H7N9*

H7N9H7N9H7N9H7N9*

H7N9*

*3/31H7N94/22104(21) (40)24(1941)9

H7N9(): Updated: 2013/4/23

*4/452(56)4/14/5H7N94/10H7N9

H7N9(): Updated: 2013/4/23

*4/13(7)244/151H7N94H7N9(): Updated: 2013/4/23

*H7N9(87)2/193/422/20-2/25112H7N94

H7N9(): Updated: 2013/4/23

*1043101215073%30-4919%308%60%H7N9()Updated: 2013/4/23:

*1,500H7N9(0.08%)H7N9()Updated: 2013/4/23:

*1,000

H7N9(): WHO EISUpdated: 2013/4/23

* H7N9

H7N9(): WHO EISUpdated: 2013/4/16

*H7N9Updated: 2013/4/23 9104(33)(3)(24) (40)(1)(3)H7N9

*43H7N9125(14)118H7N9(17H1N115H3N22B)711102(313)8H7N911307(2H3N25H1N1) H7N9H7N9Updated: 2013/4/23

*Updated: 2013/4/23

H7N919-6477%(87%)(11%)(2%) 83%17%29%H1N1(50%) H3N2 (44%) Updated: 2013/4/23

*15H7N9H7N9

H7N9*

*: Updated: 2013/4/99:00

H7N9*

(n=24) (n=7):16:86:1 ()57.7 (n=23)54.3 (n=7)3/21 (14.3%)1/7 (14.3%)19/19 (100%)5/5 (100%) ()9.0 (n=16)8.76 (n=5) ()-2.2 (n=5)

H7N9()5-77-92009 WHO339GOT,GPT,CKCBC*

H7N9()7-92-3*

631000H7N9*

*: Updated: 2013/4/57:00

H7N9?*

H7N9*

*NA/N9 H7N9 (A/wild bird/Korea/A3/2011)

PB2PB1PAHA-H7NPNA-N9MPNS2013 H7N9PB2PB1PAHA-H9NPNA-N2MPNSH9N22010~2012 HA/H7 H7N3 (A/duck/Zhejiang/2/2011)

H7N9H7N9H7N9H7N9*

H7N93/31GISAIDH7N93HH7NH7N9H9N2Nature doi:10.1038/nature.2013.12728

*H7N9:

Determination of viral pathogenicityProteinPositionPathogenicity2013 H7N9FunctionLowHighPB2627EKKreplication ability701DQDNuclear ImportPB1-F266NSNinduction of apoptosisHACleavage siteSingle basic aaMultiple basic aaSingle basic aaHA cleavageNS192DEDunknownC- terminus (PDZ)RSEVESEV13 C terminal aa truncatedunknown

H7N9TamifluAmantadine *

SARSH5N1pH1N1H7N9*10246

H7N9H7N9H7N9

*

H7N9()()()

*

H7N9()

*

H7N9()H7N9H7N9*

H7N9

*

H7N9

38()()

7()H7N9()()H7N9()

H7N9H7N9

H7N9

>38*

*

*********

**