Upload
cnr-it
View
0
Download
0
Embed Size (px)
Citation preview
c o r t e x 4 6 ( 2 0 1 0 ) 1 2 7 2 – 1 2 8 3
ava i lab le a t www.sc iencedi rec t .com
journa l homepage : www.e lsev ie r . com/ loca te /cor tex
Special issue: Research report
Letter and letter-string processing in developmental dyslexia
Maria De Lucaa,*, Cristina Buranib, Despina Paizib,d, Donatella Spinellia,c
and Pierluigi Zoccolottia,d
aNeuropsychology Unit, IRCCS Fondazione Santa Lucia, Rome, ItalybInstitute for Cognitive Sciences and Technologies (ISTC – CNR), Rome, ItalycDepartment of Education Sciences in Sport and Physical Activity, University «Foro Italico», Rome, ItalydDepartment of Psychology, Sapienza University of Rome, Italy
a r t i c l e i n f o
Article history:
Received 29 October 2008
Reviewed 27 February 2009
Revised 18 May 2009
Accepted 23 June 2009
Published online 3 July 2009
Keywords:
Developmental dyslexia
Letter recognition
Word/non-word reading
RAM
* Corresponding author. Neuropsychology UnE-mail addresses: m.deluca@hsantalucia.
0010-9452/$ – see front matter ª 2009 Elsevidoi:10.1016/j.cortex.2009.06.007
a b s t r a c t
This study evaluated letter recognition processing in Italian developmental dyslexics and
its potential contribution to word reading. Letter/bigram recognition (naming and match-
ing) and reading of words and non-words were examined. A group of developmental
dyslexics and a chronologically age-matched group of skilled readers were examined.
Dyslexics were significantly slower than skilled readers in all tasks. The rate and amount
model (RAM, Faust et al., 1999) was used to detect global and specific factors in the
performance differences controlling for the presence of over-additivity effects. Two global
factors emerged. One (‘‘letter-string’’ factor) accounted for the performance in all (and
only) word and non-word reading conditions, indicating a large impairment in dyslexics
(more than 100% reaction time – RT increase as compared to skilled readers). All the letter/
bigram tasks clustered on a separate factor (‘‘letter’’ factor) indicating a mild impairment
(ca. 20% RT increase as compared to skilled readers). After controlling for global factor
influences by the use of the z-score transformation, specific effects were detected for the
‘‘letter-string’’ (but not the ‘‘letter’’) factor. Stimulus length exerted a specific effect on
dyslexics’ performance, with dyslexics being more affected by longer stimuli; furthermore,
dyslexics showed a stronger impairment for reading words than non-words. Individual
differences in the ‘‘letter’’ and ‘‘letter-string’’ factors were uncorrelated, pointing to the
independence of the impairments. The putative mechanisms underlying the two global
factors and their possible relationship to developmental dyslexia are discussed.
ª 2009 Elsevier Srl. All rights reserved.
1. Introduction words (Pelli et al., 2003). Thus, in the presence of a reading
The present study aims to evaluate letter recognition pro-
cessing in Italian developmental dyslexics and its potential
contribution to word reading.
Psychophysical studies provide compelling evidence that
letter recognition represents an unavoidable stage in reading
it, IRCCS Fondazione Sait, maria.deluca@uniromer Srl. All rights reserved
deficit, it is important to know how much of the deficit can be
ascribed to a deficiency in letter recognition. Neuroimaging
studies (James and Gauthier, 2006; James et al., 2005) demon-
strate the presence of separate networks dedicated to letter
processing and orthographic string processing. Therefore, it is
conceivable that processing of single letters and of letter
nta Lucia, Via Ardeatina 306, 00179 Rome, Italy.a1.it (M. De Luca)..
c o r t e x 4 6 ( 2 0 1 0 ) 1 2 7 2 – 1 2 8 3 1273
strings may be dissociated behaviourally in dyslexics; namely,
defective letter-string processing can be observed in the
presence of intact letter processing.
In the case of acquired reading deficits, some disorders have
been interpreted as predominantly due to the impaired ability
to recognise letters. For example, the deficit of some of the
patients who show letter-by-letter reading can be interpreted as
due to an inefficiency in letter identification (e.g., Rosazza et al.,
2007). In the developmental domain, spared letter recognition
has been reported for letter position dyslexia (Friedmann and
Rahamim, 2007) and developmental attentional dyslexia
(Friedmann et al., 2010, this issue). It is also commonly accepted
that letter recognition is spared in surface and phonological
developmental dyslexics and that the impairment emerges at
a later stage of processing (e.g., Jackson and Coltheart, 2001).
This assumption is mostly due to results based on letter
recognition accuracy measurements.1 However, tasks requiring
letter identification may prove extremely simple. It is unlikely
(though not impossible) that children who attend school regu-
larly will make a substantial number of errors in reading single
letters. Therefore, such a task is insensitive and may underes-
timate a potential difficulty. On the other hand, using time
measures a number of studies have reported that dyslexic
children have difficulty in reading letters. For example, using
the Rapid Automatized Naming (RAN ) paradigm, children are
asked to name rapidly sequences of visual stimuli: pictured
objects, colours, letters and numbers (see Denckla and Rudel,
1974). Dyslexics are slow in naming letters as well as in naming
digits or colours (Denckla and Rudel, 1976). Nevertheless, the
actual contribution of these defective performances to the
reading deficit is difficult to assess and general slowness in
naming does not necessarily indicate that letter identification
per se is deficient. Even if sensitive measures (such as time) are
used, it is difficult to compare the level of impairment in two
tasks that vary greatly in general difficulty, such as reading
single letters and words.
This problem is not restricted to letter recognition. A wealth
of experimental studies (well beyond what can be reviewed
here) have shown that proficient readers outperform dyslexics
in a large variety of tasks (other than naming of orthographic
materials), including naming of non-orthographic stimuli,
lexical and orthographic decision, spelling, non-word repeti-
tion, phoneme segmentation, deletion and so on. Many of
these findings have proven robust enough to be replicated. At
the same time, such a large variety of defective performances
clearly call into action very different mechanisms, thus
making it difficult to propose a unitary interpretation of the
disorder. Critical confounding is produced by the presence of
‘‘over-additivity’’ effects (Salthouse and Hedden, 2002): the
more difficult conditions typically yield larger group differ-
ences in performance than the relatively simpler conditions,
over and above the presence of task-specific impairments.
Consequently, it would be important to obtain a reliable esti-
mate of the specificity of the disturbance in any given task that
discriminates dyslexics from proficient readers. A related
question is to establish if some of these numerous differences
1 A letter recognition sub-test is part of many widely usedreading batteries (e.g., in Italian, the Evaluation of DevelopmentalDyslexia and Dysgraphia by Sartori et al., (1995).
can be ascribed to a smaller set of underlying dimensions. One
effective approach for dealing with these issues is to refer to
models that make explicit predictions about the general and
specific components of individual differences in information-
processing tasks. Faust et al. (1999) proposed the rate and
amount model (RAM) that can be applied to measures of
performance pertaining to speed (e.g., reaction times – RTs).
This assumes that a) individuals possess a characteristic pro-
cessing speed that remains relatively stable across different
experimental conditions and b) that each condition requires
a certain amount of information to be processed before an
appropriate response can be initiated. Two characteristics of
this model are critical here. First, it makes explicit predictions
about the non-task-specific (hereafter, global) factor contrib-
uting to the individual performance. For example, it predicts
a linear relationship between the condition means for a group
and those of a different group varying for global processing
ability. This allows testing hypotheses about which tasks
probe the global factor. Second, the model allows disen-
tangling the contribution of the global and task-specific factors
on individual performance. It is proposed that group differ-
ences in a given task depend upon both general components in
performance and selective variations of the influence played
by the parameters manipulated (e.g., lexicality and length). In
standard parametric analyses (such as analysis of variance –
ANOVA), the former express as main effects and the latter as
interactions between the parameter and group. However,
overall differences in performance can spuriously inflate the
size of the interaction by producing over-additivity effects.
