大阪大学大学院薬学研究科研究業績集 (2010) 高分子化学 (Biophysical Chemistry) Structure and reaction mechanism of human nicotinamide phosphoribosyltransferase Takahashi R, Nakamura S, Nakazawa T, Minoura K, Yoshida T, Nishi Y, Kobayashi Y, Ohkubo T J. Biochem., 147, 95-107 (2010) Cloning, expression, crystallization and preliminary X-ray crystallographic analysis of a human condensin SMC2 hinge domain with short coiled coils Kawahara K, Nakamura S, Katsu Y, Motooka D, Hosokawa Y, Kojima Y, Matsukawa K, Takinowaki H, Uchiyama S, Kobayashi Y, Fukui K, Ohkubo T Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun., 66, 1067-1070 (2010) Characterization of HIV-1 resistance to a fusion inhibitor, N36, derived from the gp41 amino-terminal heptad repeat Izumi K, Nakamura S, Nakano H, Shimura K, Sakagami Y, Oishi S, Uchiyama S, Ohkubo T, Kobayashi Y, Fujii N, Matsuoka M, Kodama EN Antiviral Res., 87, 179-186 (2010) The middle region of an HP1-binding protein, HP1-BP74, associates with linker DNA at the entry/exit site of nucleosomal DNA Hayashihara K, Uchiyama S, Shimamoto S, Kobayashi S, Tomschik M, Wakamatsu H, No D, Sugahara H, Hori N, Noda M, Ohkubo T, Zlatanova J, Matsunaga S, Fukui K J. Biol. Chem., 285, 6498-6507 (2010) Structural analysis of lipocalin-type prostaglandin D synthase complexed with biliverdin by small-angle X-ray scattering and multi-dimensional NMR Miyamoto Y, Nishimura S, Inoue K, Shimamoto S, Yoshida T, Fukuhara A, Yamada M, Urade Y, Yagi N, Ohkubo T, Inui T J. Struct. Biol., 169, 209-218 (2010) 薬品製造化学 (Synthetic Medicinal Chemistry) Asymmetric total synthesis of (+)-hexachlorosulfolipid, a cytotoxin isolated from Adriatic mussels Yoshimitsu T, Fukumoto N, Nakatani R, Kojima N, Tanaka T J. Org. Chem., 75, 5425-5437 (2010) Convergent synthesis of fluorescence-labeled probes of Annonaceous acetogenins and

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visualization of their cell distribution Kojima N, Morioka T, Urabe D, Yano M, Suga Y, Maezaki N, Ohashi-Kobayashi A, Fujimoto Y, Maeda M, Yamori T, Yoshimitsu T, Tanaka T Bioorg. Med. Chem., 18, 8630-8641 (2010) Synthesis of fused and linked bicyclic nitrogen heterocycles by palladium-catalyzed domino cyclization of propargyl bromides Okano A, Tsukamoto K, Kosaka S, Maeda H, Oishi S, Tanaka T, Fujii N, Ohno H Chem. Eur. J., 16, 8410-8418 (2010) Construction of linked nitrogen heterocycles by palladium(0)-catalyzed intramolecular domino cyclization of 2-alkynylaziridines bearing a 2-aminoethyl group via ring expansion with isocyanate Okano A, Oishi S, Tanaka T, Fujii N, Ohno H J. Org. Chem., 75, 3396-3400 (2010) 生体機能分子化学 (Bio-Functional Molecular Chemistry) The safety of a mucosal vaccine using the C-terminal fragment of Clostridium perfringens enterotoxin Suzuki H, Kakutani H, Kondoh M, Watari A, Yagi K Pharmazie, 65, 766-769 (2010) Hepatoprotective effect of syringic acid and vanillic acid on CCl4-induced liver injury Itoh A, Isoda K, Kondoh M, Kawase M, Watari A, Kobayashi M, Tamesada M, Yagi K Biol. Pharm. Bull., 33, 983-987 (2010) A claudin-targeting molecule as an inhibitor of tumor metastasis Saeki R, Kondoh M, Kakutani H, Matsuhisa K, Takahashi A, Suzuki H, Kakamu Y, Watari A, Yagi K J. Pharmacol. Exp. Ther., 334, 576-582 (2010) Mucosal vaccination using claudin-4-targeting Kakutani H, Kondoh M, Fukasaka M, Suzuki H, Hamakubo T, Yagi K Biomaterials, 31, 5463-5471 (2010) Development of novel culture system for regulation of hepatocyte function Yagi K, Kawase M, Isoda K, Kondoh M YAKUGAKU ZASSHI, 130, 537-543 (2010) Claudin-4-targeting of diphtheria toxin fragment A using a C-terminal fragment of Clostridium perfringens enterotoxin

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Kakutani H, Kondoh M, Saeki R, Fujii M, Watanabe Y, Mizuguchi H, Yagi K Eur. J. Pharm. Biopharm., 75, 213-217 (2010) A claudin-4 modulator enhances the mucosal absorption of a biologically active peptide Uchida H, Kondoh M, Hanada T, Takahashi A, Hamakubo T, Yagi K Biochem. Pharmacol., 79, 1437-1444 (2010) Prevention of hepatic ischemia-reperfusion injury by pre-administration of catalase-expressing adenovirus vectors Ushitora M, Sakurai F, Yamaguchi T, Nakamura S, Kondoh M, Yagi K, Kawabata K, Mizuguchi H J. Control. Release, 142, 431-437 (2010) Cutting-edge research on hepatitis C treatment and the clinical perspectives Yagi K, Hayashi T YAKUGAKU ZASSHI, 130, 141-142 (2010) Potency of claudin-targeting as antitumor therapy Saeki R, Kondoh M, Uchida H, Yagi K Mol. Cell. Pharmacol., 2, 47-51(2010) 生体バリアの分子基盤を利用した創薬研究

近藤昌夫 薬剤学, 70, 309-313 (2010) 分子生物学 (Biochemistry and Molecular Biology) Activation of LDL receptor expression by small RNAs complementary to a noncoding transcript that overlaps the LDLR promoter Matsui M, Sakurai F, Elbashir S, Foster DJ, Manoharan M, Corey DR Chemistry & Biology, 17, 1344-1355 (2010) Induction of type I interferon by adenovirus-encoded small RNAs Yamaguchi T, Kawabata K, Kouyama E, Ishii KJ, Katayama K, Suzuki T, Kurachi S, Sakurai F, Akira S, Mizuguchi H Proc. Natl. Acad. Sci. USA, 107, 17286-17291 (2010) Enhanced transduction efficiency of fiber-substituted adenovirus vectors by the incorporation of RGD peptides in two distinct regions of the adenovirus serotype 35 fiber knob Matsui H, Sakurai F, Katayama K, Kurachi S, Tashiro K, Sugio K, Kawabata K, Mizuguchi H Virus Res., 155, 48-54 (2010)

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Adenovirus serotype 35 vector-induced innate immune responses in dendritic cells derived from wild-type and human CD46-transgenic mice: Comparison with a fiber-substituted Ad vector containing fiber proteins of Ad serotype 35 Sakurai F, Nakashima K, Yamaguchi T, Ichinose T, Kawabata K, Hayakawa T, Mizuguchi H J. Control. Release, 148, 212-218 (2010) Adenovirus vector-mediated efficient transduction into human embryonic and induced pluripotent stem cells Tashiro K, Kawabata K, Inamura M, Takayama K, Furukawa N, Sakurai F, Katayama K, Hayakawa T, Furue-Kusuda M, Mizuguchi H Cell. Reprogram., 12, 501-507 (2010) Optimized PEGylated adenovirus vector reduces the anti-vector humoral immune response against adenovirus and induces a therapeutic effect against metastatic lung cancer Eto Y, Yoshioka Y, Ishida T, Yao X, Morishige T, Narimatsu S, Mizuguchi H, Mukai Y, Okada N, Kiwada H, Nakagawa S Biol. Pharm. Bull., 33, 1540-1544 (2010) Prevention of hepatic ischemia-reperfusion injury by pre-administration of catalase-expressing adenovirus vectors Ushitora M, Sakurai F, Yamaguchi T, Nakamura S, Kondoh M, Yagi K, Kawabata K, Mizuguchi H J. Control. Release, 142, 431-437 (2010) A novel translational approach for human malignant pleural mesothelioma: heparanase-assisted dual virotherapy Watanabe Y, Kojima T, Kagawa S, Uno F, Hashimoto Y, Kyo S, Mizuguchi H, Tanaka N, Kawamura H, Ichimaru D, Urata Y, Fujiwara T Oncogene, 29, 1145-1154 (2010) A fiber modified adenovirus vector that targets to the EphrinA2 receptor reveals enhanced gene transfer to ex vivo pancreatic cancer Van Geer MA, Brevoord D, Kuhlmann KFD, Bakker CT, Mizuguchi H, Wesseling JG, Ten Kate FJ, Gouma DJ, Oude Elferink RPJ, Bosma PJ Int. J. Oncol., 36, 233-244 (2010) Comparison of the anti-tumor activity of native, secreted, and membrane-bound LIGHT in mouse tumor models Morishige T, Yoshioka Y, Tanabe A, Yao X, Mizuguchi H, Tsunoda S, Tsutsumi Y, Mukai Y, Okada N, Nakagawa S Int. Immunopharmacol., 10, 26-33 (2010) In vivo biological purging for lymph node metastasis of human colorectal cancer by

