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Combating Drug Resistance
Syed Khalid Saeed Bukhari
World Health Day 2011The Regional theme is combating Drug
Resistance (DR) The slogan is
"COMBAT DRUG RESISTANCE, NO action today, NO cure tomorrow"
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Pakistan30% prescription lack a diagnosis/complaint.EDL was present in 19% health facilities.1 in 6 prescription do not contain any dosage
instructions. According to EDSP 2002 report prescription
contain 52% antibiotics.
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Percentage of Encounters with antibiotic
Provinces
NWFP 49.7%
Baluchistan 49.7%
Punjab 60.7%
Gender
Males 58.8%
Females 46.4%
Prescribers
Doctor 53.3%
LHV 21.4%
Dispenser 32.4%
AGE
Child (<15 Years)
65.8%
Adult (<15 Years)
44.8%
Countries Comparison of Percentage of Antibiotics
Pakistan 52%
Bangladesh 25%
Nigeria 48%
Nepal 43%
No action today, no cure tomorrow
DR kills human lives
Challenges care and control of infectious diseases
Greatly increases care costs
Threatens healthcare gains for individuals and society
Can take us back to the pre-antibiotic era
Threatens health security and damages trade and economy
Thomas McKeown
The role of Medicine: Dream, Mirage, or Nemesis. 1980
DECLINE OF RESPIRATORY TUBERCULOSIS
DECLINE IN CHILDHOOD MEASLES
DECLINE IN CHILDHOOD DIPTHERIA
Low relative impact of health care in other
diseases
See the trend in decline of the disease was there even before the advent of modern medicine
Modern medicine contributed only a portion of further decline
The main decline was due to improved hygiene, sanitation, living conditions, lifestyles, preventive approaches, and these are all important public health practices we teach and advice
WHD 2011: What will we achieve?
Goal: To save lives and protect health by keeping precious, life-saving medicines effective and useful to combat diseases
Aims:- To raise awareness on what drives DR- To build commitment for effective policies and practices and their implementation to combat DR
Objectives: To provide policy guidance to Member States on top
priority actions to combat DR To reach and engage key stakeholders through
innovative communications, advocacy and events To promote further collaboration across sectors and
among stakeholders
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What is DR?DR arises when
Patients do not take their medicine properly and rationally
Providers do not prescribe the medicine properly Patients and community do not know proper use of
medicine & problem of drug resistance Health authorities do not maintain quality of drugsHospitals do not adopt infection control measuresHealth policy makers do not prioritize drug resistance
containmentThere is limited research on new medicine
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What is DR?.........
TB: 440,000 new multidrug resistance (MDR) TB cases annually; extensively drug resistance (XDR) TB cases reported in 58 countries so far
Malaria: Emergence of Artemisin resistance linked to ongoing use of monotherapies
HIV: With expanded use of antiretrovirals (ARVs), resistance is a concern
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What is DR…….
Methicillin-resistant Staphylococcus aureus: lethal infections in hospital settings which are becoming increasingly frequent
Multi-drug resistant E. coli and K. pneumoniae: infections are on the rise
Neisseria gonorrheae and Shigella: are becoming increasingly resistant to drugs
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What drives DR?Policy
Drug resistance plans & resources are not comprehensive
Monitoring Surveillance system is weak
Quality assurance System to ensure quality and supply of
medicine is inadequate
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What drives DR?Awareness
Consumers and communities are not aware of drug resistance
Prevention Poor Infection prevention & control
R&D Research & development for diagnostics and
drugs is insufficient
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Six Steps to Stop DR
1. Political commitment Committing to a comprehensive, financed national plan with lines of accountability and civil society engagement
2. Monitoring Strengthening surveillance and laboratory capacity
3. Quality control & assurance Ensuring medicines of good quality and regular supply
4. Rational use of medicine Regulating and promoting rational use of medicines,
including in agricultural sector, and proper patient care
5. Prevention & stopping the spread Enhancing infection prevention & control
6. R&D Fostering innovations, research & development
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To address DR, we should know: DR is complex as
it involves different diseases, settingsand demands well coordinated actions across
different sectors
DR is also a behavioral issue
DR is EVERY BODY’ problem
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WHO Global strategy In September 2001, WHO launched the first
Global Strategy for Containment of Antimicrobial Resistance which aims to encourage the urgent actions needed to reverse or at least curtail trends which have major economic as well as health implications.
WHO Policy & strategy options Addressing antimicrobial resistance requires a comprehensive multisectoral approach
Target audience” Intervention areaGovernment (health systems)Patients and the general communityPharmacistsPrescribers and dispensersHospitalsPharmaceutical industryFood production
Advocacy and intersectoral actionIntersectoral task forceResources to promote the implementation of
interventionsIndicators to monitor and evaluate the impact
of resistanceRegulations
Prescription-only statusInternational quality, safety and efficacy
standards
Policies and guidelinesNational Drug Policy and Essential Drugs
List (EDL)Surveillance
Designate or develop reference microbiology laboratory facilities
Drug resistance surveillance
Health educationAppropriate use of antimicrobialsDisease prevention (immunization, vector control)Hygiene
Education (undergraduate an postgraduate)Appropriate use and containment Disease prevention and infection controlDiagnosis and management
Management, guidelines and formulariesPrescription audits / prescription limitsStandard treatment guidelines and prescription
limitsRegulation
Professional registration based on continuing education
Promotional activitiesControl and monitor promotion for medicines
(WHO ethical criteria)Quality
Good Manufacturing Practice (GMP) of pharmaceuticals and diagnostics
National intersectoral task force on antimicrobial resistance
Legislation and regulation:prescription-only use of antimicrobials
Hospital therapeutics committees and infection control programmes
Essential drugs concept in educational programmes
WHO's responsepolicy guidance, support for surveillance,
technical assistance, knowledge generation and partnerships, including through disease prevention and control programmes;
essential medicines quality, supply and rational use;
infection prevention and control; patient safety; laboratory quality assurance
Messages on DRPolicy makers Ministries of Health, other than Ministry
health policy influencers & makers: The threat of DR is real & enormous; needs vigorous response with allocation of
proper resources, public awareness campaigns, and the establishment and enforcing of clear
policies to prevent the onset and dissemination of DR
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Messages on DRThe public:
understand and adopt the appropriate use of, or alternatives to, antimicrobials
prevent from and get treatment for infectious diseases; and
learn & adopt measures to reduce transmission
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Messages on DRPractitioners & prescribers
understand and appropriately use antimicrobials against TB, malaria and HIV and other diseases
learn and adopt disease prevention and infection control measures
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Messages on DRMedia:
promote awareness of DR as a real, enormous public health threat
encourage actions at policy levels to address DR
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Messages on DRPharmaceutical industry
promote production of quality drugs foster proper branding, publicity, and
marketing measures that favor prevention and containment of DR
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THANK YOU
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