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H2O
H2O+ + e-
3
H2O++e-
Free radical H2O++ H2O ↓
H3O++OH
( )
4
β X ↓ → (e-) ↓
Ion radical H2O→H2O++e-
↓ Free radical H2O++ H2O → H3O++OH
↓
↓
2H2O
H3O+ + OH-
5
DNA 2
→ DNA
DNA
2
DNA
2H2O → H3O++OH-
6
7
1. 2. 3.
8
9
10
11
12
13
14
= =
isotope 1H 2H 3H
(3H 14C 40K 222Rn 226Ra 238U etc) (11C 18F 99mTc 123I 201Tl etc)
15
B
16
B
17
131I
18
131I → 95%
→ 131I
19
131I
2
3
TSH
rhTSH
20
21
22
1 6 CT→2
CT
1 131I 23 24
β-
2 131I
Tg TSH Tg
1 X. 2.15. 4700.0 31.61 10 > 2 X. 9. 3. 18.5 43.04 11
X. 9.30. 44.9 0.32 3 X+1. 3. 4. 4.6 54.48 10 >
X+1. 3.17. 9.1 64.11 4 X+1.12. 2. 0.8 48.97 17
X+1.12.22. 5.3 39.91 X+2. 3.22. 0.3 0.25
5 X+2.11.15. 0.4 59.94 22 X+2.12. 5. 1.2 45.51 X+3. 3.13. 0.1 0.69 X+4. 9.18. 0.1 0.15 1 131I
131I 131I 4
131I
25
26
131I
500MBq
→
RI
27 28
B
29
30
31
32
33
89Sr
Sr Sr Sr Sr Sr
β β
34
89Sr
Sr Sr Sr Sr Sr
β β
β
35
70 2.2MBq/kg
89Sr
Ant.
RPO
89Sr
36
2.0MBq/kg
1 2 2 Sr 37
2.0MBq/kg
-4 -2 0 2 4 6 8 10 12 14 16 18 20 22 24 26 28 300
2
4
6
8
10
12
14WBC
RBC
PLT
Neutro
PSA
Sr Sr
38
α !
α β
2
α
2
100μ
β
2
X
δ 2
32P β cm
39
LET 3-5 DNA
S
7000 1 LET KeV/μ 80 0.2
μ 40 - 100 50 - 12,000 LET, linear energy transfer KassisA. Nucl Med. 2008;38:358-366 40
( )
DNA DNA
41
223Ra
Ra Ra Ra Ra Ra
α α
42
89Sr 223Ra
223RaCl2 89SrCl2
89Sr 8 5%90%
223Ra 24 1%72 64%
•
89SrCl2223RaCl2
89Sr
1 2MBq/ 3
223Ra
1 55 Bq/ 4 6
44
B
45
CD20
Pluripotent stem cell
Lymphoid stem cell
Pre-B-cell B-cell Activated B-cell
Plasma cell
Bone marrow Blood, lymph
Press. Semin Oncol 1999;265(suppl 14):58–65
®
Spies, S. M. Semin. Nucl. Med., 34 1 Suppl. 1 , 10 2004
Cross-Fire Effect Y-90 Zevalin
ADCC
CDC
47
90Y Zevalin
48
49