Faust et al. (1999) have proposed various data transformations
(including z-scores) appropriate to control for this over-addi-
tivity effect. These data transformations allow disentangling
the relative role of global influences from that of task speci-
ficity. Note that this perspective focuses on whether the size of
the group effect indicates a systematic dimensional coherence
across conditions, rather than on examining the presence of
significant group differences in each single experimental
condition separately. We have proposed that this approach
has the potential to reduce the large number of difficult-to-
interpret group differences between dyslexics and proficient
readers to one, or a few, dimensions (Zoccolotti et al., 2008).
An important methodological consideration concerns the
number of global factors that can be envisaged. Often, refer-
ence is made to a global component in performance as a single
factor indicating the contribution of ‘‘speed of processing’’ per
se to higher cognitive functioning. Anderson (1992) has
envisaged various theoretical options of how such a general
factor could modulate dyslexia (pp. 189–195). Nevertheless,
while speed of processing may be a useful concept for
understanding cognitive differences on various tasks across
the life span, with a general slowing of processing in the
elderly (Faust et al., 1999; Kail and Salthouse, 1994), it is hard to
imagine how such a general concept could account for the
relatively specific deficits shown by dyslexics. Consistently,
Bonifacci and Snowling (2008) have demonstrated that
a measure of speed of processing accounted for differences
between children of differing intelligence but not for differ-
ences between groups varying for reading skill. Thus, it seems
erroneous to expect that the non-task-specific differences in
performance between dyslexics and good readers can be
c o r t e x 4 6 ( 2 0 1 0 ) 1 2 7 2 – 1 2 8 31274
captured by a single factor. This view is expressed quite
clearly by Kail and Salthouse (1994, p. 202) in their statement
that there is no reason to assume that there is only one single
processing resource underlying all aspects of cognitive
performance.
Identifying the conditions that map onto the global factor
(or factors) which account for the differences in performance
between dyslexics and skilled readers may represent a venue
to understanding the mechanisms generating the deficit. It
should be kept in mind, however, that focusing on the face
values of the single conditions (raw data) may be misleading.
Indeed, a more convincing interpretation might be obtained
from an analysis of the communality across conditions that
contribute to the factor(s) and from the absence of a relation-
ship with conditions that do not contribute to the factor(s).
In a previous study, we applied the RAM to the vocal RTs of
dyslexics and controls in naming pictures, words and non-
words of varying length (Zoccolotti et al., 2008). Dyslexics were
slower in naming orthographic strings (both words and non-
words) but not in naming pictures corresponding to the same
words. In the raw RTs, the group by lexicality interaction indi-
cated larger RT differences in naming non-words than words in
dyslexics as compared to controls. However, this effect van-
ished when data transformations apt to control for over-addi-
tivity were used. Zoccolotti et al. (2008) concluded that
dyslexics’ impairment in reading non-words (often considered
a specific marker of phonological dyslexia; e.g., Rack et al., 1992)
could be most parsimoniously interpreted as due to a global
deficit in ‘‘naming orthographic strings’’. Since the global deficit
affected both words and non-words, we proposed that it could
be localised at a pre-lexical stage of processing. We also stated
that a full definition of the nature of the global component(s)
that affect performance awaits further work on a larger variety
of tasks and (stimuli) conditions. The present study, investi-
gating single letter and bigram processing and using different
tasks, aims to contribute to such a definition. Does a single
factor explain the speed difference between dyslexics and
skilled readers when dealing with any orthographic material? If
present, would the group difference for single letters/bigrams
have the same size as that for words (and non-words) after
controlling for over-additivity effects? In considering multiple
sources of impairment, it should be taken into account that
different forms of developmental dyslexia have been reported
(Temple, 2006); most likely, they refer to independent func-
tional impairments.
To evaluate performance with letters, we examined several
conditions including: a) a letter naming task which requires
retrieving the phonological code for the letter name; b) a syllable
reading task which probes the ability to apply grapheme-to-
phoneme conversion rules; c) a sequential matching of conso-
nant pairs which tests the ability to store and compare letter
shapes and d) a simultaneous matching task of letters varying
for case which requires abstract letter identity (Coltheart, 1981,
1987). Critically, these tasks allowed us to test a number of
components underlying letter recognition that might
contribute to the reading deficit. Thus, we may observe selective
failure in dyslexic children at some specific level of processing
(e.g., in terms of abstract phonemic or graphemic representa-
tion). Performances in these letter tasks were compared with
those in tasks requiring the naming of longer letter strings (both
words and non-words). In view of the importance of the number
of letters in modulating dyslexics’ performance, length was
systematically manipulated in the letter-string conditions.
Because of the great variety of tasks (a total of 20 experimental
conditions) we expected large between-task variations in
performances; this is an important pre-requisite for applying
the RAM and for detecting global components in the data.
Overall, the general aim of the study was to detect the
conditions that contribute to generating a difference in
performance between dyslexics and skilled readers in dealing
with orthographic materials (single letters, bigrams, syllables
and longer letter strings). It should be noted that our intention
was not to identify all the factors contributing to reading
performance, but was specifically aimed at discovering
a source of the reading impairment. Different hypotheses can
be advanced concerning the role of letter recognition in
reading performance. If the global factor accounting for the
difference between dyslexics and skilled readers refers to
slowness in processing orthographic material as such, it is
reasonable that letter processing, similarly to letter strings,
participates fully in this deficit.
Alternatively, one could posit that letter identification is
intact or only partially impaired and that the orthographic
deficit becomes severe only when strings of letters (i.e., words
and non-words) are processed. Some observations from the
visual psychophysical literature support the latter alternative.
It has been proposed that visual crowding contributes to the
genesis of dyslexia, with dyslexics showing stronger crowding
effects than normal readers (e.g., Bouma and Legein, 1977).
Crowding refers to the decrease in recognisability of a letter
surrounded by other letters placed closer than a critical
distance (Pelli et al., 2004); therefore, crowding is expected
with closely spaced letter strings but not with isolated letters.
Recently, a strong claim was made that the only limit to
reading rate in normal readers is crowding (Pelli et al., 2007). If
crowding contributes to developmental dyslexia, the perfor-
mance in identifying single letters (and bigrams) is not
expected to contribute to the same factor underlying pro-
cessing of orthographic material.
2. Methods
2.1. Participants
A group of 18 dyslexics (9 girls and 9 boys) with a mean age of
11.3 years (standard deviation – SD¼ .3) and a group of 36 (18
girls and 18 boys) skilled readers (mean age: 11.3 years,
SD¼ .3) were tested. Criteria for inclusion in the dyslexic
group were scores of at least two SDs below the norm for
either speed or accuracy in a standardised Italian reading
level examination (MT reading test, Cornoldi and Colpo, 1995;
see below). Performance was well within the normal range in
reading comprehension and Raven’s Coloured Progressive
Matrices for all children according to Italian normative data
(Pruneti et al., 1996). All participants had normal or corrected
to normal visual acuity. The two groups were matched for
chronological age, sex and nonverbal IQ levels based on their
scores on Raven’s Coloured Progressive Matrices (see
Table 1).
Table 1 – Summary of statistics (mean age in years and months, with range in parentheses; no. of male and femaleparticipants), mean scores on Raven’s test (with SD in parentheses), mean z-scores on reading speed, accuracy, andcomprehension (with SD in parentheses) for the two groups of participants (dyslexic and skilled readers).
Group Chronological age Male Female Raven’s test Reading speed Reading accuracy Reading comprehension
Dyslexic readers 11;3 (10;9–11;9) 9 9 30.5 (SD¼ 3.2) �1.3 (SD¼ 1.0) �2.8 (SD¼ .6) .6 (SD¼ .2)
Skilled readers 11;3 (10;6–11;9) 18 18 30.3 (SD¼ 3.1) .5 (SD¼ .4) .0 (SD¼ .5) .4 (SD¼ .4)
c o r t e x 4 6 ( 2 0 1 0 ) 1 2 7 2 – 1 2 8 3 1275
2.2. Reading evaluation
In the MT reading test the child reads aloud a passage of text
with a 4-min time limit; speed (s per syllable) and accuracy
(number of errors, adjusted for the amount of text read) are
scored. A comprehension sub-test was also given (but not
used as part of the selection criteria). The participant reads
a second passage silently, with no time limit, and then
responds to 10 multiple-choice questions.
