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© Proprietary & Confidential Dr. Eyal Bressler & Co. www.bressler.co.il ORTHOPEDIC PATENTS: CURRENT TRENDS, INNOVATIONS AND FUTURE OPPORTUNITIES December 16 th , 2015 Dr. Joe Wyse, Partner, Head of Patent Dept. Dr. Ilan Riess, Medical Devices Tel: 03-5765555 / [email protected] / [email protected]

© Proprietary & Confidential Dr. Eyal Bressler & Co. ORTHOPEDIC PATENTS: CURRENT TRENDS, INNOVATIONS AND FUTURE OPPORTUNITIES December

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© Proprietary & Confidential 1. Patents as a Monetizer 2. Global Orthopedic Devices Market, “Big Ortho” and IL Orthopedic Device Patent Trends 3. What is to be Done ?

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Page 1: © Proprietary & Confidential Dr. Eyal Bressler & Co.  ORTHOPEDIC PATENTS: CURRENT TRENDS, INNOVATIONS AND FUTURE OPPORTUNITIES December

© Proprietary & Confidential

Dr. Eyal Bressler & Co.www.bressler.co.il

ORTHOPEDIC PATENTS: CURRENT TRENDS, INNOVATIONS AND FUTURE OPPORTUNITIESDecember 16th, 2015

Dr. Joe Wyse, Partner, Head of Patent Dept.Dr. Ilan Riess, Medical Devices

Tel: 03-5765555 / [email protected] / [email protected]

Page 2: © Proprietary & Confidential Dr. Eyal Bressler & Co.  ORTHOPEDIC PATENTS: CURRENT TRENDS, INNOVATIONS AND FUTURE OPPORTUNITIES December

© Proprietary & Confidential

Dr. Eyal Bressler, PhD INTA, AIPPI, LLB (Biotechnol.) (Hebrew University) 1, 3

Dr Joe Wyse, PhD INTA, AIPPI (Genetics) (London University) 1

Dr Lior Itzhaki, PhD INTA, AIPPI (Chem.) (Bar Ilan University) 1

Dr. Richard Schultz, PhD (Chem.) (Harvard, UC Berkeley) 1, 2

Dr. Michael Meyklyar, PhD (Physics) (Khazan University, Weizmann Inst.) 1

Dr. Keren Hagai, PhD (Mol.Bio.) (Tel Aviv University) 1

Dr. Jeannette Fine, PhD (Physics.) (Washington University)

Dr. Noa Ofer, PhD (Mol. Bio.) (Technion)

Ms. Sigalit Avraham Bsc. LLB. LLM. (Chem, Law.) (Hebrew University) 1

Dr. Ilan Riess, PhD (Biotechnol.) (Turin University)

Mr. Dean Mai Bsc., LLB. (Computers. Law) (IDC)

Ms. Chantal Balla Bsc.,Msc. (Computer Science) (Technion)

Dr. Michael Jaffe , PhD (Engineering) (Michigan)

Dr. Limin Wang, PhD (Physics) (Penn. State, Peking )

1 – IL Pat Att; 2 – US Pat Agent; 3- IL Att at law

Dr. Neil Wilkof, LLB 3Aviv Pollak, LLB 3Rachel Nissim, BA

Idan Sides, LLB 3

Page 3: © Proprietary & Confidential Dr. Eyal Bressler & Co.  ORTHOPEDIC PATENTS: CURRENT TRENDS, INNOVATIONS AND FUTURE OPPORTUNITIES December

© Proprietary & Confidential

1. Patents as a Monetizer

2. Global Orthopedic Devices Market, “Big Ortho” and IL Orthopedic Device Patent Trends

3. What is to be Done ?

Page 4: © Proprietary & Confidential Dr. Eyal Bressler & Co.  ORTHOPEDIC PATENTS: CURRENT TRENDS, INNOVATIONS AND FUTURE OPPORTUNITIES December

© Proprietary & Confidential

Patents as a Monetizer:

Patents are used to1. Create a monopoly for a limited time. 2. Extract licensing fees from the market.3. Transfer Rights from the Inventor to a company.

