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1
p-Phenyleneethynylene Molecular Wires: Influence of Structure on
Photoinduced Electron-Transfer Properties
Mateusz Wielopolski,[a] Carmen Atienza,[a,b] Timothy Clark,[c] Dirk M. Guldi,[a]*
Nazario Martín[b,d]*
[a] Department of Chemistry and Pharmacy
Interdisciplinary & Center for Molecular Materials (ICMM)
Friedrich-Alexander-Universität Erlangen-Nürnberg
Fax: (+49) 913-185-28307
E-mail: [email protected]
[b] Departamento de Química Orgánica
Facultad de Ciencias Químicas
Universidad Complutense de Madrid
Ciudad Universitaria s/n
28040-Madrid (Spain)
E-mail: [email protected]
[c] Interdisciplinary Center for Molecular Materials
Friedrich-Alexander-Universität Erlangen-Nürnberg
Computer-Chemie-Centrum
Naegelsbachstrasse 25
91052, Erlangenand, Germany
[d] Instituto Madrileño de Estudios Avanzados en Nanociencia
(IMDEA. Nanociencia)
2
Experimental Section
Molecular Modelling: Calculations were performed using the program packages
Gaussian03 [35] and VAMP 10.0.[36] Molecular properties in the electronic ground
state were computed using density functional theory at the B3LYP/6-31G* (/6-311G**)
and the B3PW91/6-31G* (/6-311G**) levels and the restricted Hartree-Fock formalism
with the semi-empirical AM1* Hamiltonian.[S1] Excited-state calculations used a
singles-only configuration interaction (CIS) expansion with an active window of the
three to six highest occupied and lowest unoccupied molecular orbitals and the AM1
Hamiltonian.[S2] Test calculations with a singles only CI with up to 30 active orbitals
suggested that this level of theory is adequate for the problem. Excited-state geometries
were optimized in vacuo using numerical CI gradients.[S3] Solvent effects were
simulated in single-point calculations on the gas-phase optimized geometries using the
self-consistent reaction field solvation models with solvent-excluded surfaces with
atomic radii equal to 120% of those given by Bondi.[S4] Local electron affinity and
local ionization energy calculations [S5] on the AM1* optimized structures were
performed using Parasurf’07 A1 [S7] and visualized with Tramp 1.1d.[S7]
Compound 7: Compound 4 (1.14 g, 2.37 mmol) and p-ethynylbenzaldehyde 6 (324 mg,
2.48 mmol) were dissolved in dry piperidine (25 mL) and the system was flushed with
argon. Bis(triphenylphosphine)-palladium dichloride (106.75 mg, 0.152 mmol),
triphenylphosphine (30.95 mg, 0.118 mmol) and copper(I) iodine (22.56 mg, 0.118
mmol) was added. The mixture was stirred at room temperature for 16h.
Dichloromethane was added to the residue and washed with saturated NH4Cl, HCl
(10%) and NaCl. The organic phase was dried with MgSO4 and the solvent was
removed in vacuo. The crude product was purified by flash chromatography on silica
gel using hexane:AcOEt (9:1) as eluent to afford 7 (1.45 g, 2.61 mmol) as yellow solid.
Yield 41%. Mp 46-47 ºC. 1H- NMR (200 MHz, CDCl3, 25ºC): δ= 10.00 (s, 1H), 7.84
(d, J = 8.54 Hz, 2H), 7.64 (d, J = 8.05 Hz, 2H), 7.10 (s, 1), 7.00 (s, 1H), 4.00 (q, J =
1.95 Hz, 4H), 1.89-1.74 (m, 4H), 1.69-1.41 (m, 4H), 1.38-114 (m, 8H), 0.93-0.84 ppm
(m, 6H). 13C- NMR (75 MHz, CDCl3, 25ºC): δ= 191.27, 154.42, 149.49, 135.37,
131.93, 129.52, 117.93, 117.55, 114.35, 111.73, 93.06, 89.68, 70.14, 69.78, 31.54,
3
31.49, 29.21, 29.14, 25.70, 25.64, 22.61, 22.57, 14.00 ppm. FTIR (KBr): ν= 669, 756,
844, 1215, 1276, 1384, 1467, 1494, 1600, 1701, 2208, 2858, 2871, 2931, 2956, 3018,
3419 cm-1. MS (ESI): m/z (%): 486 (40) [M+], 402 (12), 316 (100). Anal. Calcd for
C27H33BrO3: %C: 66,80, %H: 6.85. Found: %C: 66,75, %H: 6.70.
2-Bromo-5-trimethylsilylacethynyl-1,4,bishexyloxybenzene 8 : 2-bromo-5-yodo-1,4-
dihexiloxibenzene 4 (1.23 g, 2.55 mmol) was dissolved in dry piperidine (25 mL)
Pd(PPh3)2Cl2 (44.22 mg, 0.063 mmol), PPh3 (33.31 mg, 0.12 mmol) and CuI (24 mg,
0.12 mmol) were added and stirred for 5 min, then trimethylsilylacetylene (4 mL, 2.81
mmol) was added to the solution. The mixture was stirred at room temperature for 3 h.
Dichloromethane was added to the mixture and washed with saturated NH4Cl, HCl
(10%) and NaCl. The organic phase was dried with MgSO4 and the solvent was
removed under vacuum. The crude product was purified by flash chromatography on
silica gel using hexane:AcOEt (9:1). The product was obtained as a white solid 8 (1.01
g, 2.22 mmol). Yield 87%. M.p.: 116 - 118 ºC. 1H-NMR (300 MHz, CDCl3, 25ºC): δ=
7.05 (s, 1H), 6.95 (s, 1H), 3.97-3.92 (m, 4H), 1.84-1.75 (m, 4H), 1.53-1.43 (m, 4H),
1.36-1.26 (m, 4H), 0.93-0.89 (m, 6H), 0.26 (s, 9H). 13C-NMR (75 MHz, CDCl3, 25ºC):
δ= 155.08, 149.65, 118.21, 113.94, 112.74, 101.03, 99.55, 70.40, 70.04, 32.01, 31.92,
30.13, 29.65, 29.54, 26.08, 26.05,23.05, 23.00, 14.49, 14.45 ppm. DEPT 135 (75 MHz,
CDCl3, 25ºC): δ= 118.21 (CH), 70.40 (CH2), 70.04 (CH2), 32.01 (CH2), 31.92 (CH2),
30.13 (CH2), 29.65 (CH2), 29.54 (CH2), 26.08 (CH2), 26.05 (CH2),23.05 (CH2), 23.00
(CH2), 14.49 (CH2), 14.45 ppm (CH3). FTIR (KBr), ν: 829, 856, 991, 1035, 1056, 1213,
1269, 1467, 1488, 1500, 2920, 2941, 2954 cm-1. EM m/z (EI), (%I): 454 (M+, 40), 368
(20), 286 (42), 271 (65), 43 (100).
Compound 9: Compound 8 (1.79 g, 3.94 mmol) and 6 (539 mg, 4.14 mmol) were
dissolved in dry toluene (30 mL) and the system was flushed with argon.
