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الهيئة القومية لضمان جودة التعليم واالعتماد
University: Alexandria
Faculty: Medicine
Programme Specifications
(Academic year: 2015/2016 )
A. Basic Information:
1. Program title: Doctorate Degree of Medical Biochemistry.
2. Program Award/Degree: Doctorate Degree.
3. Department (s) offering the program; Medical Biochemistry. 4. Program Coordinator: Professor Dr: Sabah Abdel-Hady Mahmoud
5. External evaluator(s): Prof. Dr. Yosry Mostafa
6. Type of the program: Single.
7. Date of most recent program specifications approval: 25/8/2015
B. Professional Information
1- Programme Aims
1.1 Develop updated and advanced knowledge in Medical Biochemistry and Molecular
Biology .
1.2 Prepare the students to be good teachers and efficient researches.
1.3 Apply recent laboratory investigations and recent researches in Medical Biochemistry
and molecular genetics.
2- Acdemic reference standards (ARS) & Subject benchmark statements:
Academic reference standards of Doctorate Degree in Medical Biochemistry and
Molecular biology designed and approved by Department of Medical Biochemistry .
Faculty of Medicine. Alexandria University. Based on:
Generic Academic Reference Standards (ARS): Postgraduate Medical Education, Egypt
(2009). Published by National Authority for Quality Assurance and Accreditation of
Education (NAQAAE) National
[http://naqaae.org/main/php/book/index.php]
.
Domain
Core Competencies
Ilos
A. Knowledge and
Understanding
Graduate of this
program must develop
extensive and perfect
knowledge and
understanding of:
Different metabolic
processes in the body.
A1. Revise and upgrade
their knowledge about the
metabolism and function
of different food stuffs in
the body.
A2. Discuss the advanced
knowledge about
metabolism of
macromolecules and
different tissues and its
relation to their function.
الهيئة القومية لضمان جودة التعليم واالعتماد
A3. Discuss the different
processes for xenobiotic
metabolism and
detoxication
Recent advances in
molecular biology and
cell signaling.
A4. Discuss recent and
advanced information in
molecular biology.
A5. Explain the basic and
advanced mechanisms of
cell signaling and
neurotransmitters.
B- Intellectual Skills Interpret, evaluate and
apply information from
different resources.
B1. Analyze different
information and its use in
problem solving.
B2. Review recent
publications in the field of
medical biochemistry and
molecular biology
Correlate and interpret
the results of different
laboratory tests and
clinical conditions.
B3. Improve different
laboratory methods for
better diagnosis of
diseases on molecular
basis.
B4. Implement the recent
information in
biochemistry in the
biochemistry and
molecular biology lab.
Modify and create
research methods
B5. Prepare good research
projects.
B6. Create better methods
for better diagnosis and
treatment of diseases.
Critically appraise
published relevant
literature.
B7. Critically appraise and
evaluate different papers
and research methods.
B8. Adopt the ability for
writing of good papers.
B9. Choose the correct
scientific information
from different papers
C. Professional Skills Perfect all laboratory C1. Apply perfectly basic
الهيئة القومية لضمان جودة التعليم واالعتماد
methods in medical
biochemistry and
molecular biology.
techniques used in clinical
biochemistry.
C2. Perform efficiently
the molecular biology
techniques for diagnosis
of congenital diseases.
Use and choose the
methods in
biochemistry and
molecular biology
efficiently for better
diagnosis of diseases
C3. Apply alternative
methods and procedures if
ideal lab facilities are not
present.
C4. Write and publish
scientific papers.
C5. Explain scientific
information to students
and peers.
D. General and
transferable skills Leads and co-operate
with colleagues and
seniors.
D1. Working in multi-
professional team.
D2. Lead a working team.
Adopt good teaching
methods
D3. Develop efficient
writing and presentation
skills.
Obtain and collect data
from multiple sources
D4. Develop the
capability of retrieving
scientific information and
evaluate different data.
E. Ethics and Attitudes Teach and implement
ethical regulations in his
professional and
practical practices
E1. Follow ethical rules in
research and laboratory
techniques
E2. Promote good
relations with seniors,
colleagues and students.
E3. Apply concepts of
sterilization and infection
control in laboratory.
E4. Behave as a good
example for students and
junior staff
Program courses ILOs Matrix
الهيئة القومية لضمان جودة التعليم واالعتماد
ILOs Course title
A1
A2
A3
A4
A5
B1
B2
B3
B4
B5
B6
B7
B8
C1
C2
C3
C4
C5
D1
D2
D3
D 4
E1
E2
E3
E4
Biochemistry of Nutrition
X X X X X X X X X
Cell Membrane and Transport
X X X
Laboratory Methods and their Utilization in Biochemistry
X X X X X X X X X X X X X X X
Advanced course in Metabolism of Macromolecules
X X X
X X X X X X
Clinical Chemistry
X X X X X
Medical Problem Solving in Biochemistry
X X X X X X
Lab Rotations
X X X X X X X X
Molecular Biology II
X X X X X X X X X X X
Metabolism of Xenobiotics and ROS
X X X X X X X X X X X
Cell Signaling
X X X X X X X X X
الهيئة القومية لضمان جودة التعليم واالعتماد
and Neurotransmitters
Biochemistry of the Major Metabolic Diseases
and Aging
X X X X X X X X X X X
Project in Biochemi
stry
X X X X X X X X X X X X X X
Lab Management
X X X X X X X X
Seminar and Journal Club II
X X X X X X
1. Curriculum Structure and Contents:
5.1 Program duration: 3- 7 years
5.2 Program structure: Students should fulfill a total of 52 Credit hours Obligatory subjects: 30 Credit Hours. Thesis: 20 Credit Hours. 2 Elective Subjects: 1 Credit Hour Each.
Program courses:
A. Obligatory:
Code
Number
Credit
Hours Course
Theoretical Practical Prerequisites
05160901 3 Biochemistry of Nutrition 3 0516811
05160902 2 Cell membrane and
transport
2 - ---
05160903 3
Laboratory methods and
their utilization in
Biochemistry
1.5 1.5 0516803,
0516808
05160904 2
Advanced course in
Metabolism of
Macromolecules
2 -
0516809
05160905 3 Clinical Chemistry 2 1 0516811
05160906 1
Medical problem solving
in biochemistry
1 -
0516811
الهيئة القومية لضمان جودة التعليم واالعتماد
05160907 1 Lab rotations - 1 0516803,
0516808
05160908 3 Molecular biology II 2 1 0516802
05160909 2 Metabolism of
Xenobiotics and ROS
2
0516811
05160910 3 Cell signaling and
neurotransmitters
3 - 0516807
05160911 3
Biochemistry of the major
metabolic diseases and
Aging
-
0516811
05160912 2 Project in Biochemistry - 2 0516803,
0516808
05160913 1 Lab Mangement 1 - -
05160914 1 Seminar II and Joural
Club
1 - -
B. Elective:
Code Number Course Credit hours
050280831 Medical Genetics 1
………. Basic Microbiology 1
05200801 Basic Physiology 2
0560801 Basic Pharmacology 2
05110804 Clinical Toxicology 1
05190802 Diagnostic Parasitology 1
Other -
6 Program Admission Requirements:
According to the regulations of the credit hour bylaws of the Faculty of Medicine
Alexandria University (annex).
7 Regulations for Progression and Program Completion:
According to the regulations of the credit hour bylaws of the Faculty of Medicine
Alexandria University (annex).
الهيئة القومية لضمان جودة التعليم واالعتماد
8 Methods of student assessment:
Methods Intended Learning outcomes to be
assessed
1. Written Exam
- MCQ (Objective)
- Essay
a1,a2,a3,a4,a5
b1,b2,b3,b4
2. Practical Exam c1,c2,c3,e1,e3,e4
3. Assignment c4,c5,d2,d3,d4
4.Thesis b1- b8, d1,d3,d4
9 Methods of program evaluation:
Evaluator Tool Sample
1. Students enrolled in the program Questionnaires. All
2. Alumni --------
3. Stakeholders (Employers) Focus group
4. External Evaluator (s) -----------
5. Others:
Course Specifications:
Code Credit Hours Course Prerequisites
05160901 3 Biochemistry of
Nutrition
0516811
This course includes identification of macro and micronutrients, recommended
dietary allowances, energy production by different nutrients, integration of different
compounds of intermediary metabolism, alteration in substrate load induced by dietary
modifications, conditions with particular relevance to clinical nutrition, nutrition support
(oral supplementation, tube feedings and parental nutrition), anthropometric
measurements ( body weight, skin fold thickness, endogenous 3- methyl Histidine
excretion, bioelectric impedance analysis) and biochemical measurements e.g. plasma
proteins, nitrogen balance studies. With special emphasis on the role of different vitamins
in the body, vitamin deficiencies and toxicity, vitamin supplement usage in modern
society.
