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link includes our reservation code for our room rate. I expect that we will fully reserve in our block first before using any outside hotels. If you have any questions or concerns please see me.

http://www.marriott.com/hotels/travel/msydt?groupCode=dukduka&app=resvlink&fromDate=10/15/09&toDate=10/22/09

New Departmental Research PublicationsFreiberger JJ, Yoo DS, de Lisle Dear G, et al. MultiModality Surgical and Hyperbaric Management of Mandibular Osteoradionecrosis. Int J Radiat Oncol Biol Phys. Mar 26 2009.

Vann RD, Moon RE, Freiberger JJ, et al. Decompression illness diagnosis and decompression study design. Aviat Space Environ Med. Aug 2008;79(8):797-798.

New Helpdesk WebsiteKen Childs

There is a new helpdesk ticketing system: http://aneshelpdesk.duhs.duke.edu. This new system is a far more customizable system than the former MRHAT system that was developed in 2002. The site will allow for helpdesk tickets to be put in from a Blackberry, allow for end-user ticket tracking, and in all provide a more user-friendly environment.

The MRHAT website will be shut down shortly, and all traffic will be rerouted to the new helpdesk. Please mark your bookmarks accordingly. If you have any questions/concerns, please email me, Ken Childs at [email protected].

http://anesthesiology.duke.edu 1

Bennett-Guerrero to be Featured on PBS/NOVA Show

Our very own Elliott Bennett-Guerrero, MD will be featured on the April edition of PBS’s NOVA program. The episode, “Doctors’ Diaries,” a two-part special in which he is one of seven doctors interviewed, explore their lives from medical school through midlife. The show will air Tuesday, April 7th and 14th at 8:00 pm est. For more information regarding this show, please visit: http://www.pbs.org/wgbh/nova/doctors/about.html.

ASA Hotel Room Block InformationMark F. Newman, MD

In order to maximize our impact while minimizing the overall departmental cost, we will again have a hotel arrangement this year that will allow us to consolidate and take advantage of group purchase

to reduce our food and room rental expenses. In order to accomplish this we have a room block at the Renaissance Hotel in New Orleans. You will need to book your room by visiting the site listed below. The

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NewsMonday, April 6, 2009 • Volume 11, Issue 12

Department of Anesthesiology Research ConferenceMonday’s from 5-6 pm in 5685-HAFS Monday, April 13th“Patent Basics”Speaker: TBA

This is an introduction for individuals who may have little or no exposure to the basic tenants of Patent Law. Some of the items that will be covered include: • The Basis of US Patent Law, • What rights are conferred when a patent issues, • What rights are not conferred when a patent

issues, • The three different types of patent applications

• Provisional Patent • Utility Patent • Design Patent

• The components of a Utility patent application, • Domestic filing process • International filing process • Q&A’s

Upcoming Meetings:May 12: Academic Evening October 12June 8 November 9September 14 December 14

Hyperbaric Grand RoundsMeDICINe AND WORK PeRFORMANCe

AT HIGH TeRReSTRIAl AlTITUDeS

Stephen R. Muza, Ph.D.U.S. Army Research Institute of environmental

MedicineNatick, MA USA

5 PM, Thursday, April 9Rauch Conference Room

Room 15103A, White ZoneMorris Building

Elliott Bennett-Guerrero, MD

THIS MONTH IN THe DePARTMeNT OF ANeSTHeSIOlOGy


April 2009MONDAY TUESDAY WEDNESDAY THURSDAY FRIDAY6 7 8 9 10

7:15-8:00 a.m., RM203-Pain Clinic MRC Pain Conference

2-3 p.m., VAMCVA Echocardiography Conference

4-4:45 p.m., 5685-HAFSExecutive Team Meeting

4:45-5:30 p.m., 5685-HAFSFaculty Meeting

5-6 p.m., 5685-HAFSCT Conference: “Presentation of SCA Posters“ - Drs. Aeschlimann, de Lange, Hudson, Kushins, Lem-ons, Pabich, Wood

