Poster Abstracts Wednesday, November 9, 2005 $297

Conclusion: The profile o f memory impairments is different in patients with AD, DLB and PB and may be useful in differential diagnosis of dementia.

0772 Relationship between visuospatial and visuoeonslructive hnpaixments and visual halludnation in dementia with Lewy bodies, Alzheimer's disease and Parkinson's disease

Petrovie, M ~ , Zlatic, G a , Ocic, G ~, Savic, A ~, Tomic, G ~, Knezevic, Z ~, Toncev, G 1. 1Center for Neurology, Clinical Center Kragujevac, Kragujevac, Serbia & Monwnegro; 2Institute of Neurology, Clinical Center of Serbia, Belgrade, Serbia & Montenegro

Introduction: The aim of this study was to investigate relationship between visuospatial and visuoconstructive impairment and visual hallucination in patients with dementia with Lewy body (DLB), Alzheimer's disease (AD) and Parkinson's disease (PD). Methods: Twenty-three demented patients (8 DLB patients and 15 AD patients), 10 patients with Parkinson's disease (PD) and 10 healthy subjects were analysed. All groups were matched with age (lover 65 years), educated level (eight years) and time of the beginning of the disorders (over two years). Tire baseline neuropsychological profile was examined by the global score (Mini Mental State Examination). Subscores of the visuospatial and visuoconstructive impairment were compared by Matfis Dementia Rating Scale. All types of hallucina- tions were analyzed by BEHAVE-AD test. Results: Patients with DLB were found to have significantly higher visuoconstructive and visuospatial impairment vs. AD patients (p - 0.041), and vs. PD patients (p -- 0.046). AD patients were also found to have significantly higher visuoconstructive and visuospatial impair- ment vs. PD patients (p -- 0.012; p < 0.05). DLB patients were found to have significantly more visual hallucinations vs. AD (p -- 0.001, p < 0.01) and vs. PD (p -- 0.014, p < 0.05). AD patients were found to have significantly more visual hallucinations vs. PD (p - 0.000, p < 0.01). There were no differences between the other types of tire hallucinations. Conclusion: Visuospatial and visuoc.onstructive impairment and visual hallucination examination could help in differential diagnosis between DLB, AD and PD with dementia.

0773 Does tile presence of pshnomental retlex help predict MCI comse?

Pfeffer, A, Gabryelewicz, T, Barczak, A, l~uczywek, E, Wasiak, B, Bardkowska, M. Department Of Neurodegenerative Disorders Of Medical Research Centre Of The Polish Academy Of Science/CSK MSIViA

Background: Individuals with mild cognitive impairment (MCD have a high risk to develop dementia. A large number of variables appeared to be predictors of dementia in subjects with MCI. Palmomental reflex (PMR) is more commonly found in demented patients than in age- matched healthy controls. Pedraps its presence can be taken into account as accessory marker to identify subjects with dementia at follow up from among subjects with stable MCI. Objective: To test the hypothesis, that P M R is overpresented in MCI subjects who developed dmically diagnosed dementia, when compared with stable MCI. Material and Methods: The subjects of this study were 102 patients with MCI diagnosed according to the criteria proposed by Petersen et al. (11997). Presence of palmomental reflex was evaluated at all. After 2 years follow up, all patients were divided into 3 groups: 1-42 subjects with stable MCI course, II-43 subjects with progressive symptoms of cognitive impairment, but who did not meet clinical criteria for dementia, III-17 subjects, who converted to dementia. Frequency of presence of P M R at the initial visit was compared between these three groups.

Results: P M R was present significantly more frequent in group II (153 %) and in group III (152.5 %) than in group I (126.2%). Chi2 -- 7.466, p -- 0.024. Conclusion: Presence of palmomental reflex is associated with increased risk of progressing course of cognitive impairment in our group of MCI patients.

0774 Deulenfia and plasma levels of Ab40 and Ab42 in patients with Down syndrome

Pixttilii, T, Frey, H, Heikkilfi, L, Kivimfiki, T, Wegiel, J. 1Dept Of Neurology, University Of Kuopio, Finland," 2The Joint/vlunicipal Authority for Social Services in Pirkanmaa, Finland," 3New York State Institute for Basic Research in Developmental Disabilities, New York, U.S.A.

Baekg*ound: The levels of A[342 in plasma are elevated in patients with mutations in APP and presenilin genes before clinical symptoms as well as in patients with mild cognitive impairment who develop Alzheimer's disease (AD). Patients with Down syndrome (DS) develop AD neuropathology by the time they reach 40 years of age. Our aim was to exanfine the relationship between plasma AIM0 and A[342 levels and development of dementia in patients with DS. Method: Fourty adult DS patients (126-64 years at baseline) were followed for five years. Nine patients were demented at baseline and eight patients became demented during the follow-up. Plasma A[340 was measured by a home-made sandwich ELISA and A[342 was measured by a commercially available sandwich ELISA kit (Imroge- netics, Belgimn). Results: Plasnra levels o f A[342 and A[340 were higher in DS patients than non-DS individuals. The levels remained stable in individual patients during the follow-up. There was no association between the development of dementia and plasma levels of A[340 or A[342 at baseline or during the follow-up. Conclusion: Plasma A[340 and A[342 levels are increased in DS but are not associated with development of dementia.

0775 Tile combination of CSF Ab42 and Tau or Phospho-Tau predict progression in patients with mild cognitive hnpainnent

Pixttilii, T, Herukka, S, Hallikainen, M, Soininen, H. Deparment of Neurology, University Of Kuopio

Background: Patients with mild cognitive impairment (MC 0 have an increased risk of developing dementia, particularly Alzheimer's disease (AD). However, tire etiology of the MCI is heterogeneous and some patients may never develop dementia. The aim of this study was to study CSF A[342, Tan and pTau as predictive biomarkers of AD after an extended Follow up in a hospital cohort of MCI patients. Method: The study population consisted of 108 patients (146 controls, mean age 67.4 years and 78 MCI patients, mean age 70.4 years) who were referred to the memory clinic Kuopio University Hospital or participated in an ongoing longitudinal population based study. The CSF levels of A[342, total Tau and pTau0a~, ) were measured by a commercial enzyme-linked im_munosorbent assay, ELISA (inno- genetics, Ghent, Belgiunr). Results: After the mean follow up of three years (0.5-12 years), 55 MCI patients remained stable (stable MCI) and 23 patients progressed to AD (progressive MCI). The CSF A[342, total Tau and pTau values were not significantly different between the control group and the stable MCI group. Increased Tau and pTau levels showed high sensitivity (187°'; for both) whereas decreased A[342 was tire most specific (174.5°,5) in discriminating progressive MCI. The best positive LR (4.00) was found for the combination of AIM2 and pTau.