الهيئة القومية لضمان جودة التعليم واالعتماد
Code Credit Hours Course Prerequisites
05160902 2 Cell Membrane and
Transport
-
This course includes: the supramolecular architecture of membranes, membrane lipids,
membrane proteins, membrane fusion, solute transport across membranes, ion-selective
channels transport of macromolecules, receptor mediated transport, differentiations at the
cell surface and intercellular communications (microvilli, desmosomes, gap junctions),
coats of the cell membrane and cell recognition, cell-cell recognition and specific cell
adhesion, changes in cell surface properties in cancer cells.
Code Credit Hours Course Prerequisites
05160903 2
Laboratory Methods
& Their Utilization
in Biochemistry
0516803, 0516808
This course includes: Revision of general metabolism and its regulation. Also, general
principles of biochemical investigations and techniques of centrifugation,
immunochemistry, molecular biology, chromatography, electrophoresis, spectroscopy, and
radiochemistry.
Code Credit Hours Course Prerequisites
05160905 3 Clinical Chemistry 0516811
This course includes: introduction to medical lab science (functions & responsibilities),
medical lab methods and techniques (electrophoresis, chromatography, spectrophotometry,
radioimmunoassay, etc.), overview of medical lab procedures routinely used to diagnose
common diseases (heart markers, liver function tests, kidney function tests, etc.)
Laboratory applications of the subject.
Code Credit Hours Course Prerequisites
05160904 2
Advanced Course in
Metabolism of
Macromolecules
0516809
This course includes: the assembly of macromolecules; viruses, collagen fibres,
fibrinogen and thrombin, three levels of organization of proteins, haemoglobin,
isoenzymes and multienzyme complex, assembly of conjugated proteins, assembly of
complex polysaccharides, assembly of informational molecules.
الهيئة القومية لضمان جودة التعليم واالعتماد
Code Credit Hours Course Prerequisites
05160909 2
Metabolism of
xenobiotics and
ROS
0516811
This course provides a broad understanding of the physical, biological and chemical
processes involved in pollution of the atmosphere, land and water, causes of pollution and
effect of pollutants on human health. It also includes an advanced study of the basic
principles of the metabolism of foreign compounds in mammals. The xenobiotics covered
include drugs, food additives, and agricultural, chemical and industrial chemicals. The
detoxification and toxicological implications of metabolism are emphasized.
Code Credit Hours Course Prerequisites
05160906 1
Medical Problem
Solving in
Biochemistry
0516811
Training of the student on interpretation of the clinical and laboratory findings with the
trials to find the biochemical causes behind the problem and answering questions about the
case.
Code Credit Hours Course Prerequisites
05160907 1 Lab rotations 0516803, 0516808
The student is trained in different medical laboratories in the faculty to get experience
in analytical methods applied in each of them.
Code Credit Hours Course Prerequisite
05160908 3 Molecular Biology II
0516802
This course includes: mutagenesis, oncogenes, heterogeneous gene expression with a
special focus on molecular events which regulate cell cycle transition and their relevance to
human cancer, chemical synthesis of DNA, reverse transcriptase and HIV, transposons and
related retroviruses, concepts of classical genetics (including genetic mapping, extranuclear
inheritance, polypoidy, and evolutionary genetics).
Lab and demonstrations: Manipulation and analysis of genes and genomes, gene
amplification and disease diagnosis, Southern blot and analysis of complex genome structure.
الهيئة القومية لضمان جودة التعليم واالعتماد
Code Credit Hours Course Prerequisites
05160912 2 Project in
Biochemistry 0516803, 0516808
This course includes directed laboratory research performed under the supervision of a
faculty member. Each student is required to carry out one detailed study of the scientific
literature related to the subject of the research applied.
Code Credit Hours Course Prerequisites
05160913 1 Lab management
This course revise the general principles of how to measure the lab precision and
accuracy. Also Discuss the principles of calibration of the instruments , performance and
criteria of the control material.
Code Credit Hours Course Prerequisite
05160910 3 Cell signaling and
neurotransmitters 0516807
This course includes basic concepts of receptors, steroid receptors, G-protein coupled
receptors, receptor regulation of adenyl cyclase, role of cAMP in regulation of cellular
metabolism, cyclic AMP-protein kinase, protein kinase structure and regulation, other second
messengers as calcium and phosphatidyl inositol, How is calcium mobilized as a messenger
and acts to regulate cell function?, growth factors receptors: function and regulation, Tyrosine
kinase receptors, activation of PI 3- kinase signaling, targeting the transcriptional apparatus
via cell signaling, diverse signaling pathways control of transcription, transcriptional control
via cAMP signaling, nuclear receptors: the ligand-activated transcription factors, nuclear
receptors: role of protein-protein interactions in signaling, role of multiprotein
coactivators/corepressors complexes in signaling, overview of apoptosis, death receptors and
mitochondria in apoptosis, NF-kB/IkB system, direct pathways to the nucleus: JAK/STAT
and others, Ras signaling, neurotransmitters and neuromodulators.
Code Credit Hours Course Prerequisites
05160911 3
Biochemistry of the
Major Metabolic
Diseases and Aging
0516811
This course includes an overview on the metabolic changes in common diseases in the
society as diabetes mellitus, hypertension, atherosclerosis, schestosomiasis, etc. with
special emphasis on metabolic changes of aging.
الهيئة القومية لضمان جودة التعليم واالعتماد
Code Credit Hours Course Prerequisites
05169014 1 Seminar II and
Journal Club 0516811, 0516813
This course includes special topics current to the field of biochemistry. Topics and
format for the course may vary. Study presentation is done by each student under
supervision of a faculty member.
Program director: Sabah Abdel-Hady Mahmoud
Signature:
Program coordinator:
Professor Dr: Sabah Abdel-Hady Mahmoud
Signature: Date:
Course Specifications
University: Alexandria
Faculty: Medicine
Department: Medical Biochemistry
Course Information
Course Code: 05160901 Course Name: Biochemistry of nutrition
Program in which the Course is Given : Doctorate degree of Medical Biochemistry
Number of Credit Hours 3 Clinical/PracticalTheoretical
Course Aims:
1. Identification of macro and micronutrients and their metabolic importance.
2. Implementation of principles of clinical nutrition.
3. Evaluation of anthropometric and biochemical measurements.
Intended Learning Outcomes (ILOs)
Program ILO (refer to program
matrix) Course ILOs
A. Knowledge
and
Understanding
A1. Revise and upgrade their
knowledge about the metabolism
and function of different food stuffs
in the body.
A2. Discuss the advanced knowledge
about metabolism of
macromolecules and different tissues
and its relation to their function.
A3. Relate structure of different vitamin molecules to their function.
a1. Revise the different metabolic
pathways of different food stuffs and
their functions in the body.
a2. Discuss energy production by
different food stuffs.
a3. Discuss the different functions of
macromolecules and their
metabolism in different tissues.
a4. Determine recommended dietary
allowances of different food stuffs
and macromolecules.
a5. Discuss the advanced knowledge
about metabolism of vitamins in
different tissues and its relation to
their functions
B. Intellectual
skills
B1. Interpret, evaluate and apply
information from different
resources.
b1. Integrate different metabolic pathways
in the body.
b2. Apply the information in clinical
nutrition and dietary modifications.
- 3
B2. Review recent publications in
the field of medical biochemistry
and molecular biology.
b3. Deduce manifestations and causes of
deficiency of deferent vitamins.
b4. Analyze the manifestations of
deficiency of vitamins A, D, E, K in
relation to their functions.
b5. Analyze different anthropometric and
biochemical measurements.
b6. Use recent information for better
nutritional states.
C.Professional
and Practical
Skills
D. General
Skills
D1. Work in multi- professional team.
D2. Lead a working team.
D3. Develop efficient writing and
presentation skills.
D4. Capable of retrieving scientific
information and evaluate different
data.
d1. Cooperate with her/his colleagues in
preparing work plans.
d2. Acquire the capacity of Leading a
working team.
d3. present a scientific presentation.
d4. Collect and analyze scientific data.
Course Content (Units/Topics)
Teaching/Learning Methods
Lectures self
learning
Practical/
Clinical
Small
group
discussion
Others
Assignment
This course includes:
Identification of macro and
micronutrients, recommended dietary
allowances, energy production by
different nutrients, integration of
different compounds of intermediary
metabolism, alteration in substrate
load induced by dietary modifications,
conditions with particular relevance to
clinical nutrition, nutrition support (oral
supplementation, tube feedings and
parental nutrition), anthropometric
measurements ( body weight, skin fold
thickness, endogenous 3- methyl
Histidine excretion, bioelectric
impedance analysis) and biochemical
measurements e.g. plasma proteins,
nitrogen balance studies.