Mean scores for the two groups of participants for reading
speed, accuracy and comprehension are given in Table 1. Of
the 18 dyslexic children, 4 were below the cut-off for both
speed and accuracy and 14 for accuracy only according to
standard reference data (Cornoldi and Colpo, 1995). Compre-
hension was generally spared, a common finding in Italian
dyslexic children (Judica et al., 2002). Individual profiles of
speed and reading responses are presented in Appendix A.
The analysis of the error profile for each dyslexic child in
reading the MT text was carried out based on the error scoring
proposed by Hendriks and Kolk (1997); this error classification
(developed for Dutch) may prove appropriate for an ortho-
graphically regular language such as Italian. The classification
of responses considers three main categories: sounding-out
behaviour (i.e., sounding-out parts of the word before uttering
the whole word), word substitution and residual responses
(such as the production of non-words); for an in-depth
description of the categories, see Hendriks and Kolk (1997). An
inspection of the individual performances indicates that most
children were slow (on average of ca. 80% with respect to the
skilled readers) and showed frequent sounding-out behaviour
(in 5.8% of words; categories S1 to S4), nearly always
producing a correct utterance. Word substitutions consisted
mostly of visual errors, visual–context errors, function word
substitution and derivational errors (involving 5.6% of words;
categories W1 to W8). In a proportion of cases (2.1%) the
utterance produced was a non-word. Some individual differ-
ences were also apparent. In particular, although some chil-
dren show only mild speed impairment, also in these cases
the general profile of errors held true. Overall, this pattern
discloses the slow, laborious reading characteristic of these
children with frequent recourse to sounding-out words before
uttering them; the errors on words primarily represent visual
approximations sometimes producing non-lexical responses.
This profile appears consistent with the prevalent use of the
grapheme-to-phoneme conversion routine (Zoccolotti et al.,
1999). For the aim of the present study, this group of children
appeared sufficiently homogeneous to be treated as a group.
2.3. Apparatus and general characteristics of the tasks
Stimuli were presented on the screen of a PC and controlled by
the E-Prime software. The stimuli were displayed in white on
a black background and the font was Courier 18 points,
a fixed-width font (i.e., all letters have the same width). At the
viewing distance of 57 cm, each letter subtended .6�. The order
of trials was randomised within each block by the software.
For the naming conditions, a voice key connected to the
computer measured vocal RTs in milliseconds (msec) at the
onset of pronunciation. A fixation cross was displayed for
500 msec followed by an inter-stimulus interval of 300 msec
before the display of each stimulus. Each stimulus disappeared
at the onset of pronunciation or after 4000 msec had elapsed.
An inter-trial interval of 1000 msec followed. The experimenter
noted pronunciation errors. For the same–different judge-
ments, the participant pressed one of two keys (YES–NO) con-
nected to a serial response box. In all tasks, only RTs to
correctly responded items were considered for the analyses.
2.4. Experimental tests
2.4.1. Test 1: naming lettersA list of 13 single upper case letters was used. Letters were the
five vowels of the Italian alphabet and the eight consonants
whose name corresponds to a V or CV Italian pronounceable
two-letter syllable (A, B, C, D, E, G, I, O, P, Q, T, U, and V). There
was one practice block consisting of five trials and three
experimental blocks, each consisting of 13 experimental trials
(corresponding to the 13 different letters). The order of
presentation of the trials was different across blocks. Ran-
domisation was fixed across participants. The participants
had to say the name of the letter as quickly as possible. Mean
vocal RTs to correctly named letters were measured.
2.4.2. Test 2: reading syllablesA list of 30 upper case two-letter CV syllables was used. None of
these syllables corresponded to an entry in the lexicon; their
token mean frequency drawn from the Database II: Syllables
(Stella and Job, 2001) was 4911 out of 1 million occurrences
(SD¼ 6085; range 2–25,438). There was one practice block of five
trials and one experimental block of 30 trials. Randomisation
was fixed across participants. The participant’s task was to
name the syllable as quickly as possible. Mean vocal RTs to
correctly named syllables were measured.
2.4.3. Test 3: sequential identity letter judgementA list of 40 upper case letter pairs was used. The two letters were
displayed sequentially. The size of the letters was the same as in
Test 1. They were arranged vertically, the first letter above and
the second letter below a fixation cross, with a vertical gap of .8�
between the two stimuli. There were 20 sequential pairs con-
sisting of identical letters (AA, BB, etc.) plus 20 pairs consisting
of different letters (AD, BQ, etc.). Twenty different letters were
used to generate both the ‘‘same’’ and ‘‘different’’ trials. One
practice block of 10 trials and one experimental block of 40 trials
c o r t e x 4 6 ( 2 0 1 0 ) 1 2 7 2 – 1 2 8 31276
were given. Randomisation was fixed across participants. The
first stimulus was displayed for 150 msec, immediately fol-
lowed by the second stimulus, which remained on the screen
until the participant’s response (or a 4000-msec time limit). The
participant’s task was to decide whether the second letter was
the same as or different from the previous one by pressing one
of the two response keys as quickly as possible. Mean RTs to
correct same and different letter pairs were measured.
2.4.4. Test 4: identity judgement of simultaneous letter pairsvarying for caseStimuli were 48 bigrams not corresponding to a syllable (both
letters were consonants). The size of the bigram was the same
as in Test 2. The letters of each bigram could be either the same
or different. Each bigram could be printed in upper case (BB, CD),
lower case (bb, cd) or mixed case, with the lower case letter
either presented first (bB, cD) or second (Bb, Cd). There were 4
bb-type, 4 BB-type, 8 bB, 8 Bb, 6 bc, 6 BC, 6 bC, and 6 Bc trials.
There was one practice block of 10 trials and two experimental
blocks of 24 trials each. The stimulus remained on the screen
until the participant responded (or until a 4000 msec time limit
expired). The participant’s task was to decide whether the two
letters were the same or different, irrespective of case type, by
pressing one of the two response keys as quickly as possible.
The combination of two response types (YES–NO), four stimulus
types (lower case, upper case, lower/upper case, upper/lower
case) yielded a total of eight measures of performance.
2.4.5. Test 5: reading words and non-wordsSixty words were used. Mean child written word frequency
was 290.7 (SD¼ 510.9; range¼ 49–3584) in 1 million occur-
rences, drawn from the LEXVAR database (Barca et al., 2002).
Words were 4-, 5-, 6- and 7-letters long (disyllabic and tri-
syllabic). All words were stressed with the most frequent
stress in Italian (on the penultimate syllable). There were 15
items in each length condition. The four length conditions
were matched for frequency, rated age of acquisition (AoA),
familiarity, imageability, number of orthographic neighbours
Fig. 1 – Test of RAM predictions based on results of dyslexics a
(specified in the middle inset): a) dyslexics’ condition means are
report RTs for letter and bigram tasks (conditions 1–12). Filled c
13–20). The dotted line (slope [ 1) represents equal RTs for dys
(dyslexics and skilled readers) are plotted as a function of over
(N-size), bigram frequency and orthographic complexity
(Burani et al., 2006). Sixty non-words were generated from the
word set by changing one or two letters. Non-words were
matched with words for length in letters (subtending the same
visual angle), bigram frequency, orthographic complexity and
initial phoneme. Words and non-words were presented mixed
within the same block of trials; the order of the trials within
each block was randomised. The participant was instructed to
read aloud as fast and accurately as possible the stimuli that
appeared in the centre of the computer screen. This task
yielded eight performance measures: mean RTs to 4-, 5-, 6-
and 7-letter words and non-words.