Tetrakis(triphenylphosphine)-palladium (228 mg, 0.197 mmol) and copper (I) iodine
(37.57 mg, 0.197 mmol) were added. The mixture was refluxed for 17 h. Ethyl acetate
was added to the residue and washed with saturated NH4Cl, HCl (10%) and NaCl. The
organic phase was dried with MgSO4 and the solvent was removed under vacuum. The
crude product was purified by flash chromatography on silica gel hexane: CH2Cl2 (20:1)
as eluent to afford 9 (510 mg, 1.034 mmol) as a yellow solid. Yield 65%. Mp 82-83 ºC. 1H- NMR (300 MHz, CDCl3, 25 ºC): δ= 10.02 (s, 1H), 7.86 (dd, J1 = 6.59 Hz, J2 = 1.65
4
Hz, 2H), 7.67 (brs, 2H), 3.99 (t, J = 6.1 Hz, 4H), 1.89-1.79 (m, 4H), 1.59-1.52 (m, 4H),
1.49-1.31 (m, 8H), 0.94-0.87 (m, 6H), 0.27 ppm (s, 9H). 13C- RMN (75 MHz, CDCl3):
δ= 191.78,154.52, 154.15, 135.75, 132.39, 130.18, 129.96, 117.55, 117.28, 115.03,
113.61, 101.33, 94.25, 90.55, 69.92, 32.01, 31.97, 29.69, 29.65, 26.13, 23.04, 14.48,
14.42, 0.33 ppm. FTIR (KBr): ν= 669, 756, 1215, 1465, 1488, 1600, 1701, 2399, 2931,
2958, 3018 cm-1. MS (ESI): m/z (%): 500 (100) [M+], 319 (84), 73 (24), 43 (47). Anal.
Calcd for C32H42O3Si: %C: 76.45, %H: 8.42. Found: %C: 76.56, %H: 8.61.
2-Triisopropylsilylethynyl-5-trimethylsilylethynyl-1,4-bishexyloxybenzene 11 :
Compound 8 (1.38 g, 3.04 mmol) was dissolved in dry toluene (25 mL), the system was
flushed with argon. Pd(PPh3)4 (106.75 mg, 0.152 mmol), CuI (29 mg, 0.152 mmol) and
diisisopropylamine (2mL) were added. The mixture was stirred for 5 min and then
triisopropylsilylacetylene (0.4 mL, 2.81 mmol) was added. The mixture was refluxed
for 24 h. Dichloromethane was added to the mixture and washed with saturated NH4Cl,
HCl (10%) and NaCl. The organic phase was dried with MgSO4 and the solvent was
removed under vacuum. The crude product was purified by flash chromatography on
silica gel using hexane:AcOEt (9:1). The product was obtained as a white solid 11 (1.45
g, 2.61 mmol). Yield 86%. M.p.: 115-116 ºC. 1H-NMR (300 MHz, CDCl3, 25ºC): δ=
6.88 (s, 2H), 3.98-3.91 (m, 4H), 1.79-1.77 (m, 4H), 1.57 (br, 3H), 1.52-1.47 (m, 4H),
1.36-1.30 (m, 8H), 1.14 (br, 18H), 0.93-0.90 (m, 6H), 0.25 ppm (s, 9H). 13C-NMR (75
MHz, CDCl3, 25ºC): δ= 155.08, 149.64, 118.21, 113.93, 112.72, 101.01, 99.57, 70.40,
70.04, 32.01, 31.92, 29.65, 29.53, 26.08, 26.05, 23.05, 23.01, 19.11, 14.50, 14.45,
11.76, 0.37 ppm. DEPT 135 (75 MHz, CDCl3): δ= 118.21 (CH), 70.40 (CH2), 70.04
(CH2), 32.01 (CH2), 31.92 (CH2), 29.65 (CH2), 29.53 (CH2), 26.08 (CH2), 26.05 (CH2),
23.05 (CH2), 23.01 (CH2), 19.11 (CH3), 14.50 (CH), 14.45 (CH), 11.76 (CH), 0.37 ppm
(CH3). FTIR (KBr): ν= 557, 613, 661, 810, 840, 862, 999, 031, 1058, 1201, 1222, 1247,
1272, 1384, 1404, 1467, 1498, 2150, 2866, 2895, 2941 cm-1. EM m/z (EI), (%I): 554
(M, 100), 427 (20), 343 (20), 73 (32), 43 (84).
2-Triisopropylsilylethynyl-5-ethynyl-1,4-bishexyloxybenzene 12 : Compound 11
(258 mg, 0.464 mmol) was dissolved in a mixture of THF:MeOH (1:1) 40 mL and
K2CO3 ( 64.49 mg, 0.464 mmol) was added to the solution. The solution was stirred at
room temperature for 2h. The mixture was extracted with dichloromethane and washed
with water (2 x 50mL). The organic phase was dried with MgSO4 and the solvent was
5
removed under vacuum. The product was purified by flash chromatography on silica gel
using hexane:CH2Cl2 (10:1) as eluent. The product was obtained as a yellow solid 12
(384.36 mg, 0.95 mmol). Yield 100%. M.p: 49-50 ºC. 1H-NMR (300 MHz, CDCl3,
25ºC): δ= 6.92 (brs, 2H), 3.94 (t, J = 6.5 Hz, 2H), 3.93 (t, J = 6.4 Hz, 2H), 3.33 (s, 1H),
1.85-1.72 (m, 4H), 1.48-1.38 (m, 4H), 1.36-1.28 (m, 8H), 1.26 (s, 21H), 0.93-0.89 ppm
(m, 6H). 13C-NMR (75 MHz, CDCl3, 25ºC): δ= 155.11, 149.73, 118.76, 118.35, 114.35,
111.68, 81.98, 79.92, 70.50, 70.21, 31.89, 29.51, 29.45, 26.03, 25.95, 22.97, 19.09,
14.41, 11.76 ppm. DEPT 135 (75 MHz, CDCl3): δ= 118.76 (CH), 118.35 (CH), 81.98
(CH), 70.50 (CH2), 70.21 (CH2), 31.89 (CH2), 29.51 (CH2), 29.45 (CH2), 26.03 (CH2),
25.95 (CH2), 22.97 (CH2), 19.09 (CH3), 14.41(CH3), 11.76 ppm (CH3). FTIR (KBr): ν=
659, 713, 729, 769, 810, 999, 1031, 1056, 1199, 1220, 1272, 1467, 1498, 1541, 2152,
2864, 2895, 2923, 2943, 3421 cm-1. EM m/z (EI), (%I): 482 (M, 7), 382 (20), 298 (12),
214 (100), 55 (19).
Compound 13: Compound 5 (97.89 g, 0.421 mmol) and compound 12 (224.04 mg,
0.464 mmol) were dissolved in dry THF (25 mL) and the system was flushed with
argon. Tetrakis(triphenylphosphine)-palladium (24.26 mg, 0.02 mmol), copper (I)
iodine (4 mg, 0.02 mmol) and diisopropylamine ( 1mL) were added. The mixture was
refluxed for 24h. Ethyl acetate was added to the residue and washed with saturated
NH4Cl, HCl (10%) and NaCl. The organic phase was dried with MgSO4 and the solvent
was removed under vacuum. The crude product was purified by flash chromatography
on silica gel using hexane:CH2Cl2 (20:1) as eluent to afford 13 (164.33 mg, 0.28 mmol)
as a yellow solid. Yield 67%. 1H-NMR (300 MHz, CDCl3, 25º): δ= 10.01 (s, 1H), 7.84
(dd, J1 = 6.59 Hz, J2 = 1.65 Hz, 2H), 7.58 (dd, J1 = 6.59 Hz, J2 = 1.65 Hz, 2H), 6.95
(brs, 2H), 4.01 (t, J = 6.2 Hz, 4H), 1.89-1.79 (m, 4H), 1.59-1.52 (m, 4H), 1.49-1.31 (m,
8H), 1.00 (brs, 3H), 0.8 (s, 18H), 0.4-0.6 ppm (m, 6H). 13C-NMR (75 MHz, CDCl3, 25
ºC): δ= 191.30, 158.43, 157.81, 135.80, 132.18, 129.60, 125.0, 119.89, 119.27, 118.22,
109.30,107.23, 86.12, 88.0, 68.46, 31.54, 29.53, 25.65, 22.5, 18.67, 13.97, 11.38 ppm.