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telomerase-specific oncolytic virotherapy Kojima T, Watanabe Y, Hashimoto Y, Kuroda S, Yamasaki Y, Yano S, Ouchi M, Tazawa H, Uno F, Kagawa S, Kyo S, Mizuguchi H, Urata Y, Tanaka N, Fujiwara T Ann. Surg., 251, 1079-1086 (2010) Particle tracking of intracellular trafficking of octaarginine-modified liposomes: a comparative study with adenovirus Akita H, Enoto K, Masuda T, Mizuguchi H, Tani T, Harashima H Mol. Ther., 18, 955-964 (2010) Co-administration of viral vector-based vaccines suppresses antigen-specific effector CD8 T cells Yashima S, Yoshizaki S, Shinoda K, Yoshida A, Kondo A, Mizuguchi H, Ryo A, Okuda K, Shimada M Vaccine, 28, 3257-3264 (2010) Claudin-4-targeting of diphtheria toxin fragment A using a C-terminal fragment of Clostridium perfringens enterotoxin Kakutani H, Kondoh M, Saeki R, Fujii M, Watanabe Y, Mizuguchi H, Yagi K Eur. J. Pharm. Biopharm., 75, 213-217 (2010) Adenovirus vector covalently conjugated to polyethylene glycol with a cancer-specific promoter suppresses the tumor growth through systemic administration Yao X, Yoshioka Y, Morishige T, Eto Y, Narimatsu S, Mizuguchi H, Mukai Y, Okada N, Nakagawa S Biol. Pharm. Bull., 33, 1073-1076 (2010) Mutant TNF-α, mTNF-K90R, is a novel candidate adjuvant for a mucosal vaccine against HIV Kayamuro H, Abe Y, Yoshioka Y, Katayama K, Yoshida T, Yamashita K, Yoshikawa T, Kawai Y, Mayumi T, Hiroi T, Itoh N, Nagano K, Kamada H, Tsunoda S, Tsutsumi Y Pharmazie, 65, 254-256 (2010) Interleukin-1 family cytokines as mucosal vaccine adjuvants for induction of protective immunity against influenza virus Kayamuro H, Yoshioka Y, Abe Y, Arita S, Katayama K, Nomura T, Yoshikawa T, Kubota-Koketsu R, Ikuta K, Okamoto S, Mori Y, Kunisawa J, Kiyono H, Itoh N, Nagano K, Kamada H, Tsutsumi Y, Tsunoda S J. Virol., 84, 12703-12712 (2010) 次世代アデノウイルスベクターの開発と生命科学研究への応用 (Review) 水口裕之 Drug Delivery System, 25, 493-503 (2010) iPS 細胞への遺伝子導入を用いた分化誘導の最適化 (Review) 川端健二, 田代克久, 水口裕之

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薬学雑誌, 130, 1527-1534 (2010) マイクロ RNA による遺伝子発現制御システムを搭載した遺伝子組換えアデノウイルスの開

発 (Review) 櫻井文教, 水口裕之 薬学雑誌, 130, 1497-1504 (2010) 生理活性タンパク質による治療最適化を指向した遺伝子・細胞製剤の開発 (Review) 櫻井文教, 西川元也 薬学雑誌, 130, 1487-1488 (2010) PPARγを標的とした遺伝子治療 (Review) 形山和史, 中島淳 日本臨牀, 68, 356-360 (2010) 分子合成化学 (Synthetic Organic Chemistry) Novel dienone-phenol type rearrangement of 4,4-disubstituted cyclohexadienone system using thiosilane Wada Y, Otani K, Endo N, Kita Y, Fujioka H Chem. Commun., 46, 797-799 (2010) One-pot condensation-oxidation of glyoxamide with 1,2-diamines providing imidazolines and benzimidazoles Murai K, Takaichi N, Takahara Y, Fukushima S, Fujioka H Synthesis, 520-526 (2010) C3-symmetric chiral trisimidazoline: design and application to organocatalyst Murai K, Fukushima S, Hayashi S, Takahara Y, Fujioka H Org. Lett., 12, 964-966 (2010) Mild deprotection of methylene acetals in combination with trimethylsilyl triflate–2,2’-bipyridyl Fujioka H, Senami K, Kubo O, Yahata K, Minamitsuji Y, Maegawa T Chem. Pharm. Bull., 58, 426-428 (2010) Unusual ipso substitution of diaryliodonium bromides initiated by a single-electron-transfer oxidizing process Dohi T, Ito M, Yamaoka N, Morimoto K, Fujioka H, Kita Y Angew. Chem. Int. Ed., 49, 3334-3337 (2010) Enhanced reactivity of [hydroxy(tosyloxy)iodo]benzene in fluoroalcohol media. Efficient direct

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synthesis of thienyl(aryl)iodonium salts Ito M, Ogawa C, Yamaoka N, Fujioka H, Dohi T, Kita Y Molecules, 15, 1918-1931 (2010) Organic synthesis using a hypervalent iodine reagent: unexpected and novel domino reaction leading to spiro cyclohexadienone lactones Fujioka H, Komatsu H, Nakamura T, Miyoshi A, Hata K, Ganesh J, Murai K, Kita Y Chem. Commun., 46, 4133-4135 (2010) The first asymmetric total syntheses of both enantiomers of cryptocaryone Fujioka H, Nakahara K, Oki T, Hirano K, Hayashi T, Kita Y Tetrahedron Lett., 51, 1945-1946 (2010) Remarkable effect of phosphine on the reactivity of O,P-acetal – efficient substitution reaction of O,P-acetal Fujioka H, Goto A, Otake K, Kubo O, Yahata K, Sawama Y, Maegawa T Chem. Commun., 46, 3976-3978 (2010) Facile preparation of oxazole-4-carboxylates and 4-ketones from aldehydes using 3-oxazoline-4-carboxylates as intermediates Murai K, Takahara Y, Matsushita T, Komatsu H, Fujioka H Org. Lett., 12, 3456-3459 (2010) Asymmetric bromolactonization catalyzed by a C3-symmetric chiral trisimidazoline Murai K, Matsushita T, Nakamura A, Fukushima S, Shimura M, Fujioka H Angew. Chem. Int. Ed., 49, 9174-9177 (2010) Metal-free regioselective oxidative biaryl coupling leading to head-to-tail bithiophenes: reactivity switching, a concept based on the iodonium(III) intermediate Morimoto K, Yamaoka N, Ogawa C, Nakae T, Fujioka H, Dohi T, Kita Y Org. Lett., 12, 3804-3807 (2010) Designer μ-oxo-bridged hypervalent iodine(III) organocatalysts for greener oxidations Dohi T, Takenaga N, Fukushima K, Uchiyama T, Kato D, Shiro M, Fujioka H, Kita Y Chem. Commun., 46, 7697-7699 (2010) C-C bond formation on 5-position of uridine ring by Morita-Baylis-Hillman type reaction Monguchi Y, Yasunaga K, Tsunoda T, Ando T, Maegawa T, Hirota K, Sajiki H Heterocycles, 80, 537-555 (2010) Ligand-free and heterogeneous palladium on carbon-catalyzed hetero-Suzuki-Miyaura cross-coupling

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Kitamura Y, Sako S, Tsutsui A, Monguchi Y, Maegawa T, Kitade Y, Sajiki H Adv. Synth. Catal., 352, 718-730 (2010) Palladium on carbon-catalyzed synthesis of benzil derivatives from 1,2-diarylalkynes with DMSO and molecular oxygen as dual oxidants Mori S, Takubo M, Yanase T, Maegawa T, Monguchi Y, Sajiki H Adv. Synth. Catal., 352, 1630-1634 (2010) Copper-mediated reductive amination of aryl halides with trimethylsilyl azide Monguchi Y, Maejima T, Mori S, Maegawa T, Sajiki H Chem. Eur. J., 16, 7372-7375 (2010) Palladium on carbon-catalyzed synthesis of 2- and 2,3-substituted indoles under heterogeneous conditions Monguchi Y, Mori S, Aoyagi S, Tsutsui A, Maegawa T, Sajiki H Org. Biomol. Chem., 8, 3338-3342 (2010) Palladium on charcoal-catalyzed ligand-free Stille coupling Yabe Y, Maegawa T, Monguchi Y, Sajiki H Tetrahedron, 66, 8654-8660 (2010) Synthesis of deuterium-labelled drugs by hydrogen-deuterium (H-D) exchange using heterogeneous catalysis Modutlwa N, Maegawa T, Monguchi Y, Sajiki H J. Label. Compd. Radiopharm., 53, 686-692 (2010) Diastereoselective desymmetrization of symmetric dienes and its synthetic application (Review) Nakahara K, Fujioka H Symmetry, 2, 437-454 (2010) Synthesis of the marine pyrroloiminoquinone alkaloids, discorhabdins (Review) Wada Y, Fujioka H, Kita Y Mar. Drugs, 8, 1394-1416 (2010) 実用的イミダゾリン合成法の開発とその展開 (Review) 村井健一 薬学雑誌, 130, 1011-1016 (2010) 分子反応解析学 (Analytical Chemistry) 1,1',1'',1'''-[porphyrin-5,10,15,20-tetrayltetrakis(3,1-phenylenemethylene)]tetraquinolinium

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tetrabromide Ishikawa Y, Yamashita T, Fujii S, Uno T Molbank, M704 (2010) ガスセンサーCooA と FixL と Dos に関する最近の研究 (Review) 山下沢 薬学雑誌, 130, 1181-1187 (2010) 細胞生物学 (Cell Biology) Indole enhances acid resistance in Escherichia coli Hirakawa H, Hayashi-Nishino M, Yamaguchi A, Nishino K Microb. Pathog., 49, 90-94 (2010) TolC dependency of multidrug efflux systems in Salmonella enterica serovar Typhimurium Horiyama T, Yamaguchi A, Nishino K J. Antimicrob. Chemother., 65, 1372-1376 (2010) Macrophage ABCA5 deficiency influences cellular cholesterol efflux and increases susceptibility to atherosclerosis in female LDLr knockout mice Ye D, Meurs I, Ohigashi M, Calpe-Berdiel L, Habets KLL, Zhao Y, Kubo Y, Yamaguchi A, Van Berkel TJC, Nishi T, Van Eck M Biochem. Biophys. Res. Commun., 395, 387-394 (2010) Effect of NlpE overproduction on multidrug resistance in Escherichia coli Nishino K, Yamasaki S, Hayashi-Nishino M, Yamaguchi A Antimicrob. Agents Chemother., 54, 2239-2243 (2010) Impact of the RNA chaperone Hfq on multidrug resistance in Escherichia coli Yamada J, Yamasaki S, Hirakawa H, Hayashi-Nishino M, Yamaguchi A, Nishino K J. Antimicrob. Chemother., 65, 853-858 (2010) Electron tomography reveals the endoplasmic reticulum as a membrane source for autophagosome formation Hayashi-Nishino M, Fujita N, Noda T, Yamaguchi A, Yoshimori T, Yamamoto A Autophagy, 6, 301-303 (2010) 生物有機化学 (Bioorganic Chemistry) Study on suitability of KOD DNA polymerase for enzymatic production of artificial nucleic acids