2.5. Procedure
Tests 1–4 were administered in one experimental session. The
order of presentation of the tasks was counterbalanced across
participants. Each block was preceded by a brief practice block
and followed by a short pause. Test 5 was administered in one
experimental session. A practice block of 10 trials preceded
the test.
Apart from the naming letters test, the items used for the
practice blocks in each test were different from the items used
for the experimental trials but had the same characteristics as
the experimental items.
3. Results
3.1. Testing the RAM predictions
Faust et al. (1999) predicted various linear relationships to
define the presence of global components in the data. Here, we
first tested the prediction of a linear relationship between the
means of the two groups for conditions that varied in overall
information-processing rate. Dyslexics’ and skilled readers’
condition means are plotted against each other in Fig. 1a. In
the graph, a diagonal dotted line is plotted. Points lying on the
nd skilled readers in several experimental conditions
plotted as a function of skilled readers’ means. Open circles
ircles report RTs for word and non-word tasks (conditions
lexics and skilled readers. b) SDs across individuals
all group means for the same conditions.
c o r t e x 4 6 ( 2 0 1 0 ) 1 2 7 2 – 1 2 8 3 1277
diagonal indicate identical performance of the two groups and
points above and below the line worse performance of
dyslexics and skilled readers, respectively. Therefore, since all
data points lie above the diagonal dotted line, dyslexics were
slower than skilled readers in all conditions.
Various observations can be made about this graph.
First, it should be noted that in both groups of children
there was a large variation in response time across condi-
tions both in the case of the letter/bigram tasks (data points
range from 618 msec to 1120 msec and from 537 msec to
927 msec for dyslexics and skilled readers, respectively) and
in the case of the words/non-words reading (data points
range from 702 msec to 1036 msec and from 563 msec to
701 msec for dyslexics and skilled readers, respectively).
This large variation is a pre-requisite for the detection of
global components in the data according to the RAM.
Second and most critically, inspection of the figure indi-
cates that the data can be best described by two linear
relationships, one (plotted by filled circles) accounting for
all word and non-word conditions (y¼ 2.09x� 447.3; r2¼ .96)
and one (plotted by open circles) for all the conditions
involving letters and bigrams (y¼ 1.22x� 17.3; r2¼ .98). In
contrast, a solution with a single regression line yields
a lower coefficient of determination (r2¼ .77). Third, the
deficit of dyslexics was more marked in the case of the
word/non-word conditions with a slope of b¼ 2.09 (i.e.,
dyslexics were slower than skilled readers by about a factor
of two, corresponding to a 109% difference) than in the case
of the letter–bigram conditions (b¼ 1.22, i.e., dyslexics were
slower than skilled readers by 22%).
Successively, we tested the prediction of a linear relation-
ship between overall group means and SDs across individuals
in the same conditions. To this aim, in Fig. 1b, we plotted the
condition means of the total sample against the SDs of the
same conditions. Note the general tendency for more difficult
conditions to be associated with larger variability (SD) values.
Again the best fit for the data is with two regression lines, one
accounting for the word–non-word conditions (y¼ .7x� 296.7;
r2¼ .97) and one for letter–bigram conditions (y¼ .4x� 134.1;
r2¼ .94); the proportion of explained variance decreased when
a single regression line was used to account for all the data
(r2¼ .82).
3.1.1. Comments: ‘‘letter’’ and ‘‘letter-string’’ global factorsFollowing Faust et al. (1999), we tested the presence of one
or more global components in the data employing a variety
of tasks/stimuli conditions. The results indicated that there
are two separate global influences, one accounting for
performances in the conditions with words and non-words
(hereafter, called ‘‘letter-string’’ factor) and one accounting
for performances on all letter–bigram tasks (hereafter,
‘‘letter’’ factor). It is noteworthy that the letter–bigram
conditions did not always yield faster RTs than the word/
non-word reading task. In fact, when the task involved
matching single letters (either simultaneous or sequential),
processing times could be longer than in the case of reading
a word, also in dyslexics. Therefore, the seemingly smaller
speed deficit of dyslexics in the letter–bigram tasks cannot
be attributed to a bias due to a difference in the overall
difficulty of the tasks.
3.2. Testing for the presence of specific factors
The prediction tests (see Section 3.1) refer to large-scale
components in performance and they do not exclude that the
two critical groups are further discriminated by small-scale
specific factors. To this aim, Faust et al. (1999) suggest
comparing parametric analyses (such as ANOVAs) on raw
versus transformed data. Interactions with the group factor,
which were significant in both the raw score and transformed
score analyses, indicate the selective influence of a given
parameter; in contrast, interactions that were significant only
in the raw data, but not on transformed values, indicate the
presence of a spurious interaction (over-additivity effect).
Therefore, raw data were transformed into z-scores by
taking each individual’s condition means, subtracting their
overall mean and dividing it by the SD of their condition
means. z-scores indicate an individual participant’s perfor-
mance in a given condition relative to all other conditions
based on the individual means of all conditions (therefore,
each individual has an average of 0 across conditions and an
SD¼ 1). This transformation re-scales individual perfor-
mances to a common reference; hence, it allows controlling
for global components while it preserves the information
regarding individual variability across experimental condi-
tions. Since two different global components were observed in
the data, we carried out the z-score transformation twice,
once for all letter–bigram tasks and once for all word and non-
word conditions.
It should be noted that these transformations may be
applied to open scales, such as time, but they are not suited in
the case of closed scales, such as accuracy. Consequently,
analyses in this paper mostly focus on time measures.
However, based on inspection of the data we found no indi-
cation of trade-offs between RTs and accuracy for any of the
experimental conditions.
3.3. Letter–bigram conditions
In the raw data analyses, dyslexics were slower than skilled
readers in both Test 1 (naming letters: t(52)¼ 4.78, p< .0001) and
Test 2 (reading syllables: t(52)¼ 5.11, p< .0001). In Test 3,
dyslexics were slower than skilled readers in matching single
letters [F(1,52)¼ 12.17, p< .001]; same responses were faster than
different responses [F(1,52)¼ 29.39, p< .0001], with no group by
response type interaction. In Test 4 (identity judgement),
dyslexics were slower than skilled readers in matching bigrams
[F(1,52)¼ 9.92, p< .005] and same responses were faster than
different responses [F(1,52)¼ 128.57, p< .0001]. The stimulus type
effect [F(3,156)¼ 50.73, p< .0001] indicated faster responses for
upper (774 msec) than lower case (881 msec, p< .0001, Tukey’s
honest significant difference test – HSD test) and the two mixed
case conditions (lower case first: 901 msec, p< .0001; upper
case first: 897 msec, p< .0001). The response type by stimulus
type interaction was significant [F(3,156)¼ 45.89, p< .0001]:
‘‘different’’ responses were slower than ‘‘same’’ responses for
the upper case and lower case stimuli (p< .0001) but not for the
two mixed case conditions. Note that the raw data analyses
showed no group by condition interactions.
When the same analyses were carried out on z-scores, the
effect of group washed out in all cases, including both t-test
c o r t e x 4 6 ( 2 0 1 0 ) 1 2 7 2 – 1 2 8 31278
comparisons (Tests 1 and 2) and ANOVAs (Tests 3 and 4).2 The
main effects of task were replicated. In both Tests 3 and 4, the
same responses were faster than the different responses
[F(1,52)¼ 24.4, p< .0001; and F(1,52)¼ 145.7, p< .0001, respec-
tively]. In Test 4, the stimulus type effect was significant
[F(3,156)¼ 58.7, p< .0001] and the decomposition of the effect
was similar to that of raw data. The response type by stimulus
type interaction was significant [F(3,156)¼ 60.29, p< .0001]:
same responses were better than different responses for the
upper case, lower case, and one of the mixed cases (lower case
as the second letter) stimuli (all ps at least <.01).
3.3.1. Comments: absence of specific effects in letterprocessingDyslexics were slower than skilled readers across all tests
involving letter processing, including naming and same–
different judgements. These group differences washed out in
the case of the z-scores analyses, indicating that they are
entirely explained by the global ‘‘letter’’ factor.
