IRGANOX 1098 SALICYLIC ACID TRIBUTYL PHOSPHATE DIETHANOLAMINE NABUMETONE HEXAMETHYLENETETRAMINE SUDAN I MELAMINE TETRABROMOBISPHENOL A (TBBPA) CIPROFLOXACIN 2-HYDROXYETHYL STEARATE DIETHYL PHTHALATE (DEP) CYASORB 3638 TRIPHENYL PHOSPHATE （TPP,TPHP) The structural elucidation of unknown compounds found in packaging is a complex and time-consuming process. Waters™ UNIFI™ Scientific Information System provides a simple workflow including scientific library creation, multivariate statistical analysis, elucidation, and reporting. www.waters.com/extractables ©2019 Waters Corporation. Waters, UNIFI, and The Science of What’s Possible are trademarks of Waters Corporation. January 2019 720005722EN TL-PDF [ EXTRACTABLES & LEACHABLES ] Simplifying the Screening Workflow for Extractables Testing 1. COMPLEX MS DATA User generated library with retention time, fragment, collision cross section (CCS) information can be used to confirm the presence of compounds in the sample. Concentrations can be determined with calibration standards. Data acquired on ToF mass spectrometry instruments from complex matrices can yield an overwhelming amount of raw data. 2. TARGETED SCREENING Comparison and statistical analysis tools can be used to discover other compounds of interest present in the sample. 3. NON-TARGETED SCREENING/ WHAT ELSE IS IN THE SAMPLE? A customized report can be generated that includes analysis method, processing parameters, chromatograms, spectra, and identified compound summary tables. 5. REPORT Combining the accurate mass and fragment information with structural database search can yield the identity of these compounds. 4. IDENTIFYING COMPOUNDS S C I E N T I F I C L I B R A R Y YES

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Page 1: [ EXTRACTABLES & LEACHABLES ] Simplifying the Screening ... fileTRIPHENYL PHOSPHATE（TPP,TPHP) The structural elucidation of unknown compounds found in packaging is a complex and

IRGANOX 1098

SALICYLIC ACID

TRIBUTYL PHOSPHATE

DIETHANOLAMINE

NABUMETONE

HEXAMETHYLENETETRAMINE

SUDAN I

MELAMINE

TETRABROMOBISPHENOL A (TBBPA)

CIPROFLOXACIN

2-HYDROXYETHYL STEARATE

DIETHYL PHTHALATE (DEP)

CYASORB 3638

TRIPHENYL PHOSPHATE（TPP,TPHP)

The structural elucidation of unknown compounds found in packaging is a complex and time-consuming process. Waters™ UNIFI™ Scientific Information System provides a simple workflow including scientific library creation, multivariate statistical analysis, elucidation, and reporting.

www.waters.com/extractables

[ EXTRACTABLES & LEACHABLES ]

Simplifying the Screening Workflow for Extractables Testing

1. COMPLEX MS DATA

User generated library with retention time, fragment, collision cross section (CCS) information can be used to confirm the presence of compounds in the sample. Concentrations can be determined with calibration standards.

Data acquired on ToF mass spectrometry instruments from complex matrices can yield an overwhelming amount of raw data.

2. TARGETED SCREENING

Comparison and statistical analysis tools can be used to discover other compounds of interest present in the sample.

3. NON-TARGETED SCREENING/ WHAT ELSE IS IN THE SAMPLE?

A customized report can be generated that includes analysis method, processing parameters, chromatograms, spectra, and identified compound summary tables.

5. REPORT

Combining the accurate mass and fragment information with structural database search can yield the identity of these compounds.

4. IDENTIFYING COMPOUNDS

SCIENTIFI

C LI

ARY

YES