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using base/sugar modified nucleoside triphosphates Kuwahara M, Takano Y, Kasahara Y, Nara H, Ozaki H, Sawai H, Sugiyama A, Obika S Molecules, 15, 8229-8240 (2010) A novel bridged nucleoside bearing a conformationally switchable sugar moiety in response to redox changes Baba T, Kodama T, Mori K, Imanishi T, Obika S Chem. Commun., 46, 8058-8060 (2010) Synthesis and DNA cleavage evaluation of epoxypiperidine derivatives bearing a dehydroamino acid unit Yamaguchi T, Kawada Y, Obika S, Imanishi T, Miyashita K Tetrahedron, 66, 8181-8188 (2010) Double-stranded DNA-templated cleavage of oligonucleotides containing a P3’→N5’ linkage triggered by triplex formation: the effects of chemical modifications and remarkable enhancement in reactivity Ito KR, Kodama T, Tomizu M, Negoro Y, Orita A, Osaki T, Hosoki N, Tanaka T, Imanishi T, Obika S Nucleic Acids Res., 38, 7332-7342 (2010) 2’,4’-BNA bearing a 2-pyridine nucleobase for CG base pair recognition in the parallel motif triplex DNA Hari Y, Matsugu S, Inohara H, Hatanaka Y, Akabane M, Imanishi T, Obika S Org. Biomol. Chem., 8, 4176-4180 (2010) Synthesis, RNA selective hybridization and high nuclease resistance of an oligonucleotide containing novel bridged nucleic acid with cyclic urea structure Nishida M, Baba T, Kodama T, Yahara A, Imanishi T, Obika S Chem. Commun., 46, 5283-5285 (2010) RNA interference with 2’,4’-bridged nucleic acid analogues Rahman SMA, Sato H, Tsuda N, Haitani S, Narukawa K, Imanishi T, Obika S Bioorg. Med. Chem., 18, 3474-3480 (2010) Effect of 3’-end capping of aptamer with various 2’,4’-bridged nucleotides: enzymatic post-modification toward a practical use of polyclonal aptamers Kasahara Y, Kitadume S, Morihiro K, Kuwahara M, Ozaki H, Sawai H, Imanishi T, Obika S Bioorg. Med. Chem. Lett., 20, 1626-1629 (2010) Synthesis and evaluation of novel 3,4-epoxypiperidines as efficient DNA alkylating agents Kawada Y, Kodama T, Miyashita K, Imanishi T, Obika S Heterocycles, 80, 1249-1265 (2010)

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Bridged nucleic acids: development, synthesis and properties (Review) Obika S, Rahman SMA, Fujisaka A, Kawada Y, Baba T, Imanishi T Heterocycles, 81, 1347-1392 (2010) 架橋型人工核酸 BNA の開発（４）：外部刺激応答型人工核酸スイッチへの展開 (Review) 兒玉哲也, 今西武, 小比賀聡

Antisense, 14, 35-44 (2010) 架橋型人工核酸 BNA の開発（３）：三重鎖形成を基盤とした DNA 分析法 (Review) 伊藤浩介, 今西武, 小比賀聡 Antisense, 14, 5-15 (2010) オリゴ核酸 PET 分子プローブの合成法 (Review) 窪山剛之, 小比賀聡 創薬研究への分子イメージング応用（遺伝子医学 MOOK18）(メディカルドゥ), 60-65 (2010) 細胞生理学 (Immunology) Mesenchymal progenitors distinct from satellite cells contribute to ectopic fat cell formation in skeletal muscle Uezumi A, Fukada S, Yamamoto N, Takeda S, Tsuchida K Nature Cell Biol., 12, 143-152 (2010) Generation of skeletal muscle stem/progenitor cells from murine induced pluripotent stem cells Mizuno Y, Chang H, Umeda K, Niwa A, Iwasa T, Awaya T, Fukada S, Yamamoto H, Yamanaka S, Nakahata T, Heike T FASEB J., 24, 2245-2253 (2010) Genetic background affects properties of satellite cells and mdx phenotypes Fukada S, Morikawa D, Yamamoto Y, Yoshida T, Sumie N, Yamaguchi M, Ito T, Miyagoe-Suzuki Y, Takeda S, Tsujikawa K, Yamamoto H Am. J. Pathol., 176, 2414-2424 (2010) 神経ペプチドによる樹状細胞の TLR シグナルの抑制 (Review) 橋本なぎさ, 三上統久, 辻川和丈

臨床免疫・アレルギー科, 54, 505-512 (2010) 毒性学 (Toxicology) Creation of an improved mutant TNF with TNFR1-selectivity and antagonistic activity by phage

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display technology Nomura T, Abe Y, Kamada H, Inoue M, Kawara T, Arita S, Furuya T, Minowa K, Yoshioka Y, Shibata H, Kayamuro H, Yamashita T, Nagano K, Yoshikawa T, Mukai Y, Nakagawa S, Tsunoda S, Tsutsumi Y Pharmazie, 65, 93-96 (2010) Generation of mouse macrophages expressing membrane-bound TNF variants with selectivity for TNFR1 or TNFR2 Shibata H, Abe Y, Yoshioka Y, Nomura T, Sato M, Kayamuro H, Kawara T, Arita S, Furuya T, Nagano K, Yoshikawa T, Kamada H, Tsunoda S, Tsutsumi Y Cytokine, 50, 75-83 (2010) Size-dependent cytotoxic effects of amorphous silica nanoparticles on Langerhans cells Nabeshi H, Yoshikawa T, Matsuyama K, Nakazato Y, Arimori A, Isobe M, Tochigi S, Kondoh S, Hirai T, Akase T, Yamashita T, Yamashita K, Yoshida T, Nagano K, Abe Y, Yoshioka Y, Kamada H, Imazawa T, Itoh N, Tsunoda S, Tsutsumi Y Pharmazie, 65, 199-201 (2010) Mutant TNF-α, mTNF-K90R, is a novel candidate adjuvant for a mucosal vaccine against HIV Kayamuro H, Abe Y, Yoshioka Y, Katayama K, Yoshida T, Yamashita K, Yoshikawa T, Kawai Y, Mayumi T, Hiroi T, Itoh N, Nagano K, Kamada H, Tsunoda S, Tsutsumi Y Pharmazie, 65, 254-256 (2010) Carbon nanotubes elicit DNA damage and inflammatory response relative to their size and shape Yamashita K, Yoshioka Y, Higashisaka K, Morishita Y, Yoshida T, Fujimura M, Kayamuro H, Nabeshi H, Yamashita T, Nagano K, Abe Y, Kamada H, Kawai Y, Mayumi T, Yoshikawa T, Itoh N, Tsunoda S, Tsutsumi Y Inflammation, 33, 276-280 (2010) Urban aerosols induce pro-inflammatory cytokine production in macrophages and cause airway inflammation in vivo Yoshida T, Yoshioka Y, Fujimura M, Kayamuro H, Yamashita K, Higashisaka K, Nakanishi R, Morishita Y, Nabeshi H, Yamashita T, Muroi M, Tanamoto K, Nagano K, Abe Y, Kamada H, Kawai Y, Mayumi T, Itoh N, Yoshikawa T, Tsunoda S, Tsutsumi Y Biol. Pharm. Bull., 33, 780-783 (2010) Arsenic trioxide induces down-regulation of gp46 via protein oxidation: proteomics analysis of oxidative modified proteins in As2O3-treated HTLV-1-infected cells Nabeshi H, Yoshikawa T, Kamada H, Shibata H, Sugita T, Abe Y, Nagano K, Nomura T, Minowa K, Tsunoda S, Tsutsumi Y Pharmazie, 65, 702-707 (2010) Solution of the structure of the TNF-TNFR2 complex

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Mukai Y, Nakamura T, Yoshikawa M, Yoshioka Y, Tsunoda S, Nakagawa S, Yamagata Y, Tsutsumi Y Sci. Signal., 3, ra83 (2010) Interleukin-1 family cytokines as mucosal vaccine adjuvants for induction of protective immunity against influenza virus Kayamuro H, Yoshioka Y, Abe Y, Arita S, Katayama K, Nomura T, Yoshikawa T, Kubota-Koketsu R, Ikuta K, Okamoto S, Mori Y, Kunisawa J, Kiyono H, Itoh N, Nagano K, Kamada H, Tsutsumi Y, Tsunoda S J. Virol., 84, 12703-12712 (2010) Potential adjuvant effect of intranasal urban aerosols in mice through induction of dendritic cell maturation Yoshida T, Yoshioka Y, Fujimura M, Yamashita K, Higashisaka K, Nakanishi R, Morishita Y, Kayamuro H, Nabeshi H, Nagano K, Abe Y, Kamada H, Tsunoda S, Yoshikawa T, Itoh N, Tsutsumi Y Toxicol. Lett., 199, 383-388 (2010) Safety assessment of nanomaterials using toxicokinetics and toxicoproteome analysis (Review) Nabeshi H, Yoshikawa T, Imazawa T, Tsunoda S, Tsutsumi Y Yakugaku Zasshi, 130, 465-470 (2010) From disease proteomics to biomarker development －Establishment of antibody proteomics technology and exploration of cancer-related biomarkers － (Review) Nagano K, Imai S, Nakagawa S, Tsunoda S, Tsutsumi Y Yakugaku Zasshi, 130, 487-492 (2010) Application of bioactive mutant TNF alpha to a mucosal vaccine adjuvant (Review) Kayamuro H, Yoshioka Y, Abe Y, Kamada H, Tsunoda S, Tsutsumi Y Yakugaku Zasshi, 130, 55-61 (2010) Creation of TNFR1-selective antagonist and its therapeutic effects (Review) Nomura T, Abe Y, Yoshioka Y, Nakagawa S, Tsunoda S, Tsutsumi Y Yakugaku Zasshi, 130, 63-68 (2010) Development of anti-tumor blood vessel antibodies by phage display method (Review) Yamashita T, Utoguchi N, Suzuki R, Nagano K, Tsunoda S, Tsutsumi Y, Maruyama K Yakugaku Zasshi, 130, 479-485 (2010) Development of TNF-based mucosal vaccine adjuvant for targeting infectious diseases (Review) Kayamuro H, Yoshioka Y, Abe Y, Katayama K, Arita S, Nomura T, Yoshikawa T, Itoh N, Kamada H, Tsunoda S, Tsutsumi Y Adv. Exp. Med. Biol., 691, 299-304 (2010)

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Anti-inflammatory effects of a novel TNFR1-selective antagonistic TNF mutant on established murine collagen-induced arthritis (Review) Abe Y, Nomura T, Yoshioka Y, Kamada H, Tsunoda S, Tsutsumi Y Adv. Exp. Med. Biol., 691, 493-500 (2010) Nano-safety science for assuring the safety of nanomaterials (Review) Yoshioka Y, Yoshikawa T, Tsutsumi Y Nippon Eiseigaku Zasshi, 65, 487-492 (2010) 化粧品ナノマテリアルの安全性評価の現状と技術的課題～安全なナノマテリアルの開発支援