The raw analyses did not show any group by condition
interactions. Consequently, no critical test of the specificity
assumption was carried out in these analyses. Clearly, the
manipulations tested (one letter vs two letters; naming vs
matching; lower vs upper case, etc.) did not impose a specific
additional load on the dyslexic children over and above their
overall slowness in processing letters. Furthermore, the rela-
tively small slope (b¼ 1.2) accounting for the ‘‘letter’’ factor was
presumably not large enough to yield spurious interactions with
the group factor in the ANOVAs on single task performances.
3.4. Word and non-word conditions
In the ANOVA on raw data, the main effects of group
[F(1,52)¼ 41.15, p< .001], lexicality [F(1,52)¼ 137.25, p< .001] and
length [F(1,52)¼ 77.42, p< .001] were significant, indicating
slower RTs for dyslexics, non-words and longer stimuli,
respectively. The lexicality by length interaction [F(3,156)¼ 27.62,
p< .001] indicated a more pronounced effect of length on non-
words than on words. All interactions involving the group were
significant (at least p< .05). In particular, dyslexics showed
a greater effect of length [F(3,156)¼ 16.27, p< .001; see Fig. 2a] and
a greater effect of lexicality [F(1,52)¼ 12.27, p< .001; see Fig. 2b].
The group by length by lexicality interaction [F(3,156)¼ 3.19,
p< .05] indicated that the greater length effect for non-words
was more marked in dyslexics than skilled readers.
The ANOVA on z-scores indicated main effects of lexicality
[F(1,52)¼ 1515.80, p< .001] and length [F(1,52)¼ 136.30, p< .001].
The group by length interaction was significant [F(3,156)¼ 4.80,
p< .005; see Fig. 2c], indicating more marked length effects for
dyslexics than skilled readers. The group by lexicality
2 According to the RAM, the critical comparison is betweengroup by condition interaction in raw versus transformed dataand the group effect is expected to be nil in the z-score analyses.However, since the data transformation is carried out acrossa large number of conditions, residual effects of the group effectmay indeed be found. These would indicate that the group isselectively impaired in that specific test as compared to all others.In this sense, also Student t comparisons are informative of thepotential presence of selective task influences moderating thegroup difference.
interaction was significant [F(1,52)¼ 10.22, p< .005; see Fig. 2d].
This indicated an opposite effect to that of raw RTs: dyslexics
showed a less marked lexicality effect than skilled readers; the
difference between words and non-words was 1.33 z units in
skilled readers and 1.13 in dyslexics. The group by length by
lexicality interaction was not significant.
3.4.1. Comments: specific length and lexicality effectsThe analysis of raw data for word and non-word conditions
indicated greater effects of lexicality and length (and their
interaction) in dyslexics than typically developing readers,
a pattern of results that confirms previous observa-
tions (Ziegler et al. 2003; Zoccolotti et al., 2008; see also
Marinus and de Jong, 2010, this issue).
The analyses using z-score transformation allowed deter-
mining whether small-scale specific factors accounted for the
difference between skilled readers and dyslexics over and
above the large-scale difference in reading words and non-
words. When examined in terms of z-scores, the interaction
between group and length remained significant, indicating
a residual specific role of stimulus length over and above the
influence of the global factor in performance. This finding
closely confirms previous evidence (Zoccolotti et al., 2008).
The results for the lexicality effect yielded opposite patterns
in the two analyses. In the raw data ANOVA, the difference
between words and non-words was larger in dyslexics; in the z-
score analysis (which cancels out the over-additivity effect), the
direction of the effect was the opposite, i.e., dyslexics had
slightly less marked lexicality effects than skilled readers. This
latter result points to a specific difficulty of dyslexics in the case
of words (i.e., inefficiency in accessing/retrieving items from the
orthographic lexicon) and to a spared ability in mastering the
grapheme-to-phoneme conversion rules (known to be critical in
non-word reading), a pattern generally consistent with surface
dyslexia. In previous research, we proposed that the profile of
Italian dyslexics presents several similarities with that of
surface dyslexia (Zoccolotti et al., 1999). As stated above, also
the profile of reading behaviour in the present group of
dyslexics in reading a text passage indicates a prevalent reli-
ance on the grapheme-to-phoneme conversion routine.
In a previous study (Zoccolotti et al., 2008), the group by
lexicality interaction washed out in the z-score analysis; i.e.,
the effect was entirely explained in terms of a global factor.
This discrepancy may be due to the difference in stimuli
selection. In that previous study, wordsof different length were
matched only for frequency and initial phoneme and non-
words only for initial phoneme. In the present study, an addi-
tional set of variables was taken into account (words were also
matched for rated AoA, familiarity, imageability, N-size,
bigram frequency and orthographic complexity; non-words
were also matched for N-size, bigram frequency, orthographic
complexity and initial phoneme). An experimental condition
characterized by better stimulus matching, such as the one
carried out here, may be more sensitive in capturing a rela-
tionship that runs counter to what emerged in the analyses of
the raw data. Therefore, the present results raise the inter-
esting possibility that, contrary to what has been claimed most
often in the case of English-speaking children (e.g., Rack et al.,
1992), the difference in reading non-words versus words is
actually less marked in Italian dyslexics than in skilled readers.
Fig. 2 – Group by length (a, c) and group by lexicality (b, d) interactions are presented separately for raw (RTs) and
z-transformed data: a) RTs of dyslexics and skilled readers for naming strings of letters (both words and non-words) as
a function of string length. In this and the following graphs, confidence intervals (p < .05) are reported. b) RTs of dyslexics
and skilled readers for naming words and non-words. c) Performances of dyslexics and skilled readers in naming string of
letters (words and non-words) as a function of string length. Positive values indicate better performance. d) Performances of
dyslexics and skilled readers in naming words and non-words. Positive values indicate better performance.
c o r t e x 4 6 ( 2 0 1 0 ) 1 2 7 2 – 1 2 8 3 1279
Overall, in the case of words and non-words, raw RTs indi-
cate generally larger effects in dyslexics. After controlling for
over-additivity, the length effect remained significant, indi-
cating an important role of length in modulating the reading
deficit; the lexicality effect reverted with respect to the raw data;
i.e., dyslexics had smaller lexicality effects than skilled readers.
3.5. Individual differences
One potentially interesting question concerns the presence of
individual differences regarding impairment in the ‘‘letter’’
and the ‘‘letter-string’’ factors, respectively. Kail and Salt-
house (1994) proposed that a single parameter (the slope of the
linear function) can effectively capture the individual varia-
tion in performance on a given global factor (see Eq. (3), p. 208).
Accordingly, the condition means of the skilled readers were
regressed on those of each individual dyslexic to compute the
slope for each individual dyslexic. This calculation was carried
out separately for the conditions characterising the ‘‘letter’’
factor and for those characterising the ‘‘letter-string’’ factor.
The mean slope was b¼ 2.10 (SD 1.43; range¼ .72–5.89) for
the ‘‘letter-string’’ factor and b¼ 1.22 (SD¼ .52; range¼.63–2.72) for the ‘‘letter’’ factor. The two sets of values were
not correlated (r¼ .09, n.s.).
We also correlated the individual slopes for the two factors
with the reading parameters (speed and accuracy) in the MT
test. The slope on the ‘‘letter-string’’ factor correlated highly
with reading speed (r¼�.69, p< .001): dyslexics with steeper
slopes showed slower reading times. It also correlated with
reading accuracy (r¼�.48, p< .05), with dyslexics with steeper
slopes making more errors than skilled readers. The slopes on
the ‘‘letter’’ factor did not correlate with either reading speed
(r¼ .24, n.s.) or accuracy (r¼ .21, n.s.).
The slope of a dyslexic child’s performance in reading
words and non-words captures the degree of severity of the
reading impairment (in this vein, note that slope values varied
considerably across dyslexics). The presence of a high corre-
lation between individual slopes and reading speed (and
accuracy) in a standard reading test is also consistent with
this idea. It is noteworthy that, in the case of the ‘‘letter’’
factor, the individual slopes were not related to performance
in reading (and inter-individual variation in slope values was
also much smaller). Importantly, the two sets of slopes were
entirely uncorrelated suggesting that the ‘‘letter’’ and ‘‘letter-
string’’ factors are independent.
