Rimactane0

Rifompicin

f'J SANDOZ

Composition Eoch Rimoctane· 300 mg Copsule contains rifompicin 300 mg. Eoch Rimactane' 450 mg Sugar-cooled coptob conic.ins rifompicin 450 mg. Eoch Rimoclane' 600 mg Sugar-cooled copt'.lb contains rifampicin 600 mg. Each 5 ml Rimoctone· Syrup contains ri:ompicin l 00 mg.

Theropeutic Indications • Mycobocleriol Infections Tuberculc.sis (all forms)

Rir,1oclone· must always be combined with at least one other ontituberculosis agents.

• leprosy In combination with dopsone ono clofo�imine as treatment for multibocillcry form� of leprosy [Lepromotous (LL], Borderline lepromotous {SL), Borderline {BB]]. In comb:notion with dopsone as treatment for priucibocillcry forms of leprosy [T uberculoid (TTI. Borderline Tuberculoid (BTl].

Phosology and Method of Administration 1 Mycobcclericl lnfec/ions Tub�rculosis {all lormsj I !t) t� f��{!.-.. � __

1 tdult • P, JJ.nMh1.J� t - Adults weighing less than 50 k�: J50 mg Rimocton� ij ' y t; ____ .. ____ _ -

.Adults weighir.g 50 kg or r,1ore: 6�0 ms Rimocione

Jo

· tr,U[J.J:/.:'li ___ .. ___ ----1 S::nilqren: 10 - 20 mg/kg Rimocton� doily. l __ , __ _ Maximum permissible doily dose: 600 mg doily. The chemotheropou�c agents usually employed today os combined therapy for tuberculosis ore rifompicin (RMP, Rimoctcne°). isoniozide (1Nl:IJ, pyro2incmide {PZAj, ethcmbutol {ElvlB), stre;:,tornych (!>TM). The dosage as recomme�ded by WHO ore cs follows:

Drug

RMP tNH PZA EMB STM _____

Ocilv mo/ka Mox.mci

10 600 8 <100 30 2000 20 l 1200

.J..5 ______ IJ.QO.Q_ _ -

' 2or3timescw� mo/ka Mox. mo

10 600 15 750

50 35CO _ 4C 2000 15 -- _j 1000 ·-·

For the treo:ment of sputum-positive pulmo;,ory tuberculosis, preferenc& is nowadays given to the following regiment.;: Conlinuous Therapy /7 limes c wee<} Tote! duration 9 moPths: - ,nitiol phose fer 2 mo�th!: RMP + ll�H T EMB or STM - continuation phase for 7 monlhi: RMP + !NH.

The short tenms ontituberculosis drug for adults {15 years and above), with alternatives os follows: o. Category I

Initial phase for 2 months, doily (60 limes toking the drug): RMP A50 mg + INH 300 mg + PZA 1500 mg + EMS 750 mg. Continuation phas� for 4 months, three times o wee� (54 times toking the drug): RMP 450 mg+ INH 600 mg.

b. Category II Initial phase for 3 months, doily {90 times toking the drug]: RMP 450 r.ig + INH 300 mg

+ PZA 1500 mg+ EMB 750 mg + STM 750 mg. streptomycin is only given in the first 2 months. Continuation phase for 5 months, !hree times a week (66 lirr.es toking the drug): RMP 450 mg + INH 600 mg + EMB 1250 mg.

c. Category Ill Initial phase for 2 month!, doily (60 times toking the drug): RMP 450 mg + INH 300 mg + PZA 1500 mg. Continuation phase for 4 montt,s, !hr�e times o week (54 times toking the drug): RMP 450 mg + INH 600 mg.

d. Insertion If th� treatment of culegory I ond II in ti,e end of initic.l phose/intensive still Acid Resistcnt Bacillus posirive, insertion treatment is given during l month, doily. The doily dosage for l month {30 times toking the drug): RMP 450 nig + !NH 300 mg +PZA 1500 mg+ EMB 750 mg.

In the case of oli regiments odmhislered twice or three timus weekly, the patients should be monitored with direct:y observed therapy (i.e. administration of drugs unde, supervision). Th9 some applies for relapses end treatment loiiures. Dosage recommendation for sputum· negative pulmonary tuberculosis and extrcpu!monory tuberculo�is, and dosage recommenootion for elderly and/or undemounsh;;id patients and those wah severe liver damage can be found in the rel�vont :iterature.

Ac C 2���----leprosy P!t'!:!:.�_'!f��!,. For the treatment of leprosy the WHO recommends the following e . · _________ _- Multibocillory forms (Ll, Bl, BB) fl:Ji{Jl:'Al!AN ___ -- _ -----Adult,: rilompicin {Rimoctone') 600 mg once o month under supe - . • . �nc; doily + clofozimine (lamprene') 300 mg once o month under supervision + 50 mg once u day. Children: rifompiciP {Rimoclone·) IO mg/kg once o month under �upeNision + dopsone I -2 mg/kg doily+ clo�zimine (lomprone') 200 mg once a month under supervision+ 50 mg on alternate days. Duration of treatment al l�ost 2 years, preferably until negoti,•e skin smears ore obtained.

- Poucibocillory forms (TT, BT! AQ.ults: rifompicin {Rimoctcne·j 600 mg once a month under supervisio'> + dapsone 100 mg ( 1 . 2 mg/kg) once a day. Children: rilompicin (Rimoclcne') 10 mg/kg once a mcnth under supervision + dopsone l - L mg/kg/doily. Duration of treotment of of least 6 months.