FTIR (KBr): ν= 669, 756, 1215, 1465, 1488, 1600, 1701, 2399, 2931, 2958, 3018 cm-1.
MS (ESI): m/z (%): 585 (100) [M+], 444 (80), 73 (45), 43 (60). Anal. Calcd for
C38H54O3Si: %C 77.76, %H 9.27. Found: %C: 77.56, %H: 8.91.
Compound 14: Compound 9 (884.2 mg, 1.75 mmol) was dissolved in a mixture of
THF:MeOH (1:1) 40 mL and K2CO3 ( 242.91 mg, 1.75 mmol) was added to the
6
solution. The solution was stirred at room temperature for 12h. The mixture was
extracted with dichloromethane and washed with water. The organic phase was dried
with MgSO4. The solvent was removed and the product was purified by flash
chromatography on silica gel using hexane:AcOEt (15:1) as eluent. The product was
obtained as a yellow solid 14 (686 mg, 1.42 mmol). Yield 81 %. Mp. 70-71 ºC. 1H-
NMR (300 MHz, CDCl3, 25ºC): δ= 9.95 (s, 1H), 7.81 (dd, J1 = 6.61 Hz, J2 = 1.79 Hz,
2H), 7.61-7.57 (d, 2H), 6.93 (brs, 2H), 3.97-3.90 (m, 4H), 1.80-1.68 (m, 4H), 1.49-1.18
(m, 12H), 0.86-0.78 ppm (m, 3H). 13C-NMR (75 MHz, CDCl3, 25 ºC): δ= 191.85,
154.48, 154.08, 135.77, 132.44, 130.10, 129.99, 117.98, 117.22, 113.98, 113.83, 94.30,
90.31, 80.23, 70.05, 69.92, 31.98, 31.93, 30.12, 29.64, 29.50, 26.14, 26.0, 23.05, 23.0,
14.45 ppm. MS (ESI): m/z (%): 430 (M, 80), 429 (M+, 70), 230 (55), 206 (45). Anal.
Calcld for C29H34O3: %C 80.89, %H 7.96. Found: %C: 80.56, %H: 8.01.
Compound 15: Compound 14 (142.42 mg, 0.325 mmol) and compound 4 (140 mg,
0.325 mmol) were dissolved in dry piperidine (15 mL) and the system was flushed with
argon. Bis(triphenylphosphine)-palladium dichloride (6 mg, 8.12x10-3 mmol),
triphenylphosphine (4.26 mg, 0.016mmol) and copper(I) iodine (3 mg, 0.016 mmol)
were added. The mixture was stirred at room temperature for 3h. Dichloromethane was
added to the mixture and washed with saturated NH4Cl, HCl (10%) and NaCl. The
organic phase was dried with MgSO4 and the solvent was removed under vacuum. The
crude product was purified by flash chromatography on silica gel using hexane: CH2Cl2
(20:1) as eluent. The product was obtained as a yellow solid 15 (210 mg, 0.118 mmol).
Yield 14%. M.p.: 87-89 ºC. 1H- NMR (200 MHz, CDCl3, 25ºC): δ= 10.02 (s, 1H), 7.87
(d, J = 8.3 Hz, 2H), 7.66 (d, J = 7.92 Hz, 2H), 7.09 (brs, 1H),7.00 (brs, 2H), 6.98 (s,
1H), 4.1-3.97 (m, 8H), 1.83-1.76 (m, 8H), 1.6-1.34 (m, 8H),1.34-1.25 (m, 16H), 1.00-
0.88 ppm (m,12H). 13C- NMR (75 MHz, CDCl3, 25ºC): δ= 191.43, 155.00, 154.91,
154.08, 153.72, 153.29, 149.46, 135.40, 132.03, 129.56, 118.18, 117.75, 117.56,
116.96, 115.45, 113.52, 112.75, 77.23, 76.73, 76.28, 74.94, 73.91, 73.12, 69.94, 69,83,
69.75, 69.54, 31.54, 31.51, 29.67, 29.18, 29.14, 29.09, 25.63, 25.59, 22.60, 22.57,
18.67, 18.64, 17.76, 16.22, 16.02, 15.74, 13.98 ppm. FTIR (KBr): ν= 650, 745, 770,
800, 1126, 1310, 1645, 2255 cm -1. EM m/z (ESI), (%I): 783 (M+, 70),705 (55),
604(45), 579 (35).
7
Compound 16: Compound 8 (70.22 mg, 0.154 mmol) and compound 14 (70 mg, 0.162
mmol) were dissolved in dry THF (15 mL) and the system was flushed with argon.
Tetrakistriphenylphosphine palladium (8.89 mg, 7.7x10-3 mmol), copper(I) iodine (1.46
mg, 7.7x10-3 mmol) and diisopropylamine (1mL) were added. The mixture was heated
for 28 h. Dichloromethane was added to the mixture and washed with saturated NH4Cl,
HCl (10%) and NaCl. The organic phase was dried with MgSO4 and the solvent was
removed under vacuum. The crude product was purified by flash chromatography on
silica gel using hexane: AcOEt (9:1) as eluent. The product was obtained as a yellow
solid 16 (20 mg, 0.002 mmol). Yield 17%. M.p: 77-79 ºC. 1H-NMR (300 MHz, CDCl3,
25ºC): δ= 10.03 (s, 1H), 7.88 (d, J = 8.23 Hz, 2H), 7.67 (d, J = 8.24 Hz, 2H), 7.02 (brs,
2H), 6.97 (br, 2H), 4.05 (t, J = 6.5 Hz, 8H), 1.90-1.77 (m, 8H), 1.57-1.53 (m, 8H), 1.37-
1.26 (m, 16H), 0.95-0.85 (m, 12H), 0.27 ppm (s, 9H). 13C-NMR (75 MHz, CDCl3,
25ºC): δ= 191.86, 154.53, 154.27, 153.82, 153.75, 135.71, 132.40, 129.99, 117.70,
117.41, 117.37, 117.31, 115.57, 114.69, 114.19, 113.31, 101.52, 100.63, 94.31, 92.29,
91.69, 90.71, 70.11, 70.0, 69.87, 69.82, 32.01, 29.69, 29.65, 26.16, 26.12, 26.97, 23.05,
14.45, 0.36 ppm. DEPT 135 (75 MHz, CDCl3, 25ºC) : δ= 191.86 (CHO), 132.40 (CH),
129.99 (CH), 117.70 (CH), 117.41 (CH), 117.37 (CH), 117.31 (CH), 70.11 (CH2), 70.0
(CH2), 69.87 (CH2), 69.82 (CH2), 32.01 (CH2), 29.69 (CH2), 29.65 (CH2), 26.16 (CH2),
26.12 (CH2), 26.97 (CH2), 23.05 (CH2), 14.45 (CH2), 0.36 ppm (CH3). FTIR (KBr): ν=
669, 756, 1215, 1465, 1488, 1600, 1701, 2399, 2931, 2958, 3018 cm-1. EM m/z (ESI),
(%I): 802 (M+, 70), 619 (80), 413 (30).