4. Discussion
With respect to their typically developing peers, dyslexics had
slower processing times in naming single letters, syllables and
longer letter strings. These results show that Italian dyslexics
c o r t e x 4 6 ( 2 0 1 0 ) 1 2 7 2 – 1 2 8 31280
are slower in processing orthographic material even at the
single letter level.
Interestingly, performances were slower not only in letter
naming but in all tasks involving letters or bigrams. Matching
was also slower, and this holds for a variety of stimuli (letters,
pronounceable syllables, and bigrams not corresponding to
Italian syllables). Performances in these conditions rely on
different cognitive operations. Letter naming requires retrieval of
the letter name; syllable reading probes the ability to convert
graphemes into phonemes and is the closest of these tasks to
actual reading. Matching sequentially presented letters requires
the storage and retrieval of letter shapes. Finally, comparing
same-case letters can be solved visually (‘‘physical’’ match in
Posner’s terminology); however, judging the identity of letters
that vary for case requires access to abstract grapheme repre-
sentations (i.e., ‘‘name’’ matching; Posner, 1978). Yet, the main
finding of the present study was that all letter conditions
contributed to the ‘‘letter factor’’ and that no role for other
specific components in accounting for the group differences in
performance was detected. Thus, the requirements specific to
each task do not appear relevant; i.e., letter naming versus visual
matching, physical versus letter name, etc. Thus, it can be
concluded that the deficit is located at a level of processing
shared across these conditions. Visual identification of letters
seems to be the basic processing common to all these conditions.
Even though dyslexics were slow in all tasks involving
naming or matching of either letters or bigrams, the ‘‘letter’’
factor accounting for all these performances was clearly
distinguished from the ‘‘letter-string’’ factor. Importantly, this
distinction of factors cannot be a spurious phenomenon. In
fact, it cannot be ascribed to differences in the general diffi-
culty of the tasks. For both groups of children, letter recogni-
tion tasks varied considerably in terms of processing time and
yet are accounted for very accurately by a single regression
line with a slope of b¼ 1.22.
As expected, dyslexics had slower vocal RTs than skilled
readers in reading strings of letters (both words and non-
words). The data were well fitted by a single regression line
with a slope of b¼ 2.09. Thus, the mean difference with respect
to skilled readers was large in size, more than 100% (as
compared to the ca. 20% difference in the case of the letter/
bigram tasks). Based on previous research (Zoccolotti et al.,
2008) and the present evidence, a tentative interpretation of
the global factor accounting for performance in words and
non-words can be sketched. First, it is selective for ortho-
graphic material: it does not include performances in picture
naming tasks (Zoccolotti et al., 2008). Second, it refers to
pronounceable orthographic strings independent of whether
or not they represent entries in the lexicon: this indicates
a pre-lexical locus of action of the factor (Zoccolotti et al., 2008;
present work). Third, strings must be relatively ‘‘long’’ (present
study). Tasks of letter/bigram recognition do not contribute to
the same dimensional factor as words and non-words.
It should be added that, even after controlling for the global
‘‘letter-string’’ factor, length still had a significant influence on
the dyslexics’ performance. Therefore, both the nature of the
global factor, i.e., strings of four or more letters, and
the presence of the residual specific effect of length call for the
action of mechanisms closely linked to the number of elements
in the orthographic string. The exact nature of this letter-string
effect is not yet defined. As stated above, evidence indicates
a pre-lexical locus; however, it is not clear whether this effect
should be ascribed to visual or phonological defects; a selective
deficit in integrating visual and phonological codes has also
been suggested (Rusiak et al., 2007). In the Introduction, we
mentioned the possible role of crowding as a visual mechanism
specifically sensitive to stimulus length. The crowding
hypothesis predicts perceptual difficulty in dealing with a letter
string fixated in central vision when letters to be recognised are
flanked by other letters (i.e., starting from three-letter strings).
Dyslexics should have enhanced crowding (Atkinson, 1991;
Bouma and Legein, 1977; Martelli et al., 2009; O’Brien et al., 2005;
Spinelli et al., 2002) both in the fovea and in the periphery,
where portions of long-string stimuli impinge. Interestingly, the
crowding mechanism is not expected to be active (or is
minimal) when a target is presented in the absence of flankers,
as in the case of single letter (or bigram) tasks.
A main question of the study concerns the relationship
between performance in the letter–bigram tasks and the
reading deficit. Dyslexic children showed small, but reliable,
deficits in letter tasks. However, the existence of two different
regression lines for performances in tasks with single letter/
bigram and tasks with strings of letters militates against the
idea that defective letter recognition is a core part of their
reading disturbance (if this were the case, one single regres-
sion line would have fit all data points well). Further, analysis
of individual performances indicated that deficits in the two
sets of tasks were entirely uncorrelated, confirming that the
factors contributing to letter and letter-strings processing are
distinct. Overall, deficits in letter and letter-string tasks appear
to point to the derangement of independent mechanisms.
Admittedly, the origin of the letter deficit is not clear. A general
speed processing interpretation appears unlikely in view of
Bonifacci and Snowling’s (2008) results. Alternatively, since
dyslexics have less practice with orthographic materials, this
may well be sufficient to generate the group difference that
was observed. In this vein, it is well known that performances
on simple, automatized tasks change with experience (e.g.,
Pelli et al., 2006). In the visual domain, recent studies on letter
recognition have shown improvements of performance across
years of practice, reaching adult performance late in devel-
opment (e.g., Giaschi and Regan, 1997; Martelli et al., 2002).
Further research is certainly needed; however, based on the
available information, we propose the working hypothesis
that the performance of the group of dyslexics on letter–
bigram tasks is limited by practice, while performance on
longer letter strings could be limited by crowding. Some
conditions should be taken into account with respect to this
hypothesis: first, the present results refer to a transparent
orthography; further research is needed to extend them to less
regular orthographies. Second, the group of dyslexics was
relatively homogenous and no clear-cut differences in the
individual profiles of reading behaviour were apparent.
However, it is well established that there are different forms of
reading disturbance (Temple, 2006). Therefore, while the
observed pattern is presumably prevalent among Italian chil-
dren, the present results do not exclude the possibility that
specific children may have problems at the single letter level.
After a few decades of intensive empirical research, much
has been established on developmental reading deficits.
slex
icp
art
icip
an
tsin
the
MT
rea
din
gte
st(C
orn
old
ia
nd
Co
lpo
,1
99
5).
Th
efi
rst
two
row
sre
po
rtth
ere
ad
ing
tim
e(s
ec/
ing
tim
ein
crea
se(i
np
erc
en
tag
es
wit
hre
spect
toth
eco
ntr
ol
gro
up
of
the
pre
sen
tst
ud
y).
Th
efo
llo
win
gro
ws
rep
ort
the
nce
s(U
)a
cco
rdin
gto
24
cate
go
ries
(fo
ra
nin
-dep
thd
esc
rip
tio
no
fth
eca
teg
ori
es,
see
Hen
dri
ks
an
dK
olk
,1
99
7).
Mea
n(a
nd
als
ore
po
rted
.T
he
last
colu
mn
rep
ort
sth
em
ea
np
erc
en
tag
eo
ferr
ors
for
ea
chca
teg
ory
ba
sed
on
the
tota
ln
um
ber
of
go
ries
ex
cep
tco
rrect
utt
era
nce
s).
Pa
rtic
ipa
nts
Mea
n(S
D)
SC
PJ
FA
PG
LP
VF
PG
PA
SF
GF
SV
BG
DG
DI
BS
RS
PF
AA
.33
.35
.39
.59
.32
.44
.3.5
4.3
8.5
.36
.25
.51
.43
.32
.41
.3.3
6.3
9(.