√ √ - √ √
Please check (✓) the appropriate method.
Student Assessment
Methods of Assessment
Essay Objective questions
Case OSCE/OSPE
Assignment Logbook fulfillment
Others
Schedule of Assessment
Mid-term
End of term 100 %
Distribution of Marks
Written Exam 80 %
Practical/Clinical Exam -
Others 20 %
√ √
√
✓
List of Textbooks and References
Lecture Notes
Course Text Books
1- Biochemistry. Stryer
2- Lehninger Biochemistry
3- Molecular cell Biology. Lodish
Suggested Extra Reading
1- Recent publications
2- Any specialized text books
Journals and Periodicals, others
Relevant journals
Course Instructor
Name: Pr. Dr. Soad El- Tabakh Signature:
Program Coordinator
Name: Prof. Dr. Sabah Abdel-Hady Mahmoud Signature:
Program Director (Head of Department)
Name: Prof. Dr. Sabah Abdel-Hady Mahmoud Signature:
Course Specifications
University: Alexandria
Faculty: Medicine
Department: Medical Biochemistry
Course Information
Course Code: 05160902 Course Name: cell membrane and transport
Program in which the Course is Given: Doctorate Degree of Medical Biochemistry.
Number of Credit Hours: 2 Clinical/PracticalTheoretical
Course Aims: The student in this course should
1. Develop updated and advanced knowledge in supramolecular architecture of membranes
and changes in cell surface properties in cancer cells.
2. Prepared to be efficient researches.
Intended Learning Outcomes (ILOs)
Program ILO (refer to program
matrix) Course ILOs
A. Knowledge
and
Understanding
A2. Discuss the advanced
knowledge about metabolism of
macromolecules and different
tissues and its relation to their
function.
a1. Discuss advanced knowledge about
the supramolecular architectur of
membranes, membrane lipids,
membrane proteins, and membrane
fusion.
a2. Describe solute transport across
membranes,
a3. Illustrate ion-selective channels
transport of macromolecules, and
receptor mediated transport.
a4. Describe differentiations at the cell
surface and intercellular
communications (microvilli,
desmosomes, gap junctions).
a5. Describe cell recognition, cell-cell
recognition and specific cell
adhesion
_ 2
D.
General Skills
D4. Develop the capability of
retrieving scientific information
and evaluate different data.
d1. Critically appraise and
evaluate different papers and
researches relevant to cell
membrane and transport.
Course Content (Units/Topics)
Teaching/Learning Methods
Lectures self
learning
Practical/
Clinical
Small
group
discussion
Others
Assignment
This course includes basic
knowledge about the supramolecular
architecture of membranes,
membrane lipids, membrane
proteins, membrane fusion, solute
transport across membranes, ion-
selective channels transport of
macromolecules, receptor mediated
transport, differentiations at the cell
surface and intercellular
communications (microvilli,
desmosomes, gap junctions), and
cell recognition, cell-cell recognition
and specific cell adhesion, changes
in cell surface properties in cancer
cells.
✓ ✓ ✓ ✓
Please check (✓) the appropriate method.
Student Assessment
Methods of Assessment
Essay Objective questions
Case OSCE/OSPE
Assignment Logbook fulfillment
Others
Schedule of Assessment
Mid-term -
End of term 100 %
Distribution of Marks
Written Exam 80 %
Practical/Clinical Exam -
Others 20 %
List of Textbooks and References
Lecture Notes
-
Course Text Books
1. Lehninger Biochemistry
2. Molecular cell Biology Lodish
Suggested Extra Reading
1. Recent publications
2. Any specialized text books
Journals and Periodicals, others
Relevant journals
Course Instructor
Name: Prof. Dr: Samia AbdelFatah Sharaf Signature:
Program Coordinator
Name: Prof. Dr: Sabah Abdel-Hady Mahmoud Signature:
Program Director (Head of Department)
Name: Prof.Dr: Sabah Abdel-Hady Mahmoud Signature:
✓ ✓
✓ ✓
✓
Course Specifications
University: Alexandria
Faculty: Medicine
Department: Medical Biochemistry
Course Information
Course Code: 05160903 Course Name: Laboratory Methods & Their
Utilization in Biochemistry
Program in which the Course is Given: Doctorate program of Medical Biochemistry
Number of Credit Hours 3 Theoretical Clinical/Practical
Course Aims:
1. Identify the components of the scientific method and explain each.
2. Perform and evaluate scientific experiments.
3. Design scientific experiments.
4. Upgrade integrated knowledge in metabolism and molecular biology.
5. Interpret the molecular basis of metabolic disorders.
Intended Learning Outcomes (ILOs)
Program ILO (refer to program
matrix) Course ILOs
A. Knowledge
and
Understanding
A1. Revise and upgrade their
knowledge about the metabolism
and function of different food
stuffs in the body.
a1. Revise general metabolism
a2. Discuss the principles of regulation
of metabolism
a3. Revise the general principles of
biochemical investigations
a4. Discuss the principle of different
laboratory techniques.
B. Intellectual
skills
B2. Review recent publications in
the field of medical biochemistry
and molecular biology
B3. Improve different laboratory
methods for better diagnosis of
diseases on molecular basis.
b1. Explain the metabolic behavior of
the body in different situations
b2. Relate the metabolism of different
tissues to each other’s
b3. Interpret the biochemical disorders
according to molecular basis
b4. Evaluate different laboratory
methods in respect of accuracy,
sensitivity and specificity.
1.5 1.5
B4. Implement the recent
information in biochemistry in the
biochemistry and molecular
biology lab.
B7. Critically appraise and
evaluate different papers and
research methods.
b5. Compare the utility of different
laboratory methods in specific item
estimation.
b6. Modify the existing laboratory
techniques.
b7. Design scientific experiments
b8. Review and critically appraise recent
publications in the field of laboratory
methodology.
C.
Professional
and Practical
Skills
C1. Apply perfectly basic
techniques used in clinical
biochemistry.
C2. Perform efficiently the
molecular biology techniques for
diagnosis
C3. Apply the accumulated
integrated knowledge to daily life.
C.4 Upgrade practical skills in
biochemistry and molecular
biology
C5. Apply alternative methods and
procedures if ideal lab facilities are
not present.
c1. Practice and perfect different
laboratory methods.
c2. Perfect the molecular biology
techniques for diagnosis of diseases.
c3. Use and choose the methods in
biochemistry and molecular biology
efficiently for better diagnosis of
diseases.
D. General
Skills
D1. Develop the capability of
retrieving scientific information
and evaluate different data.
D2. Develop efficient writing and
presentation skills
d1. Collect scientific information and
evaluate different data.
d2. Acquire the capacity of writing
scientific papers and presentation
skills.
E. Ethics &
Attitude
E1. Follow ethical rules in
research and laboratory techniques
E2. Promote good relations with
seniors, colleagues and students
E3. Apply concepts of sterilization
and infection
e1 Follow ethical rules in research and
laboratory techniques
e2 Create good relations with all junior
and senior staffs.
e3 Follow sterilization and anti-
infection roles.
Course Content
(Units/Topics)
Teaching/Learning Methods
Lectures
self
learning
Practical/
Clinical
Small
group
discussion
Others
Assignment
This course includes:
general principles of
biochemical
investigations and
techniques of
centrifugation,
immunochemistry,
molecular biology,
chromatography,
electrophoresis,
spectroscopy, and
radiochemistry.
✓
✓ ✓ ✓
Please check (✓) the appropriate method.
Student Assessment
Methods of Assessment
Essay Objective questions
Case OSCE/OSPE
Assignment 10%
Logbook fulfillment
Others
Schedule of Assessment
Mid-term(Written & practical) 20%
Practical 20%
End of term 50%
Distribution of Marks
Written Exam 70%
Practical/Clinical Exam 20%
Others 10%
List of Textbooks and References
Lecture Notes
-
Course Text Books
• Biochemistry by Lubert Stryer
• Harper’s Biochemistry
• Devlin
• Clinical Chemistry
• Fundamentals of clinical
Chemistry. Tietz
• Varley. Biochemical methods
Suggested Extra Reading
- Any related recent text book
Journals and Periodicals, others
- Relevant journals & periodicals
Course Instructor:
Name: Prof. Dr: Sabah Abdel-Hady Mahmoud Signature:
Name: Prof. Dr. Gihan Mohamed Sharara Signature:
Program Coordinator
Name: Prof. Dr: Sabah Abdel-Hady Mahmoud Signature:
Program Director (Head of Department)
Name: Prof. Dr: Sabah Abdel-Hady Mahmoud Signature:
✓
✓
0
%
3
0
%
0
✓
Course Specifications
University: Alexandria
Faculty: Medicine
Department: Medical Biochemistry
Course Information
Course Code: 05160904 Course Name: Advanced Course in Metabolism
of Macromolecules
Program in which the Course is Given
Number of Credit Hours 2 Clinical/PracticalTheoretical
Course Aims:
Graduate of this program must :
1- Develop updated and advanced knowledge about metabolism of macromolecules at different
tissues.
