The LAGEP (Laboratory of Automatic Control and Chemical Engineering) develops its research activities at the interface of Engineering and Health Sciences leading as well to base research as well as to transfer towards the important industrial sector in the region Rhône-Alpes. Its objective is to gather the experts in Automatic Control, Chemical Engineering and Pharmaceutical Engineering from both the University and the CNRS (Centre National de la Recherche Scientifique) for the development of research activities in their domain of expertise as well as cross-domain activities organized in the four research themes presented below.

THEMATIC GROUPS

NONLINEAR SYSTEMS AND PROCESSES

The research topic of the SNLEP team concerns the theorical development and implementation of tools in order to: Analyze, Modelize, Simulate, Control and Optimize Systems in Process Engineering.Our theoretical developments are motivated by practical applications encountered through collaborations with industrial and academic partners. More specifically, our work focuses on model design and reduction, parametric identification, observation, diagnosis and control.

PHARMACEUTICAL ENGINEERING

The design of new formulations containing active molecules is the key point to enhance the efficiency. These formulations can be fabricated in the form of capsules or tablets using various engineering processes in order to control the active molecules location and distribution inside the used matrix. The active molecules or the final drug should answer various criteria driven by the targeted diseases, application way and patient’s age.

• Pharmaceutical science (formulation and

• Solid elaboration (lyophilisation and crystallisation)

• Capsules preparation, colloidal physics and physical chemistry

• Modelling and process engineering,• Life science (biodisponibility, skin penetration)

SOLID ENGINEERING

The ‘Solid Engineering’ group is focused on the study of the solid manufacturing processes from the initial state (obtained by dissolution, wet granulation, raw material division) to the final dry state. Solid particles are mainly obtained by such processes as crystallization-precipitation, agglomeration, conductive, convective or spray drying, freeze-drying. The scope of the group activities goes from the study of the internal fundamental mechanisms (heat and mass transfer, solid phase transition, polymorphism,

desolvatation) to the process monitoring and control in an industrial context.

PROCESS DYNAMICS AND CONTROL OF SYSTEMS OF CONSERVATION LAWS

The design of energy efficient, reliable and intensive processes requires the development of dynamical models of complex, network structured processes. Different multi-scale processes are considered such as adsorption, reactive extrusion processes, heat pumps, thermal storages using phase changes in fluids and cristallization in emulsion processes, involving mass and heat transport in heterogeneous and reactive media with moving interface. Nonlinear control laws are developped based on their formulation as port Hamiltonian systems or input-output contact systems. Control laws for systems of conservation laws are developed based on the semi-group theory, Riemann invariants with recent developments for systems with moving interfaces.

HATEM FESSIProfessor, Université Claude Bernard Lyon 1

| LABORATORY CHEMICAL ENGINEERING AND AUTOMATIC CONTROL (LAGEP) UMR 5007, UNIVERSITÉ CLAUDE BERNARD LYON 1 – CNRS – CPE LYON

| FiguresCentre, top: experimentation using Buchi atomizer Centre, bottom: Hair decontamination studiesRight, top: Density Measurement of caffeine tablets by X-raysRight, bottom: nanoparticles PLA.

COLLABORATIONSThe LAGEP has numerous collaborations within national and international projects. The funding of these project is obtained through public agencies (ANR, FUI, GGCIS, European Union) or industrial partnerships in chemical engineering (IFP, TOTAL, RHODIA, ARKEMA ..), systems and control engineering (Renault V.I., IFP, ACSISYSTEMES…) and pharmaceutical engineering 5SANOFI AVENTIS, VOVARTIS, PFIZER, L’OREAL, J&J, ..).

KEYWORDSEncapsulation, targetting, Emulsions, Nanoparticles,pharmaceutical technologies, Diagnostic, therapy, automatic control, simulation, identification, separation processes, chemical reactors, Crystallization, precipitation, Drying, freeze-drying,

STAFFVincent Andrieu Junior researcher of the CNRSChristine Bebon Associate professorMarie-Alexandrine Bolzinger Associate professorSandrine Bourgeois Associate professorStéphanie Briancon ProfessorNadia Chapel Administrative and Financial OfficerCatherine Charcosset senior researcher of the CNRSYves Chevalier senior researcher of the CNRSCHOROT Thierry Associate professorClaudia Cogne Associate professorDidier Colson Associate professorGenevièvre Conod-Nardi Technician

Françoise Couenne Junior researcher of the CNRSSéverine Crastes-Vessot ProfessorGhania Degobert Associate professorHélène Desmorieux Associate professorValerie Dos Santos Martins Associate professorPascal Dufour Associate professorHamid Elaissari senior researcher of the CNRSHatem Fessi ProfessorKoffi Fiaty Associate professorEmilie Gagniere Associate professorOlivier Garrigues EngineerHassan Hammouri ProfessorBoussad Hamroun Associate professorChristian Jallut ProfessorJean-Paul Klein ProfessorPierre Laurent Associate professorDenis Mangin Associate professorJean-Claude Marques Associate professorBernhard Maschke ProfessorMadiha Nadri Associate professorSami Othman Associate professorRoman Peczalski ProfessorJocelyne Pelletier EngineerFrançois Puel Associate professorMickael Rodrigues Associate professorUlysse Serres Associate professorNida Sheibat-Othman Junior researcher of the CNRSSebastien Urbaniak TechnicianClaire Valentin ProfessorJean-Pierre Valour Engineer and Project OfficerXu Cheng-Zhong Professor

3-6 Post-Docs40-45 PhD Students 10-15 Graduate Students

| FiguresLeft, top: skin descriptionLeft, bottom : Pilot Freeze-dryerRight, top : Polymers particles preparationRight, bottom : monodisperse particles

DOMAINE SCIENTIFIQUE LYONTECH – LA DOUA LAGEP – UNIVERSITÉ CLAUDE BERNARD LYON 1

Bâtiment CPE Lyon 43 Boulevard du 11 Novembre 1918 69 622 Villeurbanne cedex France

TEL.: 33 (0)4 72 43 18 93FAX: 33 (0)4 72 43 16 82hatem.fessi@univ-lyon1.fr

www.lagep.univ-lyon1.fr

| EQUIPMENT

› Climatic chamber,› In situ probe (video, FBRM, NIR)› Contact vacuum dryer,› Crystallization setups from 100ml to 30 litres› DSC, TGA, labtop SEM, flow ability ring shear

tester , › 3D-powder mixer , HPLC, GPC, vaccum

studies, › Nanosizer, ultracentrifugation, › Freeze Dryer› DVS (dynamic vapour sorption analyzer)› Rheometer

| EXPERTISES› Crystallization-precipitation-agglomeration› Drying (contact, convective), spray-drying› Freeze-Drying, wet granluation› Pharmaceutical process,