Discussion over the thesis title

Arunkumar RengarajPhd research Scholar (2014 March -)

Under the Guidance of Prof.Yun Suk Huh

Department of Biological EnginneringInha university

Teaching Experience

Since June, 2012: Working as an Assistant Professor in Dept. of Biotechnology, Prathyusha Institute of Technology and

Management, Tiruvallur, Chennai, India -602 025.Industry Experience

Aug 2011 to May 2012: Worked as an Executive in Research and Development at Tex Biosciences (Pvt.) Ltd sister

company of Hospira pharma ceuticals , Chennai.

Qualification

From 2009 to 2011 - M.Tech. (Biotechnology) @ Bannari Amman Institute of Technology affiliated to Anna University,

Coimbatore, TN, India. [First class with CGPA 8].

From 2005 to 2009 - B.Tech. (Biotechnology) @ P.S.R Engineering College affiliated to Anna University, Sivakasi, TN,

India. [First class with 75 %].

Paper Published

Papers under correction

Dendrimer~5-FU conjugate for targeting E6& E7 oncoproteins in cervical cancer: a combined experimental/ in silico approach†

Arunkumar Rengaraj,aѱ Subbiah Balaji,bѱ Giribabu Krishnamoorthy,a Yuvaraj Haldorai,c Dhanusha Yesudhas,d Nam-Soo Heo,a

Soonjo Kwon,e  Sangdun Choi,d Young-Kyu Han,c N. Hema Shenpagamb* and Yun Suk Huha*

Writing for nanoscale

Porous, 2D covalent organic framework/Fe3O4 nanocomposite for strontium ion recovery from sea water

Arunkumar Rengaraj,a ǂ Yuvaraj Haldorai,bǂ Pillaiyar Puthiaraj,c Seung Kyu Hwang,a Taegong Ryu,d Junho Shin,d Young-Kyu Han,b

Yun Suk Huha*

(MIL-125)~PEG~FA for thernostatics and anticancer drug delivery for Breast cancer

Under process

Polymethylene blue mediated heparin sesnor

Looking for CV

CVD grown graphene-Au mediated LSPR sensor

Looking for graphene

Polymer for Anticancer drug delivery

 

Cancer is one of the devastating disease to human society with the mortality rate of 8.2million peoples per year.

So there is a huge need of interdisciplinary research, hope nanotechnology is a key to cure to this diseases.

Nanomaterials are the particles which have unique property due to its nano-size and I am obsessed with its unique ability to

interact with the biological molecules without causing damage to the cellular system.

Nano-polymers are one of its kind which has so many interesting characters like less toxicity, high surface area, drug holding

property and binding with the cellular macro-moles.

These polymers (POP, dendrimers) can be synthesize using organic and inorganic monomers as binding blocks via different

chemical reactions.

In this research 20-200nm organic polymers were synthesized and characterized using FE-TEM, SEM, XPS, XRD, Zeta poten-

tial analysis, UV spectroscopic and Fluorescence spectroscopy analysis.

MTT assay was used to check the toxicity of this material and Laser confocal imaging, Bio-TEM analysis is used to localize the

nanoparticle within the cell.

These nanoparticles were loaded with the cancer drugs such as Doxorubicin and 5-Flurouracil via chemical bonding, hydropho-

bic-hydrophilic interaction. Molecular docking was used to analysis the interaction of polymer-drug conjugate with the target

protein present in the cancer cells. Hematological analysis, histochemical analysis of tissue sections were used to check the

safety of this nanoparticles over therapeutic application on cancer.

Drug delivery

Dendrimer~5-FU conjugate for targeting E6& E7 oncoproteins in cer-vical cancer: a combined experimental/ in silico approach†

(MIL-125)~PEG~FA for thernostatics and anticancer drug delivery for Breast cancer

Electrochemical sensor for the detection of Biomolecules

In this modern life, biosensors are very important tool for detection and treatment of particular disease.

Because they are cheap, stable and sensitive to particular analyst.

In my research I am having more concern over the detection of macromolecules using electrochemical sensor.

Detection of macromolecules like cholesterol and heparin are very complex because of their structure ,charge and molecular weight .

Here we are utilizing metal oxide, polymers to detect these analyst based on electrochemical reaction (oxidation or reduction) and charge interaction.

We are utilizing different type of analyt to check the selectivity of these molecules towards particular analyst.

The sensitivity of the detection is measured using chronoamperometry and DPV

The stability of the sensor was checked for wide range of cycles and duration

Biosensor

Polymethylene blue mediated heparin sensor