2- Relate structure of different macromolecules to their function.
3- Correlate abnormal structure-function relationship of these molecules to metabolic diseases.
Intended Learning Outcomes (ILOs)
Program ILO (refer to program
matrix) Course ILOs
A. Knowledge
and
Understanding
A1. Revise and upgrade their
knowledge about the metabolism
and function of different food
stuffs in the body.
a1. Revise different metabolic pathways
in human body.
a2. Describe high order structure of
different globular proteins as
hemoglobin & enzymes.
a3. Discuss how the structure of these
molecules can affect their function.
a4. Explain role of fibrous &
specialized proteins and
proteoglycans of extra cellular
matrix in many normal and
pathologic processes.
-- 2
A2. Discuss the advanced
knowledge about metabolism of
macromolecules and different
tissues and its relation to their
function.
a5. Discuss genetic, physiologic and
pathologic aspects of glycomics;
glycoproteins, proteoglycan &
glycolipids.
B. Intellectual
skills
B1. Analyze different information
and its use in problem solving.
B2. Review recent publications in
the field of medical biochemistry
and molecular biology.
B7. Critically appraise and
evaluate different papers and
research methods.
b1. Evaluate different laboratory
methods specific for each metabolic
disease.
b2. Select different papers and research
methods.
b3. Evaluate and solve problem
situations related to metabolic
diseases.
b4. Review and critically appraise
recent publications in the field of
macromolecules biology and
pathology.
C.Professional
and Practical
Skills
C3. Apply alternative methods
and procedures if ideal lab
facilities are not present.
C4. Implement knowledge about
signaling in researches e.g. to
target a signal pathway in
treatment of diseases.
c1. Use and choose efficient methods for
better diagnosis of diseases.
c2. Link knowledge about biology to
molecular markers for detection and to
prospective lines of treatment.
D. General
Skills
E. Ethics &
Attitude
D3. Develop efficient writing and
presentation skills.
D4. Develop the capability of
retrieving scientific information
and evaluate different data.
E1. Follow ethical rules in
research and laboratory
techniques.
E2. Promote good relations with
seniors, colleagues and students.
d1. Acquire the capability of retrieving
scientific information and evaluate
different data.
d2. Develop efficient writing and
presentation skills.
e1. Follow ethical rules in research.
e2. Promote good relations with
seniors, colleagues and student.
Course Content (Units/Topics)
Teaching/Learning Methods
Lectures
self
learning
Practical/
Clinical
Small
group
discussion
Others
Assignment
This course includes: the
assembly of macromolecules;
collagen fibres, fibrinogen and
thrombin, three levels of
organization of proteins,
haemoglobin, isoenzymes and
multienzyme complex,
assembly of conjugated
proteins, assembly of complex
polysaccharides, assembly of
informational molecules.
This course involves the
structure- function relationships
of different macromolecules and
✓ ✓ ✓ ✓
biomedical implications. It
includes
- High ordered structure
of globular proteins as
hemoglobin and
enzymes & molecular
basis of genetic diseases.
- Mechanism of action of
enzymes and
multienzyme complexes.
- Fibrous ( collagen,
elastin, fibrillin,..) &
specialized proteins
(fibronectin, laminin,…)
and proteoglycans (
GAGs as heparin,..) of
extra cellular matrix in
many normal and
pathologic processes
(development, aging,
inflammation, cancer
spread,…..).
- Glycoproteins;
assembly, degradation,
and role in biologic
processes (fertilization,
cell adhesion,
inflammation,..) &
genetic diseases (I-
disease, …), other
diseases (viral, HIV,
RA,..).
Please check (✓) the appropriate method.
Student Assessment
Methods of Assessment
Essay Objective questions
Case OSCE/OSPE
Assignment Logbook fulfillment
Others
Schedule of Assessment
Mid-term(Written & practical) -
End of term 100 %
Distribution of Marks
Written Exam 80 %
Practical/Clinical Exam 0 %
Others 20 %
List of Textbooks and References
Lecture Notes
-
Course Text Books
1. Harper’s illustrated Biochemistry.
2. Devlin’s textbook of Biochemistry.
3. Lehninger Biochemistry.
4. Stryer’s Biochemistry.
Suggested Extra Reading
- Any related recent text book.
Journals and Periodicals, others
- Relevant journals & periodicals.
Course Instructor:
Name: Professor Dr: Hanan Kamal AbdelAziz Signature:
Program Coordinator
Name: Prof. Dr: Sabah Abdel-Hady Mahmoud Signature:
Program Director (Head of Department)
Name: Prof.Dr: Sabah Abdel-Hady Mahmoud Signature:
✓
✓
✓
Course Specifications
University: Alexandria
Faculty: Medicine
Department: Medical Biochemistry
Course Information
Course Code: 05160905 Course Name: Clinical Chemistry
Program in which the Course is Given within the courses assigned to the doctorate degree of
medical Biochemistry
Number of Credit Hours 3 Theoretical Clinical/Practical
Course Aims: The student in this course must
1. Develop updated and advanced knowledge in medical lab science and Laboratory applications.
1.2 Prepare the students to be efficient researches.
1.3 Apply recent laboratory investigations and recent researches in Medical Biochemistry and
molecular genetics.
Intended Learning Outcomes (ILOs)
Program ILO (refer to program
matrix) Course ILOs
A. Knowledge
and
Understanding
A1. Revise and upgrade their
knowledge about the metabolism
and function of different organs in
the body.
a1. Revise the general principles of
biochemical investigations
a2. Discuss the principle of different
laboratory techniques
a3. Interpret the diagnostic, specific tests
used in the clinical chemistry field.
B. Intellectual
skills
B1. Analyze different information
and its use in problem solving.
B2. Review recent publications in
the field of medical biochemistry
and molecular biology
b1. Interpret, evaluate and apply
information from different resources.
b2. Critically appraise published relevant
literature
1 2
C.Professional
and Practical
Skills
C1. Apply perfectly basic
techniques used in clinical
biochemistry.
c1. Practice and perform different
laboratory methods.
c2. Determine the methods in
biochemistry and molecular biology
efficiently for better diagnosis of
diseases
D. General
Skills
D1. Working in multi- professional
team.
d1. Working in the team clinical chemistry lab.
Course Content (Units/Topics)
Teaching/Learning Methods
Lectures self
learning
Practical/
Clinical
Small
group
discussion
Others
Assignment
This course includes: introduction to
medical lab science (functions &
responsibilities), medical lab methods
and techniques (electrophoresis,
chromatography, spectrophotometry,
radioimmunoassay, etc.), overview of
medical lab procedures routinely used
to diagnose common diseases (heart
markers, liver function tests, kidney
function tests, etc. Laboratory
applications of the subject.
✓ ✓ ✓ ✓
Please check (✓) the appropriate method.
Student Assessment
Methods of Assessment
Essay Objective questions
Case OSCE/OSPE
Assignment Logbook fulfillment
Others
Schedule of Assessment
Mid-term 20 %
End of term 80 %%
Distribution of Marks
Written Exam 70 %
Practical/Clinical Exam 20 -
Others 10 %
List of Textbooks and References
Lecture Notes
Course Text Books
• Clinical Chemistry
• Fundamentals of clinical
Chemistry. Titz
• Varley. Biochemical methods
Suggested Extra Reading
Any related recent text book
Journals and Periodicals, others
Relevant journals & periodicals
Course Instructor
Name: Dr: Fayrouz El-Sayed Signature:
Program Coordinator
Name: Prof. Dr: Sabah Abdel-Hady Mahmoud Signature:
Program Director (Head of Department)
Name: Prof.Dr: Sabah Abdel-Hady Mahmoud Signature:
✓ ✓
✓
✓
Course Specifications
University: Alexandria
Faculty: Medicine
Department: Medical Biochemistry
Course Information
Course Code: 05160906
Course Name: Medical Problem Solving in
Biochemistry
Program in which the Course is Given: Doctorate Degree of Medical Biochemistry
Number of Credit Hours 1 lClinical/PracticaTheoretical
Course Aims: helping students learn and critical thinking by training them on interpretation of the
clinical and laboratory findings.
