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SCIENCEVOL. 97 FRIDAY, FEBRUARY 5, 1943 No. 2510

Digitalis and Some of Its Derivatives: DR. HARRY Special Articles:GOLD .1................... The Lethal Effect of Triethylene Glycol Vapor on

Food and Nutrition as Related to the War: DR. Air-Borne Bacteria and Influenza Virus: DR. 0. H.CHARLES GLEN KING ................ ....... 129 ROBERTSON and OTHERS. Preventing the Bacterial

Obituary: Oxidation of Rubber: DR. ALBERT E. DIMOND andMax Har'rison Demorest: FRAN9OIS E. MATTHES. DR. JAMES G. HORSFALL.142R~ecent Deaths ............................................... 131 Scientific Apparatus and Laboratory Methods:

Scientific Events:The Inter-American Institute of Agricultural Sci- A Simple Method for Converting a Line-RecordThewes d ellwsipsinCheisry

Int r- n iin tnto a Shadowgram: DR. FREDERIC A. GIBBS. A

ences; duePont owshi in Chemisty The Method for the Study of Invertebrate Blood in-Detroit Meeting of the Ameriean Chemieal So- Vitro: DR. EMIL LIEBMANN. ..145ciety; The Torrey Botanieal Club; Wartime Train-ing in Scientific and Technological Fields ........................ 132

ng ~~~~~~Science News ........................................... ............... 10Scientific Notes and News ............ ...................... 135

Discussion:The Hardy-Weinberg Law.: PROFESSOR CURTSTERN. The Shot-Put and the Earth's Rotation: SCIENCE: A Weekly Journal devoted to the Advance-PROFESSOR PAUL KIRKPATRICK. The Water Hya- ment of Science, edited by J. MCKEEN CATTELL and pub-cinth in California: PROFESSOR IRA L. WIGGINS. lished every Friday byScience, War and Football: PROFESSOR S. C. THE SCIENCE PRESSBROOKS.137 T ESS...............

Lancaster, PennsylvaniaSpecial Correspondence:Reorganization of Conservation Work in Maryland: Annual Subscription, $6.00 Single Copies, 15 Cts.PROFESSOR JULIAN D. CORRINGTON ... 140

SCIENCE is the official organ of the American Associa-Scientific Books: tion for the Advancement of Science. Information regard-Photography: DR. HENRY C. STAEHLE. Drugs and ing membership in the Association may be secured fromPholCatography DR.M..the office of the permanent secretary in the SmithsonianCell Catalysts: DR. M. H. SEEVERS......................141 Institution Building, Washington, D. C.

DIGITALIS AND SOME OF ITS DERIVATIVES'By Dr. HARRY GOLD

DEPARTMENT OF PHARMACOLOGY, CORNELL UNIVERSITY MEDICAL COLLEGE

Ladies and Gentlemen: I WISH first to acknowledgethe honor conferred upon me by the New EnglandHeart Association through the invitation to addressyou this evening. The opportunity to discuss thesubject of digitalis in the city of Bostgn, steeped inthe traditions of cardiovascular research and rich ineminent leadership in cardiological practice, is indeeda great privilage. I feel doubly honored to have thisopportunity on the occasion arranged as a tribute tothe memory of one of New England's most distin-guished physicians.

I have planned to present the results of experimentsand to discuss briefly lines of evidence having to dowith various phases of the nature of the action of1Annual Jackson Lecture of the New England Heart

Association, delivered at the Boston Medical Library,April 24, 1942.

digitalis and its glycosides. Some are based on ex-periments performed on animals, others directly onhuman subjects. The account is not intended toexhaust the subject. It represents for the most partexplorations in this field carried out during the pastfew years by a group of collaborators in our labora-tory and clinics.2One of the popular formulations regarding the

mechanism by which digitalis abolishes heart failureis based on the view that the essential action ofdigitalis is an action on the "tone" of the heart muscle.There is no general agreement as to the nature of the

2 From the Department of Pharmacology of CornellUniversity Medical College and the Cardiac Services ofthe Beth Israel Hospital and the Hospital for Joint Dis-eases in New York City. Chief collaborators: Drs. Me-Keen Cattell, Nathaniel T. Kwit, Janet Travell, HaroldOtto, Milton Kramer, Theodore Fox and William Zahm.