© 2004 Nu Skin ® SYSTEM PRESENTATION Nu Skin ® Tri-Phasic White ™ The Scientific Method for Brilliant Skin

© 2004 Nu Skin®

SYSTEM PRESENTATION

Nu Skin® Tri-Phasic White™

The Scientific Method for Brilliant Skin

© 2004 Nu Skin®

SYSTEM PRESENTATION



System Presentation ›

NU SKIN® TRI-PHASIC WHITE™ The scientific method for brilliant skin

© 2004 Nu Skin®

SYSTEM PRESENTATION



The Beauty of Fair Skin

© 2004 Nu Skin®

SYSTEM PRESENTATION



The Beauty of Fair, Even Skin

© 2004 Nu Skin®

SYSTEM PRESENTATION



Leading Skin Care Researchers

© 2004 Nu Skin®

SYSTEM PRESENTATION



Dr. Bryan Fuller

© 2004 Nu Skin®

SYSTEM PRESENTATION



The Pigmentation Process

© 2004 Nu Skin®

SYSTEM PRESENTATION



Where Does the Pigmentation Process Begin?

• Lower part of epidermis

© 2004 Nu Skin®

SYSTEM PRESENTATION



Role of the Melanocyte

• Melanocytes are located just below a layer of surface skin cells called keratinocytes.

Melanin in production

Melanocytes

Layers of keratinocytes

Epidermis

Melanin visible at the surface of the skin.

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SYSTEM PRESENTATION



Pigmentation Process: Three Phases

• Activation: melanin production is initiated.• Synthesis: melanin is actually produced

by melanocytes. • Expression: melanin is transported to

surface of the skin.

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SYSTEM PRESENTATION



Activation Phase

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SYSTEM PRESENTATION



Factors Causing Melanin Production

HormonesStress

UV Light

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SYSTEM PRESENTATION



Synthesis Phase

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SYSTEM PRESENTATION



Synthesis Phase

Following the activation phase, the melanocyte begins the synthesis of melanin. Three main chemical reactions exist within the synthesis phase.


(skin cells)

Melanin is formed inside the melanocyte.

Epidermis

Melanocyte

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SYSTEM PRESENTATION



Tyrosine to Dopa

Tyrosine Dopa

Tyrosinase

1. Tyrosinase, an enzyme essential to melanin synthesis, functions to convert tyrosine, an amino acid, to another amino acid called dopa.

© 2004 Nu Skin®

SYSTEM PRESENTATION



Dopa to Dopaquinone

Tyrosine Dopa Dopaquinone

Tyrosinase

2. Tyrosinase then converts dopa into dopaquinone, a secondary chemical.

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SYSTEM PRESENTATION



Dopaquinone to Phaeo or Eu Melanin

Tyrosine Dopa

Phaeo-melanin

Dopaquinone

Eu-melanin

3. Dopaquinone, in a final reaction, is converted into one of two types of melanin.

TyrosinaseTyrosinase

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SYSTEM PRESENTATION



Phaeo and Eu Melanin

Phaeo-melanin

Dopaquinone

Eu-melanin

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SYSTEM PRESENTATION



Synthesis of Melanin

Efficiently “packaged” within a melanosome, the melanin is now ready for delivery to the skin in the expression phase.


Melanocytes


Epidermis


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SYSTEM PRESENTATION



Expression Phase

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SYSTEM PRESENTATION



Expression Phase: The ProcessMelanin becomes visible at the

surface of the skin.

Melanin-filled melanosomes move up dendrite-like arms of the melanocyte and are deposited inside the keratinocytes.

Layers of keratinocytes (skin cells)

Melanocyte

Detailed illustration of melanocyte

© 2004 Nu Skin®

SYSTEM PRESENTATION



Expression of Melanin on Skin’s Surface


Melanocytes


Epidermis


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SYSTEM PRESENTATION



© 2004 Nu Skin®

SYSTEM PRESENTATION



The Discoloration ProcessIn addition to the normal pigmentation process, where the hormone MSH initiates the activation of melanin synthesis, other factors can also cause melanin production.

Hormones(Pregnancy)

Stress

Irritants(Pollution)

UV Light(Sun)

© 2004 Nu Skin®

SYSTEM PRESENTATION



Melanocytes and Hyperpigmentation


(skin cells)

Melanocyte

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SYSTEM PRESENTATION



Activation Synthesis Expression

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SYSTEM PRESENTATION



Nu Skin® Tri-Phasic White™ System

Targets all three phases of the skin discoloration pathway:

Activation Synthesis Expression DISCOLORATION

Activation Synthesis Expression

© 2004 Nu Skin®

SYSTEM PRESENTATION



Tri-Phasic White™ System

A comprehensive skin brightening system, Tri-Phasic White™ works to minimize the activation, synthesis, and expression of discoloration on the skin’s surface.

© 2004 Nu Skin®

SYSTEM PRESENTATION



System Benefits

Reduces the appearance of:• Existing dark spots• Uneven skin tone• Discoloration

Helps prevent the formation of:• New dark spots • Discoloration

Helps maintain:• Even skin tones• Bright skin tones

System Benefits

© 2004 Nu Skin®

SYSTEM PRESENTATION



Clinical Study • 12-week clinical study.• 29 Japanese women, with mild to moderate

discoloration on the face.• Nu Skin® Tri-Phasic White™ System applied to

face twice per day according to standard use instructions.