に向けて～ (Review) 吉川友章, 吉岡靖雄, 角田慎一, 堤康央 コスメティックステージ, 4, 44-48 (2010) 革新的技術/素材の恩恵を最大限に享受した豊かな社会の構築に向けて ～ナノマテリアルの

安全性確保基盤の構築を例に～ (Review) 吉川友章, 吉岡靖雄, 堤康央 生産と技術, 6, 52-56 (2010) 新規粘膜ワクチンアジュバントとしての機能性サイトカインの開発 (Review) 萱室裕之, 角田慎一, 堤康央 Drug Delivery System, 25, 22-28 (2010) 創薬プロテオミクスと DDS の融合によるバイオ医薬の開発に向けて (Review) 堤康央 Progress in Drug Delivery System, 19, 5-10 (2010) 非晶質ナノシリカの経皮吸収性/生体内動態と安全性との連関追求 (Review) 吉川友章, 吉岡靖雄, 角田慎一, 堤康央 ナノ材料のリスク評価と安全性対策 (フロンティア出版), 44-53 (2010) 神経薬理学 (Molecular Neuropharmacology) Increased ethanol preference and serotonin 1A receptor-dependent attenuation of ethanol-induced hypothermia in PACAP-deficient mice Tanaka K, Kunishige-Yamamoto A, Hashimoto H, Shintani N, Hayata A, Baba A Biochem. Biophys. Res. Commun., 391, 773-777 (2010)

Endogenous pituitary adenylate cyclase activating polypeptide is involved in suppression of edema in the ischemic brain Nakamachi T, Ohtaki H, Yofu S, Dohi K, Watanabe J, Mori H, Sato A, Hashimoto H, Shintani N,

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Baba A, Shioda S Acta Neurochir. Suppl., 106, 43-46 (2010)

Increased stathmin1 expression in the dentate gyrus of mice causes abnormal axonal arborizations Yamada K, Matsuzaki S, Hattori T, Kuwahara R, Taniguchi M, Hashimoto H, Shintani N, Baba A, Kumamoto N, Yamada K, Yoshikawa T, Katayama T, Tohyama M PLoS One, 5, e8596 (2010)

Possible association between the pituitary adenylate cyclase-activating polypeptide (PACAP) gene and major depressive disorder Hashimoto R, Hashimoto H, Shintani N, Ohi K, Hori H, Saitoh O, Kosuga A, Tatsumi M, Iwata N, Ozaki N, Kamijima K, Baba A, Takeda M, Kunugi H Neurosci. Lett., 468, 300-302 (2010)

Mice deficient in pituitary adenylate cyclase activating polypeptide display increased sensitivity to renal oxidative stress in vitro Horvath G, Mark L, Brubel R, Szakaly P, Racz B, Kiss P, Tamas A, Helyes Z, Lubics A, Hashimoto H, Baba A, Shintani N, Furjes G, Nemeth J, Reglodi D Neurosci. Lett., 469, 70-74 (2010)

PACAP-deficient mice exhibit light parameter-dependent abnormalities on nonvisual photoreception and early activity onset Kawaguchi C, Isojima Y, Shintani N, Hatanaka M, Guo X, Okumura N, Nagai K, Hashimoto H, Baba A PLoS One, 5, e9286 (2010)

Regulation of autonomic nerve activities by central pituitary adenylate cyclase-activating polypeptide Tanida M, Shintani N, Morita Y, Tsukiyama N, Hatanaka M, Hashimoto H, Sawai H, Baba A, Nagai K Regul. Pept., 161, 73-80 (2010)

15d-prostaglandin J2 enhancement of nerve growth factor-induced neurite outgrowth is blocked by the chemoattractant receptor-homologous molecule expressed on T-helper type 2 cells (CRTH2) antagonist CAY10471 in PC12 cells Hatanaka M, Shibata N, Shintani N, Haba R, Hayata A, Hashimoto H, Baba A J. Pharmacol. Sci., 113, 89-93 (2010)

Cardioprotective effect of endogenous pituitary adenylate cyclase-activating polypeptide on Doxorubicin-induced cardiomyopathy in mice Mori H, Nakamachi T, Ohtaki H, Yofu S, Sato A, Endo K, Iso Y, Suzuki H, Takeyama Y, Shintani N,

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Hashimoto H, Baba A, Shioda S Circ. J., 74, 1183-1190 (2010)

Environmental factors during early developmental period influence psychobehavioral abnormalities in adult PACAP-deficient mice Ishihama T, Ago Y, Shintani N, Hashimoto H, Baba A, Takuma K, Matsuda T Behav. Brain Res., 209, 274-280 (2010)

Comparison of intestinal cold preservation injury on pituitary adenylate cyclase-activating polypeptide in knockout and wild-type mice Ferencz A, Nedvig K, Fekecs T, Rácz B, Wéber G, Hashimoto H, Baba A, Helyes Z, Reglödi D Transplant. Proc., 42, 2290-2292 (2010)

Mice deficient in neuropeptide PACAP demonstrate increased sensitivity to in vitro kidney hypoxia Horvath G, Racz B, Szakaly P, Kiss P, Laszlo E, Hau L, Tamas A, Helyes Z, Lubics A, Hashimoto H, Baba A, Reglodi D Transplant. Proc., 42, 2293-2295 (2010)

GnRH-induced PACAP and PAC1 receptor expression in pituitary gonadotrophs: a possible role in the regulation of gonadotropin subunit gene expression Purwana IN, Kanasaki H, Oride A, Mijiddorj T, Shintani N, Hashimoto H, Baba A, Miyazaki K Peptides, 31, 1748-1755 (2010)

Impaired nocifensive behaviours and mechanical hyperalgesia, but enhanced thermal allodynia in pituitary adenylate cyclase-activating polypeptide deficient mice Sándor K, Kormos V, Botz B, Imreh A, Bölcskei K, Gaszner B, Markovics A, Szolcsányi J, Shintani N, Hashimoto H, Baba A, Reglodi D, Helyes Z Neuropeptides, 44, 363-371 (2010)

Regulation of oxidative stress by pituitary adenylate cyclase-activating polypeptide (PACAP) mediated by PACAP receptor Ohtaki H, Satoh A, Nakamachi T, Yofu S, Dohi K, Mori H, Ohara K, Miyamoto K, Hashimoto H, Shintani N, Baba A, Matsunaga M, Shioda S J. Mol. Neurosci., 42, 397-403 (2010)

Intra-islet PACAP protects pancreatic β-cells against glucotoxicity and lipotoxicity Nakata M, Shintani N, Hashimoto H, Baba A, Yada T J. Mol. Neurosci., 42, 404-410 (2010)

Presence of endogenous PACAP-38 ameliorated intestinal cold preservation tissue injury Ferencz A, Weber G, Helyes Z, Hashimoto H, Baba A, Reglodi D

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J. Mol. Neurosci., 42, 428-434 (2010)

Comparison of intestinal warm ischemic injury in PACAP knockout and wild-type mice Ferencz A, Kiss P, Weber G, Helyes Z, Shintani N, Baba A, Reglodi D J. Mol. Neurosci., 42, 435-442 (2010)

Pituitary adenylate cyclase-activating polypeptide deficiency enhances oxazolone-induced allergic contact dermatitis in mice Kemény A, Reglődi D, Cseharovszky R, Hashimoto H, Baba A, Szolcsányi J, Pintér E, Helyes Z J. Mol. Neurosci., 42, 443-449 (2010)

Apelin is a crucial factor for hypoxia-induced retinal angiogenesis Kasai A, Ishimaru Y, Kinjo T, Satooka T, Matsumoto N, Yoshioka Y, Yamamuro A, Gomi F, Shintani N, Baba A, Maeda S Arterioscler. Thromb. Vasc. Biol., 30, 2182-2187 (2010)

Phenotypic characterization of transgenic mice overexpressing neuregulin-1 Kato T, Kasai A, Mizuno M, Fengyi L, Shintani N, Maeda S, Yokoyama M, Ozaki M, Nawa H PLoS One, 5, e14185 (2010)

薬剤学 (Biotechnology and Therapeutics) Creation of lysine-deficient mutant lymphotoxin-α with receptor selectivity by using a phage display system Yoshioka Y, Watanabe H, Morishige T, Yao X, Ikemizu S, Nagao C, Ahmad S, Mizuguchi K, Tsunoda S, Tsutsumi Y, Mukai Y, Okada N, Nakagawa S Biomaterials, 31, 1935-1943 (2010) Comparison of the anti-tumor activity of native, secreted, and membrane-bound LIGHT in mouse tumor models Morishige T, Yoshioka Y, Tanabe A, Yao X, Mizuguchi H, Tsunoda S, Tsutsumi Y, Mukai Y, Okada N, Nakagawa S Int. Immunopharmacol., 10, 26-33 (2010) Cancer gene therapy by IL-12 gene delivery using liposomal bubbles and tumoral ultrasound exposure Suzuki R, Namai E, Oda Y, Nishiie N, Otake S, Koshima R, Hirata K, Taira Y, Utoguchi N, Negishi Y, Nakagawa S, Maruyama K J. Control. Release, 142, 245-250 (2010) Titanium dioxide induces different levels of IL-1β production dependent on its particle