Compound 17: 1H-NMR (300 MHz, CDCl3, 25ºC): δ= 10.03 (s, 2H), 7.87 (d, J = 8.5
Hz, 4H), 7.66 (d, J = 8.3 Hz, 4H), 7.01 (s, 4H), 4.03 (t, J = 6.4 Hz, 8H), 1.90-1.81 (m,
8H), 1.54-1.52 (m, 8H), 1.38-1.26 (m, 24H), 0.95-0.88 ppm (m, 12H). 13C-NMR (75
MHz, CDCl3, 25ºC): δ= 191.85, 155.32, 154.10, 135.81, 132.46, 130.00, 117.88,
117.26, 114.51, 113.73, 94.89, 90.39, 80.01, 79.96, 70.18, 69.90, 31.98, 31.94, 29.62,
29.48, 26.14, 26.01, 23.06, 23.02, 14.47 ppm. FTIR (KBr): ν= 729, 775, 823, 997,
1028, 1163, 1213, 1217, 1388, 1411, 1467, 1492, 1600, 1701, 2206.4, 2345, 2729,
2852, 2923 cm-1. EM m/z (ESI), (%I): 881 (M + Na, 10), 857 (M+, 40), 785 (30).
Compound 18: Compound 8 (357 mg, 0.788 mmol) and 12 (400 mg, 0.828 mmol)
were dissolved in dry THF (50 mL) and the system was flushed with argon. Pd(PPh3)4
(45.52 mg, 0.039 mmol), CuI (7.5 mg, 0.039 mmol) and iPr2NH ( 0.3mL) were added.
8
The mixture was heating under reflux for 48 h. Dichloromethane was added to the
mixture and washed with saturated NH4Cl, HCl (10%) and NaCl. The organic phase
was dried with MgSO4 and the solvent was removed. The crude product was purified by
flash chromatography on silica gel using hexane: AcOEt (9:1) as eluent. The product
was obtained as yellow solid 17 (683.39 mg, 0.709 mmol). Yield 90%. M.p.: 62-64 ºC. 1H- NMR (300 MHz, CDCl3, 25ºC): δ= 6.92 (s, 2H), 6.91 (s, 2H), 3.99 (t, J = 6.5 Hz,
4H), 3.93 (t, J= 6.3 Hz, 4H), 1.82-1.79 (m, 8H), 1.50-1.48 (m, 8H), 1.38-1.26 (m, 16H),
0.94-0.89 ppm (m, 12H). 13C-NMR (75 MHz, CDCl3, 25ºC): δ= 155.12, 154.53, 118.04,
117.48, 115.44, 112.97, 104, 97.8, 80, 79.9, 70.25, 69.64, 32.07, 31.94, 30.11, 29.76,
29.52, 26.24, 26.00, 23.04, 23.00, 19.10, 14.49, 14.45, 11.76 ppm. EM m/z (ESI), (%I):
963 (M, 40), 95 (M+, 60), 963 (20), 877 (10). FTIR (KBr), ν: 659, 862, 945, 997, 1047,
1072, 1197, 1220, 1271, 1384, 1400, 2854, 2925, 2954 cm-1.
Compound 19: Compound 4 (632.35 mg, 1.443 mmol) and 12 (697 mg, 1.443 mmol)
were dissolved in dry piperidine (15 mL) and the system was flushed with argon.
Bis(triphenylphosphine)-palladium dichloride (25.32 mg, 0.036 mmol),
triphenylphosphine (18.88 mg, 0.072 mmol) and copper(I) iodine (13.74 mg, 0.072
mmol) were added. The mixture was stirred at room temperature for 3h.
Dichloromethane was added to the mixture and washed with saturated NH4Cl, HCl
(10%) and NaCl. The organic phase was dried with MgSO4 and the solvent was
removed under vacuum. The crude product was purified by flash chromatography on
silica gel using hexane: CH2Cl2 (10:1) as eluent. The product was obtained as a yellow
solid 19 (665 mg, 0.793 mmol). Yield 55%. M.p.: 58-60ºC. 1H-NMR (200 MHz,
CDCl3, 25ºC): δ= 7.08 (s, 1H), 7.00 (s, 1H), 6.93 (s, 2H), 4.04-3.88 (m, 8H), 189-1.70
(m, 8H), 1.55-1.46 (m, 8H), 1.37-1.25 (m, 16H), 1.14 (brs, 21H), 0.93-0.87 ppm (m,
12H). 13C-NMR (75 MHz, CDCl3, 25ºC): δ= 154.34, 154.04, 153.23, 149.46, 118.19,
117.95, 117.77, 116.55, 114.29, 114.04, 113.25, 112.99, 103.00, 96.47, 90.64, 90.61,
70.09, 69.96, 69.82, 69.27, 31.67, 31.60, 31.56, 31.50, 29.69, 29.43, 29.30, 29.20,
29.17, 25.84, 25.64, 25.60, 22.57, 18.69, 14.04, 14.00, 11.38 ppm. EM m/z (ESI), (%I):
863 (M++Na, 70), 837 (M+, 20), 686 (30). 403 (30), 203 (45). FTIR (KBr), ν: 756, 908,
1647, 2252, 2399 cm-1.
Compound 20: Compound 19 (308 mg, 0.368 mmol) and trimethylsilylacetylene
(0.16mL, 1.189 mmol) were dissolved in dry THF (15 mL) and the system was flushed
9
with argon. Pd(PPh3)4 (45.06 mg, 0.039 mmol), copper(I) iodine (7.55 mg, 0.039 mmol)
and diisopropylamine (0.33mL) were added. The mixture was stirred and heating at
reflux during for 4 days. Dichloromethane was added to the mixture and washed with
saturated NH4Cl, HCl (10%) and NaCl. The organic phase was dried with MgSO4 and
the solvent was removed under vacuum. The crude product was purified by flash
chromatography on silica gel using hexane: CHCl3 (90:1) as eluent. The product was
obtained as a yellow solid 20 (306.3 g, 0.358 mmol). Yield 97%. M.p: 70-72 ºC. 1H-
NMR (300 MHz, CDCl3, 25ºC): δ= 6.94 (brs, 4H), 3.99-3.93 (m, 8H), 1.85-1.79 (m,
8H), 1.6-1.4 (m, 8H), 1.39-1.30 (m, 24H), 1.2-1.05 (m, 21H), 0.90-0.87 (m, 12H), 0.26
ppm (s, 9H). 13C-NMR (75 MHz, CDCl3, 25ºC): δ= 154.35, 154.20, 153.36, 153.28,
117.93, 117.43, 117.05, 116.59, 114.61, 114.34, 114.05, 113.67, 103.05, 101.23,
100.08, 96.53, 91.61, 91.22, 69.86, 69.68, 69.47, 69.27, 31.72, 31.65, 30.95, 29.74,
29.47, 29.34, 29.29, 25.89, 25.74, 25.68, 22.66, 18.74, 14.10, 14.06, 11.42, 0.00 ppm.