09)
en
tage)
50
57
77
166
47
98
35
144
73
129
64
14
132
95
45
86
36
64
78
(42)
tion
Mea
n(S
D)
Rela
tiv
e%
of
err
or
corr
ect
U84.5
84.9
82.7
80.1
88.2
83
83
87.8
85.6
82.3
86.7
86.7
88.2
80.8
86.3
80.8
84.5
80.8
84.3
(2.7
)
ligh
tly
rdIt
ali
an
00
00
00
0.4
00
00
00
00
0.4
.04
(.1) (c
onti
nu
edon
nex
tpage
)
c o r t e x 4 6 ( 2 0 1 0 ) 1 2 7 2 – 1 2 8 3 1281
Nevertheless, most research has focused on a single or a few
experimental manipulations. The resulting large body of
evidence does not easily fit into a single coherent framework
and there is some difficulty as to which stimuli/tasks
generate the impairments that represent the core symptoms
of the disturbance. To this end, we used the approach of
varying several stimuli/task parameters to identify the
conditions that allow for systematic dimensional coherence
in comparing dyslexics’ and skilled readers’ performances.
Here, we have confirmed previous evidence (Zoccolotti et al.,
2008) that performance in reading words and non-words is
explained by a global factor (i.e., the ‘‘letter-string’’). This
accounts for the large-scale difference that distinguishes
dyslexics from skilled readers. Further, we have shown that
tasks requiring letter recognition do not probe the same
factor (even though they do generate reliable group differ-
ences). These findings are in keeping with the crucial role of
stimulus length in modulating the reading disturbance.
Therefore, we believe that the approach described here is
able to isolate the conditions that have a core relationship
with the disorder. Indeed, this may prove effective in bridging
behavioural studies on developmental dyslexia to those using
different methodologies, such as brain imaging and psycho-
physics. Recent imaging studies in reading have focussed on
the role of the fusiform gyrus in the left occipito-temporal
junction, a region often referred to as the visual word form
area (VWFA; Cohen et al., 2000, 2002). Interestingly, these
studies have shown that the VWFA is activated by the
presentation of both words and non-words while it is not
activated (or minimally activated) by the presentation of
single letters. In fact, it has been demonstrated that, different
from orthographic strings, letter processing activates areas
anterior to the VWFA (James and Gauthier, 2006; James et al.,
2005). Research on developmental dyslexics has shown that
these children have a marked underactivation of VWFA (for
a presentation of these results see Wimmer et al., 2010, this
issue). Psychophysical research in good readers has demon-
strated that reading speed is limited by the number of letters
that can be acquired within each fixation (visual span, Legge
et al., 2001). Recently, Pelli et al. (2007) proposed that the
visual span is simply the number of characters that are not
crowded (uncrowded span) and that reading rate is propor-
tional to the uncrowded span. The uncrowded span would
thus be the sole determinant of reading speed. Studies from
these different perspectives appear to converge on the critical
role of the perceptual integration processes (presumably
mediated by areas in the left occipital-temporal lobe) allow-
ing the mastery of strings of orthographic symbols. Merging
evidence from these different approaches may be the key to
the understanding of developmental reading disturbances.
Ap
pen
dix
AIn
div
idu
al
da
tao
fd
ysy
lla
ble
)a
nd
the
rea
dp
erc
en
tag
es
of
utt
era
SD
)p
erf
orm
an
ces
are
err
ors
(su
mo
fa
llca
te
Spee
d
Seco
nd
sp
er
syll
ab
le
Rea
din
gti
me
incr
ea
se(p
erc
Res
pon
seca
tego
ryan
ddes
crip
Cor
rect
utt
eran
ces
C1:
corr
ect
U;
rep
eti
tio
ns
of
C2:
mo
reo
rle
ssco
rrect
U,
s
dev
iati
ng
fro
mth
est
an
da
form
(dia
lect
al
va
ria
nt)
Acknowledgments
This study was supported by a grant from Italian Department
of Health. Cristina Burani, Despina Paizi and Pierluigi Zocco-
lotti are members of the Marie Curie Research Training
Network: ‘‘Language and Brain’’ (RTN:LAB; European
Commission, MRTN-CT-2004-512141).
Appendix A (continued)
Participants Mean (SD)
SC PJ FA PG LP VF PG PA SF GF SV BG DG DI BS R PF AA
Sounding-out behaviour
S1: with correct U 4.8 5.5 8.1 5.2 5.5 5.9 4.4 1.1 6.3 7.7 4.8 3.3 3 9.2 6.6 9. 4.4 7.7 5.7 (2.2) 36.5
S2: with stress error 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 (0) 0
S3: with phonetization error 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 (0) 0
S4: with non-word response 0 0 0 .4 0 0 .4 0 0 0 0 0 0 0 0 0 0 0 .04 (.1) .3
S5: residuals; other responses 0 0 .4 0 .4 .4 0 0 0 0 0 0 0 0 0 0 0 0 .1 (.1) .4
Word substitutions
W1: visual error 1.5 .4 .4 .7 1.1 1.5 1.1 1.1 .7 3 .4 0 .4 1.1 .7 .4 .7 .7 .9 (.7) 5.6
W2: semantic error 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 (0) 0
W3: context error 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 .4 .02 (.1) .1
W4: visual–semantic error 0 0 0 0 0 0 0 .4 .4 0 .4 0 0 0 0 0 0 0 .1 (.1) .4
W5: visual–context error 1.8 1.5 .4 1.5 .7 1.1 .4 1.8 .7 1.1 .7 .0 .7 1.1 .0 .7 1.8 .7 .9 (.6) 6
W6: function word substitution 1.5 1.8 1.1 .7 1.5 1.1 2.2 1.8 .4 1.8 1.8 4.1 1.1 .7 1.1 1. 1.1 2.6 1.5 (.8) 9.8
W7: derivational error 1.1 1.5 1.8 4.4 .7 3 3.7 3.3 1.1 1.1 .4 1.8 2.6 1.5 1.5 3. 4.1 1.1 2.1 (1.3) 13.6
W8: residual error 0 0 0 0 0 0 0 0 .4 0 0 0 0 0 0 0 0 0 .02 (.1) .1
Residual responses
R1: U has wrong assignment of stress, but
is correct otherwise
0 0 0 0 0 0 0 0 0 .4 .4 .4 .4 0 .4 .4 .4 .4 .2 (.2) 1
R2: U contains a phonetization error 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 (0) 0
R3: U is a visually related non-word 2.2 1.1 1.5 3 .4 .7 1.5 .4 2.6 2.6 3.7 1.5 3 3.7 1.8 1. 1.5 4.8 2.1 (1.2) 13.1
R4: U is a non-word that is not visually
related
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 (0) 0
R5: word omission .4 1.1 0 .4 .4 0 0 1.5 .4 0 0 1.1 .4 0 .7 1. .4 0 .4 (.5) 2.7
R6: word addition 0 0 1.8 .7 .4 0 0 0 .4 0 0 .4 .4 0 .4 .7 0 0 .3 (.5) 1.8
R7: word transposition: different order of
words
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 (0) 0
R8: ambiguous U; sounding-out behaviour
with word substitution.
0 0 0 .4 0 0 0 0 0 0 0 0 0 0 0 0 0 0 .02 (.1) .1
R9: ambiguous U 2.2 2.2 1.8 2.6 .7 3.3 3.3 .4 1.1 0 .7 .7 0 1.8 .4 .7 1.1 .4 1.3 (1.1) 8.4
co
rt
ex
46
(2
01
0)
12
72
–1
28
31
28
2
S
2
1
7
1
1
c o r t e x 4 6 ( 2 0 1 0 ) 1 2 7 2 – 1 2 8 3 1283
r e f e r e n c e s
Anderson M. Intelligence and Development: a Cognitive Theory.Oxford, UK: Blackwell, 1992.
Atkinson J. Review of human visual development: Crowdingand dyslexia. In Stein JF (Ed), Vision and Visual Dyslexia.Houndmills: MacMillan Press, 1991: 44–77.