Note that most licensing business is done before the patent is granted. Patents are written for the investor/partner/competitor

Page 5: © Proprietary & Confidential Dr. Eyal Bressler & Co.  ORTHOPEDIC PATENTS: CURRENT TRENDS, INNOVATIONS AND FUTURE OPPORTUNITIES December

© Proprietary & Confidential

Global Orthopedic Device Market : 10 Predictions/FactsTransparency Market Research, DeLoitte ,Decision Resources Group, Becker

1. The global orthopedic device market $41.2 billion by 2019. compound annual growth rate of 4.9 %.

2. Elderly population - osteoporosis, osteoarthritis, bone injuries, obesity: Growth : Middle East, China, India and other Asian countries.

3. Technology advancements — particularly bioabsorbable implants — coupled with the increased success rate of these implants and fixators in emerging markets.

4. The orthopedic knee devices are largest share of the total orthopedic device market revenue in 2012. But, product recalls may cause decline in United States and European markets over the next five years.

5. The global market for hip devices : compound annual growth rate of more than 5.9 percent through 2019 high rate of hip fractures and demand for hip replacement procedures.

6. The orthopedic consumables market -anchors and staples —$457 million by 2019. Anchors are 80 percent of the market share in 2019.

Page 6: © Proprietary & Confidential Dr. Eyal Bressler & Co.  ORTHOPEDIC PATENTS: CURRENT TRENDS, INNOVATIONS AND FUTURE OPPORTUNITIES December

© Proprietary & Confidential

Global Orthopedic Device Market : 10 Predictions/FactsTransparency Market Research, DeLoitte ,Decision Resources Group, Becker

7. North America dominates the global orthopedic device market. Bioabsorbable implants, growing elderly population and increasing obesity in the United States will contribute to North America's leadership in the market.

8. US healthcare spending growth 4.4 percent, Healthcare reform will likely create more consolidation and pressure to control costs. Europe was the second largest regional market for orthopedic devices in 2012. Increasing demand for drug eluting stents and infusion pumps. Europe expected to have slow healthcare spending growth.

9. Asia-Pacific market will be the fastest growing region in the world for orthopedic devices. Middle Eastern countries 10 percent ,China 14% India 17% Spinal implants and bone growth substitutes, the Asia Pacific market is expected to reach $7 billion by 2022, according to a Decision Resources Group report.

10. The major players in the global hip and knee orthopedic devices market are DePuy Synthes, Zimmer and Stryker. Medtronic, DePuy, Stryker and NuVasive dominate the overall spine device market. There have been huge financial transactions among these companies recently consolidation is expected to continue in the short term. The biggest transactions from 2014 include Zimmer's $13.4 billion merger with Biomet and Medtronic's $42.9 billion acquisition of Covidien.

Page 7: © Proprietary & Confidential Dr. Eyal Bressler & Co.  ORTHOPEDIC PATENTS: CURRENT TRENDS, INNOVATIONS AND FUTURE OPPORTUNITIES December

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An Orthopedic Device, however good, will never help a patient until it’s a final product, deliverable to the market.

THE HARD TRUTH

Let’s quickly overview “Big Ortho” : Top 10 companies, so that we can understand who IL inventors and companies should target their

innovations towards.

This is called “Patent Driven Competitive Market Analysis”

It tells us what to invent and to whom to sell, and how to monetize.

Page 8: © Proprietary & Confidential Dr. Eyal Bressler & Co.  ORTHOPEDIC PATENTS: CURRENT TRENDS, INNOVATIONS AND FUTURE OPPORTUNITIES December

© Proprietary & Confidential

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Johnson & Johnson2013 worldwide orthopedics sales: $8.9 billion2020 projected worldwide orthopedics sales: $11.3 billion2020 market share projection: 27.7 percent

72 patents/ 4 in IL

Page 9: © Proprietary & Confidential Dr. Eyal Bressler & Co.  ORTHOPEDIC PATENTS: CURRENT TRENDS, INNOVATIONS AND FUTURE OPPORTUNITIES December

© Proprietary & Confidential

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Stryker2013 worldwide orthopedics sales: $5.2 billion2020 projected worldwide orthopedics sales: $7.4 billion2020 market share projection: 16.2 percent

132 patents

Page 10: © Proprietary & Confidential Dr. Eyal Bressler & Co.  ORTHOPEDIC PATENTS: CURRENT TRENDS, INNOVATIONS AND FUTURE OPPORTUNITIES December

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Zimmer (excluding revenues from pending Biomet merger)

2013 worldwide orthopedics sales: $4.3 billion2020 projected worldwide orthopedics sales: $5.6 billion2020 market share projection: 12.2 percent

