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New Zealand, November 2005
Mark R. Bartlett, Ph.D., Senior Director, Pharmanex Research & Development
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3
Green Tea and Longevity
66
68
70
72
74
76
78
80
82
Mea
n A
ge
of
Dea
th
.
Men Women
3 or less
4 to 9
over 10
Green TeaConsumption(Cups/Day)
Prospective, 11-year cohort study of 8,552 subjects in Yoshimi, Japan, 1986-1997. From: H. Fujiki et al., Ann. N.Y.Acad.Sci., 928:274, 2001; used with author’s permission
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HOW LONG WILL YOU LIVE?HOW LONG WILL YOU LIVE?
“… there is a correlation of the concentration of a number of different antioxidants in serum with increasing lifespan of mammalian species.”
Dr. Richard Cutler, National Institute of ageing,
Washington, D.C. Dr. Richard Cutler
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Highly reactive, short-lived molecules
Damage cells and genetic material (DNA) 70,000 free radical attacks
on DNA every day in a cell Ageing process Implicated in most health
conditions Many different types of free
radicals
Free Radicals
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Most Vulnerable to free radicals…
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Where do Free Radicals come from?• Environmental pollution (smog, ozone, NO2) • Radiation exposure:
– sunlight (UV-light), X-rays, etc.• Smoking:
– 10,000,000,000,000,000 free radicals/cigarette!
• Eating and Breathing: metabolism in your mitochondria
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Antioxidants fight free radicals Slow down ageing processes & improve health:
over 30,000 research studies on antioxidant health benefits
affecting over 50 health conditions, including cardiovascular function, eye health, CNS health, skin health, etc.
Many antioxidants work together: “Antioxidant defence System”
Relies on a steady supply of dietary antioxidants
Stop Free Radicals with Antioxidants
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“… low levels of the antioxidant vitamins (vitamins A, E, and C) may increase risk for several chronic diseases. Most people do not consume an optimal amount of all vitamins by diet alone.”
“It appears prudent for all adults to take vitamin supplements.”
Journal of the American Medical Association (JAMA) June 2002
Robert H. Fletcher, MD, MSc; Kathleen M. Fairfield, MD, DrPH, Harvard UniversityJournal of the American Medical Association 2002; 287: 3127-3129
A Landmark Endorsement
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Antioxidants: More than just One…• Vitamin E: 8 natural forms• Vitamin C • Metallo-enzymes (cofactors)
– Selenium, Zinc, Manganese• Flavonoids:
– Catechins, polyphenols etc
• Carotenoids:– Β-carotene, lutein, lycopene, α-carotene
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Antioxidant protection
Vitamin CLutein
Lycopene
Betacarotene
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LifePak® 40+ Antioxidants
• All 8 forms of natural vitamin E• Buffered vitamin C• Selenium, Copper, Zinc, Manganese• 6 Carotenoids:
– as found in 5-10 fruits & vegetables per day • Over 20 Flavonoids:
– 6 Catechins, Quercetin, naringenin, hesperidin, 3 Soy isoflavones, Over 10 grape seed polyphenols
• Alpha-Lipoic Acid: 25 mg
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LifePak is NOT just a multivitamin!
What is LifePak®
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You Choose
Spend all day eating this
Or add LifePak to
your lifestyle
15
LifePak® Science is Measurable
• First to show antioxidant and cardiovascular benefits in double-blind studies
• 200,000+ published studies on LifePak’s antioxidants
• Nearly 800,000 published studies on LifePak’s 50+ ingredients
• First multivitamin/mineral supplement to pass top 3 safety certification tests
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LifePak® Clinical Study
42.1 42
43.4
50.9
30
35
40
45
50
55
60
65
Baseline Endpoint
PlaceboLifePak
p < 0.001
331299
335
716
0
200
400
600
800
1000
1200
Baseline Endpoint
PlaceboLifePak
p < 0.001
3.4773.429
6.248
3.305
0
1
2
3
4
5
6
7
8
Baseline Endpoint
PlaceboLifePak
p < 0.001
Smidt CR, Seidehamel RJ, Devaraj S, Jialal I. FASEB Journal Vol.13 No.4, p.A546, March 1999.