5-6 p.m., 6686-HAFSGVTCCM Conference: “Liver Transplant M&M” - Kerri Wahl, MD

6:15-7:15 a.m., 5685-HAFSCT Anesthesia Fellow/Faculty Preceptor Seminar: “Mitral Valve Repair” - G. Burkhard Mackensen, MD

6:30 a.m., 2001DNResident Conference Lectures: “Prematurity & Its Implications” - Richard Ing, MB

7:15 a.m., 2001DNGrand Rounds: “SUMO Conju-gation in Stressed Cells” - Wulf Paschen, PhD

7:15-8:00 a.m., RM203-Pain ClinicMRC Pain Journal Club

12:00-12:45 p.m., 2001DNCritical Care Grand Rounds: “An Introduction to Small Bowel Trans-plantation” - Debra Sudan, MD

4-5 p.m., 5680A-HAFSPediatric Conference: “Albumin-Friend or Foe” - Craig Weldon, MD

5-6 p.m., 5680B-HAFSResident Education Sessions: “Topic TBA” - Stephen Klein, MD

5-6 p.m., 5685-HAFSDepartment Fellow/Faculty Fel-low/Faculty Preceptor Seminar: “Patient Safety Topics” - Jonathan Mark, MD

13 14 15 16 17



5-6 p.m., 5685-HAFSDepartment of Anesthesiology Research Conference: “Patient Basics” - Speaker TBA

5-6 p.m., 5685-HAFSCT Conference: “Alpha 2 Agonists for ICU Sedation” - Charles Brud-ney, MD

5-6 p.m., 6686-HAFSGVTCCM Conference: “Nitrous Oxide: Friend or Foe?” - John Nardiello, MD

IRB Deadline: Submit 1 original and 3 copies to Dr. Gan’s office by 5 p.m.

6:15-7:15 a.m., 5685-HAFSCT Anesthesia Fellow/Faculty Pre-ceptor Seminar: “Prosthetic Valve Assessment” - Joseph Mathew, MD

6:30 a.m., 2001DNResident Conference Lectures: “Pediatric Regional Anesthesia” - Allison Ross, MD

7:15 a.m., 2001DNGrand Rounds: “Molecular Basis of Postoperative Delirium” - Madan Kwatra, PhD


12:00-12:45 p.m., 2001DNCritical Care Conference

4-5 p.m., 5680A-HAFSPediatric Conference

5 p.m., Location TBAEducation Executive Committee Meeting

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4-5:30 p.m., 5685-HAFSExecutive Team Meeting

5-6 p.m., 5685-HAFSCT Conference: NO CONFERENCE

5-6 p.m., 6686-HAFSGVTCCM Conference: “The Uganda Experience” - Tony Roche, MD

6:15-7:15 a.m., 5685-HAFSCT Anesthesia Fellow/Faculty Preceptor Seminar: NO CONFERENCE

6:30 a.m., 2001DNResident Conference Lectures: “Pediatric Anesthesia Review“ - John Eck, MD

7:15 a.m., 2001DNGrand Rounds: “The Duke Enter-prise Data Warehouse” - Jeffrey Ferranti, MD

5 p.m., Chen Conference RoomNeuroradiology Conference


12:00-12:45 p.m., 2001DNCritical Care Grand Rounds


5-6 p.m., 5685-HAFSResident Education Sessions: “Topic TBA” - Warwick Ames, MD

5-6 p.m., 5685-HAFSDepartment Fellow/Faculty Fellow/Faculty Preceptor Seminar:“Industry, Academics, Money, & Ethics” - Joseph Mathew, MD

27 28 29 30 May 1, 2009



4-5 p.m., 5420B-DNPerioperative Leadership Group Meeting

5-6 p.m., 5685-HAFSCT Conference

5-6 p.m., 6686-HAFSGVTCCM Conference: “NICOM (Non Invasive Cardiac Output Monitor)” - Cheetah Medical Repre-sentative [Non-CME]

IRB Deadline: Submit 1 original and 3 copies to Dr. Gan’s office by 5 p.m.