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characteristics through caspase-1 activation mediated by reactive oxygen species and cathepsin B Morishige T, Yoshioka Y, Tanabe A, Yao X, Tsunoda S, Tsutsumi Y, Mukai Y, Okada N, Nakagawa S Biochem. Biophys. Res. Commun., 392, 160-165 (2010) Evaluation of synthetic cell-penetrating peptides, pro-rich Peptide and octaargine derivatives, as adenovirus vector carrier Kida S, Eto Y, Yoshioka Y, Nakagawa S, Kawasaki K, Maeda M Protein Pept. Lett., 17, 164-167 (2010) Creation of a lysine-deficient LIGHT mutant with the capacity for site-specific PEGylation and low affinity for a decoy receptor Morishige T, Yoshioka Y, Inakura H, Tanabe A, Yao X, Tsunoda S, Tsutsumi Y, Mukai Y, Okada N, Nakagawa S Biochem. Biophys. Res. Commun., 393, 888-893 (2010) Tumor-targeting CTL expressing a single-chain Fv specific for VEGFR2 Kanagawa N, Yanagawa T, Mukai Y, Yoshioka Y, Okada N, Nakagawa S Biochem. Biophys. Res. Commun., 394, 54-58 (2010) Creation of a LIGHT mutant with the capacity to evade the decoy receptor for cancer therapy Morishige T, Yoshioka Y, Inakura H, Tanabe A, Yao X, Tsunoda S, Tsutsumi Y, Mukai Y, Okada N, Nakagawa S Biomaterials, 31, 3357-3363 (2010) Creation of an improved mutant TNF with TNFR1-selectivity and antagonistic activity by phage display technology Nomura T, Abe Y, Kamada H, Inoue M, Kawara T, Arita S, Furuya T, Minowa K, Yoshioka Y, Shibata H, Kayamuro H, Yamashita T, Nagano K, Yoshikawa T, Mukai Y, Nakagawa S, Tsunoda S, Tsutsumi Y Pharmazie, 65, 93-96 (2010) The effect of surface modification of amorphous silica particles on NLRP3 inflammasome mediated IL-1β production, ROS production and endosomal rupture Morishige T, Yoshioka Y, Inakura H, Tanabe A, Yao X, Narimatsu S, Monobe Y, Imazawa T, Tsunoda S, Tsutsumi Y, Mukai Y, Okada N, Nakagawa S Biomaterials, 31, 6833-6842 (2010) Simple PEG conjugation of SPIO via an Au-S bond improves its tumor targeting potency as a novel MR tumor imaging agent Kojima H, Mukai Y, Yoshikawa M, Kamei K, Yoshikawa T, Morita M, Inubushi T, Yamamoto TA, Yoshioka Y, Okada N, Seino S, Nakagawa S Bioconjug. Chem., 21, 1026-1031 (2010)

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Optimized PEGylated adenovirus vector reduces the anti-vector humoral immune response against adenovirus and induces a therapeutic effect against metastatic lung cancer Eto Y, Yoshioka Y, Ishida T, Yao X, Morishige T, Narimatsu S, Mizuguchi H, Mukai Y, Okada N, Kiwada H, Nakagawa S Biol. Pharm. Bull., 33, 1540-1544 (2010) Cytotoxicity of amorphous silica particles against macrophage-like THP-1 cells depends on particle-size and surface properties Morishige T, Yoshioka Y, Inakura H, Tanabe A, Yao X, Tsunoda S, Tsutsumi Y, Mukai Y, Okada N, Nakagawa S Pharmazie, 65, 596-599 (2010) The utility of poly(γ-glutamic acid) nanoparticles as antigen delivery carriers in dendritic cell-based cancer immunotherapy Matsuo K, Ishii Y, Matsuo K, Yoshinaga T, Akashi M, Mukai Y, Yoshioka Y, Okada N, Nakagawa S Biol. Pharm. Bull., 33, 2003-2007 (2010) Solution of the structure of the TNF-TNFR2 complex Mukai Y, Nakamura T, Yoshikawa M, Yoshioka Y, Tsunoda S, Nakagawa S, Yamagata Y, Tsutsumi Y Sci. Signal., 3, ra83 (2010) A phagocytotic inducer from herbal constituent, pentagalloylglucose enhances lipoplex-mediated gene transfection in dendritic cells Kato S, Koizumi K, Yamada M, Inujima A, Takeno N, Nakanishi T, Sakurai H, Nakagawa S, Saiki I Biol. Pharm. Bull., 33, 1878-1885 (2010) Adenovirus vector covalently conjugated to polyethylene glycol with a cancer-specific promoter suppresses the tumor growth through systemic administration Yao X, Yoshioka Y, Morishige T, Eto Y, Narimatsu S, Mizuguchi H, Mukai Y, Okada N, Nakagawa S Biol. Pharm. Bull., 33, 1073-1076 (2010) 感染症予防対策に向けた新規経皮ワクチン製剤の開発 (Review) 松尾一彦, 岡田直貴, 中川晋作 臨床と微生物, 37, 207-212 (2010) 新規経皮ワクチンデバイスを用いた「貼るワクチン」の開発 (Review) 松尾一彦, 権英淑, 岡田直貴, 中川晋作 BIO Clinica, 25, 401-405 (2010) DDS 技術を基盤とした経皮ワクチン製剤の開発 (Review) 松尾一彦, 岡田直貴, 中川晋作

Drug Delivery System, 25, 8-14 (2010)

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腫瘍標的ＭＲイメージングにおける造影剤開発 (Review) 向洋平, 中川晋作

JSMI Report, 3, 14-17 (2010) Ⅰ型 TNF 受容体選択的アンタゴニストの創出とその自己免疫疾患治療薬としての可能性

(Review) 野村鉄也, 阿部康弘, 吉岡靖雄, 中川晋作, 角田慎一, 堤康央

薬学雑誌, 130, 63-68 (2010) 経皮吸収型ワクチン製剤の開発 松尾一彦, 岡田直貴, 中川晋作

次世代ワクチンの産業応用技術 (シーエムシー出版), 104-111 (2010) 天然物化学 (Natural Products Chemistry) Hypoxia-selective growth inhibition of cancer cells by furospinosulin-1, a furanosesterterpene isolated from an Indonesian marine sponge Arai M, Kawachi T, Setiawan A, Kobayashi M ChemMedChem, 5, 1919-1926 (2010) Probe molecule equipped with boronic acid moiety as a reversible cross-linking group improves its binding affinity Kotoku N, Guo X, Arai M, Kobayashi M Bioorg. Med. Chem. Lett., 20, 4152-4155 (2010) Trichoderins, novel aminolipopeptides from a marine sponge-derived Trichoderma sp., are active against dormant mycobacteria Pruksakorn P, Arai M, Kotoku N, Vilchèze C, Baughn AD, Moodley P, Jacobs WR Jr, Kobayashi M Bioorg. Med. Chem. Lett., 20, 3658-3663 (2010) 海洋生物からの医薬シーズの探索 荒井雅吉, 小林資正 有機合成化学協会誌, 68, 470-479 (2010) 薬物治療学 (Medicinal Pharmacology) Environmental factors during early developmental period influence psychobehavioral abnormalities in adult PACAP-deficient mice Ishihama T, Ago Y, Shintani N, Hashimoto H, Baba A, Takuma K, Matsuda T Behav. Brain Res., 209, 274-280 (2010)

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Effects of acute and chronic administration of atomoxetine and methylphenidate on extracellular levels of noradrenaline, dopamine and serotonin in the prefrontal cortex and striatum of mice Koda K, Ago Y, Cong Y, Kita Y, Takuma K, Matsuda T J. Neurochem., 114, 259-270 (2010) The Na+/Ca2+ exchanger-mediated Ca2+ influx triggers nitric oxide-induced cytotoxicity in cultured astrocytes Kitao T, Takuma K, Kawasaki T, Inoue Y, Ikehara A, Nashida T, Ago Y, Matsuda T Neurochem. Int., 57, 58-66 (2010) Stress-evoked tyrosine phosphorylation of signal regulatory protein α regulates behavioral immobility in the forced swim test Ohnishi H, Murata T, Kusakari S, Hayashi Y, Takao K, Maruyama T, Ago Y, Koda K, Jin FJ, Okawa K, Oldenborg PA, Okazawa H, Murata Y, Furuya N, Matsuda T, Miyakawa T, Matozaki T J. Neurosci., 30, 10472-10483 (2010) Protein aggregation in neurons following OGD: a role for Na+ and Ca2+ ionic dysregulation Chen X, Kintner DB, Baba A, Matsuda T, Shull GE, Sun D J. Neurochem., 112, 173-182 (2010) Excessive Na+/H+ exchange in disruption of dendritic Na+ and Ca2+ homeostasis and mitochondrial dysfunction following in vitro ischemia Kintner DB, Chen X, Currie J, Chanana V, Ferrazzano P, Baba A, Matsuda T, Cohen M, Orlowski J, Chiu SY, Taunton J, Sun D J. Biol. Chem., 285, 35155-35168 (2010) Ca2+ extrusion via Na+-Ca2+ exchangers in rat odontoblasts Tsumura M, Okumura R, Tatsuyama S, Ichikawa H, Muramatsu T, Matsuda T, Baba A, Suzuki K, Kajiya H, Sahara Y, Tokuda M, Momose Y, Tazaki M, Shimono M, Shibukawa Y J. Endod., 36, 668-674 (2010) Alterations of emotional and cognitive behaviors in matrix metalloproteinase-2 and -9-deficient mice Mizoguchi H, Ibi D, Takuma K, Toth E, Sato J, Itohara S, Nabeshima T, Yamada K The Open Behavioral Science Journal, 4, 19-25 (2010) 感覚情報処理機能障害に対するガランタミンの有効性とそのメカニズム (Review) 吾郷由希夫 薬学雑誌, 130, 1305-1310 (2010)

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臨床薬効解析学 (Clinical Pharmacology and Pharmacogenomics) Therapeutic activation of signal transducer and activator of transcription 3 by interleukin-11 ameliorates cardiac fibrosis after myocardial infarction Obana M, Maeda M, Takeda K, Hayama A, Mohri T, Yamashita T, Nakaoka Y, Komuro I, Takeda K, Matsumiya G, Azuma J, Fujio Y Circulation, 121, 684-691 (2010) SHP2 mediates gp130-dependent cardiomyocyte hypertrophy via negative regulation of skeletal alpha-actin gene Nakaoka Y, Shioyama W, Kunimoto S, Arita Y, Higuchi K, Yamamoto K, Fujio Y, Nishida K, Kuroda T, Hirota H, Yamauchi-Takihara K, Hirano T, Komuro I, Mochizuki N J. Mol. Cell. Cardiol., 49, 157-164 (2010) RGS2 determines the preventive effects of ARB against vascular remodeling: Toward personalized medicine of ARB in anti-hypertensive therapy Fujio Y Hypertension Res., 33, 1221-1222 (2010) Pharmacogenomics of adrenergic receptors; from hypertension to heart failurer Nonen S, Azuma J, Fujio Y The Open hypertension J., 3, 14-18 (2010) Cardiac and skeletal muscle abnormality in taurine transporter-knockout mice Ito T, Oishi S, Takai M, Kimura Y, Uozumi Y, Fujio Y, Schaffer SW, Azuma J J. Biomed. Sci., 17(Suppl 1), S20 (2010) Increasing cardiac contractility after myocardial infarction exacerbates cardiac injury and pump dysfunction Zhang H, Chen X, Gao E, MacDonnell SM, Wang W, Kolpakov M, Nakayama H, Zhang X, Jaleel N, Harris DM, Li Y, Tang M, Berretta R, Leri A, Kajstura J, Sabri A, Koch WJ, Molkentin JD, Houser SR Circ. Res., 107, 800-809 (2010) The IP3 receptor regulates cardiac hypertrophy in response to select stimuli Nakayama H, Bodi I, Maillet M, DeSantiago J, Domeier TL, Mikoshiba K, Lorenz JN, Blatter LA, Bers DM, Molkentin JD Circ. Res., 107, 659-666 (2010) Enhanced basal contractility but reduced excitation-contraction coupling efficiency and β- adrenergic reserve of hearts with increased Cav1.2 acitvity Tang M, Zhang X, Li Y, Guan Y, Ai X, Szeto C, Nakayama H, Zhang H, Ge S, Molkentin JD, Houser SR, Chen X