LDL Protection*
Vitamin E
Beta-carotene
Antioxidant and Cardiovascular Health
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The QuestionsSkin Carotenoids – the Most Reliable Predictor of Antioxidant Status
Carotenoids Vitamins C & E Body’s InternalAntioxidant Systems
• Carotenoids are the body’s first line of defence against free radicals.• Carotenoid levels are most sensitive to oxidative stress
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VITAMIN CcycleVITAMIN E
cycle
THIOLcycle
NAD(P)H + H+
NAD(P)+
Lipid–water interface
ROOHROH
PUFA
O2– and other radicals
Metabolism, strenuous exercise,cigarette smoke, pollution, eating
ROO•RO•
The Antioxidant Network
Carotenoids
Carotenoids
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Antioxidant Status can be measured …
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Pharmanex has the two most powerful tools of the entire nutritional supplement industry worldwide:
LifePak: one of the best multi-nutrient supplements
BioPhotonic Scanner: the best consumer test for antioxidant nutrition.
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See YOUR antioxidant score in 3 minutes!
• Measures your own antioxidant protection (skin carotenoids).
• Measure antioxidant effect of LifePak in your own body!
• Easy & non-invasive.• Scientifically and clinically
validated.
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• Invented by Werner Gellermann, Ph.D. (U. Utah)• Patent rights licensed to Pharmanex• Scientifically validated (4 clinical studies)• Measures carotenoid antioxidants in skin
– Important part of the body’s antioxidant defence system
– good indicator of your antioxidant status• Highly specific for carotenoids • Based on Raman spectroscopy
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What is Raman Spectroscopy?Intense monochromatic light (one colour only) interacts with molecules that have vibrational energy (e.g., carotenoids) and gets scattered at a higher wavelength (colour). Sir C. V. Raman, Nobel Prize in Physics, 1930
Carotenoid molecules shift blue laser light colour to green:
from 473 nm to 510 nm
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2004 Data — 33,000 PeopleF
req
ue
ncy
LifePak
5-9 Fruits & Vegetables
Average (2-3 Fruits & Vegetables)Smokers
Obesity
LifePak + 5-9 Fruits & Vegetables
10,000 - 19,000
20,000 - 29,000
30,000 - 39,000
40,000 - 49,000
50,000+
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Knowing LifePak is working
LifePak Users vs. Non-usersAU & NZ
37,200
28,826
40,732
31,028
-
5,000
10,000
15,000
20,000
25,000
30,000
35,000
40,000
45,000
AU Never UsedLifePak
AU LifePakRegular Users
NZ Never UsedLifePak
NZ LifePakRegular Users
Av
era
ge
Sc
an
Sc
ore
31% higher29% higher
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2004 Data: Eat Fruits & Vegetables
31,100
28,560
24,773
21,981
10,000
15,000
20,000
25,000
30,000
35,000
1 or Less 2 to 3 4 to 5 6 or More
Reported Daily Fruit & Vegetable Servings
Ram
an
In
ten
sit
y, C
ou
nts
.
n = 9,336 n = 13,600 n = 6,916 n = 2,796
p < 0.01 p < 0.01 p < 0.01
2004 Data of 32,648 Non-Supplement Users
V. L
ow |
Low
| M
od.|
Hig
h
27
Smoking
19890
13030
17600 17591
1305611593
0
5000
10000
15000
20000
25000
30000
Non-Smokers
Smokers(all)
PastSmokers
< 1/day 1-5/day > 5/day
n = 1047
n = 58
p < 0.01
n = 39 n = 10
n = 16
n = 32
2002 Data: Don’t Smoke!
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2004: Maintain Normal Body Weight!
29,236
25,612
20,835
16,603
10,000
15,000
20,000
25,000
30,000
35,000
< 25 25-29 30-39 > 40
Body Mass Index (BMI, kg/m2)
Ram
an
In
tesit
y, C
ou
nts
.
n = 11,588 n = 8,475 n = 422
p < 0.01 p < 0.01 p < 0.01
n = 4,550
2004 Data of 25,035 Subjects Overweight people need extra antioxidant protection through diet and supplementation.
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Accepted by the Scientific Community• New York Academy of Sciences, Feb 2003• Oxygen Club of California, Feb 2003 and Feb 2004• FASEB/American Society of Nutritional Sciences - April
2003 and April 2004• Gordon Research Conference, Jan 2004• Review paper published in Current Topics in Nutraceutical
Research, May 2004• American College of Nutrition, October 2004
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Skin Carotenoid ScaleBLUEBLUE 50,000+: Truly outstanding diet and lifestyle habits.
Long term. Excellent supplements, good genetics.
GREENGREEN 40,000 - 49,000: Excellent diets high in fruits & vegetables and excellent supplements.