EM m/z (ESI), (%I): 854 (M, 40), 756. FTIR (KBr): ν= 636, 769 , 812, 1029, 1211,
1274, 1340, 1386, 1419, 1458, 1473, 2148, 2864, 2941 cm-1.
Compound 21: Compound 20 (306.3 g, 0.358 mmol) was dissolved in a mixture of
THF:MeOH (1:1) 40 mL and K2CO3 (49.76 mg, 0.358 mmol) was added to the
solution. The solution was stirred at room temperature for 2h. The mixture was
extracted with dichloromethane and washed with water. The organic phase was dried
with MgSO4 and the solvent was removed under pressure. The product was purified by
flash chromatography on silica gel using hexane:AcOEt (15:1) as eluent. The product
was obtained as a yellow solid 21 (280.40 mg, 0.358 mmol). Yield 100 %. 1H-NMR
(300 MHz, CDCl3, 25ºC): δ= 7.04 (s, 1H), 7.01 (s, 1H), 6.99 (s, 1H), 6.97 (s, 1H), 4.08-
3.93 (m, 8H), 3.35 (s, 1H), 2.05.1.79 (m, 8H), 1.51-1.44 (m, 8H), 1.34-1.32 (m, 24H),
1.26 (brs, 3H) 1.15 (s, 18H), 0.91-0.84 ppm (m, 12H). 13C-NMR (75 MHz, CDCl3,
25ºC): δ= 154.71, 154.53, 153.68, 153.66, 118.27, 117.39, 116.91, 115.35, 114.58,
114.47, 112.87, 103.38, 96.96, 92.03, 91.37, 82.67, 80.45, 78.65, 70.19, 70.09, 69.98,
69.63, 37.50, 32.10, 32.01, 31.94, 30.11, 29.84, 29.70, 29.63, 29.54, 26.27, 26.05,
26.01, 23.04, 22.99, 19.11, 14.53, 14.49, 14.44, 11.78 ppm. FTIR (KBr): ν= 735, 845,
900, 1140, 1250, 1270, 1315, 1625, 2230, 3250 cm-1. EM m/z (ESI), (%I): 781 (M+, 55),
782 (M, 15), 560 (47).
10
Compound 22: Compound 21 (70.22 mg, 0.154 mmol) and 5 (70 mg, 0.162 mmol)
were dissolved in dry THF (15 mL) and the system was flushed with argon. Pd(PPh3)4
(8.89 mg, 7.7 x 10-3 mmol), copper(I) iodine (1.46 mg, 7.7 x 10-3 mmol) and
diisopropylamine (1 mL) were added. The mixture was refluxed for 28 h.
Dichloromethane was added to the mixture and washed with saturated NH4Cl, HCl
(10%) and NaCl. The organic phase was dried with MgSO4 and the solvent was
removed under vacuum and the crude product was purified by flash chromatography on
silica gel using hexane: AcOEt (9:1) as eluent. The product was obtained as a yellow
solid 22 (20 mg, 0.002 mmol). Yield 64%. M.p: 77-78 ºC. 1H-NMR (300 MHz, CDCl3,
25ºC): δ= 10.00 (s, 1H), 7.84 (d, J = 8.2 Hz, 2H), 7.56 (d, J = 8.2 Hz, 2H), 6.95 (brs,
4H), 3.7-3.8 (m, 8H), 1.8-1.6 (m, 8H), 1.51-1.24 (m, 8H), 0.9 (brs, 3H), 0.6 (brs, 21H),
0.6-0.4 ppm (m, 12H). 13C-NMR (75 MHz, CDCl3, 25ºC): δ= 191.83, 156.76, 155.80,
154.80, 149.87, 135.75, 132.37, 130.17, 129.98, 119.89, 118.30, 117.92, 114.73,
112.07, 109.30, 107.23, 105.53, 93.46, 90.06, 70.55, 70.18, 32.33, 31.95, 31.91, 30.10,
29.77, 29.60, 29.53, 26.10, 26.05, 23.10, 23.10, 23.03, 22.9, 18.67, 14.53, 14.43, 11.38
ppm. FTIR (KBr): ν= 770, 865, 1218, 1282, 1465, 1697, 2260, 2320, 2570 cm-1. EM
m/z (ESI), (%I): 885 (M+, 55), 872 (67), 746 (100), 692 (32), 606 (84), 292 (33).
2-Trimethylsilylethynyl-5-iodo-1,4-bishexyloxybenzene 23: Compound 8 (1g, 2.204
mmol) was dissolved in dry THF (20mL), n-BuLi (2.204 mmol) was slowly added at 0
ºC. The mixture was stirring for 3 h at 0 ºC. After, I2 (559 mg, 2.204 mmol) solution in
dry THF (10 mL) was added and stirring for 12 h at room temperature. The mixture was
washed with Na2S2O3, NaCl and the organic phase was dried with MgSO4. The solvent
was removed under pressure and the crude product was purified by flash
chromatography on silica gel using hexane as eluent. The product was obtained as white
solid 23 (1.763 mmol). Yield 80%. 1H-NMR (300 MHz, CDCl3, 25ºC): δ= 7.25 (s, 1H),
6.83 (s, 1H), 3.96-3.93 (m, 4H), 1.82-1.72 (m, 4H), 1.53-1.42 (m, 4H), 1.36-1.25 (m,
4H), 0.94-0.88 (m, 6H), 0.25 ppm (s, 9H). 13C-NMR (75 MHz, CDCl3, 25ºC):
δ= 155.25, 155.06, 124.15, 116.67, 113.76, 101.17, 99.82, 88.30, 70.46 70.14, 32.00,
31.89, 30.11, 29.67, 29.53, 26.14, 26.07, 23.04, 23.00, 14.48, 14.45, 0.34 ppm. FTIR
(KBr): ν= 761, 808, 1205, 1375, 1460, 2153 cm-1. EM m/z (EI), (%I): 500 (M, 100),
442 (67), 330 (55).
11
Compound 24: Compound 16 (150 mg, 0.186 mmol) was dissolved in a mixture of
THF:MeOH (1:1) (40 mL) and K2CO3 ( 25.85 mg, 0.186 mmol) was added to the
solution. The solution was stirred at room temperature for 2 h. The mixture was
extracted with dichloromethane and washed with water (2 x 50 mL). The organic phase
was dried with MgSO4. The solvent was removed under vacuum and the product was
purified by flash chromatography on silica gel hexane:AcOEt (15:1) as eluent to afford
24 as yellow solid. Yield 100%.