• Consistent and cumulative improvements over weeks four, eight, and 12.

• Measured: brightness, radiance, even color, roughness improvement, area, and overall improvement.

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SYSTEM PRESENTATION



• 93% improved in brightness.• 97% improved in radiance.• 97% improved in even skin color.• 79% improved in smoothness.• 83% decreased in area of mottled appearance.• 100% improved in overall appearance.

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Nu Skin® Tri-Phasic White™ Performance by Clinical Grader

% o

f Sub

ject

s wi

th Im

prov

emen

t

A B C D E F

A. BrightnessB. RadianceC. Even color

D. SmoothnessE. Mottled areaF. Overall improvement

© 2004 Nu Skin®

SYSTEM PRESENTATION



0

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Nu Skin® Tri-Phasic White™ Self-Assessment

% Im

prov

emen

t

A B C D E F

Questions Asked Participants

% of Positive Responses at 12 weeks

A Leaves skin moisturized? 97%

B Leaves skin soft? 76%C Products worked

well together? 86%

D Whitening ability? 58%E Leaves skin

brighter? 76%

F Lightens spots? 52%

© 2004 Nu Skin®

SYSTEM PRESENTATION



Tri-Phasic White™ System Products

• Cleanser

• Toner

• Radiance Mask*

• Essence

• Day Milk Lotion

• Night Cream

* Sold separately. Radiance Mask is a line extension product of the Tri-Phasic White™ System.

© 2004 Nu Skin®

SYSTEM PRESENTATION



Nu Skin® Tri-Phasic White™ Cleanser

Key Benefit• Reduces expression of discoloration by

inhibiting pigment transfer.

Key Ingredient• Creatinine—helps inhibit the transfer of

pigment.

© 2004 Nu Skin®

SYSTEM PRESENTATION



Nu Skin® Tri-Phasic White™ Toner

Key Benefits• Reduces expression of discoloration. • Minimizes activation of discoloration.

Key Ingredients• Fairtrex™—non-acid exfoliation complex.• Carnosine— blocks irritation receptors.

© 2004 Nu Skin®

SYSTEM PRESENTATION



Nu Skin® Tri-Phasic White™ Radiance Mask*Key Benefits

• Helps inhibit activation and synthesis of discoloration.

• Illuminates skin tone, promoting a radiant complexion.

Key Ingredients• Portulaca oleracea extract—targets the

activation of discoloration. • Tetrahydro-diferuloylmethane—helps block

the synthesis of discoloration.

* Sold separately. Radiance Mask is a line extension product of the Tri-Phasic White™ System.

© 2004 Nu Skin®

SYSTEM PRESENTATION



Nu Skin® Tri-Phasic White™ Essence

Key Benefit• Inhibits synthesis of discoloration.

Key Ingredient• Brightex™—proprietary whitening blend that

helps inhibit the formation of melanin.

© 2004 Nu Skin®

SYSTEM PRESENTATION



Nu Skin® Tri-Phasic White™ Day Milk Lotion

Key Benefit• Minimizes activation of discoloration.

Key Ingredients• Hexapeptide-2—partially blocks hormone

receptor.• UVA/UVB sunscreen (SPF 15)—helps

absorb and reflect high energy sun rays.

© 2004 Nu Skin®

SYSTEM PRESENTATION



Nu Skin® Tri-Phasic White™ Night Cream

Key Benefit:• Minimizes activation of discoloration.

Key Ingredient:• Diacetyl boldine—blocks stress receptors.

© 2004 Nu Skin®

SYSTEM PRESENTATION



ACTIVATION

of Discoloration

SYNTHESIS

of Discoloration

EXPRESSION

of Discoloration

Tri-Phasic White™ Cleanser

Creatinine

Tri-Phasic White™ Toner

Carnosine Fairtrex™

Tri-Phasic White™ Radiance Mask

Portulaca oleracea extract Tetrahydro-diferuloylmethane

Tri-Phasic White™ Essence

Brightex™

Tri-Phasic White™ Day Milk Lotion

Hexapeptide-2

UVA and UVB sunscreens SPF 15

Tri-Phasic White™ Night Cream

Diacetyl boldine

© 2004 Nu Skin®

SYSTEM PRESENTATION



Usage

Day Night

Tri-Phasic White™ Cleanser Tri-Phasic White™ Cleanser

Tri-Phasic White™ Toner Tri-Phasic White™ Toner

Tri-Phasic White™ Radiance Mask* Tri-Phasic White™ Radiance Mask*

Tri-Phasic White™ Essence Tri-Phasic White™ Essence

Tri-Phasic White™ Day Milk Lotion Tri-Phasic White™ Night Cream

* Sold separately.

© 2004 Nu Skin®

SYSTEM PRESENTATION



Live Better, Longer

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© 2004 Nu Skin ® SYSTEM PRESENTATION Nu Skin ® Tri-Phasic White ™ The Scientific Method for Brilliant Skin