YELLOWYELLOW 30,000 - 39,000: Better lifestyle. Healthy diet with fruits & vegetables and/or good supplements.
ORANGEORANGE 20,000 - 29,000: Average lifestyle
REDRED Under 19,000: Poor diet. Unhealthy lifestyle, no/ineffective supplements, poor genetics. Smoking?
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Advice from The ExpertAdvice from The Expert
“Everyone should use the Pharmanex BioPhotonic Scanner to learn their optimal body defence score. Once you have your number, work to increase it and maintain it with a rich diet in fruits, vegetables and vitamin supplements.”
Dr. Lester PackerCNN Money 09.17.02
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Motivation
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What is LifePak®?A comprehensive nutritional wellness program delivering the optimum amounts of all essential and generally beneficial nutrients for long-term health and well-being.
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LifePak® - Anti-ageing FormulaHealth Benefits
Optimum supplementation for general well-being
1. Addresses nutrient deficiencies2. Cardiovascular benefits3. Complete bone nutrition4. Promotes healthy immune function5. Supports normal blood sugar metabolism6. Protects against ageing symptoms7. Raises your antioxidant defence
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1. Nutrient Deficiencies
Percent of Adults Not Meeting RDA
0
10
20
30
40
50
60
70
80
90
Males
Females
37
1. Nutrient Deficiencies
Percent of LifePak Users Not Meeting RDA
0
10
20
30
40
50
60
70
80
90
Males
Females
38
Over 20 Antioxidants: protect blood lipids (LDL) from oxidation by free radicals
2. Cardiovascular Benefits
(means +/- SD)
42.1 4243.4
50.9
30
35
40
45
50
55
60
65
Start After 6 Weeks
PlaceboLifePak
p < 0.001
LifePak’s silent benefits: You don’t feel them at first, but you will appreciate them years later!
Oxidized LDL clingsto artery lining,causing plaque build-up
Artery
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Calcium & Magnesium: maintain normal blood pressure & heart rhythm
B-Vitamins: maintain normal (low) blood homocysteine (a risk factor for heart disease)
Flavonoids: promote blood circulation (platelet aggregation and microcirculation)
2. Cardiovascular Benefits Over 40 Antioxidants: protect blood lipids
(LDL) from oxidation by free radicals
40
0
5
10
15
20
25
30
35
40
45
50
0 20 40 60 80 100
Optimum Bone Mass
Typical Bone Mass
Osteoporosis Zone
Age (years)
Bon
e M
ass
3. Bone Nutrients
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Bone Mineralisation
US & EU: 23 million bone fractures per year due to osteoporosis = $27 billion medical costs
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3. Bone Nutrients• Calcium and magnesium are building blocks
of bone health and involved in development and maintenance of bone structure and strength.
• Vitamin D helps proper calcium absorption, and regulates calcium and magnesium bone metabolism.
• Vitamin K helps transport calcium to the bones.
• Vitamin A helps in the building of strong bones.
• Copper assists in maintaining normal bone strength.
• Zinc is involved in bone metabolism.
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4. Immune Function
Percent of Adults Not Meeting RDA
0
10
20
30
40
50
60
70
80
90 Males
Females
LifePak supports normal immune function• Vitamins C & E• Multi-Carotenoid Blend• Vitamin A, Vitamin B6 & Zinc
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LifePak promotes normal blood sugar, glucose tolerance and insulin metabolism
Chromium:– essential for normal insulin function– most diets are low in chromium (<50 mcg/day)
5. Blood Sugar & Insulin
Vitamin CVitamin EAlpha-Lipoic AcidMagnesiumZinc
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Spock, did somebodysay “Anti-ageing”?
Pharmanex has a logical approach
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LifePak Addresses a Major Cause of ageing:
DNA Damage• DNA (DeoxyriboNucleic Acid) is your
genetic blueprint • DNA enables healthy cell renewal into old
age
6. Ageing Symptoms
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DNA is damaged by free radicals, which are cell toxins:
A
Antioxidants “catch” free radicals before they cause damage
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Extent of DNA Damage73,000 DNA damage events per cell every day!