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Am. J. Physiol. Heart Circ. Physiol., 299, H519-H528 (2010) IL-11 の心血管系における作用 (Review) 尾花理徳，前田真貴子，藤尾慈 循環器内科, 67, 156-162 (2010) 分子生理病態学 (Molecular Pathophysiology) Genetic analysis of young adult patients with aortic disease not fulfilling the diagnostic criteria for Marfan syndrome Akutsu K, Morisaki H, Okajima T, Yoshimuta T, Tsutsumi Y, Takeshita S, Nonogi H, Ogino H, Higashi M, Morisaki T Circ. J., 74, 990-997 (2010) The cellular prion protein identifies bipotential cardiomyogenic progenitors Hidaka K, Shirai M, Lee JK, Wakayama T, Kodama I, Schneider MD, Morisaki T Circ. Res., 106, 111-119 (2010) Nongenetic method for purifying stem cell-derived cardiomyocytes Hattori F, Chen H, Yamashita H, Tohyama S, Satoh Y, Yuasa S, Li W, Yamakawa H, Tanaka T, Onitsuka T, Shimoji K, Ohno Y, Egashira T, Kaneda R, Murata M, Hidaka K, Morisaki T, Sasaki E, Suzuki T, Sano M, Makino S, Oikawa S, Fukuda K Nat. Methods, 7, 61-66 (2010) A novel Thr56Met mutation of the autosomal recessive hypercholesterolemia gene associated with hypercholesterolemia Harada K, Miyamoto Y, Morisaki H, Ohta N, Yamanaka I, Kokubo Y, Makino H, Harada-Shiba M, Okayama A, Tomoike H, Okamura T, Saito Y, Yoshimasa Y, Morisaki T J. Atheroscler. Thromb., 17, 131-140 (2010) Differentiation of pharyngeal endoderm from mouse embryonic stem cell Hidaka K, Nitta T, Sugawa R, Shirai M, Schwartz RJ, Amagai T, Nitta S, Takahama Y, Morisaki T Stem Cells Dev., 19, 1735-1743 (2010) Association of four genetic loci with uric acid levels and reduced renal function: the J-SHIPP Suita study Tabara Y, Kohara K, Kawamoto R, Hiura Y, Nishimura K, Morisaki T, Kokubo Y, Okamura T, Tomoike H, Iwai N, Miki T Am. J. Nephrol., 32, 279-286 (2010) Establishment and analysis of SLC22A12 (URAT1) knockout mouse

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Hosoyamada M, Takiue Y, Morisaki H, Cheng J, Ikawa M, Okabe M, Morisaki T, Ichida K, Hosoya T, Shibasaki T Nucleosides Nucleotides Nucleic Acids, 29, 314-320 (2010) RNA-binding motif protein 24 regulates myogenin expression and promotes myogenic differentiation Jin D, Hidaka K, Shirai M, Morisaki T Genes Cells, 15, 1158-1167 (2010) Common variants in the ATP2B1 gene are associated with susceptibility to hypertension: The Japanese Millennium Genome Project Tabara Y, Kohara K, Kita Y, Hirawa N, Katsuya T, Ohkubo T, Hiura Y, Tajima A, Morisaki T, Miyata T, Nakayama T, Takashima N, Nakura J, Kawamoto R, Takahashi N, Hata A, Soma M, Imai Y, Kokubo Y, Okamura T, Tomoike H, Iwai N, Ogihara T, Inoue I, Tokunaga K, Johnson T, Caulfield M, Munroe P on behalf of the Global Blood Pressure Genetics Consortium, Umemura S, Ueshima H, Miki T Hypertension, 56, 973-980 (2010) C-reactive protein uptake by macrophage cell line via class-A scavenger receptor Fujita Y, Kakino A, Harada-Shiba M, Sato Y, Otsui K, Yoshimoto R, Sawamura T Clin. Chem., 56, 478-481 (2010) LOX index, a novel predictive biochemical marker for coronary heart disease and stroke Inoue N, Okamura T, Kokubo Y, Fujita Y, Sato Y, Nakanishi M, Yanagida K, Kakino A, Iwamoto S, Watanabe M, Ogura S, Otsui K, Matsuda H, Uchida K, Yoshimoto R, Sawamura T Clin. Chem., 56, 550-558 (2010) Induction of hypertrophic chondrocyte-like phenotypes by oxidized LDL in cultured bovine articular chondrocytes through increase in oxidative stress Kishimoto H, Akagi M, Zushi S, Teramura T, Onodera Y, Sawamura T, Hamanishi C Osteoarthritis Cartilage, 18, 1284-1290 (2010) Pitavastatin reduces lectin-like oxidized low-density lipoprotein receptor-1 ligands in hypercholesterolemic humans Matsumoto T, Fujita M, Sawamura T, Kakino A, Sato Y, Fujita Y, Matsuda H, Nakanishi M, Uchida K, Nakae I, Kanda H, Yoshida A, Miwa K, Hayashi H, Mitsunami K, Horie M Lipids, 45, 329-335 (2010) High efficiency CD91- and LOX-1-mediated re-presentation of gp96-chaperoned peptides by MHC II molecules Matsutake T, Sawamura T, Srivastava PK Cancer Immun., 10, 7 (2010)

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LOX-1 mediates vascular lipid retention under hypertensive state Nakano A, Inoue N, Sato Y, Nishimichi N, Takikawa K, Fujita Y, Kakino A, Otsui K, Yamaguchi S, Matsuda H, Sawamura T J. Hypertens., 28, 1273-1280 (2010) Dihydrotestosterone suppresses foam cell formation and attenuates atherosclerosis development Qiu Y, Yanase T, Hu H, Tanaka T, Nishi Y, Liu M, Sueishi K, Sawamura T, Nawata H Endocrinology, 151, 3307-3316 (2010) Lectin-like oxidized low-density lipoprotein receptor-1 is required for the adipose tissue expression of proinflammatory cytokines in high-fat diet-induced obese mice Takanabe-Mori R, Ono K, Sowa N, Wada H, Takaya T, Horie T, Satoh-Asahara N, Shimatsu A, Fujita M, Sawamura T, Hasegawa K Biochem. Biophys. Res. Commun., 398, 576-580 (2010) Left ventricular expression of lectin-like oxidized low-density lipoprotein receptor-1 in failing rat hearts Takaya T, Wada H, Morimoto T, Sunagawa Y, Kawamura T, Takanabe-Mori R, Shimatsu A, Fujita Y, Sato Y, Fujita M, Kimura T, Sawamura T, Hasegawa K Circ. J., 74, 723-729 (2010) Aldosterone augments LOX-1-mediated low-density lipoprotein uptake in human umbilical artery endothelial cells Taye A, Sawamura T, Morawietz H Pharmacol. Rep., 62, 311-318 (2010) 肺高血圧の遺伝子異常 (Review) 森崎裕子, 森崎隆幸 Annual Review 循環器, 227-234 (2010) 尿酸の代謝経路 (Review) 森崎隆幸, 森崎裕子 綜合臨牀, 59, 184-189 (2010) インフォームド・コンセントと倫理委員会 (Review) 森崎隆幸 日本臨牀, 68 (suppl 8), 317-321 (2010) 分子遺伝疫学の倫理的課題と人権 (Review) 森崎隆幸 公衆衛生, 74, 768-771 (2010)

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遺伝子診断をどうするか (Review) 森崎隆幸, 森崎裕子 血管疾患を診る・治す (新・心臓病診療プラクティス１５) (文光堂), 194-195 (2010) 臨床薬物学 (Clinical Pharmaceuticals) Evaluation of environmental contaminations and occupational exposures involved in preparation of chemotherapeutic drugs Maeda S, Miyawaki K, Matsumoto S, Oishi M, Miwa Y, Kurokawa N Yakugaku Zasshi, 130, 903-910 (2010) The impact of antimicrobial stewardship by infection control team in a Japanese Teaching Hospital Miyawaki K, Miwa Y, Tomono K, Kurokawa N Yakugaku Zasshi, 130, 1105-1111 (2010) 遺伝子機能解析学 (Experimental Genome Research) A newly cloned pig dolichyl-phosphate mannosyltransferase for preventing the transmission of porcine endogenous retrovirus to human cells Yamamoto A, Nakatsu S, Kondo A, Asato T, Okabe M, Fukuzawa M, Miyagawa S Transpl. Int., 23, 424-431 (2010) Expression of complement regulatory protein on porcine endogenous retrovirus (PERV) depends on molecular size Yamamoto A, Kobayashi C, Yamashita S, Miyazawa T, Okabe M, Fukuzawa M, Miyagawa S Transpl. Immunol., 23, 71-76 (2010) The ubiquitin ligase Riplet is essential for RIG-I-dependent innate immune responses to RNA virus infection Oshiumi H, Miyashita M, Inoue N, Okabe M, Matsumoto M, Seya T Cell Host Microbe, 8, 496-509 (2010) Novel method of gene transfer in birds: intracytoplasmic sperm injection for green fluorescent protein expression in quail blastoderms Mizushima S, Takagi S, Ono T, Atsumi Y, Tsukada A, Saito N, Sasanami T, Okabe M, Shimada K Biol. Reprod., 83, 965-969 (2010) Complement regulation in the GalT KO era Miyagawa S, Yamamoto A, Matsunami K, Wang D, Takama Y, Ueno T, Okabe M, Nagashima H,