Intended Learning Outcomes (ILOs)
Program ILO (refer to program
matrix) Course ILOs
A. Knowledge
and
Understanding
B. Intellectual
skills
B1. Analyze different information
and its use in problem solving.
b1. Be exposed to multiple
examples of biochemical
health problems.
b2. Acquire the ability to use
available lab results and
information to solve health
problems.
b3. Formulate and solve
biochemical problems of
clinical interest.
b4. Integrate different parts of
biochemistry with clinical
situations.
- 1
B2. Review recent publications in
the field of medical biochemistry
and molecular biology
B7. Critically appraise and
evaluate different papers and
research methods.
B8. Adopt the ability for writing of
good papers.
b5. Use recent publications and
text books in reaching to
interpret and predict solutions
to biochemical problems.
b6. Collect, evaluate, correlate
and interpret the biochemical
data to reach a final
conclusion that lead to
diagnosis and treatment.
b7. Acquire the ability of writing
a scientific report and papers
in relation to biochemical
health problems
C.Professional
and Practical
Skills
C5. Explain scientific information
to students and peers.
c1. Prepare exercise in
biochemical health problems
c2. Explain the plan leading to
solving of the biochemical
problem.
D. General
Skills
D1. d2. Lead a working team.
d1. Guide a team through a health
problem process
d2. Survey and accept and discuss
the team members opinions
Course Content (Units/Topics)
Teaching/Learning Methods
Lectures self learning Practical/
Clinical
Small
group
discussion
Others
Assignment
This course includes:
training of the student on
interpretation of the clinical and
laboratory findings with the
trials to find the biochemical
causes behind the problem and
answering questions about the
case.
✓ ✓ ✓
Please check (✓) the appropriate method.
Student Assessment
Methods of Assessment
Essay Objective questions
Case OSCE/OSPE
Assignment Logbook fulfillment
Others
Schedule of Assessment
Mid-term 40 %
End of term 60%
Distribution of Marks
Written Exam 70%
Practical/Clinical Exam -
Others 30%
✓ ✓
✓
✓
List of Textbooks and References
Lecture Notes
-
Course Text Books
- Biochemistry, Case Oriented
Approach.
-
Suggested Extra Reading
- Devlin. Biochemistry
Journals and Periodicals, others
- Clinical chemistry
Course Instructor:
Name: Prof. Dr: Fayrouz El-Sayed Signature:
Program Coordinator
Name: Prof. Dr: Sabah Abdel-Hady Mahmoud Signature:
Program Director (Head of Department)
Name: Prof.Dr: Sabah Abdel-Hady Mahmoud Signature:
Course Specifications
University: Alexandria
Faculty: Medicine
Department: Medical Biochemistry
Course Information
Course Code: 05160907 Course Name: Lab rotations
Program in which the Course is Given: Doctorate degree of Medical Biochemistry
Number of Credit Hours Theoretical Clinical/Practical
Course Aims:
1. Develop updated and advanced knowledge in different medical laboratories of different
specialties.
2. Prepare the students to be efficient researches.
3. Apply recent laboratory investigations and recent researches in Medical Biochemistry and
molecular genetics.
Training of students in
Intended Learning Outcomes (ILOs)
Program ILO (refer to program
matrix) Course ILOs
A. Knowledge
and
Understanding
B. Intellectual
skills
B1 Utilize different diagnostic
assays effectively.
B2 Choose better practical
methods for better
diagnosis of diseases.
b1. Use alternative diagnostic methods.
b2. Apply the suitable diagnostic assays
according to the current situation.
1 -
C.Professional
and Practical
Skills
C1. Apply perfectly basic
techniques used in clinical
biochemistry (elisa,
immunodiffusion, enzyme
activity assay, colorimetric
methods and others).
c1. Perfect the basic lab techniques
(ELISA, immunodiffusion, enzyme
activity assay and colorimetric
methods
c2. Apply lab safety roles in the labs
she/he responsible for.
D. General
Skills
D2. Co-operate efficiently in a
multi-professional team
working.
D3. Recognize and respect the
views and opinions of other team
members.
D4. Use information technology
to access, evaluate, and interpret
scientific data.
d1. Acquire the capacity of working in a
team.
d2. Respect the views and opinions of
other team members.
d3. Interpret scientific data.
E. Ethics and
Attitudes
E1. Promote high standards of
personal and organizational
integrity, compassion,
honesty, and respect for
seniors, colleagues,
assistants, and students.
E2. Deal with reagents,
instruments, and
equipments with caution
and preservation.
e1. Be a good example for assistants,
and students.
e2. Implement the regular roles of
dealing with reagents and
instruments.
e3. Be accurate in analyzing the results
and avoid fabrication.
Course Content (Units/Topics)
Teaching/Learning Methods
Lectures self
learning
Practical/
Clinical
Small
group
discussion
Others
Assignment
The student is trained in different
medical laboratories in the faculty to get
experience in analytical methods
applied in each of them
✓
Please check (✓) the appropriate method.
Student Assessment
Methods of Assessment
Essay Objective questions
Case OSCE/OSPE
Assignment Logbook fulfillment
Others
Schedule of Assessment
Mid-term 0%
End of term 100%%
Distribution of Marks
Written Exam %
Practical/Clinical Exam 90%
Others 10%
List of Textbooks and References
Lecture Notes
-
Course Text Books
Clinical Chemistry
Suggested Extra Reading
Journals and Periodicals, others
Course Instructor
Name: Professor. Dr. Ehsan Mohamed AbdelRahman Signature:
Program Coordinator
Name: Prof. Dr: Sabah Abdel-Hady Mahmoud Signature:
Program Director (Head of Department)
Name: Prof.Dr: Sabah Abdel-Hady Mahmoud Signature:
✓
✓
Course Specifications
University: Alexandria
Faculty: Medicine
Department: Medical Biochemistry
Course Information
Course Code: 05160908 Course Name: Molecular Biology II
Program in which the Course is Given
Number of Credit Hours 3 Theoretical Clinical/Practical
Course Aims:
To help Graduate to
1. Develop updated and advanced knowledge in Molecular Biology .
2. Prepare the students to perfect laboratory methods in molecular biology and efficient researches
3. Apply recent laboratory investigations and recent researches in Medical Biochemistry and
molecular genetics.
Intended Learning Outcomes (ILOs)
Program ILO (refer to program
matrix) Course ILOs
A. Knowledge
and
Understanding
A4. Discuss recent and advanced
information in molecular biology.
a1. Revise
- Principles of heredity.
- The components of gene expression.
2. Relate structure of nucleic acids to
their function.
a2. Discuss different regulators of gene
expression in both prokaryotes and
eukaryotes.
a3. Describe regulators of cell cycle &
apoptosis.
a4. Explain mechanisms of oncogenesis.
1 2
B. Intellectual
skills
B1. Analyze different information
and its use in problem solving.
B2. Review recent publications in
the field of medical biochemistry
and molecular biology.
B7. Critically appraise and
evaluate different papers and
research methods.
b1. Evaluate different laboratory
methods in respect of accuracy,
sensitivity and specificity for each
genetic disease.
b2. Combine different methods for
better diagnosis of genetic diseases.
b3. Select different papers and research
methods.
b4. Evaluate and solve problem
situations related to genetic diseases.
b5. Correlate defects in gene expression
& repair to carcinogenesis.
b6. Review and critically appraise recent
publications in the field of molecular
biology.
C.Professional
and Practical
Skills
C2. Perform efficiently the
molecular biology techniques for
diagnosis of congenital diseases.
C3. Apply alternative methods
and procedures if ideal lab
facilities are not present.
c1. Perfect the molecular
biology techniques for
diagnosis.
c2. Use and choose the methods
in molecular biology
efficiently for better
diagnosis of diseases.
c3. Link knowledge about
cancer biology to molecular
markers for detection and to
prospective lines of
treatment.
D. General
Skills
E. Ethics &
Attitude
D3. Develop efficient writing and
presentation skills.
D4. Develop the capability of
retrieving scientific information
and evaluate different data.
E1. Follow ethical rules in
research and laboratory
techniques.
E2. Promote good relations with
seniors, colleagues and students.
E3. Apply concepts of
sterilization and infection control
in laboratory.
d1. Acquire the capacity of using
scientific information for writing
scientific papers.
d2. Retrieving and evaluate different
data.
e1 Keep confidentiality in research and
laboratory.
e2 Promote good relations with all the
staff she/he working with
e3 Apply strict sterilization and anti-
infection procedures.
e4 Be accurate in analyzing the results
and avoid fabrication.