Compound 22 (150 mg, 0.186 mmol) was dissolved in THF (40 mL) and
tetrabutylammonium fluoride (0.186 mmol) was added to the solution. The solution was
stirred at room temperature for 1 h. The mixture was extracted with dichloromethane
and washed with water (2 x 50 mL). The organic phase was dried with MgSO4. The
solvent was removed under vacuum and the product was purified by flash
chromatography on silica gel using hexane:AcOEt (15:1) as eluent to afford 24 as
yellow solid. Yield 90 %.1H-NMR (300 MHz, CDCl3, 25ºC): δ= 10.02 (s, 1H), 7.87 (d,
J = 8.07 Hz, 2H), 7.64 (d, J=8.04 Hz, 2H), 7.10-6.93 (m, 4H), 4.22 (t, J = 5.4 Hz, 8H),
3.36 (s, 1H), 1.88-1.83 (m, 8H), 1.68-1.51 (m, 8H), 1.34-1.25 (m, 16H), 0.91-0.89 ppm
(m, 12H). 13C-NMR (75 MHz, CDCl3, 25ºC): δ= 191.83, 154.52, 154.28,153.85,153.72,
135.72, 132.39, 130.21, 129.99, 118.23, 117.39, 117.31, 115.47, 115.11, 113.40,
113.10, 94.35, 92.35, 91.75, 90.69, 82.84, 80.41, 70.09, 69.97, 69.87, 32.01, 31.94,
30.12, 29.70, 29.65, 29.54 , 26.17, 26.06, 23.06, 23.O, 14.46 ppm. FTIR (KBr): ν= 733,
856, 950, 1130, 1210, 1470, 1578, 1645, 2230 cm-1. EM m/z (ESI), (%I): 840 (M+, 70),
619 (80), 413 (30).
General procedure for the preparation of exTTF-oPPE dyad 26a-b : Dyad 26a: 4-
Ethynylbenzaldehyde 6 (30.84 mg, 0.237 mmol) and compound 25 (80 mg, 0.158
mmol) was dissolved in dry piperidine (10 mL) then the system was flushed with argon.
Bis(triphenylphosphine)-palladium dichloride (2.8 mg, 0.004 mmol),
triphenylphosphine (1.16 mg, 0.004mmol) and copper (I) iodine (1 mg, 0.004 mmol)
were added. The mixture was stirred at room temperature for 24 h. Dichloromethane
was added to the residue and washed with saturated NH4Cl, water and NaCl. The
organic phase was dried with MgSO4 and the solvent was removed under vacuum. The
crude product was purified by flash chromatography on silica gel using hexane:CH2Cl2
(3:1) to afford 26a as red solid (210 mg, 0.118 mmol). Yield 85% . Mp. 183-184 ºC. 1H-
12
NMR (CDCl3, 300 MHz, 25 ºC): δ= 10.01 (s, 1H), 7.88 (brs, 1H), 7.87-7.84 (m, 2H),
7.72-7.66 (m, 5H), 7.32-7.26 (m, 2H), 6.30 ppm (s, 4H). 13C-NMR (CDCl3, 75 MHz,
25ºC): δ= 191.39, 137.27, 136.86, 136.04, 135.3, 135.34, 135.15, 135.14, 132.12,
129.73, 129.56, 129.31, 128.06, 126.14, 125.07, 124.98, 124.91, 121.53, 121.07,
119.69, 117.38, 117.32, 117.28, 117.12, 93.96, 88.79 ppm. FTIR(KBr): ν= 640, 669,
754, 1163, 1259, 1458, 1508, 1546, 1600, 1607, 1697, 2923 cm-1. UV/vis (CH2Cl2):
λmax: 230, 332, 363, 387, 445 nm. MS (ESI): m/z (%): 508 (100) [M+], 406 (12), 254
(12). Anal. Cacld for C29H16OS4: %C: 68.47, %H: 3.17. Found: %C: 69.53, %H: 4.43.
Dyads 26b-c: Compound 25 (111.92 mg, 0.221 mmol) and compound 14 (100 mg,
0.232 mmol) were dissolved in dry THF (30 mL) and the system was flushed with
argon. Tetrakis(triphenylphosphine)-palladium (6.4 mg, 5.53x10-3 mmol), copper (I)
iodine (84.9 mg, 6.18853x10-3 mmol) and diisopropylamine (1mL) were added to the
solution. The mixture was refluxed for 3h (26b) and 48 h (26c). The mixture was
extracted with dichloromethane and washed with NH4Cl, water and NaCl. The organic
phase was dried with MgSO4 and the solvent was removed under vacuum. The solid
was purified by flash chromatography on silica gel.
Dyad 26b: Eluent: hexane:CH2Cl2 (3:1). 26b was obtained as red solid 115 (94.3 g,
0.11 mmol). Yield 50 %. Mp. 207-208 ºC. 1H-NMR (300 MHz, CDCl3, 25 ºC): δ=
10.03 (s, 1H), 8.46 (d, J = 1.51 Hz, 1H), 8.36-8.30 (m, 3H), 7.92-7.82 (m, 4H), 7.77-
7.68 (m, 3H), 7.08 (s, 1H), 7.06 (s, 1H), 6.95 (brs, 4H), 4.09-4.03 (m, 4H), 1.91-1.85
(m, 4H), 1.6-1.55 (m, 4H), 1.39-1.26 (m, 8H), 0.93-0.89 ppm (m, 6H). 13C-NMR (75
MHz, CDCl3, 25 ºC): δ= 191.86, 182.92, 154.30, 154.23, 136.83, 135.81, 134.75,
134.63, 133.97, 133.82, 132.74, 132.71, 132.60, 132.47, 131.98, 131.94, 130.57,
130.01, 129.0, 128.84, 127.80, 127.73, 117.75, 117.56, 117.26, 117.18 (CH), 114.48,
114.02, 76.43, 76.02, 75.63, 70.04, 69.98, 31.99, 30.11, 29.66, 26.17, 23.07, 14.47 ppm.
FTIR (KBr): ν= 669, 756, 1215, 1467, 1488, 1508, 1600, 1701, 2343, 2360, 2931, 2958,
3018 cm-1. MS (ESI): m/z (%): 809 (15) [M+], 808 (M+, 88), 707 (75), 637 (10).
UV/vis (CH2Cl2) : λmax: 446, 402, 317, 228 nm. Anal. Calcd for C49H44O3S4: %C:
72.74, %H: 5.48. Found: %C: 72.80, % H: 5.40.
Dyad 26c: Eluent:hexane: CH2Cl2 (1:1). 26c was obtained as a yellow solid (94.3 g,
0.11 mmol) with 38% yield. Mp: 135-135 ºC. 1H-NMR (300 MHz, CDCl3, 25ºC): δ=
13
10.03 (s, 1H), 7.89 (brs, 2H), 7.73-7.67 (m, 5H), 7.45 (dd, J1 = 8.09 Hz, J2 = 1.51 Hz,
1H), 7.33-7.30 (m, 2H), 7.04 (brs, 4H), 6.33 ppm (d, J = 4.5 Hz, 4H). 13C-NMR (75
MHz, CDCl3, 25ºC): δ= 191.84, 154.31, 154.11, 153.97, 153.85, 144.63, 137.04,
136.93, 135.90, 135.71, 135.61, 132.40, 130.27, 129.99, 129.48, 128.27, 126.48,
125.39, 125.31, 122.17, 121.72, 121.19, 117.70, 117.57, 117.48, 117.35, 115.70,
114.76, 114.34, 113.28, 95.86, 94.29, 92.50, 91.67, 90.75, 86.67, 70.16, 70.08, 69.90,
32.33, 32.12, 32.04, 32.01, 30.76, 30.11, 29.84, 29.70, 26.27, 26.17, 26.09, 23.39,
23.10, 23.06, 14.55, 14.47 ppm. FTIR (KBr): ν= 756, 908, 1647, 2252, 2399 cm-1. EM
m/z (ESI), (%I): 1108 (M+, 70), 1008 (80), 777 (30). 685 (30). UV-vis (CH2Cl2), λmax:
233, 277, 309, 366, 412 nm. Anal. Calcd for C69H72O5S4: %C 74.69, %H 6.54. Found:
%C: 74.55, %H: 6.60.