DNA repair enzymes fix most of the damage
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Reduce DNA Damage1. Reduce your exposure to free radicals!
don’t smoke avoid excessive sun exposure (use
sunscreens) avoid polluted areas
2. Improve your antioxidant defence! eat more fruits & vegetables take LifePak
50
A
LifePak providesan arsenal of nutrients that fight DNA damage,
protect DNA, andenhance DNA repair
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LifePak & DNA Damage
LifePak Nutrient Function
Vitamin C &
Vitamin E
DNA damage DNA repair
Vitamin B6,
Folic Acid &
Vitamin B12
Essential for DNA synthesis, replication and repair
Zinc Stabilizes DNA DNA synthesis
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LifePak Nutrient Function
Multi-Carotenoids beta-carotene lycopene
lutein
DNA damage
Multi-Flavonoids
green tea catechins quercetin
grape seed extract citrus bioflavonoids
soy isoflavones
DNA damage DNA repair
-Lipoic Acid DNA damage
LifePak & DNA Damage
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Recent Study in Am. J. Clin. Nutr.
55
How Can I Improve My Antioxidant and Anti-inflammatory protection?• Take Optimum Omega™ with LifePak®
– LifePak + Optimum Omega = Foundation– comprehensive benefits
– enhances absorption of LifePak®*
– 600-1,200 mg omega-3 fatty acids• 300-600 mg EPA• 200-400 mg DHA
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• Make sure all your meals contain antioxidants & phytonutrients!– Take LifePak + Optimum Omega with
your two main meals!– Include fruits & vegetables into your
other meal(s) and snacks!
57
58
Live Better, Longer
Phar
man
ex
Prod
ucts
Solu
tions
And
Wei
ght M
gmnt
Optimal Nutrition - LifePak Family
Inflammation protection – Optimum Omega
Optimal Health
Free Radical Protection – LifePak Family
59
Primary Benefits of LifePak Prime
OPTIMALLY FORMULATED FOR MEN OVER 40 ANDPOSTMENOPAUSAL WOMEN
1. Helps protect the body against symptoms of ageing 2. Protects cells with an advanced antioxidant network including
over 40 different antioxidants3. Promotes optimal bone health and maintains bone strength in
mature users 4. Promotes healthy immune function5. Supports normal blood sugar levels and healthy blood6. Supports a healthy cardiovascular system 7. Assists in brain functions8. Helps maintain eye function and health9. Assists in sexual function and energy production10. Corrects nutritional deficiencies
60
Primary Benefits of LifePak Women
FORMULATED FOR PRE AND PERIMENOPAUSAL WOMEN
1. Corrects nutritional deficiencies2. Supplies an optimal level of bone nutrients and helps
prevent osteoporosis3. Promotes healthy immune function4. Supports normal blood sugar metabolism5. Supplies a comprehensive blend of nutrients to
support a healthy cardiovascular system6. Offers anti-ageing benefits and cell protection
against damaging free radical attacks by providing a powerful antioxidants network
7. Helps provide premenstrual syndrome symptom (PMS) relief
8. Assists in relief of menopause symptoms9. Helps prevent urinary tract infection (UTI)
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Jungamals® LifePak for Kids
• A comprehensive children’s multivitamin/mineral supplement
• A balanced bone support formula including calcium for strengthening bones
• Promotes healthy immune function with vitamin C, zinc, and other essential nutrients
• Provides a complete balance of vitamins optimally formulated to assist in important normal functions of building the body and utilising the body’s resources
• Provides chelated minerals magnesium, calcium, iron and zinc
• Chewable, great orange, berry & cherry flavours
It is LifePak for kids aged 2 and up!
62
Fruit Phytonutrients
• At least 1,000 phytochemicals identified with cell protective effects
• Very few (25) studied• Fruits and vegetables – more than meets the eye• We don’t eat enough fruits and vegetables
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– R&D evaluated hundreds of fruits for…• Extraordinary antioxidant power (Scanner)• Extraordinary nutritional contents• Quality of scientific efficacy data• Impeccable safety data• History of traditional folklore usage
3 years ago…Pharmanex began Searching the World for Superfruits
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= gâc fruit + 3 superfruits= 3 years of Pharmanex research= 3 Pharmanex research labs1. Gâc fruit (Chinese Bitter Cucumber)2. Chinese Lycium (Wolfberry)3. Cili fruit 4. Siberian Pineapple (Seabuckthorn)
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Lipocarotenes™• Nature’s unique nutrient
delivery system in
• Gâc & Siberian Pineapple: – contain fatty acids (unique among
fruits)– with carotenoids & vitamin E pre-
dissolved– Gâc carotenes: 40 % improved
uptake**compared to beta-carotene powder. Vuong LT et al., Am J Clin Nutr 2002;75:872-879.
66
ot âc?
New G3 Super Juice Coming in 2006New G3 Super Juice Coming in 2006
67