Course Content (Units/Topics)
Teaching/Learning Methods
Lectures
self
learning
Practical/
Clinical
Small
group
discussion
Others
Assignment
This course includes:
mutagenesis, oncogenes,
heterogeneous gene expression
with a special focus on
molecular events which regulate
cell cycle transition and their
relevance to human cancer,
chemical synthesis of DNA,
reverse transcriptase and HIV,
transposons and related
retroviruses, concepts of
classical genetics (including
genetic mapping, extranuclear
inheritance, polypoidy, and
evolutionary genetics).
Lab and demonstrations:
Manipulation and analysis of
genes and genomes, gene
amplification and disease
diagnosis, Southern blot and
analysis of complex genome
structure.
✓ ✓
✓ ✓ ✓ ✓ ✓
Please check (✓) the appropriate method.
Student Assessment
Methods of Assessment
Essay Objective questions
Case OSCE/OSPE
Assignment Logbook fulfillment
Others
✓
✓
✓ ✓
✓
Schedule of Assessment
Mid-term(Written & practical) 40%
End of term 60%
Distribution of Marks
Written Exam 70%
Practical/Clinical Exam 20%
Others 10%
List of Textbooks and References
Lecture Notes
-
Course Text Books
1. Harper’s illustrated Biochemistry.
2. Devlin’s textbook of Biochemistry.
3. Lehninger Biochemistry.
4. Molecular cell biology. Lodish
Suggested Extra Reading
- Any related recent text book.
Journals and Periodicals, others
- Relevant journals & periodicals.
Course Instructor:
Name: Professor Dr: Eman Ahmed Shaat. Signature:
Program Coordinator
Name: Prof. Dr: Sabah Abdel-Hady Mahmoud Signature:
Program Director (Head of Department)
Name: Prof.Dr: Sabah Abdel Hady Signature:
Course Specifications
University: Alexandria
Faculty: Medicine
Department: Medical Biochemistry
Course Information
Course Code: 05160909 Course Name: Metabolism of xenobiotics and
ROS
Program in which the Course is Given: Doctorate program of Medical Biochemistry
Number of Credit Hours 2 Theoretical Clinical/Practical
Course Aims: The students should:
1. Develop updated and advanced knowledge in- Physical, biological and chemical processes
involved in pollution of the atmosphere, land and water
2. Apply recent laboratory investigations and recent researches in the field of pollution and
metabolism of xenobiotics
3. Know the classification of free radical, oxidants, sources and metabolism of each,
antioxidant mechanisms and abnormalities caused by alteration of the balance between
oxidants and antioxidants.
Intended Learning Outcomes (ILOs)
Program ILO (refer to program
matrix) Course ILOs
A. Knowledge
and
Understanding
A1. Discuss the different
processes for xenobiotic
metabolism and detoxication
A2. Revise and upgrade their
knowledge about the metabolism
and function of different food
stuffs in the body.
A3. Discuss the advanced
knowledge about metabolism of
macromolecules and different
tissues and its relation to their
function.
a1. Discuss basic metabolism of foreign
compounds in the body.
a2. List different sources of pollution.
a3. Describe detoxication process in the
body.
a4. Revise classification of oxidants
a5. Discuss the sources of oxidants in the
body
a6. Explain the effects of each of these
molecules in the body.
a7. Discuss the metabolism of oxidants.
a8. Explain the role of natural
antioxidant molecules
2
B. Intellectual
skills
B1. Analyze different information
and its use in problem solving.
B2. Review recent publications in
the field of medical biochemistry
and molecular biology
B7. Critically appraise and
evaluate different papers and
research methods.
B8. Adopt the ability for writing of
good papers.
b1. Choose better information for
problem solving.
b2. Review recent publications in
metabolism of different drugs and
foreign substances in the body.
b3. Evaluate information in different
papers and research methods.
b4. Acquire the ability to write scientific
papers.
C.Professional
and Practical
Skills
C1. Apply perfectly basic
techniques used in clinical
biochemistry.
c1. Adopt the ability to do basic
techniques in clinical chemistry
perfectly
D. General
and
Transferrable
Skills
D2. Lead a working team.
D3. Develop efficient writing and
presentation skills.
d1. Adopt efficient leadership skills.
d2. Acquire the ability for efficient
writing and presentation skills.
E. Ethics and
Attitudes
E1. Follow ethical rules in
research and laboratory
techniques.
E4. Behave as a good example for
students and junior staff.
e1. Adopt the ethical rules in research and
laboratory techniques.
e4. Behave as a good example for students
and junior staff
Course Content
(Units/Topics)
Teaching/Learning Methods
Lectures self
learning
Practical/
Clinical
Small
group
discussion
Others
Assignment
This course provides a
broad understanding of the
physical, biological and
chemical processes involved in
pollution of the atmosphere,
land and water, causes of
pollution and effect of
pollutants on human health. It
also includes an advanced study
of the basic principles of the
metabolism of foreign
compounds in mammals. The
xenobiotics covered include
drugs, food additives, and
agricultural, chemical and
industrial chemicals. The
detoxification and toxicological
implications of metabolism are
emphasized.Classification of
free radicals oxidants, sources
and metabolism of each,
antioxidant mechanisms and
abnormalities caused by
alteration of the balance
between oxidants and
antioxidants.
√ √ √ √ √
Please check (✓) the appropriate method.
Student Assessment
Methods of Assessment
Essay Objective questions
Case OSCE/OSPE
Assignment Logbook fulfillment
Others
Schedule of Assessment
End of term 100 %
Distribution of Marks
Written Exam 70 %
Assignment 20 %
Others 10 %
List of Textbooks and References
Lecture Notes
Course Text Books
1. Clinical Chemistry
2. Lehninger Biochemistry
3. Harper’s Biochemistry
Suggested Extra Reading
Fundamentals of clinical Chemistry. Titz
Journals and Periodicals, others
Relevant journals in Xenobiotic
metabolism ,free radical and antioxidants
Course Instructor
Name: Pr. Safaa Hussein Mohy el Dine Abou Dia Signature:
Program Coordinator
Name: Prof. Dr: Sabah Abdel-Hady Mahmoud Signature:
Program Director
Name: Prof.Dr: Sabah Abdel-Hady Mahmoud Signature:
√ √
√
√ √
Course Specifications
University: Alexandria
Faculty: Medicine
Department: Medical Biochemistry
Course Information
Course Code: 05160910 Course Name: Cell signaling and
neurotransmitters
Program in which the Course is Given within the courses assigned to the doctorate degree of
medical Biochemistry
Number of Credit Hours 3 Theoretical Clinical/Practical
Course Aims: the students must get deep and advanced knowledge and implementation of:
1. concepts of receptors and their second messengers.
2. cell to cell signaling
3. growth factors' receptors: function and regulation.
4. diverse signaling pathways.
5. apoptosis, death receptors and role of mitochondria in apoptosis.
6. neurotransmitters and neuromodulators.
Intended Learning Outcomes (ILOs)
Program ILO (refer to program
matrix) Course ILOs
A. Knowledge
and
Understanding
A5. Explain the basic and advanced
mechanisms of cell signaling and
neurotransmitters.
a1. Revise
- basic concepts of receptors,
- definitions of kinases and
phophatases and their role in signal
transduction
- general mechanisms for signal
transduction across membranes of
any cell that must respond to its
environment
a2. Describe the role of G proteins in
coupling ligand induced
conformational changes
a3. Discuss receptor regulation.
- 3
B. Intellectual
skills
B1. Analyze different information and
its use in problem solving.
B2. Review recent publications in the
field of medical biochemistry and
molecular biology
B7. Critically appraise and evaluate
different papers and research
methods.
b1. Differentiate between kinases
activated by second messengers
and those activated by primary
messengers (ligand-gated
receptor Tyr kinases)
b2. Correlate the neuron responses
mediated by neurotransmitters
and binding gated receptor/ion
channels compares and G-protein
coupled receptors.
b3. Analyze the different causes
leading to apoptosis, death
receptors and mitochondria in
apoptosis
b4. Draw a diagrams showing the
general features of signal
transduction e.g. kinases
mediated signal transduction
pathways that lead to activation
of gene expression, /STAT, Ras
signaling and others. b5. Explain the bound receptor
activation of specific effector
proteins.
b6. Link different cell signaling to
carcinogenesis pathways.
b7. Evaluate different papers and
researches relevant to cell
signaling.
C.Professional
and Practical
Skills
C4. Develop the capability of
retrieving scientific information and
evaluate different data.
c1. Implement knowledge about
signaling in researches e.g. to
target a signal pathway in
treatment of diseases.