General procedure for the preparation of exTTF-oPPE-C60 triads 27a-c:
[60]fullerene (85 mg, 0.118 mmoles) was dissolved in chlorobenzene (ultrasound 30
min), the corresponding aldehyde N-methylglycine (1.5eqv) was added. The mixture
was heated under reflux for 3 h. After the evaporation of the solvent, the residue was
purified by flash chromatography on silica gel. The black solid obtained after
chromatography was further purified by repeated centrifugation in methanol and diethyl
ether to yield the corresponding triads 27a-c as brown solids.
Compound 27a: Eluent: CS2:hexano (2:1). Yield 33%. Mp > 300 ºC.1H- NMR (300
MHz,CDCl3, 25ºC): δ= 7.87 (brs, 2H), 7.76 (brs, 1H), 7.69-7.63 (m, 5H), 7.42-7.29 (m,
3H), 6.38 (d, J = 6.8 Hz, 4H), 5.09 (s, 1H), 5.05 (s, 1H), 4.38 (d, J=9.33 Hz, 1H), 2.94
ppm (s, 3H). 13C- NMR (75 MHz, CDCl3, 25ºC): δ= 156.53, 154.28, 153.63, 153.38,
147.84, 147.81, 147.15, 146.93, 146.89, 146.82, 146.78, 146.74, 146.70, 146.65,
146.57, 146.50, 146.29, 146.19 146.17, 146.02, 145.96, 145.91, 145.86, 145.79, 145.73,
145.25, 144.94, 143.72, 143.60, 143.26, 143.19, 143.16, 142.86, 142.80, 142.71,
142.67, 142.61, 142.48, 142.46, 142.25, 142.16, 140.82, 140.78, 140.61, 140.24,
138.07, 138.04, 137.57, 137.47, 137.15, 136.48, 136.32, 136.05, 135.89, 135.69,
132.67, 130.28, 129.90, 129.80, 129.27, 128.41, 126.89, 126.86, 125.62, 125.58,
125.51, 124.52, 122.26, 121.78, 121.29, 118.94, 118.12, 118.02, 92.15, 90.88, 83.81,
77.65, 70.62, 69.47, 40.67, 30.86 ppm. FTIR(KBr): ν= 527, 1259, 1375, 1460, 2923,
2850, 3434 cm-1. UV-vis (CH2Cl2) : λmax: 232, 255, 313, 376, 431, 444 nm. EM m/z
(EI), (%I): 1255 (100) [M], 1254 [M+].
14
Compound 27b: Eluent: toluene. Yield 63%. Mp > 300 ºC. 1H-NMR (300 MHz,
CDCl3, 25ºC): δ= 8.4 (d, J = 1.5 Hz, 1H), 8.35-8.29 (m, 3H), 7.90 (dd, J1 = 8.1 Hz, J2 =
1.65, 2H), 7.87-7.81 (m, 3H), 7.64-7.61 (d, J = 7.96, 2H), 7.05 (s, 1H), 7.03 (s, 1H),
6.79 (s, 4H), 5.03 (d, J =9.19 Hz, 1H), 4.98 (s, 1H), 4.30 (d, J = 9.19 Hz, 1H), 4.07-4.02
(m, 4H), 2.86 (s, 3H), 1.90-1.83 (m, 4H), 1.6-1.5 (m, 4H), 1.38-1.35 (m, 8H), 0.92-0.87
ppm (m, 6H). 13C-NMR (75 MHz, CDCl3, 25ºC): δ= 193.17, 183.01, 182.90, 155.68,
154.35, 154.04, 147.77, 146.76, 146.66, 146.36, 145.70, 145.13, 144.75, 143.56,
143.04, 142.51, 142.38, 142.08, 140.59, 140.32, 140.04, 136.79, 134.57, 133.99,
133.90, 132.65, 132.51, 130.52, 129.88, 127.76, 127.71, 118.75, 117.38, 117.20,
114.47, 113.35, 93.89, 91.54, 75.88, 70.02, 40.46, 39.88, 35.11, 31.95, 30.12, 29.63,
26.15, 23.04, 14.48, 14.43 ppm. FTIR (KBr): ν= 527, 669, 758, 1186, 1217, 1222,
2395, 2150, 2175 cm-1. EM m/z (EI), (%I): 1554 (56)[ M+], 1384 (35). UV-vis
(CH2Cl2), λmax: 250, 317, 384, 491 nm.
Compound 27c : Eluent : chloroform. Yield 53 %. Mp > 300 ºC. 1H-NMR (300 MHz,
CDCl3, 25ºC): δ= 8.45 (brs, 1H), 8.36-8.30 (m, 3H), 7.91-7.82 (m, 5H), 7.63-7.60 (m,
2H), 7.06 (s, 2H), 7.04 (s, 2H), 7.01 (s, 2H), 7.00 (s, 2H), 5.02 (d, J = 9.19 Hz, 1H),
4.99 (s, 1H), 4.30 (d, J = 9.19 Hz, 1H), 4.09-4.01 (m, 4H), 2.85 (s, 3H), 1.88-1.80 (m,
4H), 1.59-1.57 (m, 4H), 1.36-1.26 (m, 8H), 0.93-0.84 ppm (m, 6H). 13C-NMR (75 MHz,
CDCl3, 25ºC): δ= 183.03, 182.92, 154.35, 154.10, 153.90, 153.86, 147.81, 146.80,
146.67, 146.43, 146.37, 146.26, 146.12, 145.93, 145.79, 145.72, 145.16, 144.93,
144.67, 143.56, 143.41, 143.12, 142.83, 142.54, 142.48, 142.29, 142.06, 141.90,
140.65, 140.58, 140.36, 140.13, 136.79, 135.84, 134.71, 134.60, 133.99, 133.89,
133.83, 132.88, 132.84, 132.74, 132.62, 132.44, 131.93, 131.30, 130.52, 130.25,
129.85, 129.74, 129.20, 128.99, 128.81, 128.68, 127.78, 127.71, 11751, 117.38, 115.76,
114.90, 113.88, 113.15, 93.87, 92.40, 91.95, 91.67, 83.64, 70.12, 70.09, 69.95, 68.55,
32.02, 31.97, 31.95, 30.11, 29.66, 26.07, 23.06, 14.49, 14.46 ppm. FTIR (KBr): ν= 526,
756, 928, 1050, 2232, 2399 cm-1. EM m/z (EI), (%I): 1855 (33)[M], 1275 (50), 720
(67). UV-vis (CH2Cl2), λmax: 494, 396, 314, 245 nm.
General procedure for the preparation of reference compounds: C60 (138.96 mg,
0.193 mmol) was dissolved in chlorobenzene (20 mL) (ultrasound 30 min), compound 9
(97 mg, 0.193 mmol) and N-methylglycine (25.76 mg, 0.289 mmol) were added. The
15
mixture was heated under reflux for 3 h. After the evaporation of the solvent, the
residue was purified by column chromatography on silica gel.
