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Actinomycetes Page 3

1 B Actino

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Page 1: 1 B Actino

Actinomycetes

Page 3

Page 2: 1 B Actino

Actinomycetes (order)

Three genera

Actinomyces species Nocardia species Streptomyces species

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Gram Positive Filamentous Bacteria

GENUS OXYGEN GRANULE ACIDFAST

Mycobacteria aerobe no yes

Actinomyces ANAEROBE YES no

Nocardia aerobe sometime

PARTIALLY

Streptomyces aerobe YES no

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Actinomycosis

A chronic suppurative and granulomatous disease of the cervico-facial, thoracic or abdominal areas

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Actinomycosis

Actinomyces israelii

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Ecological Niche

Actinomyces

Endogenous (man and animals)

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CLINICAL SPECIMENSActinomyces

Pus

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Sulphur

granules

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Drug of Choice

Penicillin

(large doses)

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Serological Test

None available

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Nocardiosis

Subcutaneous infections, pulmonary infections, and brain abscesses

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Ecological Association

SoilEndogenous ?

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Geographic Distribution

World wide

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Nocardiosis

N. asteroides – Pulmonary

N. brasiliensis - Abscesses

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Clinical Specimens

Sputum Pus Biopsy tissue

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Serological Test

None available

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Drug of Choice

Sulfamethoxazole-Trimethoprim

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STREPTOMYCOSIS

Streptomyces species

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Mycetoma

Streptomyces species

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Ecological Association

Soil

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Streptomyces may invade bone

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Clinical specimens

Pus Biopsy material

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Serological Test

None available

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Treatment

Surgical debridement Sulfa drugs Amphotericin B

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