6:15-7:15 a.m., 5685-HAFSCT Anesthesia Fellow/Faculty Preceptor Seminar

6:30 a.m., 2001DNResident Conference Lectures: “Common Pediatric Problems& their Anesthetic Implications” - Heather Frederick, MD

7:15 a.m., 2001DNGrand Rounds: “Anesthesia Reim-bursement” - Andrea Styron, MD


12:00-12:45 p.m., 2001DNCritical Care Conference


Upcoming events:2009 Academic evening: May 12, 2009 | 5:45 p.m. | Millennium Hotel, Durham, NCResident Practice Oral exams: Monday, May 18, 2009 | 4 - 6 p.m.2009 Resident Graduation Banquet: May 30, 20092009 ASA: October 17-21, 2009 | New Orleans, LA21st Annual Alumni Reception: October 18, 2009 | 7-10 p.m. | New Orleans, LA


ANeSTHeSIOlOGy NeWS

Call for Artwork - Academic evening 2009Cathleen Peterson-Layne, MD

To continue to the tradition of highlighting various talents in the department, you are invited (and encouraged) to submit your artwork for display at our Seventeenth Annual Academic Evening on Tuesday, May 12th. Everyone is welcome to participate. Last year, several folks revealed their talent in photography, sketching, painting, bead work, and

weaving.

Please let me know the type and size of each item you would like to display so that we can plan for easels - tabletop and floor.

If you would like your artwork to be considered for the program cover, please send an electronic copy to me ([email protected]) by April 10th.

If you have any questions about Academic Evening, please do not hesitate to ask.

Cellular Target May Prove Useful in Treating Deadly Brain TumorsBy Duke Medicine News and Communications

Duke University Medical Center researchers have identified a receptor on the surface of cells that may give them another avenue of attack against gliolastoma, the most common and most deadly type of brain cancer.

The neurokinin 1 receptor (NK1R), which may be expressed in all human glioblastoma cells, may prove to be an appropriate target for therapies aimed at treating these brain tumors, according to a study led by researchers in the Duke Department of Anesthesiology and the Preston Robert Tisch Brain Tumor Center at Duke.

“There are some previously identified cellular targets for therapy which are now being investigated in clinical trials, and the findings from our research represent potential alternate or complementary targets that may help patients facing this devastating disease,” said Madan Kwatra, PhD, a researcher in Duke’s department of anesthesiology, and senior investigator on this study.

“Patients generally die from the disease within 18 months of glioblastoma diagnosis.”

The results of the study were published in the March 30, 2009 online edition of the Journal of Neurochemistry. The study was funded by the National Institutes of Health.

The researchers examined stimulation of the receptor NK1R in human glioblastoma cells growing in a dish, and found that activation of NK1R led to the activation of Akt, a cellular protein that suppresses the natural

cell death process.

“In human cancers, this would translate into a proliferation of cancer cell growth,” said Kwatra.

The researchers also showed that blocking NK1R activity reduced Akt activity, which then led to greater cell death.

“This finding suggests that if we are able to block NK1R activity, we may have a better shot at stalling cancer growth,” Kwatra said.

A previous study showed NK1R activity in 10 out of 10 glioblastomas and nine out of 12 astrocytomas, a lower-grade malignant brain tumor.

Current therapies to treat glioblastomas are directed toward blocking the activity of another cellular receptor called epithelial growth factor receptor (EGFR).

A recent clinical trial using an EGFR inhibitor found that patients whose tumors expressed high levels of phosphorylated -- or chemically altered -- Akt did not respond to treatment, Kwatra said.

“This underscores the importance of discovering the origin of active Akt in glioblastomas,” he said. “We propose that the elevated levels of phosphorylated Akt may come from active forms of NK1R, and it’s possible that a better response might be obtained by simultaneously blocking EGFR and NK1R.”

Future studies may examine the role of a NK1R inhibitor in glioblastoma patients, perhaps as a corollary to treatment with an EGFR blocker such as erlotinib, which is currently being studied in clinical trials.