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Fukuzawa M Xenotransplantation, 17, 11-25 (2010) Survey of glycoantigens in cells from α1-3galactosyltransferase knockout pig using a lectin microarray Miyagawa S, Takeishi S, Yamamoto A, Ikeda K, Matsunari H, Yamada M, Okabe M, Miyoshi E, Fukuzawa M, Nagashima H Xenotransplantation, 17, 61-70 (2010) The X-linked imprinted gene family Fthl17 shows predominantly female expression following the two-cell stage in mouse embryos Kobayashi S, Fujihara Y, Mise N, Kaseda K, Abe K, Ishino F, Okabe M Nucleic Acids Res., 38, 3672-3681 (2010) Identification and disruption of sperm-specific angiotensin converting enzyme-3 (ACE3) in mouse Inoue N, Kasahara T, Ikawa M, Okabe M PLoS ONE, 5, e10301 (2010) Humanized gene replacement in mice reveals the contribution of cancer stroma-derived HB-EGF to tumor growth Ichise T, Adachi S, Ohishi M, Ikawa M, Okabe M, Iwamoto R, Mekada E Cell Struct. Funct., 35, 3-13 (2010) Establishment and analysis of SLC22A12 (URAT1) knockout mouse Hosoyamada M, Takiue Y, Morisaki H, Cheng J, Ikawa M, Okabe M, Morisaki T, Ichida K, Hosoya T, Shibasaki T Nucleosides Nucleotides Nucleic Acids, 29, 314-320 (2010) Transgenic mouse sperm that have green acrosome and red mitochondria allow visualization of sperm and their acrosome reaction in vivo Hasuwa H, Muro Y, Ikawa M, Kato N, Tsujimoto Y, Okabe M Exp. Anim., 59, 105-107 (2010) Sperm equatorial segment protein 1, SPESP1, is required for fully fertile sperm in mouse Fujihara Y, Murakami M, Inoue N, Satouh Y, Kaseda K, Ikawa M, Okabe M J. Cell. Sci., 123, 1531-1536 (2010) Fertilization: a sperm's journey to and interaction with the oocyte (Review) Ikawa M, Inoue N, Benham AM, Okabe M J. Clin. Invest., 120, 984-994 (2010)

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医薬基盤科学 (Biomedical Innovation) Induction of type I interferon by adenovirus-encoded small RNAs Yamaguchi T, Kawabata K, Kouyama E, Ishii KJ, Katayama K, Suzuki T, Kurachi S, Sakurai F, Akira S, Mizuguchi H Proc. Natl. Acad. Sci. USA, 107, 17286-17291 (2010) Adenovirus serotype 35 vector-induced innate immune responses in dendritic cells derived from wild-type and human CD46-transgenic mice: Comparison with a fiber-substituted Ad vector containing fiber proteins of Ad serotype 35 Sakurai F, Nakashima K, Yamaguchi T, Ichinose T, Kawabata K, Hayakawa T, Mizuguchi H J. Control. Release, 148, 212-218 (2010) Adenovirus vector-mediated efficient transduction into human embryonic and induced pluripotent stem cells Tashiro K, Kawabata K, Inamura M, Takayama K, Furukawa N, Sakurai F, Katayama K, Hayakawa T, Furue-Kusuda M, Mizuguchi H Cell. Reprogram., 12, 501-507 (2010) Prevention of hepatic ischemia-reperfusion injury by pre-administration of catalase-expressing adenovirus vectors Ushitora M, Sakurai F, Yamaguchi T, Nakamura S, Kondoh M, Yagi K, Kawabata K, Mizuguchi H J. Control. Release, 142, 431-437 (2010) In vivo biotinylation of the vasculature in B-cell lymphoma identifies BST-2 as a target for antibody-based therapy Schliemann C, Roesli C, Kamada H, Borgia B, Fugmann T, Klapper W, Neri D Blood, 115, 736-744 (2010) Human herpesvirus 6 encoded glycoprotein Q1 gene is essential for virus growth Tang H, Kawabata A, Yoshida M, Oyaizu H, Maeki T, Yamanishi K, Mori Y Virology, 407, 360-367 (2010) Characterization of varicella-zoster virus-encoded ORF0 gene comparison of parental and vaccine strains Koshizuka T, Ota M, Yamanishi K, Mori Y Virology, 405, 280-288 (2010) Rapid and efficient introduction of a foreign gene into bacterial artificial chromosome-cloned varicella vaccine by Tn7-mediated site-specific transposition Somboonthum P, Koshizuka T, Okamoto S, Matsuura M, Gomi Y, Takahashi M, Yamanishi K, Mori Y Virology, 402, 215-221 (2010)

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Characterization of the varicella-zoster virus ORF50 gene, which encodes glycoprotein M Sadaoka T, Yanagi T, Yamanishi K, Mori Y J. Virol., 84, 3488-3502 (2010) Anti-inflammatory effects of a novel TNFR1-selective antagonistic TNF mutant on established murine collagen-induced arthritis (Review) Abe Y, Nomura T, Yoshioka Y, Kamada H, Tsunoda S, Tsutsumi Y Adv. Exp. Med. Biol., 691, 493-500 (2010) iPS 細胞への遺伝子導入を用いた分化誘導の最適化 (Review) 川端健二, 田代克久, 水口裕之 薬学雑誌, 130, 1527-1534 (2010) 疾患プロテオミクスからバイオマーカーの創出へ ー抗体プロテオミクス技術の確立とがん

関連マーカーの探索― (Review) 長野一也, 今井直, 中川晋作, 角田慎一, 堤康央 薬学雑誌, 130, 487-492 (2010) ポストゲノム新時代の創薬基盤技術開発研究 ～創薬バイオマーカーの探索研究を例に～ (Review) 長野一也, 鍋師裕美，角田慎一 薬学雑誌, 130, 463-464 (2010) 抗体プロテオミクス技術による乳がん関連バイオマーカーの探索とその評価 (Review) 長野一也 薬学雑誌, 130, 1701-1706 (2010) 創薬バイオマーカー蛋白質の効率的な探索基盤「抗体プロテオミクス技術」の開発 (Review) 長野一也 Drug Delivery System, 25, 428-429 (2010) 衛生・微生物学 (Environmental Science and Microbiology) Rapid enumeration of respiratory active mycobacteria with fluorescent double staining Ichijo T, Izumi Y, Yamaguchi N, Nasu M J. Microbiol. Methods, 82, 327-329 (2010) High-frequency phage-mediated gene transfer in freshwater environments determined at single-cell level Kenzaka T, Tani K, Nasu M ISME Journal, 4, 648-659 (2010)

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Transfer of a phage T4 gene into Enterobacteriaceae, determined at the single-cell level Kenzaka T, Nasu M, Tani K Appl. Environ. Microbiol., 76, 1274-1277 (2010) Soil microbial community structure in an Asian dust source region (Loess plateau) Kenzaka T, Sueyoshi A, Baba T, Li PF, Tani K, Yamaguchi N, Nasu M Microbes Environ., 25, 53-57 (2010) Similarity of bacterial community structure between Asian dust and its sources determined by rRNA gene-targeted approaches Nishimura Y, Kenzaka T, Sueyoshi A, Li PF, Fujiyama H, Baba T, Yamaguchi N, Nasu M Microbes Environ., 25, 22-27 (2010) Simple and reliable swabbing procedure for monitoring microbes in the International Space Station Yamaguchi N, Hieda H, Nasu M Eco-Engineering, 22, 27-30 (2010) Oligonucleotide probes for phylogenetic detection of waterborne bacteria Ichijo T, Yamaguchi N, Tani K, Nasu M J. Health Sci., 56, 321-325 (2010) A great leap forward in microbial ecology (Review) Okabe S, Oshiki M, Kamagata Y, Yamaguchi N, Toyofuku M, Yawata Y, Tashiro Y, Nomura N, Ohta H, Ohkuma M, Hiraishi A, Minamisawa K Microbes Environ., 25, 230-240 (2010) 環境の変化と微生物生態系 (Review) 那須正夫 化学療法の領域, 26, 2372-2376 (2010) 環境微生物検出技術のイノベーション (Review) 山口進康 化学療法の領域, 26, 2434-2444 (2010) 地球を巡る微生物－健康な生活を保証する (Review) 山口進康, 那須正夫 ファルマシア, 46, 659-663 (2010) 生命情報解析学 ( Molecular Medicine )

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Structural and dynamic features of the MutT protein in the recognition of nucleotides with the mutagenic 8-oxoguanine base Nakamura T, Meshitsuka S, Kitagawa S, Abe N, Yamada J, Ishino T, Nakano H, Tsuzuki T, Doi T, Kobayashi Y, Fujii S, Sekiguchi M, Yamagata Y J. Biol. Chem., 285, 444-452 (2010) Sterol-regulatory-element-binding protein 2 and nuclear factor Y control human farnesyl diphosphate synthase expression and affect cell proliferation in hepatoblastoma cells Ishimoto K, Tachibana K, Hanano I, Yamasaki D, Nakamura H, Kawai M, Urano Y, Tanaka T, Hamakubo T, Sakai J, Kodama T, Doi T Biochem. J., 429, 347-357 (2010) Estrogen attenuates vascular remodeling in Lp(a) transgenic mice Nakagami F, Nakagami H, Osako MK, Iwabayashi M, Taniyama Y, Doi T, Shimizu H, Shimamura M, Rakugi H, Morishita R Atherosclerosis, 211, 41-47 (2010) in vitro と in vivo で異なるレポータージーンアッセイの結果 (Review) 岡田欣晃, 土井健史 生産と技術, 62, 51-56 (2010) 情報・計量薬学 (Pharmainformatics and Pharmacometrics) Ecotoxicity prediction using 3D descriptors Hidaka S, Shiraishi H, Ohmayu Y, Yamasaki H, Okamoto K, Kawashita N, Yasunaga T, Takagi T J. Comput. Aided Chem., 11, 11-18 (2010) Highly conserved sequences for human neutralization epitope on hemagglutinin of influenza A viruses H3N2, H1N1 and H5N1: Implication for human monoclonal antibody recognition Yamashita A, Kawashita N, Kubota-Koketsu R, Inoue Y, Watanabe Y, Ibrahim MS, Ideno S, Yunoki M, Okuno Y, Takagi T, Yasunaga T, Ikuta K Biochem. Biophys. Res. Commun., 393, 614-618 (2010) Nonlinear classification of hERG channel inhibitory activity by unsupervised classification method Hidaka S, Yamasaki H, Ohmayu Y, Matsuura A, Okamoto K, Kawashita N, Takagi T J. Toxicol. Sci., 35, 393-399 (2010) Can anti-infective drugs improve the infection-related symptoms of patients with cancer during the terminal stages of their lives? Nakagawa S, Toya Y, Okamoto Y, Tsuneto S, Goya S, Tanimukai H, Matsuda Y, Ohno Y, Eto H,