Barca L, Burani C, and Arduino LS. Word naming times andpsycholinguistic norms for Italian nouns. Behavior ResearchMethods, Instruments & Computers, 34: 424–434, 2002. Availableat: http://www.istc.cnr.it/material/database/lexvar.shtml.
Bonifacci P and Snowling MJ. Speed of processing and readingdisability: A cross-linguistic investigation of dyslexia andborderline intellectual functioning. Cognition, 107: 999–1017, 2008.
Bouma H and Legein CHP. Foveal and parafoveal recognitionof letters and words by dyslexics and by average readers.Neuropsychologia, 15: 69–80, 1977.
Burani C, Barca L, and Ellis AW. Orthographic complexity andword naming in Italian: Some words are more transparentthan others. Psychonomic Bulletin and Review, 13: 346–352, 2006.
Cohen L, Dehaene S, Naccache L, Lehericy S, Dehaene-Lambertz G,Hena VMA, et al. The visual word form area. Spatial and temporalcharacterization of an initial stage of reading in normal subjectsand posterior split-brain patients. Brain, 123: 291–307, 2000.
Cohen L, Lehericy S, Chochon F, Lemer C, Rivaud S, and Dehaene S.Language-specific tuning of visual cortex? Functional propertiesof the visual word form area. Brain, 125: 1054–1069, 2002.
Coltheart M. Disorders of reading and their implications formodels of normal reading. Visible Language, 15: 245–286, 1981.
Coltheart M. Functional architecture of the language-processingsystem. In Coltheart M, Sartori G, and Job R (Eds), TheCognitive Neuropsychology of Language. Hove, London: Erlbaum,1987: 1–25.
Cornoldi C and Colpo G. Nuove prove di lettura MT per la scuola mediainferiore, manuale. Firenze: O.S. Organizzazioni Speciali, 1995.
Denckla MB and Rudel R. Rapid ‘‘automatized’’ naming ofpictured objects, colors, letters and numbers by normalchildren. Cortex, 10: 186–202, 1974.
Denckla MB and Rudel RG. Rapid ‘‘automatized’’ naming (R.A.N):dyslexia differentiated from other learning disabilities.Neuropsychologia, 14: 471–479, 1976.
Faust ME, Balota DA, Spieler DH, and Ferraro FR. Individualdifferences in information-processing rate and amount:Implications for group differences in response latency.Psychological Bulletin, 125: 777–799, 1999.
Friedmann N, Kerbel N, and Shvimer L. Developmentalattentional dyslexia. Cortex, 46(10): 1216–1237, 2010.
Friedmann N and Rahamim E. Developmental letter positiondyslexia. Journal of Neuropsychology, 1: 201–236, 2007.
Giaschi D and Regan D. Development of motion-defined figure-ground segregation in preschool and older children, using a letter-identification task. Optometry and Vision Science, 74: 761–767, 1997.
Hendriks AW and Kolk HJ. Strategic control in developmentaldyslexia. Cognitive Neuropsychology, 14: 321–366, 1997.
Jackson N and Coltheart M. Routes to Reading Success and Failure.Hove: Psychology Press, 2001.
James KH and Gauthier I. Letter processing automatically recruitsa sensory–motor brain network. Neuropsychologia, 44:2937–2949, 2006.
James KH, James TW, Jobard G, Wong ACN, and Gauthier I. Letterprocessing in the visual system: Different activation patternsfor single letters and strings. Cognitive, Affective and BehavioralNeuroscience, 5: 452–466, 2005.
Judica A, De Luca M, Spinelli D, and Zoccolotti P. Training ofdevelopmental surface dyslexia modifies performance andeye fixation duration in reading. NeuropsychologicalRehabilitation, 12: 177–197, 2002.
Kail R and Salthouse TA. Processing speed as a mental capacity.Acta Psychologica, 86: 199–225, 1994.
Legge GE, Mansfield JS, and Chung STL. Psychophysics of reading:XX. Linking letter recognition to reading speed in central andperipheral vision. Vision Research, 41: 725–743, 2001.
Marinus E and de Jong PF. Variability in the word-readingperformance of dyslexic readers:Effectsof letter length, phonemelength and digraph presence. Cortex 46(10): 1259–1271, 2010.
Martelli M, Baweja G, Mishra A, Chen I, Fox J, Majaj NJ, et al. Howefficiency for identifying objects improves with age. Perception,31: 111, 2002 (supplement).
MartelliM,DiFilippoG,Spinelli D,andZoccolottiP. Crowding, readingand developmental dyslexia. Journal of Vision, 9: 1–18, 2009.
O’Brien BA, Mansfield JS, and Legge GE. The effect of print size onreading speed in dyslexia. Journal of Research in Reading, 28:332–349, 2005.
Pelli DG, Burns CW, Farell B, and Moore-Page DC. Feature detectionand letter identification. Vision Research, 46: 4646–4674, 2006.
Pelli DG, Farell B, and Moore DC. The remarkable inefficiencyof word recognition. Nature, 423: 752–756, 2003.
Pelli DG, Palomares M, and Majaj NJ. Crowding is unlike ordinarymasking: Distinguishing feature integration from detection.Journal of Vision, 4: 1136–1169, 2004.
Pelli DG, Tillman KA, Freeman J, Su M, Berger TD, and Majaj NJ.Crowding and eccentricity determine reading rate. Journalof Vision, 7: 1–36, 2007.
Posner MI. Chronometric Explorations of Mind. Hillsdale, NJ:Lawrence Erlbaum Associates, 1978.
Pruneti C, Fenu A, Freschi G, Rota S, Cocci D, Marchionni M, et al.Aggiornamento della standardizzazione italiana del test delleMatrici Progressive Colorate di Raven (CPM). Bollettino diPsicologia Applicata, 217: 51–57, 1996.
Rack JP, Snowling MJ, and Olson RK. The nonword reading deficitin developmental dyslexia: A review. Reading ResearchQuarterly, 27: 29–52, 1992.
RosazzaC,Appollonio I, IsellaV,andShalliceT.Qualitativelydifferentforms of pure alexia. Cognitive Neuropsychology, 24: 393–418, 2007.
Rusiak P, Lachmann T, Jaskowski P, and van Leeuwen C. Mentalrotation of letters and shapes in developmental dyslexia.Perception, 36: 617–631, 2007.
Salthouse TA and Hedden T. Interpreting reaction time measuresin between-group comparisons. Journal of Clinical andExperimental Neuropsychology, 24: 858–872, 2002.
SartoriG, JobR,andTressoldiPE.Batteriaper lavalutazionedelladislessiae delladisortografia evolutiva. Firenze: Organizzazioni Speciali, 1995.
Spinelli D, De Luca M, Judica A, and Zoccolotti P. Crowding effectson word identification in developmental dyslexia. Cortex,38: 179–200, 2002.
Stella V and Job R. Le sillabe PD/DPSS. Una base di dati sulla frequenzasillabicadell’italianoscritto.Giornale ItalianodiPsicologia,28:633–639,2001. Available at: http://dpss.psy.unipd.it/files/strumenti.php.
Temple CM. Developmental and acquired dyslexias. Cortex,42: 898–910, 2006.
Wimmer H, Schurz M, Sturm D, Richlan F, Klackl J, Kronbichler M,et al. A dual-route perspective on poor reading in a regularorthography: An fMRI study. Cortex, 46(10): 1284–1298, 2010.
Ziegler JC, Perry C, Ma-Wyatt A, Ladner D, and Schulte-Korne G.Developmental dyslexia in different languages: Language-specific or universals. Journal of Experimental Child Psychology,86: 169–193, 2003.
Zoccolotti P, De Luca M, Di Pace E, Judica A, Orlandi M, andSpinelli D. Markers of developmental surface dyslexia ina language (Italian) with high grapheme–phonemecorrespondence. Applied Pyscholinguistics, 20: 191–216, 1999.
Zoccolotti P, De Luca M, Judica A, and Spinelli D. Isolating globaland specific factors in developmental dyslexia: A study basedon the rate and amount model (RAM). Experimental BrainResearch, 186: 551–560, 2008.