“The FDA has already approved a drug for combating chemotherapy-induced nausea and vomiting that happens to be an NK1R inhibitor, so that might be a possibility for study in conjunction with erlotinib,” Kwatra said.

Other researchers involved in this study include Toshimasa Akazawa, Shawn Kwatra, Laura Goldsmith, Mark Richardson, Elizabeth Cox and John Sampson.

Comings and GoingsPlease welcome Betsy Hales to the Department of Anesthesiology. Betsy is a new DataBase Analyst I working for CARE. She started with the department on March 23, 2009.

Please welcome Ken Honjo to the Department of Anesthesiology. Ken is a new Visiting Research Scholar working in the Basic Sciences Division. He started with the Department on April 1, 2009.

Upcoming Faculty Development eventsTuesday, April 7, 2009 - 5:30 p.m.Money Flow in the School of MedicineBilly NewtonRauch Conference Room - 15103 Morris Building

Thursday, April 30, 2009 - 5:30 pmGetting Promoted in the Clinical Sciences at Duke: A Guide for Junior FacultyAnn J. Brown, MD, MHSMedical Student Amphitheater, Duke South

Madan Kwatra, PhD

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Seventeenth Annual Academic Evening

Tuesday, May 12, 2009 at 5:45 pmMillennium Hotel

Durham, NC

CALL FOR ABSTRACTS

ACAD

EMIC

EVE

NING

Medical Students, CRNAs, Residents, Fellows, and Junior Faculty are invited to submit abstracts for presentation.

Abstracts may represent original clinical, laboratory scientific or case reports. Submission to other scientific organizations (e.g. ASA, Gulf Atlantic Residents’ Conference) is allowed. In fact, we encourage those of you who have ASA abstracts in preparation to submit them for the Academic Evening. All

submissions will be accepted for poster presentation.

Abstracts must be no longer than one full page (8.5” x 11”) including diagrams and tables.

Entries are due Wednesday, April 15th at 5 pm. Please submit electronically in MS Word to June Santa. Please submit one

unblinded copy and one blinded copy of each abstract, as well as the completed abstract cover sheet.*

*PLEASE NOTE: THE ABSTACT COVER SHEET CAN BE DOWNLOADED FROM THE STAFF INTRANET AT

HTTP://ANESTHESIOLOGY.DUKE.EDU

Questions? Contact June Santa at [email protected],684-6252 or Cathleen Peterson-Layne, MD at

[email protected], 970-6408.http://anesthesiology.duke.edu 4


ANeSTHeSIOlOGy NeWS

Magic Kingdom® Park©Disney

2nd Annual Emerging Technologies in the OR

June 7-10, 2009Disney’s Yacht and Beach Club ResortLake Buena Vista, Florida

For registration questions please contact Katherine Siler at 919-681-6437 or email at [email protected]

anesthesiology.duke.edu

Sponsored by the Duke University School of Medicine

DUKE CME: TRANSFORMING KNOWLEDGE

Duke University School of Medicine and The Department of AnesthesiologyPRESENTS


Duke University School of Medicine and The Department of AnesthesiologyPRESENTS

SAV

E TH

E D

ATE

Sponsored

by the Duke

University

School of

Medicine.

Mark your calendars for another year of cutting-edge research and updated information designed for medical personnel of all skill levels.

http://anesthesiology.duke.edu

12th Annual Duke Cardiothoracic Update and TEE Review Course

June 18-21, 2009Crowne Plaza ResortHilton Head Island, South Carolina

NEW!Featuring

Heartworks™TEE Simulator

Pre-ASA Symposium/Workshop 6th Annual Ultrasound for Every AnesthesiologistFriday, October 16, 2009Renaissance Arts HotelNew Orleans, Louisiana

SAVE THE DATE


Duke University School of Medicine and The Department of AnesthesiologyPRESENT

Sponsored by the Duke University School of Medicine.

