340 3.55% 3.32% All 34,226 100.0 856 858 2.50% 2.51%
Supporting Evidence
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*Sum of all candidates across all 136 match runs. Some candidates appeared in multiple match runs.
Impact of Paired Donor ABO Points on Race/Ethnicity Match Rates
(# matches / # candidates)Race/Ethnicity # Candidates* % of
CandidatesCurrent Policy
(0 points)Paired Donor
ABO(0-500 points)
White 21045 65.1 2.5% 2.6% Black 5068 15.7 2.8% 2.8% Hispanic 4463 13.8 2.0% 1.9% Asian 1358 4.2 6.1% 6.3% Other 399 1.2 1.8% 1.8% All 32333 100.0 2.6% 2.7%
Supporting Evidence
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*Sum of all candidates across all 136 match runs. Some candidates appeared in multiple match runs.
Impact of Paired Donor ABO Points on Age Match Rates
(# matches / # candidates)Candidate
Age#
Candidates*% of
CandidatesCurrent Policy (0 points)
Paired Donor ABO
(0-500 points)
0-17 626 1.9 1.9% 1.9% 18-34 6,362 19.7 2.5% 2.3% 35-49 9,543 29.5 2.3% 2.4% 50-64 12,650 39.1 3.0% 3.0% 65+ 3,154 9.8 2.9% 2.9% All 32,335 100.0 2.6% 2.7%
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