Compound 28: Eluent: Chloroform. Yield 43 %. Mp > 300 ºC. 1H-NMR (300 MHz,
CDCl3, 25ºC): δ= 7.80 (brs, 2H), 7.60 (d, J = 8.51 Hz, 2H), 6.93 (s, 2H), 5.00 (d, J =
9.33 Hz, 1H), 4.96 (s, 1H), 4.29 (d, J = 9.47 Hz, 1H), 4.01-394 (m, 4H), 2.83 (s, 3H),
1.87-1.75 (m, 4H), 1.54-1.49 (m, 4H), 1.36-1.31 (m, 8H), 0.93-0.83 (m, 6H), 0.26 ppm
(s, 9H). 13C-NMR (75 MHz, CDCl3, 25ºC): δ= 156.52, 154.51, 154.30, 153.83, 153.57,
147.72, 147.04, 146.83, 146.73, 146.67, 146.63, 146.56, 146.51, 146.41, 146.36,
146.34, 146.15, 145.93, 145.83, 145.74, 145.67, 145.64, 145.58, 145.10, 145.02,
144.78, 143.55, 143.40, 143.09, 142.98,142.94, 142.67, 142.64, 142.51, 142.43, 142.29,
142.26, 142.09, 141.95, 140.59, 140.56, 140.28, 139.99, 137.70, 137.25, 136.88,
136.29, 136.11, 132.27, 129.67, 123.89, 117.55, 117.13, 114.35, 114.11, 101.47,
100.59, 94.99, 87.04, 83.69, 70.41, 69.93, 69.82, 69.44, 40.44, 32.02, 31.98, 29.68,
29.64, 26.10, 23.05, 14.51, 0.36 ppm. FTIR (KBr): ν= 526, 553, 574, 758, 842, 1161,
1215, 1247, 1377, 1409, 1463, 1490, 1508, 2150, 2779, 2854, 2925, 2949 cm-1. EM m/z
(ESI), (%I): 1249 (M, 40), 1248 (M+, 35), 1024 (10), 924 (23), 817 (8). UV-vis
(CH2Cl2), λmax: 253, 312, 357 nm.
Compound 29: Eluent: Chloroform. Yield 60%. Mp > 300 ºC. 1H-NMR (300 MHz,
CDCl3, 25ºC): δ= 7.81 (brs, 2H), 7.56-7.55 (m, 2H), 6.87 (brs, 4H), 5.02 (d, J = 9.03
Hz, 1H), 4.98 (s, 1H), 4.30 ( d, J = 9.42 Hz, 1H), 3.99-3.95 (m, 8H), 2.86 (s, 3H), 1.86-
1.75 (m, 8H), 1.55-1.50 (m, 8H), 1.49-1.40 (m, 16H), 1.01-0.89 ppm (m, 12H). 13C-
NMR (75 MHz, CDCl3, 25ºC): δ= 155.00, 154.91, 154.08, 153.72, 153.29, 149.46,
147.75, 146.78, 146.39, 146.19, 146.03, 145.69, 145.10, 144.84, 143.05, 142.61,
142.49, 142.35, 132.43, 135.40, 132.03, 129.56, 118.18, 117.75, 117.56, 116.96,
115.45, 113.52, 112.75, 83.75, 77.23, 76.73, 76.28, 74.94, 73.91, 73.12, 69.94, 69,83,
69.75, 69.54, 31.54, 31.51, 29.67, 29.18, 29.14, 29.09, 25.63, 25.59, 22.60, 22.57,
18.67, 18.64, 17.76, 16.22, 16.02, 15.74, 13.98 ppm. FTIR (KBr): ν: 526, 660, 745, 800,
1126, 1310, 1645, 2255 cm-1. UV-vis (CH2Cl2), λmax: 230, 255, 317, 380, 397 nm. EM
m/z (MALDI-TOF): 1290 [M+].
16
Figure S1. Electrostatic potential as calculated by AM1 CIS for the ground and charge-
separated states of 27a-c. The positive charge is represented in red and the negative in
blue.
17
Stabilization of CT States by Solvent and Geometrical Relaxation
Single-point calculations on the relaxed structures of the ground and excited states in
the simulated solvents hexane (ε=2.023), CCl4 (ε=2.229), benzene (ε=2.274), ether
(ε=4.197), chloroform (ε=4.806), methylene chloride (ε=8.930), pyridine (ε=12.40),
acetone (ε=20.56), ethanol (ε=24.55) nitrobenzene (ε=43.82), acetonitrile (ε=35.94) and
dimethyl sulfoxide (ε=46.45) were performed in order to judge the solvent effects on
the relative stabilities of the different states for 27a-c.
Figure S2. Dependence of the calculated heats of formation, ∆Hf, for the discussed
states of 27c on solvent permittivity: ground state (circles), local excited state
(triangles), BCT (squares), CT (rotated squares).
Figure S2 shows the dependence of the calculated heats of formation, ∆Hf, of the
discussed states of 27c on solvent permittivity ((ε-1/(2ε+1)). By optimizing the local-
excited (LE) state, the BCT state and the CT state of 27c, it was possible to determine
the energy levels of the three different Franck-Condon states and get more insight into
the electron-transfer pathway. The calculations reveal that the relative energies of the
different states and conformations and their solvent dependence are reproduced
remarkably well in accordance with the experimental trends. As illustrated in Figure S2,
with higher solvent polarity the energy splitting between the different states increases
significantly whereas their relative energies decrease due to solvent stabilization.
Equally important, one can see that the BCT becomes more and more accessible as the
polarity of the solvent increases. This behavior was also observed in the photophysical
18
experiments. However, no crossing between the CT and BCT state, even in nonpolar
media, was observed during the calculations. The results for the monomer 27a and the
dimer 27b reveal equal solvent dependence of the discussed states. However, in these
two compounds no BCT is present. The heat of formation of the CT states is increasing
almost linearly from monomer to trimer. These trends prove the observations resulting
from the photophysical measurements and confirm the suggested charge-transfer
behavior of the C60-oPPE-exTTF. Thus, the calculations support the hypothesis that in
all solvents an excitation of the triad results in the CT state, which supports our
interpretation of the electron-transfer mechanism.
Calculating the Coulson charge on exTTF and C60 gives a value of 1.0 e- and -1.1 e-,
respectively, for all the triads, indicating complete transfer of one electron from the
donor to the acceptor with some delocalization of the positive charge (4.6 %) into the
bridge. ExTTF is clearly oxidized with the positive charge localized on the sulfur atoms
(0.6 e-), whereas C60 is reduced with the charge being delocalized throughout the carbon
cage. This confirms the one-electron charge transfer from donor to acceptor.
References
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[S2] Dewar, M. J. S.; Zoebisch, E.; Healy, E. F.; Stewart, J. J. P. J. Am. Chem. Soc.
1985, 107, 3902. Holder, A. J. In Encyclopedia of Computational Chemistry; Schleyer,
P. v. R., Allinger, N. L., Clark, T., Gasteiger, J., Kollman, P. A., Schaefer, H. F., III,
Schreiner, P. R., Eds.; Wiley: Chichester, 1998; Vol. 1, p 8
[S3] Dewar, M. J. S.; Liotard, D. A. J. Mol. Struct. (THEOCHEM) 1990, 206, 123
[S4] Bondi, A. J. Phys. Chem. 1964, 68, 441
[S5] Local molecular properties and their use in predicting reactivity, B. Ehresmann,
B. Martin, A. H. C. Horn and T. Clark, J. Mol. Model. 2003, 9, 342-347.; QSAR and
QSPR based solely on surface properties?, T. Clark, J. Mol. Graph. Model. 2004, 22,
519-525