anesthesiology.duke.eduImage Credit: Jean-Paul Gisclair

ClassifiedsReal estate & Rentals

Huge, beautiful apartment in great lo-cation for rent. Ideal for Visiting Duke Faculty or Fellows. Recently renovated top floor of 203 Watts Street. 1920’s Arts & Crafts style duplex. 2 full bedrooms, 1 bath plus office/den. All new bath-room. High ceilings, great light. Eat-in kitchen and formal dining room. Large living room. Completely and tastefully

furnished and fully equipped with cookware, utensils, dish ware and linens. Washer/Dryer in unit. Lease terms negotiable. Owner lives in first floor unit, providing quick and friendly service and repairs. Electric-ity, Internet, Cable TV, and Water/Sewer included. Tenant pays for gas-fired heat (new more efficient furnace just installed). $1900/month. Pets require additional damage deposit. Non-Smokers only, please. Contact Adam by phone at 919-452-3751 or [email protected] for more details.

1301 Antler Point Dr. Durham NC 27713. Year Built: 2006, 3020 sq. ft., 4 bedroom(s), 3 full bath(s), 15 min. to Duke, UNC, or RTP, 2 minutes to South-point Mall, Backyard backs to American Tobacco Trail, Lots of upgrades, see MLS for details, $385,000 - MLS ID #1652795. If interested please email lrostami@fmre-

alty.com or call (919)358-3520.

25 Scottish Lane Durham, NC. Nice townhome convenient to Duke, UNC, and shopping. Great school district. $165,900. Contact Mark Hutchins Smart Move Realty (919) 294-0041.

45 Birnham Lane Durham, NC. Gor-geous all brick home in beautiful golf course community on a spacious cul-de-sac lot. The master features a won-derful sitting area with fireplace and recently renovated bathroom. Bonus/In-law suite has elevator (rarity in this

price range). Recently remodeled eat-in kitchen features new SS ap-pliances and beautiful granite countertops. There is a wonderful sun room and deck off the kitchen. $620,000 Contact Mark Hutchins Smart Move Realty (919) 294-0041.

Pets

Brindle Boxer Mix Needs His Forever Home. Please consider adopting this loving, sweet, playful, gentle Brindle Boxer mix. Rudy is about 2 years old, still puppyish, housebro-ken, neutered, loves all dogs. His ideal home would include a young dog to play with and a fenced yard. Weighing about 64 pounds, he is full grown, and is up-to-date on all shots and heartworm preventative. He was found injured as a stray, and while recovering was in a foster

home with two dogs, and since then fostered in a home socializing with several dogs. He is great with all of them: male and female, large and small, dominant and submissive. If interested, please contact Wendy at 919-489-4858 or email [email protected].


THe BACK PAGe

Merchandise

Two pairs of size 45 Dansko clogs for sale. I bought these clogs for internship last year but after using them for a few weeks I realized they just don’t work well with my feet. The black pair are a bit more heavily used so I’m asking $30 for them and $40

for the brown pair. If interested please contact Russell Roberson at pager 970-6853 or via eamil at [email protected].

2GB Silver IPod Shuffle for sale. Brand new and still in packaging. Won at office party and was already happy with my MP3 player so haven’t used this device. Asking $40. If interested contact Russell Roberson at pager 970-6853 or via email at [email protected].

Thursday, May 7, 2009 - 5:30-8:30 pmSpring Faculty Meeting and DinnerVarious SpeakersSarah P. Duke Gardens, Doris Duke Center

For the most up-to-date information and to register for events please visit http://facdev.medschool.duke.edu.

April 1 - 12 Birthday WishesSyreena Bibbs Dr. Adeyemi OlufolabiDr. Ryan Fink Dr. Charles PeeryDaniel Geniton Dale PotterDr. Joel Goldberg Joseph RybickiCarrie Hines Ricky SellarsDr. Nancy Knudsen Dr. Huaxin ShengDr. Daniel LaValley Dr. Cathy ThomasKelly Lochmuller Allison WeaverSanders Massey III Zhiquan ZhangDr. Karen Nielsen

Note: If you do not want your name listed here, please send a removal notice to [email protected].

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Documents

04-06-09