천연물 약리 및 독성학

Pharmacology and Toxicology of Natural Products

장일무서울대학교 천연물과학연구소

Development of Life Science

from 19th C to 20th C

• Anatomy(Body Structure)– Histology (tissue)

– cytology(cell)

– Developmental Anat.(Prenatal devl.)

– Gross, Surface Anat.

– Comparative Anat.(humans vs animals)

• Physiology(Function)

– systems phy.(renal, GI)

– Cell Phy.

– Immunology(Defense)

• Anatomy + • Physiology– Medical Phys. (phys. D

ysfunction and diseases

Radiology(structure/function of organs within living body

Pathology (Diseased tissue)

Pharmacology(Drug Action in the body)

•biochemistry, molecular biology, microbiology natural products chemistry & informatics, plant physiology

Integration and Development

Classification of Organisms• Kingdom (Plant and Animal)(animal-eucaryotic cells that

lack walls, plastids,and photosynthetic pigments

• Phylum (Chordata): Dorsal hollow of nerve cord

• Subphylum (Vertebrata) : Vertebral column

• Class (Mammalia) : mammary glands, and hair

• Order (Primates) : brain and prehensile hands

• Family (Hominidae) Large cerebrum, bipedal locomotion

• Genus (Homo) : Flattened face, prominent chin and nose with inferiorly positioned nostrils

• Species (Sapiens) : Largest cerebrum

• Sub-species

Body Cavity

• Posterior Cavity– Cranial Cavity

– Vertebral Cavity

• Anterior Cavity– Thoracic Cavity

– Abdominopelvic Cavity

• Abdominal Cavity

• Pelvic Cavity

Normal Range of Blood

• Arterial PH 7.35-7.43

• Bicarbonate 21.3-28.5 mEq/L

• Sodium 136-151 mEq/L

• Calcium 4.6-5.2 mEq/L

• Oxygen 17.2-22.0 ml/100 ml

• Urea 12-35 mg/100 ml

• AA’ 3.3-5.1 mg/100ml

• Protein 6.5-8.0 g/100ml

• Total Lipids 350-850 mg/100 ml

• Glucose 75-110 mg/100 ml

Terminology derived Greek and Latin• Vermis-worm, cochlea-snail shell, cancer-crab, uvula-grape ( 동식

물 )• thyroid-shield, xiphos-sword, thorax-breastplate, Sella-saddle, stapes-s

tirrup ( 전쟁도구나 환경 )

• Directional terms for the Human Body– Superior(toward the top), inferior(toward to the bottom), anterior(f

ront), posterior (back), medial (midline), lateral(the side of body), internal (deep), external(outside), Proximal( 근접 , toward to the mail mass), Distal (away from main mass), visceral (related to internal organs), parietal (related to the body wall)

• Singular and Plural– axilla-axillae, Thorax-thoraces, lumen-lumenia,cortex-cortices, di

agnosis-diagnoses, epididymis, epididymides, appendix-appendices, carcinoma-carcinomata, mitochondrion-mitochondria, cilium-cillia, tarsus-tarsi, corpus-corpora, viscus-vicera, pharynx-pharynges, ovary-ovaries