D. General
Skills
D3. Develop efficient writing and
presentation skills.
D4. Develop the capability of
retrieving scientific information and
evaluate different data.
d1 Aquire efficient presentation skills.
d2 Collec scientific information and
evaluate different data.
E. Ethics and
Attitudes E2. Promote good relations with
seniors, colleagues and students.
E4. Behave as a good example for
students and junior staff
1. Create good working atmosphere with
seniors, colleagues and students.
2. Act as a good example for students and
junior staff and all assistants.
Course Content (Units/Topics)
Teaching/Learning Methods
Lectures self
learning
Practical/
Clinical
Small
group
discussion
Others
Assignment
This course includes basic
concepts of receptors, steroid
receptors, G-protein coupled
receptors, receptor regulation of
adenyl cyclase, role of cAMP in
regulation of cellular metabolism,
cyclic AMP-protein kinase, protein
kinase structure and regulation, other
second messengers as calcium and
phosphatidyl inositol, How is
calcium mobilized as a messenger
and acts to regulate cell function?,
growth factors receptors: function
and regulation, Tyrosine kinase
receptors, activation of PI 3- kinase
signaling, targeting the
transcriptional apparatus via cell
signaling, diverse signaling
pathways control of transcription,
transcriptional control via cAMP
signaling, nuclear receptors: the
ligand-activated transcription
factors, nuclear receptors: role of
✓ ✓ ✓ ✓
protein-protein interactions in
signaling, role of multiprotein
coactivators/corepressors complexes
in signaling, overview of apoptosis,
death receptors and mitochondria in
apoptosis, NF-kB/IkB system, direct
pathways to the nucleus: JAK/STAT
and others, Ras signaling,
neurotransmitters and
neuromodulators.
Please check (✓) the appropriate method.
Student Assessment
Methods of Assessment
Essay Objective questions
Case OSCE/OSPE
Assignment Logbook fulfillment
Others
Schedule of Assessment
Mid-term 30%
End of term 70%%
Distribution of Marks
Written Exam 70%
Practical/Clinical Exam -
Others 30%
✓ ✓
✓ ✓
✓
List of Textbooks and References
Lecture Notes
-
Course Text Books
• Biochemistry. Stryer
• Lehninger Biochemistry
• Molecular cell Biology. Lodish
Suggested Extra Reading
• Recent publications
• Any specialized text books
Journals and Periodicals, others
Relevant journals
Course Instructor
Name: Prof. Dr: Sabah Abdel-Hady Mahmoud Signature:
Program Coordinator
Name: Prof. Dr: Sabah Abdel-Hady Mahmoud Signature:
Program Director (Head of Department)
Name: Prof. Dr: Sabah Abdel-Hady Mahmoud Signature:
Course Specifications
University: Alexandria
Faculty: Medicine
Department: Medical Biochemistry
Course Information
Course Code: 05160911 Course Name: Biochemistry of the Major
Metabolic Diseases and Aging
Program in which the Course is Given within the courses assigned to the doctorate degree of
medical Biochemistry
Number of Credit Hours 3 Theoretical Clinical/Practical
Course Aims: the students must:
1. Develop updated and advanced knowledge in metabolic changes in common diseases in the
society as diabetes mellitus, hypertension, atherosclerosis, schestosomiasis.
Special emphasis on metabolic changes of aging. 2. Prepare the students to be good teachers and efficient researches.
Intended Learning Outcomes (ILOs)
Program ILO (refer to program
matrix) Course ILOs
A. Knowledge
and
Understanding
A1. Revise and upgrade their
knowledge about the metabolism
and function of different food
stuffs in the body.
A2. Discuss the advanced
knowledge about metabolism of
macromolecules and different
tissues and its relation to their
function.
a1. Revise basic concepts of metabolic
diseases. E.g. Diabetes mellitus
a2. Discuss metabolic changes in:
- Diabetes mellitus.
- Atherosclerosis.
- Aging
a3. Explain different tissue affection in
aging. E.g
- muscloskletal system
- Cardiovascular system.
- Endocrine
3
B. Intellectual
skills
B1. Analyze different information
and its use in problem solving.
B2. Review recent publications in
the field of medical biochemistry
and molecular biology
B7. Critically appraise and
evaluate different papers and
research methods.
B8. Adopt the ability for writing of
good papers.
b1. Interpret the clinical and
biochemical data in different
metabolic diseases.
b2. Review recent publications in
the field of diabetes mellitus,
atherosclerosis, aging ,….
Etc
b3. Evaluate different papers and
research methods in the field
of aging.
b4. Acquir the ability for writing
of papers.
b5. Select the prper scientific
information from heh/his
readings.
C.Professional
and Practical
Skills
C4. Develop the capability of
retrieving scientific information
and evaluate different data.
c1. Implement knowledge about the
major metabolic diseases in the
treatment of diseases.
D. General
Skills
D3. Develop efficient writing and
presentation skills.
D4. Develop the capability of
retrieving scientific information
and evaluate different data.
d1. Adopt the ability for presentation
skills.
d2. Acquire the capability of evaluation
of different data.
E. Ethics and
Attitudes
E2. Promote good relations with
seniors, colleagues and students.
E4. Behave as a good example for
students and junior staff
e1. Promote good relations with seniors,
colleagues and students throughout
the work period.
e2. Act in the lab as a good example for
all the juniors and assessments.
Course Content (Units/Topics)
Teaching/Learning Methods
Lectures self
learning
Practical/
Clinical
Small
group
discussion
Others
Assignment
This course includes an overview on
the metabolic changes in common
diseases in the society as diabetes
mellitus, hypertension, CVS diseases
(atherosclerosis) , schestosomiasis,
chronic neurodegenerative diseases (
Alzheimer, Parkinsonism) etc. with
special emphasis on metabolic
changes of aging.
✓ ✓ ✓ ✓
Please check (✓) the appropriate method.
Student Assessment
Methods of Assessment
Essay Objective questions
Case OSCE/OSPE
Assignment Logbook fulfillment
Others
Schedule of Assessment
Mid-term 30%
End of term 70%
Distribution of Marks
Written Exam 70%
Practical/Clinical Exam -
Others 30%
✓ ✓
✓ ✓
✓
List of Textbooks and References
Lecture Notes
-
Course Text Books
• Biochemistry. Case oriented approach.
• Biochemistry. Stryer
• Lehninger Biochemistry
• Molecular cell Biology. Lodish
Suggested Extra Reading
• Recent publications
• Any specialized text books
Journals and Periodicals, others
Relevant journals
Course Instructor
Name: Prof. Dr: Samia Mohamed Eliwa Signature:
Program Coordinator
Name: Prof. Dr: Sabah Abdel-Hady Mahmoud Signature:
Program Director (Head of Department)
Name: Prof.Dr: Sabah Abdel-Hady Mahmoud Signature:
Course Specifications
University: Alexandria
Faculty: Medicine
Department: Medical Biochemistry
Course Information
Course Code: 05160912 Course Name: Project in Biochemistry
Program in which the Course is Given: Doctorate program of Medical Biochemistry
Number of Credit Hours 2 Theoretical Clinical/Practical
Course Aims: The students Should be trained to do directed laboratory research performed under
the supervision of a faculty member.
Intended Learning Outcomes (ILOs)
Program ILO (refer to program
matrix)
Course ILOs
A. Knowledge
and
Understanding
B. Intellectual
skills
B1. Analyze different information
and its use in problem solving.
B2. Review recent publications in
the field of medical biochemistry
and molecular biology
B3. Improve different laboratory
methods for better diagnosis of
diseases on molecular basis.
B4. Implement the recent
information in biochemistry in the
biochemistry and molecular
biology lab.
b1. Use different information in problrm
solving.
b2. Appraise recent papers in
biochemistry and molecular biology.
b3. Modify laboratory methods to help in
getting better results.
b4. Use the recent information in
biochemistry and molecular biology
lab.
2 -
B5. Prepare good research
projects.
b5. Acquire the ability to prepare good
research project.
C.Professional
and Practical
Skills
C1. Apply perfectly basic
techniques used in clinical
biochemistry.
C2. Perform efficiently the
molecular biology techniques for
diagnosis of congenital diseases.
C3. Apply alternative methods and
procedures if ideal lab facilities are
not present.
C4. Implement knowledge about
signaling in researches e.g. To
target a signal pathway in
treatment of diseases.
C5. Write and publish scientific
papers.
