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بسم الله الرحمن الرحيمبسم الله الرحمن الرحيم
Leukocytes
•Leukopenia•Leukocytosis
Leukopenia(Agranulocytosis)
Leukopenia(Agranulocytosis)
• Myeloid stem cell suppression• Ineffective granulopoisis• Heriditary disorders, kostmann
syn.• Immune destruction• Spleenic sequestration• Peripheral destruction
• Myeloid stem cell suppression• Ineffective granulopoisis• Heriditary disorders, kostmann
syn.• Immune destruction• Spleenic sequestration• Peripheral destruction
Leukocytosis
Normal Lymph node
Lymphadenitis
• Acute nonspecific lym.
• Chronic non specific lym.– Follicular hyperplasia– Sinus histiocytosis– Paracortical hyperplasis
Neoplastic proliferation of leukocytes
–Lymphomas–Leukemias–Plasmacell dyskerasia–Langerhans cell histiocytosis
–Lymphomas–Leukemias–Plasmacell dyskerasia–Langerhans cell histiocytosis
Lymphoproliferative disorders
Lymphoproliferative disorders
• Lymphomas
• Leukemias
• Plasma cell dyscrasia
• Lymphomas
• Leukemias
• Plasma cell dyscrasia
Myeloid Neoplasms
Myeloid Neoplasms
•Acute Leukemias•Chronic Leukemias•Myelodysplastic disorders•Myeloproliferative disorders
•Acute Leukemias•Chronic Leukemias•Myelodysplastic disorders•Myeloproliferative disorders
LymphomasLymphomas
•Hodgkins lymphoma (HD)•Non Hodgkins lymphoma (NHL)
•Hodgkins lymphoma (HD)•Non Hodgkins lymphoma (NHL)
Hodgkin's Lymphoma
Non Hodgkin's lymphomaNon Hodgkin's lymphoma
LeukemiaClassification
•Acute Aml , ALL•Chronic CML , CLL
•Acute Aml , ALL•Chronic CML , CLL
Myeloblast Lymphoblast
Myeloblast Lymphoblast
• Chromatin Fine Clamp• Nucleoli 3 – 5 1- 2• Granules Variable Non• PA - +• Tdt %5 % 95• Sudan Black + - • Mpo + -
• Chromatin Fine Clamp• Nucleoli 3 – 5 1- 2• Granules Variable Non• PA - +• Tdt %5 % 95• Sudan Black + - • Mpo + -
A.M.LA.M.L
A.L.L
Myelo dysplastic syndromes
•Refractory anemia•R.A with ring sideroblast•R.A with excess blast•Chronic myelomonocytic leukemia
•RAED in trans Formation•CMML in trans Formation
Chronic myeloproliferative disorders
•CML •P.V•MMM disease•E.T
Chronic lymphoproliferative disorders
• CLL• PLL• NHL• HCL
Plasma Cell neoplasms
•Multiple myeloma•Solitary plasmacytomaWaldenstorm macroglobulinemia
•Heavy chain diseases•Primary Amiloidosis•Monoclonal Gamma pathy U.S
HistiocytosesLangerhans H /
HistiocytosisX
•Eosinophilic granuloma
•Acute disseminated H.
((Letterer – Siwe synd))
•Hand schuller chrisrian disease
Morphologic aspects
•HLA – DR•CDa•Birbeck (HX) granules