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Tsugane M, Takagi T, Uejima E J. Palliative Med., 13, 535-540 (2010) Statistical examination to determine whether only 48-h value for serum concentration during high-dose methotrexate therapy is a predictor for clinical adverse events using ordered logistic regression analysis Kanbayashi Y, Nomura K, Okamoto K, Matsumoto Y, Horiike S, Takagi T, Taniwaki M Ann. Hematology, 89, 965-969 (2010) Design and evaluation of antiretroviral peptides corresponding to the C-terminal heptad repeat region (C-HR) of human immunodeficiency virus type 1 envelope glycoprotein gp41 Soonthornsata B, Tian YS, Utachee P, Sapsutthipas S, Isarangkura-na-ayuthaya P, Auwanit W, Takagi T, Ikuta K, Sawanpanyalert P, Kawashita N, Kameoka M Virology, 405, 157-164 (2010) Statistical identification of predictors for peripheral neuropathy associated with administration of bortezomib, taxanes, oxaliplatin or vincristine using ordered logistic regression analysis Kanbayashi Y, Hosokawa T, Okamoto K, Konishi H, Otsuji E, Yoshikawa T, Takagi T, Taniwaki M Anti-Cancer Drugs, 21, 877-881 (2010) 機械学習の美学

高木達也

CICSJ Bull., 27, 137-139 (2009) (2010 年 2 月発行) Structure of the prion protein and its gene: an analysis using bioinformatics and computer simulation (Review) Sakudo A, Xue G, Kawashita N, Ano Y, Takagi T, Shintani H, Tanaka Y, Onodera T, Ikuta K Curr. Protein Pept. Sci., 11, 166-179 (2010) 環境病因病態学 (Clinical and Experimental Pathophysiology) Renal angiomyolipoma with pseudocapsule mimicking renal cell carcinoma Itou Y, Nakanishi K, Nishizawa Y Eur. J. Radiol. Ex., 74, e1-e3 (2010) The pure anti-androgen bicalutamide inhibits cyclin A expression both in androgen-dependent and -independent cell lines Katayama H, Murashima T, Saeki Y, Nishizawa Y Int. J. Oncol., 36, 553-562 (2010)

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伝統医薬解析学 (Applied Pharmacognosy) Curdione plays an important role in the inhibitory effect of Curcuma aromatica on CYP3A4 in Caco-2 cells Hou XL, Hayashi-Nakamura E, Takatani-Nakase T, Tanaka K, Takahashi K, Komatsu K, Takahashi K Evid. Based Complement. Alternat. Med., (2010) doi: 10.1093/ecam/nep229 Quality and safety issues related to traditional animal medicine: role of taurine Takahashi K, Azuma Y, Shimada K, Saito T, Kawase M, Schaffer SW J. Biomed. Sci., 17(Suppl 1), S44 (2010) The relation between clinical effects of Tokishakuyakusan and the identity of Paeonia lactiflora materials Shimada K, Kawase M, Shibahara N, Nakamura Y, Saito T, Takahashi K J. Ethnopharmacol., 132, 438-442 (2010) 和漢薬の特質 ：ウコン類生薬における品質の多様性 (Review) 高橋京子 生物工学会誌, 88, 395-398 (2010) An approach towards avoidance of pharmacokinetic interaction by Kampo formulations (Review) Takahashi K, Takahashi Ko Basics of Evidences-based Herbal Medicine (Research Signpost), 19-36 (2010) Potentiality of Chinese traditional medicine, danshen (Salvia miltiorrhiza), as a preventive medicine in cardiovascular diseases (Review) Takahashi K Basics of Evidences-based Herbal Medicine (Research Signpost), 69-88 (2010) 病院薬学教育研究部 (Hospital Pharmacy Education) A retrospective chart review of opioid-induced nausea and somnolence on commencement for cancer pain treatment Okamoto Y, Tsuneto S, Tsugane M, Takagi T, Uejima E J. Opioid Management, 6, 431-434 (2010) Light-induced deterioration test of carboplatin under clinical settings Okamoto Y, Tazumi K, Sanada Y, Tsugane M, Uejima E YAKUGAKU ZASSHI, 130, 1369-1374 (2010)

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Can anti-infective drugs improve the infection-related symptoms of patients with cancer during the terminal stages of their lives? Nakagawa S, Toya Y, Okamoto Y, Tsuneto S, Goya S, Tanimukai H, Matsuda Y, Ohno Y, Eto H, Tsugane M, Takagi T, Uejima E J. Palliative Medicine, 13, 535-540 (2010) Do different opioids for cancer pain differ in incidences of nausea and somnolence during the commencing time? Okamoto Y, Tsuneto S, Tsugane M, Takagi T, Tanimukai H, Uejima E Palliative Medicine, 24, S113 (2010) 癌性疼痛管理における強オピオイド徐放性製剤の搬送・投薬にかかわる業務量および経済性

の検討 岡本禎晃, 薮本千鶴, 中島季代子, 荒木浩, 山中吉隆, 上島悦子 新薬と臨牀, 59, 919-923 (2010) 緩和ケアチームにおける服薬指導－大阪大学医学部附属病院緩和ケアチームの場合 沖代奈央, 大野由美子, 岡本禎晃 緩和ケア, 20(Suppl.), 16-27 (2010) 臨床薬学エッセンシャル (4) 欧米と日本の臨床薬学のエポックと今日の臨床薬学 (Review) 上島悦子

医薬ジャーナル, 46, 152-157 (2010) 臨床薬学エッセンシャル (5) 医療経済と薬学の関わり (Review) 上島悦子

医薬ジャーナル, 46, 178-182 (2010) 化学療法剤および抗生物質に関する文献紹介 (48) (Review) 上島悦子

化学療法の領域, 26, 306-308 (2010) 化学療法剤および抗生物質に関する文献紹介 (50) (Review) 上島悦子

化学療法の領域, 26, 696-699 (2010) 化学療法剤および抗生物質に関する文献紹介 (52) (Review) 上島悦子

化学療法の領域, 26, 1298-1300 (2010) 化学療法剤および抗生物質に関する文献紹介 (54) (Review) 上島悦子

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化学療法の領域, 26, 1702-1704 (2010) 化学療法剤および抗生物質に関する文献紹介 (56) (Review) 上島悦子

化学療法の領域, 26, 2118-2121 (2010) 化学療法剤および抗生物質に関する文献紹介 (58) (Review) 上島悦子

化学療法の領域, 26, 2490-2492 (2010) がん性疼痛におけるアセトアミノフェンの臨床的位置と使用方法 (Review) 岡本禎晃, 恒藤暁

ペインクリニック, 31, 781-790 (2010) 服薬指導の新しい知識，最新情報 (Review) 岡本禎晃 緩和ケア, 20(Suppl.), 167-172 (2010) 総論 医療用麻薬パッチ製剤が使える 慢性疼痛に対する薬物療法が変わった (Review) 岡本禎晃, 松田陽一, 柴田政彦 エキスパートナース, 26, 53-67 (2010) がん疼痛治療におけるトラマドールの臨床的位置と使用方法 (Review) 岡本禎晃, 恒藤暁 ペインクリニック, 31, 1673-1680 (2010) がんの統合医療 伊藤壽記, 上島悦子（監訳）岡本禎晃, 津金麻実子（分担訳） メディカル・サイエンス・インターナショナル (2010) 応用環境生物学 (Applied Environmental Biology) A short period of mannitol stress but not LiCl stress led to global translational repression in plants Matsuura H, Kiyotaka U, Ishibashi Y, Kubo Y, Yamaguchi M, Hirata K, Demura T, Kato K Biosci. Biotechnol. Biochem., 74, 2110-2112 (2010) Floricultural Salvia plants have a high ability to eliminate bisphenol A Okuhata H, Ikeda K, Miyasaka H, Takahashi S, Matsui T, Nakayama H, Kato K, Hirata K J. Biosci. Bioeng., 110, 99-101 (2010)

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Identification of urine metabolites of TFAP, a cyclooxygenase-1 inhibitor Kakuta H, Fukai R, Xiaoxia Z, Ohsawa F, Bamba T, Hirata K, Tai A Bioorg. Med. Chem. Lett., 20, 1840-1843 (2010) Synthesis of anti-tumor dimeric indole alkaloids in Catharanthus roseus was promoted by irradiation with near-ultraviolet light at low temperature Asano M, Harada K, Yoshikawa T, Bamba T, Hirata K Biosci. Biotechnol. Biochem., 74, 386-389 (2010) 機能性核酸化学 (Functional Nucleic Acid Chemistry) Facile synthesis of 1-methyl-1H-benzo[b]azepines from 1-methylquinolinium iodides and diazo(trimethylsilyl)methylmagnesium bromide Morita M, Hari Y, Aoyama T Synthesis, 4221-4227 (2010) 2’,4’-BNA bearing a 2-pyridine nucleobase for CG base pair recognition in the parallel motif triplex DNA Hari Y, Matsugu S, Inohara H, Hatanaka Y, Akabane M, Imanishi T, Obika S Org. Biomol. Chem., 8, 4176-4180 (2010) Synthesis of 3-substituted 3-(trimethylsiloxy)pyrrolidines from β-aminoketones and lithium trimethylsilyldiazomethane Hari Y, Yokoyama T, Aoyama T Heterocycles, 80, 679-687 (2010) 生命分子合成化学 (Synthetic Organic and Medicinal Chemistry) Mild deprotection of methylene acetals in combination with trimethylsilyl triflate 2,2'-bipyridyl Fujioka H, Senami K, Kubo O, Yahata K, Minamitsuji Y, Maegawa T Chem. Pharm. Bull., 58, 426-428 (2010) Remarkable effect of phosphine on the reactivity of O,P-acetal efficient substitution reaction of O,P-acetal Fujioka H, Goto A, Otake K, Kubo O, Yahata K, Sawama Y, Maegawa T Chem. Commun., 46, 3976-3978 (2010) Synthesis of deuterium-labelled drugs by hydrogen deuterium (H D) exchange using heterogeneous catalysis Modutlwa N, Maegawa T, Monguchi Y, Sajiki H

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J. Labelled Compd. Radiopharm., 53, 686-692 (2010)