C6. Explain scientific information
to students and peers.
c1. Perfect basic techniques in clinical
chemistry.
c2. Apply modern biochemical and
molecular biology techniques.
c3. Use different methods if ideal lab
facilities are not present.
c4. Use recent knowledge in promoting
research methods.
c5. Acquire the capacity of Writing and
publishing scientific papers.
c6. Share in scientific discussions with
students and peers.
D. General
Skills
D1. Working in multi-
professional team.
D2. Lead a working team.
d1. Adopt the ability to work in multi-
professional team.
d2. Acquire good leadership skills.
d3. Acquire good writing and
presentation skills.
E. Ethics and
Attitudes
E3. Apply concepts of
sterilization and infection control
in laboratory.
e1. Implement principles of sterilization
and infection control in laboratory.
Course Content (Units/Topics)
Teaching/Learning Methods
Lectures self
learning
Practical/
Clinical
Small
group
discussion
Others
Assignment
This course includes directed
laboratory research performed under
the supervision of a faculty member.
Each student is required to carry out
one detailed study of the scientific
literature related to the subject of the
research applied.
√ √
Please check (✓) the appropriate method.
Student Assessment
Methods of Assessment
Essay Objective questions
Case OSCE/OSPE
Assignment Logbook fulfillment
Others
Schedule of Assessment
Mid-term 20 %
End of term 80 %
Distribution of Marks
Written Exam
Practical/Clinical Exam 70%
Others 30 %
√
√
√
List of Textbooks and References
Lecture Notes
Course Text Books
1. Varley. Biochemical methods
Suggested Extra Reading
Fundamentals of clinical Chemistry. Titz
Journals and Periodicals, others
Any relevant journals
Course Instructor
Name: Dr. Iman Soliman Kamha Signature:
Program Coordinator
Name: Prof. Dr: Sabah Abdel-Hady Mahmoud Signature:
Program Director
Name: Prof. Dr: Sabah Abdel-Hady Mahmoud Signature:
Course Specifications
University: Alexandria
Faculty: Medicine
Department: Medical Biochemistry
Course Information
Course Code: 05160913 Course Name: lab. Management
Program in which the Course is Given :Doctorate Degree of Medical Biochemistry.
Number of Credit Hours 1 Theoretical Clinical/Practical
Course Aims:
1. Develop updated and advanced knowledge in measurement of the precision and accuracy
of the lab, check the methods and reagents, calibration of the instruments and performance,
criteria of the control material Medical Biochemistry and Molecular Biology .
2. Prepare the students to be efficient researches.
3. Apply recent laboratory investigations and recent researches in Medical Biochemistry
and molecular genetics.
Intended Learning Outcomes (ILOs)
Program ILO (refer to program
matrix) Course ILOs
A. Knowledge
and
Understanding
A1. Revise and upgrade the
knowledge about how to manage
the laboratory technically
administratively and financially.
a1. Revise the general principles of how
to measure the lab precision and
accuracy .
a2. Discuss the principles of calibration
of the instruments , performance and
criteria of the control material.
B. Intellectual
skills
B1. Improve different laboratory
methods for better diagnosis of
diseases on molecular basis.
B4. Implement the recent
information in biochemistry in the
biochemistry and molecular
biology lab.
b1. Evaluate different laboratory
methods in respect of accuracy,
sensitivity and specificity
1
C.Professional
and Practical
Skills
C1. Apply perfectly basic
techniques used in clinical
biochemistry.
C2. Apply alternative methods and
procedures if ideal lab facilities are
not present.
c1. Apply perfectly basic techniques
used in precautions for sample
collection, sample storage,
transportation, and waste disposal,
storages of quality assurance (pre-
analytic, analytic, post-analytic).
c2. Establish the mean and standard
deviation and plotting of control data
on a chart.
c3. Identify the source of analytic error
and assessment errors.
c4. Improve lab techniques used for
diagnosis of diseases.
D. General
Skills
D1. Develop the capability of
retrieving scientific information
and evaluate different data.
d1 Develop efficient writing and
presentation skills.
E. Ethics and
Attitudes
E1. Follow ethical rules in
research and laboratory
techniques
E2. Apply concepts of
sterilization and infection
control in laboratory
e1 Keep patient's privacy and
confidentiality.
e2 Promote good relations with seniors,
colleagues and student.
e3 Implement strictly the roles of
sterilization in all lab procedures
requiring it.
Course Content (Units/Topics)
Teaching/Learning Methods
Lectures self
learning
Practical/
Clinical
Small
group
discussion
Others
Assignment
This course ensures
laboratory staff and patients that
laboratory results are reliable and
relevant. Measurement of the
precision and accuracy of the lab,
check the methods and reagents,
calibration of the instruments and
performance, criteria of the control
material, establishment of mean and
standard deviation and plotting of
control data on a chart, identification
of the source of analytic error,
assessment errors, precautions for
sample collection, sample storage,
transportation, and waste disposal,
storages of quality assurance (pre-
analytic, analytic, post-analytic). The
practical sessions are applications on
the tutorials, with identification of
the source of analytic error,
assessment errors. The practical
work is done through group work or
single and concluded by discussion
and grading of the best performing
group in each session.
✓ ✓ ✓
Please check (✓) the appropriate method.
Student Assessment
Methods of Assessment
Essay Objective questions
Case OSCE/OSPE
Assignment Logbook fulfillment
Others
Schedule of Assessment
Mid-term -----
End of term 100%
Distribution of Marks
Written Exam 80%
Practical/Clinical Exam ----
Others 20 %
List of Textbooks and References
Lecture Notes
-
Course Text Books
1. Clinical Chemistry
2. Fundamentals of clinical
Chemistry. Titz
3. Varley. Biochemical methods
Suggested Extra Reading
- Any related recent text book
Journals and Periodicals, others
- Relevant journals & periodicals
Course Instructor
Name: Prof Dr.Amel Fouad Ketat Signature:
Program Coordinator
Name: Prof. Dr: Sabah Abdel-Hady Mahmoud Signature:
Program Director (Head of Department)
Name: Prof.Dr: Sabah Abdel-Hady Mahmoud Signature:
✓ ✓
✓
Course Specifications
University: Alexandria
Faculty: Medicine
Department: Medical Biochemistry
Course Information
Course Code: 05160914 Course Name: Seminar and Journal ClubII
Program in which the Course is Given : Doctorate Degree of Medical Biochemistry.
Number of Credit Hours 1 Theoretical Clinical/Practical
Course aims to let the student be acquainted with the special topics current to the field of biochemistry
and to practice the presentation skills as a faculty member.
Intended Learning Outcomes (ILOs)
Program ILO (refer to program
matrix) Course ILOs
A. Knowledge
and
Understanding
B. Intellectual
skills
B5. Share in research projects.
B6. Select good papers and
research methods.
b1. Participate in research projects.
b2. Choose good relevant papers and
research methods which are
appropriate for research projects
C.Professional
and Practical
Skills
- 1
D. General &
Transferrable
Skills
D1. Acquire updated knowledge from
various sources and present it to peers
in systematized manner.
D3. Recognize and respect the views
and opinions of other team members.
D4. Use information technology to
access, evaluate, and interpret
scientific data.
d1. Adopt the ability to search for recent
information and present it to peers
clearly.
d2. Respect and discuss other opinions.
d3. Use information technology to access,
evaluate, and interpret scientific data.
E. Ethics &
Attitude
E4. Demonstrate commitment to
lifelong learning and professional
service including active participation
in professional organizations.
e1. Demonstrate commitment to lifelong
learning and professional service
including active participation
inprofessional organizations
Course Content (Units/Topics)
Teaching/Learning Methods
Lectures
self
learning
Practical/
Clinical
Small
group
discussion
Others
Assignment
This course includes
special topics current to the field
of biochemistry. Topics and
format for the course may vary.
Study presentation is done by
each student under supervision
of a faculty member
✓ ✓
Please check (✓) the appropriate method.
Student Assessment
Methods of Assessment
Essay Objective questions
Case OSCE/OSPE
Assignment Logbook fulfillment
Others
Schedule of Assessment
Mid-term(Written ) %
Assignment 80 %
Self learning, commitment & attitude 20%
End of term %
Distribution of Marks
Written Exam %
Practical/Clinical Exam
Others 100%
List of Textbooks and References
Lecture Notes
-
Course Text Books
-
Suggested Extra Reading
1. Recent publications.
2. Any specialized text books
Journals and Periodicals, others
Relevant journals.
Course Instructor:
Name: Dr: Nadia Ahmed Barghash Signature:
Program Coordinator
Name: Dr: Sabah Abdel-Hady Mahmoud Signature:
Program Director (Head of Department)
Name: Prof.Dr: Sabah Abdel-Hady Mahmoud Signature:
✓ ✓
✓