281 patents

Page 11: © Proprietary & Confidential Dr. Eyal Bressler & Co.  ORTHOPEDIC PATENTS: CURRENT TRENDS, INNOVATIONS AND FUTURE OPPORTUNITIES December

© Proprietary & Confidential

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Biomet2013 worldwide orthopedics sales: $2.9 billion2020 projected worldwide orthopedics sales: $3.9 billion2020 market share projection: 8.6 percent

37 patents / 2 in IL

Page 12: © Proprietary & Confidential Dr. Eyal Bressler & Co.  ORTHOPEDIC PATENTS: CURRENT TRENDS, INNOVATIONS AND FUTURE OPPORTUNITIES December

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Medtronic2013 worldwide orthopedics sales: $3 billion2020 projected worldwide orthopedics sales: $3.2 billion2020 market share projection: 7 percent

101 patents / 4 in IL

Page 13: © Proprietary & Confidential Dr. Eyal Bressler & Co.  ORTHOPEDIC PATENTS: CURRENT TRENDS, INNOVATIONS AND FUTURE OPPORTUNITIES December

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Arthrex2013 worldwide orthopedics sales: $1.5 billion2020 projected worldwide orthopedics sales: $2.9 billion2020 market share projection: 6.3 percent

50 patents

Page 14: © Proprietary & Confidential Dr. Eyal Bressler & Co.  ORTHOPEDIC PATENTS: CURRENT TRENDS, INNOVATIONS AND FUTURE OPPORTUNITIES December

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Smith & Nephew2013 worldwide orthopedics sales: $2 billion2020 projected worldwide orthopedics sales: $2.5 billion2020 market share projection: 5.6 percent

156 patents

Page 15: © Proprietary & Confidential Dr. Eyal Bressler & Co.  ORTHOPEDIC PATENTS: CURRENT TRENDS, INNOVATIONS AND FUTURE OPPORTUNITIES December

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NuVasive2013 worldwide orthopedics sales: $646 million2020 projected worldwide orthopedics sales: $1 billion2020 market share projection: 2.2 percent

42 patents

Page 16: © Proprietary & Confidential Dr. Eyal Bressler & Co.  ORTHOPEDIC PATENTS: CURRENT TRENDS, INNOVATIONS AND FUTURE OPPORTUNITIES December

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Globus Medical2013 worldwide orthopedics sales: $434 million2020 projected worldwide orthopedics sales: $778 million2020 market share projection: 1.7 percent

56 patents

Page 17: © Proprietary & Confidential Dr. Eyal Bressler & Co.  ORTHOPEDIC PATENTS: CURRENT TRENDS, INNOVATIONS AND FUTURE OPPORTUNITIES December

© Proprietary & Confidential

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Wright Medical Group2013 worldwide orthopedics sales: $474 million2020 projected worldwide orthopedics sales: $600 million2020 market share projection: 1.3 percent

57 patents

Page 18: © Proprietary & Confidential Dr. Eyal Bressler & Co.  ORTHOPEDIC PATENTS: CURRENT TRENDS, INNOVATIONS AND FUTURE OPPORTUNITIES December

© Proprietary & Confidential

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Patents with IL Owners : Trends

Page 19: © Proprietary & Confidential Dr. Eyal Bressler & Co.  ORTHOPEDIC PATENTS: CURRENT TRENDS, INNOVATIONS AND FUTURE OPPORTUNITIES December

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Orthopedic patents : IL ownersPatents 64

Page 20: © Proprietary & Confidential Dr. Eyal Bressler & Co.  ORTHOPEDIC PATENTS: CURRENT TRENDS, INNOVATIONS AND FUTURE OPPORTUNITIES December

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Observation :

Few IL patents are owned by “Big Ortho”IL is not extracting the licensing fees available.IL companies, hospitals, TTO’s Universities, and inventors are not reaching their investment potential.

Solution :

Study the patents of “Big Ortho” top 10 THEN strategize IL R&D and patent portfolios.For IL companies, “Big Ortho” is the end user, not the patient.Through “Big Ortho” you will you get to the patient and the licensing fees and the investment.

Page 21: © Proprietary & Confidential Dr. Eyal Bressler & Co.  ORTHOPEDIC PATENTS: CURRENT TRENDS, INNOVATIONS AND FUTURE OPPORTUNITIES December

Thank You

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